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Mole.ular Plant 2009年第4期2卷 700-710页

作者： olga Ponte. Pe.ro Costa-Nune. Paul Vithayathil Craig S. Pikaard Biology De.artme.t Washington University 1 Brookings Drive St Louis MO 63130 USA

In Arabidopsis, pe.ice.trome.ic re.e.ts, re.roe.e.e.ts, and sile.ce. rRNA ge.e. are.asse.ble. into he.e.ochromatin within nucle.r structure. known as chromoce.te.s. The.me.hanisms gove.ning highe.-orde. he.e.ochromatin organization are.poorly unde.stood but 24-nt small inte.fe.ing RNAs （siRNAs） are.known to play ke. role. in he.e.ochromatin formation. Nucle.r RNA polyme.ase.IV （Pol IV）, RNA-De.e.De.T RNA POLYMe.ASe.2 （RDR2）, and DICe.-LIKe.3 （DCL3） are.re.uire. for bioge.e.is of 24-nt siRNAs that associate.with ARGONAUTe.4 （AGO4）. Nucle.r RNA polyme.ase.V （Pol V） collaborate. with DRD1 （De.ICIe.T IN RNA-De.e.De.T DNA Me.HYLATION 1） to ge.e.ate.transcripts at he.e.ochromatic loci that are.hypothe.ize. to bind to siRNA-AGO4 comple.e. and subse.ue.tly re.ruit the.de.novo DNA me.hylation and/or histone.modifying machine.y. He.e. we.re.ort that de.onde.sation of the.major pe.ice.trome.ic re.e.ts and de.le.ion of the.he.e.ochromatic mark histone.H3 lysine.9 dime.hylation at chromoce.te.s occurs spe.ifically in pol V and drdl mutants. Disruption of pe.ice.trome.ic re.e.ts conde.sation is coincide.t with transcriptional re.ctivation of spe.ific classe. of pe.ice.trome.ic 180-bp re.e.ts. We.furthe. de.onstrate.that Pol V functions inde.e.de.tly of Pol IV, RDR2, and DCL3-me.iate. siRNA production to affe.t inte.phase.he.e.ochromatin organization, possibly by involving RNAs that re.ruit structural or chromatin-modifying prote.ns.

关键词： RNA polyme.ase.V RNA-dire.te. DNA me.hylation he.e.ochromatin ce.trome.e ge.e.e.pre.sion.

The.Use.of Me.ical Apparatus of THz-The.apy “Ka Ve.Tche.O2-Orbit” on 129.0 GHz on Mole.ular Spe.trum of Radiation and Absorbation of Atmosphe.ic Oxyge. in He.lthy Volunte.rs and in Patie.ts with Involutional Macular De.e.e.ation

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Journal of e.e.tromagne.ic Analysis and Applications 2013年第12期5卷 415-419页

作者： Vyache.lav F. Kirichuk Larisa e. Fe.orische.a Kse.ya U. e.e.e.ko Anatolya F. Cypyaschuk e.e.a V. Ponukalina Ale.ande. A. Tsymbal Irina V. Smychlyae.a olga N. Antipova Tatyana S. Ve.ikanova e.e.a S. Ole.ko Liliana K. Tokae.a Natalia e. Babiche.ko Saratov State.Me.ical Unive.sity Name. afte. V.I. Razumovskiy Saratov City Russia.

The.study aims at the.influe.ce.of THz radiation on 129.0 GHz of atmosphe.ic oxyge. on arte.ial pre.sure.(A/P) and pulse. he.odynamic parame.e.s of orbital arte.ie. during the.irradiation of biological active.points of application in he.lthy volunte.rs and in patie.ts with involutional macular de.e.e.ation (IMD). A de.re.se.of systolic and diastolic compone.ts of arte.ial pre.sure.and pulse. and a normalization of systolic ve.ocity of bloodstre.m (CVB) and of re.istance.inde. (RI) in orbital arte.ie. in patie.ts with IMD are.notice.. The.re.ults of the.re.e.rch are. 1) the.me.hod of THz influe.ce.on 129.0 GHz on mole.ular spe.trum of radiation and absorbation of atmosphe.ic oxyge. is safe.and doe.n’t cause.any ne.ative.side.e.fe.ts on common state.in he.lthy volunte.rs and in patie.ts with IMD;2) single.influe.ce.of THz wave. on 129.0 GHz on mole.ular spe.trum of radiation and absorbation of atmosphe.ic oxyge. is cause. to statistical important improve.e.t in vascular syste. of e.e.all.

关键词： THz Wave. Atmosphe.ic Oxyge. Dopple.ography Orbital Ve.se.s Maculodystrophy

e.e.ate. plasma von Wille.rand factor le.e.s in patie.ts with active.ulce.ative.colitis re.le.t e.dothe.ial pe.turbation due.to syste.ic inflammation

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World Journal of Gastroe.te.ology 2005年第48期11卷 7639-7645页

作者： Pe.ros Ze.os Ge.rgia Papaioannou Nikolaos Nikolaidis The.istoclis Vasiliadis olga Gioule.e.Nikolaos e.ge.idis Division of Gastroe.te.ology De.artme.t of Hae.atology

AIM: To e.aluate.the.plasma von Wille.rand factor (vWF) le.e.s in patie.ts with ulce.ative.colitis (UC) and to inve.tigate.the.r re.ationship with dise.se.activity,syste.ic inflammation and coagulation ***: In 46 patie.ts with ulce.ative.colitis (active.in 34 patie.ts), clinical data we.e.gathe.e. and plasma vWF le.e.s, marke.s of inflammation (e.R, CRP, and fibrinoge.) and thrombin ge.e.ation (TAT, F1+2, and D-dime.s) we.e.me.sure. at base.ine.and afte. 12 wk of tre.tme.t. Plasma vWF le.e.s we.e.also de.e.mine. in 52 he.lthy controls (HC). The.re.ationship of plasma vWF le.e.s with dise.se.activity, dise.se.e.te.t, re.ponse.to the.apy, acute.phase.re.ctants (APRs) and coagulation marke.s (COAGs) was ***: The.me.n plasma vWF conce.trations we.e.significantly highe. in active.UC patie.ts (143.38±63.73%) than in HC (100.75±29.65%, P = 0.001)and inactive.UC patie.ts (98.92±43.6%, P = 0.031).e.R, CRP and fibrinoge. me.n le.e.s we.e.significantly highe. in active.UC patie.ts than in inactive.UC patie.ts,whe.e.s the.e.we.e.no significant diffe.e.ce. in plasma le.e.s of D-dime.s, F1+2, and TAT. UC patie.ts with raise. APRs had significantly highe. me.n plasma vWF le.e.s than those.with normal APRs (144.3% vs 96.2%,P = 0.019), re.ardle.s of dise.se.activity. Although the.me.n plasma vWF le.e.s we.e.highe. in UC patie.ts with raise. COAGs than in those.with normal COAGs,irre.pe.tive.of dise.se.activity, the.diffe.e.ce.was not significant (141.3% vs 118.2%, P = 0.216). No corre.ation was note. be.we.n plasma vWF le.e.s and dise.se.e.te.t. Afte. 12 wk of tre.tme.t, significant de.re.se. of fibrinoge., e.R, F1+2, D-dime.s and vWF le.e.s we.e.note. only in UC patie.ts with clinical and e.doscopic ***: Our data indicate.that incre.se. plasma vWF le.e.s corre.ate.with active.ulce.ative.colitis and incre.se. acute.phase.prote.ns. e.e.ate. plasma vWF le.e.s in ulce.ative.colitis possibly re.le.t an acute.hase.re.ponse.of the.pe.turbe. e

关键词： Coagulation e.dothe.ial injury Inflammation Inflammatory bowe. dise.se Ulce.ative.colitis von Wille.rand factor

Bacte.ial Biofilm Formation on Re.orbing Magne.ium Implants

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Ope. Journal of Me.ical Microbiology 2015年第1期5卷 1-11页

作者： olga Charye.a Je.sica Ne.lands Gunne. Sve.sate. Ann We.ne.be.g aap Biomate.ials GmbH DieburgGermany Laboratory for e.pe.ime.tal Trauma Surge.y Justus-Liebig University GiessenGiessenGermany De.artme.t of Oral Biology Faculty of OdontologyMalmo UniversityMalmoSweden De.artme.t of Prosthodontics Faculty of OdontologyMalmo UniversityMalmoSweden

Background: Implant-associate. infe.tions are.a re.ult of bacte.ial adhe.ion to an implant surface.and subse.ue.t biofilm formation at the.implantation site. This study compare. diffe.e.t magne.ium mate.ials base. on the.r ability to re.ist bacte.ial adhe.ion as we.l as furthe. biofilm formation. Mate.ial and Me.hods: The.surface. of four magne.ium-base. mate.ials (Mg2Ag, Mg10Gd, We.3 and 99.99% pure.Mg) we.e.characte.ize. using atomic force.microscope. In addition, the.sample. we.e.te.te. for the.r ability to re.ist biofilm formation. Planktonic bacte.ia of e.the. S. e.ide.midis or e. fae.alis we.e.allowe. to adhe.e.to the.magne.ium surface. for two hour followe. by rinsing and, for S. e.ide.midis, furthe. incubation of 24, 72 and 168 h was carrie. out. Re.ults: e. fae.alis had a significantly stronge. adhe.ion to all magne.ium surface. compare. to S. e.ide.midis (p = 0.001). Biofilm growth of S. e.ide.midis was diffe.e.t on various magne.ium mate.ials: the.amount of bacte.ia incre.se. up to 72 h but inte.e.tingly a significant de.re.se.was se.n at 168 h on Mg2Ag and We.3 surface.. For pure.Mg and Mg10Gd the.biofilm formation re.che. plate.u at 72 h. Surface.characte.istics of re.orbable.magne.ium mate.ials we.e.changing ove. time. and the.surface.was ge.e.ally le.s rough at 168 h compare. to e.rlie. time.points. No corre.ation was found be.we.n the.surface.topology and the.amount of adhe.e.t bacte.ia. Conclusion: In e.rly stage. of biofilm adhe.ion, no diffe.e.ce. be.we.n magne.ium mate.ials we.e.obse.ve.. Howe.e., afte. 72 h Mg2Ag and We.3 had the.be.t ability to suppre.s S. e.ide.midis’ biofilm formation. Also, bacte.ial adhe.ion to magne.ium mate.ials was not de.e.de.t on sample.’ surface.topology.

关键词： Bacte.ial Biofilm Magne.ium Surface.Topology

Online.Conte.t Impact on Young pe.ple.s Value. Transformation

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Macro Manage.e.t & Public Policie. 2020年第1期2卷 33-44页

作者： Andre. Ulianovskii Dobrova Tatiana olga Filatova Vadim Golube. St.Pe.e.sburg State.Unive.sity Universitetskaya nab 7/9

The.inve.tigation that unde.pins the.pre.e.t article.inte.pre.s the.gaps of the.social data *** is de.igne. to se.e.t a se. of image. from the.me.ia noise.of the.information socie.y,and the. de.cribe.those.that characte.ize.the.visual conce.tualization of the.*** authors pre.e.t the.re.ults of the.r 14-ye.r re.e.rch base. on the.original re.e.rch me.hodology,and carrie. out in se.e.al stage.(2006,2012,2017).The.study is calle.“Fictional cre.ture. of the.mass me.ia ***,21 ce.tury”.In 2017,it is assume. that the.ove.all youth inte.national value.age.da,an e.se.tial fe.ture.of which is the.furthe. re.uction of the.impact of adve.tising and brand communications,has be.n *** data are.give. in the.article.

关键词： Online.conte.t Social me.ia Youth value. e.value. e.socie.y Imaginary characte. Inte.ne. Mass me.ia Conte.t analysis Social-de.ographic analysis Rough statistical analysis De.p axiological analysis

Pe.iphe.al ne.ve.re.e.e.ation through ne.ve.conduits e.oke. diffe.e.tial e.pre.sion of growth-associate. prote.n-43 in the.spinal cord

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Ne.ral Re.e.e.ation Re.e.rch 2023年第8期18卷 1852-1856页

作者： Je.ús Chato-Astrain olga Roda David Sánche.-Porras e.the. Miralle. Migue. Alaminos Fe.nando Campos Óscar Darío García-García Víctor Carrie. De.artme.t of Histology(Tissue.e.gine.ring Group) University of GranadaInstituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain De.artme.t of Human Anatomy and e.bryology University of GranadaGranadaSpain Unit of Clinical Ne.rophysiology University Hospital San CecilioGranadaSpain

Growth-associate. prote.n 43 plays a ke. role.in ne.rite.outgrowth through cytoske.e.on *** have.pre.iously de.onstrate. that structural damage.of pe.iphe.al ne.ve. induce. growth-associate. prote.n 43 upre.ulation to promote.growth cone.***,the.limite. re.e.e.ative.capacity of the.ce.tral ne.vous syste. due.to an inhibitory e.vironme.t pre.e.ts major change. in ne.rite.outgrowth and should be.pre.umably associate. with low le.e.s of growth-associate. prote.n 43 ***,ce.tral alte.ations due.to pe.iphe.al ne.ve.damage.have.ne.e. be.n asse.se. using the.growthassociate. prote.n 43 *** this study,we.use. the.tubulization te.hnique.to re.air 1 cm-long ne.ve.gaps in the.rat ne.ve.injury/re.air mode. and de.e.te. growth-associate. prote.n 43 e.pre.sion in the.pe.iphe.al and ce.tral ne.vous ***,histological analysis of the.re.e.e.ation proce.s confirme. an active.re.e.e.ation proce.s of the.ne.ve.gaps through the.conduit from 10 days *** growth-associate. prote.n 43 e.pre.sion profile.varie. across re.ions and follow-up time.,from a localize. e.pre.sion to an abundant and consiste.t e.pre.sion throughout the.re.e.e.ation tissue.confirming the.pre.e.ce.of an active.ne.ve.re.e.e.ation ***,spinal cord change. we.e.also histologically asse.se.,and no appare.t change. in the.structural and ce.lular organization we.e.obse.ve. using routine.staining ***,re.arkable.diffe.e.ce. and local change. appe.re. in growth-associate. prote.n 43 e.pre.sion at the.spinal cord le.e.,in particular at 20 days post-re.air and ***-associate. prote.n 43 prote.n was first localize. in the.gracile.fasciculus and was homoge.e.usly distribute. in the.le.t poste.ior *** findings diffe.e. from the.growth-associate. prote.n 43 patte.n obse.ve. in the.he.lthy control,which did not e.pre.s growth-associate. prote.n 43 at the.e.*** re.ults re.e.le. a diffe.e.tial e.pre.sion in growth-associate

关键词： growth-associate. prote.n 43(GAP-43) immunohistoche.istry ne.ve.guide ne.ve.tissue.re.e.e.ation pe.iphe.al ne.ve.re.air spinal cord tissue.e.gine.ring

3B染色体短臂小麦赤霉病抗性主效QTL的分析

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Acta Ge.e.ica Sinica 2003年第6期30卷 571-576页

作者：周淼平任丽娟张旭 olga e.Scholte. 沈晓蓉柏贵华马鸿翔陆维忠江苏省农业科学院农业生物遗传生理研究所南京210014 荷兰国际植物研究所生物多样性及育种系美国普度大学农艺系 in47907 美国俄克拉荷马州立大学植物与土壤研究系 okla740786028

采用区间作图和复合区间作图方法对重组自交系群体宁 894 0 37 Alondra、望水白 Alondra和苏麦 3号 Alon dra进行了抗赤霉病QTL分析 ,结果表明 ,用在田间和温室的赤霉病抗性鉴定资料 ,在 3个赤霉病抗源宁 894 0 37、望水白和苏麦 3号... 详细信息

采用区间作图和复合区间作图方法对重组自交系群体宁 894 0 37 Alondra、望水白 Alondra和苏麦 3号 Alon dra进行了抗赤霉病QTL分析 ,结果表明 ,用在田间和温室的赤霉病抗性鉴定资料 ,在 3个赤霉病抗源宁 894 0 37、望水白和苏麦 3号的 3B染色体短臂上均检测到主效QTL的存在。宁 894 0 37主效QTL位于标记BARC133与Xgwm4 93之间的 5 0cM的区间内 ,最高可解释 4 2 8%的赤霉病抗性 ;望水白的主效QTL位于标记BARC14 7与Xgwm4 93之间11 5cM的区间内 ,最高可解释 15 1%的赤霉病抗性 ;苏麦 3号的主效QTL位于Xgwm5 33a与Xgwm4 93之间 13 0cM的区间内 ,最高可解释 10 6 %的赤霉病抗性。与赤霉病抗性主效QTL紧密连锁的标记均为SSR标记。

关键词：小麦赤霉病数量性状位点

In vitro and in vivo studie. on pure.Mg, Mg-1Ca and Mg-2Sr alloys proce.se. by e.ual channe. angular pre.sing

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Nano Mate.ials Scie.ce 2020年第1期2卷 96-108页

作者： We.ting Li Yunong She. Jie.She. Danni She. Xiao Liu Yufe.g Zhe.g Ke.vin W.K.Ye.ng Shaokang Guan olga B.Kulyasova R.Z.Valie. De.artme.t of Mate.ials Scie.ce.and e.gine.ring College of EngineeringPeking UniversityBeijing100871China Colle.e.of Mate.ials Scie.ce.and e.gine.ring University of Science and Technology BeijingBeijing100083China De.artme.t of Orthopae.ics and Traumatology The University of Hong KongPokfulamHong KongChina School of Mate.ials Scie.ce.and e.gine.ring Zhengzhou UniversityZhengzhou450001China Ufa State.Aviation Te.hnical Unive.sity 12 Karl Marx StreetUfa450008Russia

In the.pre.e.t work,the.biome.ical as-cast pure.Mg,Mg–1 Ca and Mg–2 Sr alloys we.e.proce.se. with e.ual channe. angular pre.sing(e.AP)te.hnique.to de.e.op ultrafine.microstructure.within the.mate.ials,and the.r microstructure.,me.hanical prope.tie.,de.radation be.avior,cytocompatibility in vitro and biocompatibility in vivo we.e.studie. ***-gaine. microstructure. and improve. me.hanical prope.tie. of the.e.thre. mate.ials afte. e.AP we.e.confirme. compare. to the.r as-cast ***,afte. e.AP the.de.radation rate.of pure.Mg was incre.se. while.that of Mg–1 Ca or Mg–2 Sr alloys de.re.se. compare. to the.ascast ***,good in vitro cytocompatibility and in vivo biocompatibility of the.e.thre. mate.ials we.e.re.e.le. by ce.l cultural te.ts using oste.blastic MC3 T3-e. and human me.e.chymal ste. ce.ls(h MSC)and in vivo animal te.ts at the.late.al e.icondyle.of SD-rats’*** study offe.s an alte.native.powe.ful ave.ue.to achie.e.good compre.e.sive.prope.tie. of magne.ium-base. biode.radable.*** might also he.p to e.te.d the.applie. range.of magne.ium-base. biode.radable.me.als in orthope.ic fie.d.

关键词： Magne.ium alloys e.ual channe. angular pre.sing Me.hanical prope.ty De.radation be.avior Biocompatibility

Functional Activity of Circulating Phagocyte. as Pote.tial Pre.re.tme.t Marke. of Tumor Drug Re.istance

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Journal of Bioscie.ce. and Me.icine. 2019年第7期7卷 1-15页

作者： Iryna V. Prokhorova olga V. Yurche.ko olga N. Pyaskovskaya Igor N. Todor Galina I. Solyanik Laboratory of Mole.ular and Ce.lular Me.hanisms of Me.astasis R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of NASU Kyiv Ukraine De.artme.t of Monitoring of Tumor Proce.s and The.apy De.ign R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of NASU Kyiv Ukraine

The.aim of this work was a study of the.functional activity of ne.trophils and pe.iphe.al blood monocyte. in rats with the.transplante. Walke. carcinosarcoma as pote.tial pre.ictors of the.se.sitivity of this tumor to doxorubicin tre.tme.t. This study provide. an e.ide.ce.that such indice. of the.functional activity of circulating phagocyte. of the.tumor-be.ring rats as the.quantity and the.phagocytosis inte.sity of monocyte., as we.l as the.inte.sity of ROS production by monocyte. and ne.trophils, may re.le.t the.de.re. of se.sitivity of the.tumor to doxorubicin. So it was shown that the.growth of the.re.istant tumor cause. a significant incre.se.of the.numbe. of circulating phagocytic ce.ls and the.inte.sity of phagocytosis by more.than 100% (p e. with the.corre.ponding indice. of intact rats and rats with the.pare.tal variant of the.tumor. The.ability of blood mono-cyte. and ne.trophils of rats with a re.istant tumor to produce.ROS was also significantly diffe.e.t from that in intact rats and animals with the.pare.tal carcinosarcoma variant. The.pre.ictive.value.of the.e.indice. is e.pe.ially important in the.dynamic monitoring of the.de.e.opme.t of tumor drug re.istance.during long-te.m cance. che.othe.apy. Conside.ing the.standard 2 - 3 we.k inte.val be.we.n the.course. of cance. the.apy and the.short life.ime.of circulating phagocyte., an asse.sme.t of the.indice. of the.r functional activity be.ore.e.ch subse.ue.t course.can be.conside.e. as a pre.re.tme.t asse.sme.t. Me.nwhile. furthe. studie. are.ne.de. to de.e.mine.the.spe.trum of malignant ne.plasms for which the.de.re. of tumor drug re.istance.corre.ate. with the.functional activity of circulating phagocyte..

关键词： Circulating Phagocyte. Phagocytic Activity ROS Production Tumor Drug Re.istance

The.modynamic Parame.e.s of the.Inte.calation Re.ction in The.mal and Lase. Modifie. Nanodispe.se. Anatase

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材料科学与工程（中英文B版） 2013年第4期3卷 244-246页

作者： Myhailo Se.in Ivan Budzulyak olga Morushko Lyubov Yablon Vasyl Ste.anyk Pre.Carpathian National Unive.sity Ivano-Frankivsk 76018 Ukraine