检索结果-南通市图书馆

Neutrophils in chronic inflammatory diseases

Cellular & Molecular Immunology 2022年第2期19卷 177-191页

作者： Andrea Herrero-Cervera oliver soehnlein Ellinor Kenne Institute for Experimental Pathology Center for Molecular Biology of InflammationWestfälische Wilhelms-Universität MünsterMünsterGermany Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden.

Chronic inflammation is a component of many disease conditions that affect a large group of individuals *** inflammation is characterized by persistent,low-grade inflammation and is increased in the aging *** are normally the first responders to acute inflammation and contribute to the resolution of ***,in chronic inflammation,the role of neutrophils is less well understood and has been described as either beneficial or detrimental,causing tissue damage and enhancing the immune *** evidence suggests that neutrophils are important players in several chronic diseases,such as atherosclerosis,diabetes mellitus,nonalcoholic fatty liver disease and autoimmune *** review will highlight the interaction of neutrophils with other cells in the context of chronic inflammation,the contribution of neutrophils to selected chronic inflammatory diseases,and possible future therapeutic strategies.

关键词： Chronic Inflammation Disease Neutrophil Neutrophil extracellular traps

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trilateral interaction between innervation,leukocyte,and adventitia:a new driver of atherosclerotic plaque formation

引用

Signal Transduction and Targeted Therapy 2022年第8期7卷 2670-2672页

作者： Yahya Sohrabi Holger Reinecke oliver soehnlein Department of Cardiology I—Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzechia Institute of Experimental Pathology(ExPat) Center for Molecular Biology of Inflammation(ZMBE)University Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Department of Physiology and Pharmacology(FyFa) Karolinska InstitutetStockholmSweden

A recent study by Mohanta et *** a new understanding of neuroimmune interactions in *** atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic *** continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or *** disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood *** such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.

关键词： sympathetic acute hence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

引用

Cellular & Molecular Immunology 2021年第6期18卷 1528-1544页

作者： Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster oliver soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats ModiQuest B.V. OssThe Netherlands Citryll B.V. OssThe Netherlands Department of Internal Medicine 3-Rheumatology and Immunology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital ErlangenErlangenGermany Department of Medicine Division of Rheumatology and ImmunologyMedical University of South CarolinaCharlestonSCUSA Laboratory of Molecular Hematology Democritus University of ThraceAlexandroupoliGreece Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany German Center for Cardiovascular Research(DZHK) Partner Site Munich Heart AllianceMunichGermany Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden

Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ *** or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic ***,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic *** with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and *** show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic *** citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET *** suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related ***,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of *** our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner.

关键词： Neutrophil Extracellular Traps Autoimmunity Citrullination Therapeutic Antibody NET inhibition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：