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结核分枝杆菌利福平和异烟肼耐药特点分析

结核分枝杆菌利福平和异烟肼耐药特点分析

遥感方法用于调查近代活动的区域断裂所产生的红外辐射、大地热流和地球化学晕

中华医学会结核病学分会2006年学术会议

作者：申阿东焦伟伟李墨 Igor Mokrousov olga Narvskaya 孙桂芝刘佳文首都医科大学附属北京儿童医院俄罗斯圣彼得堡巴斯德研究所北京胸科医院检验科

目的研究北京地区结核分枝杆菌利福平(RIF)和异烟肼(INH)耐药特点,寻找理想的基因位点作为耐药检测分子标志:了解北京地区结核分枝杆菌的基因型分布特点;评价改进的利福平寡核苷酸探针杂交技术(RIFO杂交)在结核分枝杆菌耐药性快速检测...

目的研究北京地区结核分枝杆菌利福平(RIF)和异烟肼(INH)耐药特点,寻找理想的基因位点作为耐药检测分子标志:了解北京地区结核分枝杆菌的基因型分布特点;评价改进的利福平寡核苷酸探针杂交技术(RIFO杂交)在结核分枝杆菌耐药性快速检测中的应用价值。

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海洋地质 2013年第3期29卷 13-14页

作者： Nikolay V. VILOR Lyudmila D. ANDRULAITIS olga V. ZARUBINA 万荣胜(翻译)

搭载在NOAA和EOS卫星上的AVHRR和MODIS辐射计，可对近期活跃的区域性断裂表面发出的3．7～11μm范围的红外（IR）辐射进行测量和记录。结果显示在秋季一初冬夜间，IR辐射强度有明显反差。

关键词：红外辐射区域断裂遥感方法地球化学大地热流近代 MODIS AVHRR

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来自网络电话的召唤

商业周刊（中文版） 2005年第12期 82-83页

作者：奥尔加·卡里夫（olga Kharif）马忠元（译者）

尽管还存在一些不足，但是网络电话意味着更为低廉的价格。

关键词：网络电话消费者价格市场需求

Zinc phosphate-based nanoparticles as a novel antibacterial agent: in vivo study on rats after dietary exposure

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Journal of Animal Science and Biotechnology 2019年第2期10卷 463-474页

作者： Pavel Horky Sylvie Skalickova Lenka Urbankova Daria Baholet Silvia Kociova Zuzana Bytesnikova Eliska Kabourkova Zuzana Lackova Natalia Cernei Milica Gagic Vedran Milosavljevic Vendula Smolikova Eva Vaclavkova Pavel Nevrkla Pavel Knot olga Krystofova David Hynek Pavel Kopel Jiri Skladanka Vojtech Adam Kristyna Smerkova Department of Animal Nutrition and Forage Production Mendel University in BrnoZemedelska 1CZ-613 00 BrnoCzech Republic Department of Chemistry and Biochemistry Mendel University in BrnoZemedelska 1CZ-613 00 BrnoCzech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 123CZ-612 00 BrnoCzech Republic Institute of Animal Science Komenskeho 1239CZ-517 41 Kostelec nad OrliciCzech Republic Department of Animal Breeding Mendel University in BrnoZemedelska 1CZ-613 00 BrnoCzech Republic.

Background: Development of new nanomaterials that inhibit or kil bacteria is an important and timely research topic. For example, financial losses due to infectious diseases, such as diarrhea, are a major concern in livestock productions around the world. Antimicrobial nanoparticles(NPs) represent a promising alternative to antibiotics and may lower antibiotic use and consequently spread of antibiotic resistance traits among bacteria, including ***: Four formulations of zinc nanoparticles(Zn A, Zn B, Zn C, and Zn D) based on phosphates with spherical(Zn A, Zn B)or irregular(Zn C, Zn D) morphology were prepared. The highest in vitro inhibitory effect of our NPs was observed against Staphylococcus aureus(inhibitory concentration values, IC50, ranged from 0.5 to 1.6 mmol/L), fol owed by Escherichia coli(IC500.8–1.5 mmol/L). In contrast, methicil in resistant S. aureus(IC501.2–4.7 mmol/L) was least affected and this was similar to inhibitory patterns of commercial Zn O-based NPs and Zn O. After the successful in vitro testing, the in vivo study with rats based on dietary supplementation with zinc NPs was conducted. Four groups of rats were treated by 2,000 mg Zn/kg diet of Zn A, Zn B, Zn C, and Zn D, for comparison two groups were supplemented by 2,000 mg Zn/kg diet of Zn O-N and Zn O, and one group(control) was fed only by basal diet. The significantly higher(P < 0.05) Zn level in liver and kidney of al treated groups was found, nevertheless Zn NPs did not greatly influence antioxidant status of rats. However,the total aerobic and coliform bacterial population in rat feces significantly decreased(P < 0.05) in al zinc groups after 30 d of the treatment. Furthermore, when compared to the Zn O group, Zn A and Zn C nanoparticles reduced coliforms significantly more(P < 0.05).Conclusions: Our results demonstrate that phosphate-based zinc nanoparticles have the potential to act as antibiotic agents.

关键词： Aerobic bacteria Antibiotics Coliforms Nanomaterials Oxidative stress

Detection of Human Papillomavirus DNA and E6/E7 mRNA from HPV Genotypes 16, 18, 31 and 33 in Histologically Confirmed Cases of Cervical Cancer and Precancerous Lesions in Burkina Faso

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American Journal of Molecular Biology 2023年第4期13卷 276-290页

作者： Théodora Mahoukèdè Zohoncon Shoukrat Ohuwa Toyin Bello Prosper Bado Rogomenoma Alice Ouédraogo Estelle Ouédraogo Ina Marie Angèle Traoré Abdoul Karim Ouattara Florencia Wenkunni Djigma Albert Théophane Yonli Assita Sanou-Lamien olga Mélanie Lompo Jacques Simpore Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculté des Sciences de la Santé Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Centre Hospitalo-Universitaire Yalgado Ouedraogo Ouagadougou Burkina Faso Pathological Anatomy and Cytology Laboratory Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Introduction: Cervical cancer, caused by persistent high-risk human papillomavirus (HPV) infection, remains a global public health problem. The cellular transformation and maintenance of the malignant phenotype of these HPVs are attributed to the viral oncoproteins E6 and E7. Objective: This study aims to detect the presence of human papillomavirus DNA and E6/E7 oncoprotein mRNA of HPV genotypes 16, 18, 31 and 33 in cases of cervical cancer and precancerous lesions, histologically confirmed in Burkina Faso. Methods: This descriptive cross-sectional study focused on cases of cervical cancer and high-grade intraepithelial neoplasia (CIN) and was conducted from June to December 2022. One hundred (100) samples of fixed and paraffin-embedded tissues were collected from the pathological anatomy and cytology laboratories of hospitals in the capital of Burkina Faso. High-risk human papillomavirus (HR-HPV) DNA was detected using multiplex real-time PCR, while the presence of E6 and E7 mRNA in cervical cancer and high-grade CIN samples was determined using real-time Reverse Transcriptase-PCR (RT-PCR) with TaqMan probes. Results: The mean age of women diagnosed with cervical cancer and high-grade CIN was 50.81 ± 13.65 years, ranging from 22 to 82 years. Cervical cancer and high-grade CIN were positive for at least one high-risk human papillomavirus (HR-HPV) in 80% of cases. The most prevalent genotypes observed were HPV16, 18, 31, and 33, collectively accounting for 70.08% of cases. Of the 89 samples that tested positive for HR-HPV genotypes 16, 18, 31, and 33, 88 (98.88%;95% CI: [94.58 - 99.94]) were also positive for the presence of mRNA encoding the E6 and E7 oncoproteins of HPV16, 18, 31, and 33. Conclusion: In the presence of HPV DNA, testing for E6 and E7 oncoprotein mRNA could serve as a promising biomarker and valuable tool for improved assessment of the progression to cervical cancer.

关键词： HPV E6/E7 Cervical Cancer Precancerous Lesions Burkina Faso

基于HYDRUS-1D的秸秆覆盖条件下黑土区玉米田土壤水盐运移规律

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干旱地区农业研究 2023年第5期41卷 43-50页

作者：刘继龙吕航曹晓强李济桢张玲玲奥列格东北农业大学水利与土木工程学院黑龙江哈尔滨150030 农业农村部农业水资源高效利用重点实验室黑龙江哈尔滨150030 东北农业大学文理学院黑龙江哈尔滨150030

为揭示不同秸秆覆盖量对黑土区玉米田农田土壤水盐运移的影响机制,基于田间试验结果,利用HYDRUS-1D模型对秸秆覆盖下农田土壤水盐运移过程进行模拟,分析不同秸秆覆盖量对土壤水盐动态的影响规律。结果表明:秸秆覆盖可以增强土壤保水性... 详细信息

为揭示不同秸秆覆盖量对黑土区玉米田农田土壤水盐运移的影响机制,基于田间试验结果,利用HYDRUS-1D模型对秸秆覆盖下农田土壤水盐运移过程进行模拟,分析不同秸秆覆盖量对土壤水盐动态的影响规律。结果表明:秸秆覆盖可以增强土壤保水性、抑制土壤盐分积累,随秸秆覆盖量增加,秸秆覆盖对土壤水盐运移的作用效果更加明显,在玉米全生育期内秸秆半量覆盖及全量覆盖较裸地40 cm耕层内各土层平均含水率分别提高3.38%~5.78%和5.26%~9.62%、平均电导率分别降低4.61%~8.93%和8.87%~12.41%。基于HYDRUS-1D模型模拟结果可知,土壤含水率模拟值与实测值的决定系数介于0.903~0.940,标准误差介于0.010~0.014 cm^(3)·cm^(-3),平均相对误差介于3.46%~4.64%;土壤电导率模拟值与实测值的决定系数介于0.817~0.853,标准误差介于0.091~0.111 mS·cm^(-1),平均相对误差介于4.06%~5.46%。误差分析表明HYDRUS-1D模型模拟精度较高,能够用于模拟研究区秸秆覆盖条件下农田土壤水盐运移过程。

关键词：秸秆覆盖玉米田土壤水盐运移 HYDRUS-1D模型黑土区

Rural social-ecological systems navigating institutional transitions: case study from Transylvania (Romania)

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Ecosystem Health and Sustainability 2016年第2期2卷 25-37页

作者： Tibor Hartel Kinga-olga Réti Cristina Craioveanu Róbert Gallé Răzvan Popa Alina Ioniţă LászlóDemeter LászlóRákosy Bálint Czúcz Department of Environmental Sciences and Arts Sapientia Hungarian University of TransylvaniaStr.Calea Turzii 4Cluj-NapocaRomania Faculty of Environmental Science and Engineering RO-400294Fântânele street 30Babes-Bolyai UniversityCluj-NapocaRomania Department for Taxonomy and Ecology Str.Clinicilor 5-7400006Faculty of BiologyBabes-Bolyai UniversityCluj-NapocaRomania Department of Ecology Faculty of ScienceUniversity of SzegedH-6726 Szeged Közép fasor 52SzegedHungary Foundation ADEPT Str.Principala nr.166SaschizRomania Propark-Fundația pentru Arii Protejate BrasovStrada Lungă175500051Romania Misgurnus Association 530204 Miercurea-Ciucstr.Ion Caianu nr.67Romania MTA Centre for Ecological Research Institute of Ecology and BotanyAlkotmány u.2-42163VácrátótHungary

Traditional rural social-ecological systems(SES)share many features which are crucial for sus-tainable *** European countries such as Romania,are still rich in traditional cultural ***,these landscapes are increasingly under internal(e.g.,people’s aspirations toward western socioeconomic ideals)and external(institutional changes,globalization of the commodity market,connectivity with other cultures)***,understanding the ways how traditional SES navi-gated past and more recent changes is of crucial importance in getting insights about the future trajectory of these ***,we present the rural SES from the Saxon region of Transylvania through the lens of institutional transitions which happened in the past century in this *** show that the rural SES went through episodic collapses and renewals,their cyclic dynamic being related to the episodic chang-es of the higher level formal *** episodic collapses and renewals created a social-ecolog-ical momentum for the sustainability of these *** we recognize that policy effectiveness depends on institutional stability(and institutions are unstable and prone to collapses),maintaining those social-ecological system properties which can assure navigation of societies through the challenges imposed by global changes should be in the heart of every governance *** properties includes wide extent of native vegetation,fertile soils,wide range of provisioning ecosystem services,genuine links between people and landscapes and knowledge about the social-ecological *** features could provide important capitals and memory elements for the(re)emergence of social-ecological systems(old or new).

关键词： adaptive cycles collapse and renewal resilience social-ecological feedback social-ecological memory Special Feature:Ecosystem Management in Transition in Central and Eastern Europe sustainability.

Problems of Rational Therapy for Epilepsy during Pregnancy

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Open Journal of Obstetrics and Gynecology 2014年第9期4卷 506-515页

作者： Diana V. Dmitrenko Natalia A. Shnayder Ilia A. Kiselev Andrej V. Shulmin Natalia V. Zhirova Evgeniya A. Shapovalova Elena A. Kantimirova Elena N. Bochanova olga F. Veselova Yulia S. Panina Anastasiya V. Muravieva Neurological Center of Epileptology Neurogenetics and Brain Research University Clinic of Voyno-Yasenetsky Krasnoyarsk State Medical University Krasnoyarsk Russia

Epilepsy is one of the most frequent neurological disorders. In these circumstances, more than 25% of the patients are women of reproductive age. The aim of our research was to analyze the effectiveness and safety of antiepileptic therapy in women with epilepsy during pregnancy and to analyze the pregnancies’ outcomes. We included in our research 121 pregnancies of 101 women aged at the moment of childbearing about 26.9 ± 4.57 years old. Idiopathic forms of epilepsy were predominant among all causes—47.1% (р < 0.01). Of all cases, 65.4% remained seizure-free from generalized tonic-clonic seizures (GTCS), including 69.6% of all idiopathic epilepsy cases and 68.6% among symptomatic ones. The antiepileptic drugs (AED) dosages were exceeding teratogenic level at the moment of conception in 54.7% of the cases. Worse control of epileptic seizures was associated with Benzobarbital (66.7%) and Lamotrigine (50.0%). Women with epilepsy did not receive specialized neurological therapy before conception in most cases, which leaded to the usage of AED teratogenic doses and less effectiveness of AED during pregnancy. It is necessary to plan the pregnancy and prescribe rational treatment for epilepsy starting at the stage of planning and during gestation in order to obtain a better seizures control and to decrease congenital disorders risk in fetus.

关键词： Epilepsy Women Pregnancy Anticonvulsants Rational Therapy Outcomes

原发性灼口综合征:文献综述和可能与疼痛调节有关的初步发现

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中国口腔医学继续教育杂志 2019年第6期22卷 368-375页

作者： Cibele Nasri-Heri Diana Shigdar Deyaaeddin.Alnaas olga Anna Korczeniewska Rotem Eliav Gary M.Heir 赵伟威(译) 韩莹(审) 不详北京大学口腔医院北京市海淀区100081

原发性灼口综合征(primary burning mouth syndrome,BMS)是一种慢性灼伤性疼痛,影响舌头和口腔黏膜。目前,还没有明确的诊断标准;因此,诊断是通过排除潜在的局部和系统的可以导致烧灼感的原因。原发性BMS的病因尚不清楚;然而,原发性BMS... 详细信息

原发性灼口综合征(primary burning mouth syndrome,BMS)是一种慢性灼伤性疼痛,影响舌头和口腔黏膜。目前,还没有明确的诊断标准;因此,诊断是通过排除潜在的局部和系统的可以导致烧灼感的原因。原发性BMS的病因尚不清楚;然而,原发性BMS与神经性疼痛相关是最易被接受的理论。本文综述了BMS的诊断、机制和治疗,重点介绍了BMS与疼痛模型的关系。初步数据表明,原发性BMS和一个错误的抑制疼痛系统之间存在联系。

关键词：灼口综合征疼痛模型诊断标准神经性疼痛口腔黏膜初步数据文献综述 BMS