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Data and subject heterogeneity and data sharing:keys to translational success in spinal cord injury research?

Neural Regeneration Research 2023年第8期18卷 1730-1731页

作者： Karim Fouad olivia h.wireman John C.Gensel Faculty of Rehabilitation Medicine Department of Physical TherapyNeuroscience and Mental Health InstituteUniversity of AlbertaAlbertaCanada Spinal Cord and Brain Injury Research Center(SCoBIRC) Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA

Spinal cord injury(SCI)is a highly devastating and com plex inj u ry with many seconda ry *** a treatment for SCI has been a rollercoaster ride through exciting peaks and sobering *** a matter of fact,there are still ... 详细信息

关键词： damage treatment SCI

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Female Carriers of the Met Allele of the BDNF Val66Met Polymorphism Develop Weaker Fear Memories in a Fear-Potentiated Startle Paradigm

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Journal of Behavioral and Brain Science 2022年第5期12卷 211-235页

作者： Phillip R. Zoladz Mackenzie R. Riggenbach Jordan N. Weiser Jennifer J. hipskind Leighton E. wireman Kelsey L. hess Tessa J. Duffy Julie K. handel MacKenzie G. Kaschalk Kassidy E. Reneau Brianne E. Mosley Psychology Program The School of Health and Behavioral Sciences Ohio Northern University Ada USA

The val66met polymorphism of the bdnf gene, which is associated with compromised brain-derived neurotrophic factor (BDNF) signaling, impaired synaptic plasticity, and impaired learning, may increase one’s susceptibility to stress- and anxiety-related disorders. Indeed, previous work has reported greater anxiety-related behaviors and impairments of fear conditioning and extinction in individuals who carry the met allele that results from this polymorphism. Nevertheless, findings in this area of research have been equivocal. Thus, we examined the influence of the val66met polymorphism on fear conditioning, extinction, and extinction memory testing. One hundred and twenty healthy participants completed differential fear conditioning in a fear-potentiated startle paradigm, followed by extinction and extinction memory testing 24 and 48 hr later, respectively. Participants were genotyped for the val66met polymorphism and divided into met allele carriers and non-carriers. Results revealed that, although both met-carriers and non-carriers developed conditioned fear, met-carriers exhibited significantly weaker fear acquisition than non-carriers. This difference persisted throughout extinction and extinction memory testing and, during these last two days of testing, was primarily evident in females. These results are consistent with previous work demonstrating that this polymorphism is associated with impaired amygdala-dependent fear learning and extend such findings by demonstrating that females may be more sensitive to such effects.

关键词： Fear Conditioning Extinction Polymorphism BDNF Val66Met Startle

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