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Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission

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Neural Regeneration Research 2025年第5期20卷 1403-1404页

作者： oliver Kann Lennart Soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Interdisciplinary Center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

关键词： consequences Figure restoration

Technical Perspective:Research on General-Purpose Brain-Inspired Computing Systems

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Journal of Computer Science & Technology 2024年第1期39卷 1-3页

作者： oliver Rhodes Department of Computer Science University of ManchesterManchester M139PLU.K

Brain-inspired computing is a popular research area with the potential to advance our understanding of brain function,artificial intelligence,and next-generation computing *** referred to as"neuromorphic",these systems and algorithms hope to harness mechanisms present in brains to make step changes in perfor-mance over regular von Neumann based approaches[1].

关键词： artificial computing Brain

ON KARUSH-KUHN-TUCKER POINTS FOR A SMOOTHING METHOD IN SEMI-INFINITE OPTIMIZATION

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Journal of Computational Mathematics 2006年第6期24卷 719-732页

作者： oliver Stein Department o.f Mathematics-C RWTH Aachen University Germany

We study the smoothing method for the solution of generalized semi-infinite optimization problems from （O. Stein, G. Still： Solving semi-infinite optimization problems with interior point techniques, SIAM J. Control Optim., 42（2003）, pp. 769-788）. It is shown that Karush-Kuhn-Tucker points of the smoothed problems do not necessarily converge to a Karush-Kuhn-Tucker point of the original problem, as could be expected from results in （F. Facchinei, H. Jiang, L. Qi： A smoothing method for mathematical programs with equilibrium constraints, Math. Program., 85（1999）, pp. 107-134）. Instead, they might merely converge to a Fritz John point. We give, however, different additional assumptions which guarantee convergence to Karush-Kuhn：Tucker points.

关键词： Generalized semi-infinite optimization Stackelberg game Constraint qualifi-cation Smoothing NCP function.

Social media as passive geo-participation in transportation planning-how effective are topic modeling&sentiment analysis in comparison with citizen surveys?

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Geo-Spatial Information Science 2020年第4期23卷 275-292页

作者： oliver Lock Christopher Pettit City Futures Research Centre Faculty of Built EnvironmentUniversity of New South Wales(UNSW)SydneyAustralia Expanded Perception and Interaction Centre(Epicentre) Faculty of Art&DesignUniversity of New South Wales(UNSW)SydneyAustralia

We live in an era of rapid urbanization as many cities are experiencing an unprecedented rate of population growth and *** transport is playing an increasingly important role in urban mobility with a need to move people and goods efficiently around the *** such pressures on existing public transportation systems,this paper investigates the opportunities to use social media to more effectively engage with citizens and customers using such *** research forms a case study of the use of passively collected forms of big data in cities-focusing on Sydney,***,it examines social media data(Tweets)related to public transport ***,it joins this to longitudinal big data-delay information continuously broadcast by the network over a year,thus forming hundreds of millions of data ***,tones,and sentiment are modeled using machine learning and Natural Language Processing(NLP)*** resulting data,and models,are compared to opinions derived from a citizen survey among *** validity of such data and models versus the intentions of users,in the context of systems that monitor and improve transport performance,are *** such,key recommendations for developing Smart Cities were formed in an applied research context based on these data and techniques.

关键词： Social media smart cities public participation urban sensing transport planning natural language processing machine learning big data

Genitalia-associated microbes in insects

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Insect Science 2015年第3期22卷 325-339页

作者： oliver Otti Animal Population Ecology Animal Ecology I Bayreuth Center of Ecology and Environmental Research (BayCEER) University of Bayreuth Universitatsstrasse 30 95440 Bayreuth Germany

In sexual reproduction different types of symbiotic relationships between insects and microbes have become established. For example, some bacteria have evolved almost exclusive vertical transmission and even define the compatibility of insect mating partners. Many strictly sexually transmitted diseases have also been described in insects. Apart from such rather specific relationships the role of opportunistic infections in the reproductive process has been widely neglected. Opportunistic microbes transmitted passively during mating might impose an energetic cost, as the immune system will need to be alert and will use resources to fight potential intruders. Through mating wounds and contaminated reproductive organs opportunistic microbes might be transferred to mating partners and even enter the body cavity. Females as the ＂receiving＂ sex are particularly likely to have evolved adaptations to avoid or reduce opportunistic infections. Males of several species show highly complex seminal fluids, which as well as containing components that influence a males＇ fertilization success, also possess antimicrobial substances. The role of antimicrobials in the reproductive process is not well understood. Some evidence hints at the protection of sperm against microbes, indicating a role for natural selection in shaping the evolution of reproductive traits. By highlighting the potential importance of microbes in sexual selection and their role in reproduction in general I will make a case for studies in sexual selection, especially the ones investigating postcopulatory processes, that should incorporate environmental, as well as genotypic variation, in reproductive traits.

关键词： genital microbiome interactions sexually transmitted microbes spermmicrobe

Potential synergistic implications for stromal-targeted radiopharmaceuticals in bone-metastatic prostate cancer

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Asian Journal of Andrology 2011年第3期13卷 366-368,510页

作者： oliver Sartor Departments of Medicine and Urology Tulane Medical School New Orleans LA 70115 USA

Genetic heterogeneity and chemotherapy-resistant ＇stem cells＇ represent two of the most pressing issues in devising new strategies for the treatment of advanced prostate cancer. Though curative strategies have long been present for men with localized disease, metastatic prostate cancer is currently incurable. Though substantial improvements in outcomes are now possible through the utilization of newly approved therapies, novel combinations are clearly needed. Herein we describe potentially synergistic interactions between bone stromal-targeted radiopharmaceuticals and other therapies for treatment of bone-metastatic prostate cancer. Radiation has long been known to synergize with cytotoxic chemotherapies and recent data also suggest the possibility of synergy when combining radiation and immune-based strategies. Combination therapies will be required to substantially improve survival for men with castrate-resistant metastatic prostate cancer and we hypothesize that bone-targeted radiopharmaceuticals will play an important role in this Drocess.

关键词： bone immunotherapy metastasis prostate cancer radiopharmaceuticals radium samarium stroma strontium XL-184

Twists and turns on the way to progress in metastatic castrate-resistant prostate cancer

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Asian Journal of Andrology 2010年第6期12卷 790-792页

作者： oliver Sartor Department of Medicine and Urology Tulane University New Orleans Louisiana 70115 USA

Harnessing the body＇s immune system for the treatment of metastatic cancer has been a dream since the late 19th century [1]. Since that time progress has been intermittent and mostly disappointing. Interferon and Interleukin-2 represented steps forward but in retrospect the steps were not large and rarely are these agents used in the clinic today except as the control arm of randomized studies designed to demonstrate that a new drug is better.

关键词： Twists turns to progress metastatic castrate-resistant

Real-Time Watercolor for Animation

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Journal of Computer Science & Technology 2006年第2期21卷 159-165页

作者： Thomas Luft oliver Deussen Depurtment of Computer and Information Science University of KonstanzKonstanzGermang

We present algorithms that allow for reat-time rendering of 3D-scenes with a watercolor painting appearance,Our approach provides an appropriate simplification of the visual complexity,initates characteristic natural effects of watercolor,and provides two essential painting techniques,the wet-on-wet and the wet-on-dry *** concentrate on efficient algorithms based on image space processing rather than on an exact *** allows for the real-time rendering of *** an animation a high frame-to-frame coherence can be achieved due to a stable segmentation ***,we seamlessly integrate a smooth illumination into the watercolor renderings nsing information from the 3D-scenc.

关键词： non-photorealistic rendering watercolor painting,real-time rendering

Denosumab in bone-metastatic prostate cancer： known effects on skeletal＇related events but unknown effects on quality of life

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Asian Journal of Andrology 2011年第4期13卷 612-613页

作者： oliver Sartor Departments of Medicine and Urology Tulane University School of Medicine New Orleans LA USA

The purpose of new pharmaceuticals is to improve how patients feel, function or survive. Exceptions exist when surrogates are developed and we know that those surrogates correlate well with one of the above. Hypercholesterolemia is a well-accepted example. We know that high cholesterol is a reasonable indicator that results in increased risk of strokes and heart attacks. Thus, we treat hypercholesterolemia in hopes that our patients＇ health will improve.

关键词： Biological sciences Neuroscience