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Mexican Guidelines for the Diagnosis and Treatment of Chronic My.loid Leukaemia

Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Rosa Sosa Ramón Rivas Carlos Best Juan Hernández Adrián Morales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguay. José Espinoza Juan Labardini Luis Valero Judith Cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas My.na Candelaria Francisco Torres Juan Kassack Oscar de Jesús pérez Ramírez Jorge Aquino Guillermo Díaz Mariela Cardiel Margarita Rodríguez patricia Montoy. Juan Contreras María Chávez Sandra Chávez David Gómez olga Cantú Jorge Duque Luis pita Eduardo Lobato Julio López Antonio López pedro González Jorge Cortés Haematology.and Oncology.Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology.Deparment from Hospital Juárez Mexico City Mexico Haematology.Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology.Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology.Department Cancerology National Institute (INCan) Mexico City Mexico Haematology.Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology.Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology.Department General Hospital of Sonora State Sonora Mexico Haematology.Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias Clinic at ISSEMy. Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los Mochis General Hospital Sinaloa Mexico Renaissance Clinic Morelia Mexico State Council for AIDS prevention and Control Chihuahua Mexico Universidad Autónoma de y.catán Mérida Mexico

Background: This document includes recommendations and guidelines issued by.a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic My.loid Leukaemia (CML) by.initiative of Instituto Nacional de Cancerología and with the support of the Leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality.on the diagnosis and treatment of CML and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELpHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country.will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： Chronic My.loid Leukaemia Management Guidelines Diagnosis Treatment.

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Global wood anatomical perspective on the onset of the Late Antique Little Ice Age (LALIA) in the mid-6th century.CE

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Science Bulletin 2022年第22期67卷 2336-2344页

作者： Ulf Büntgen Alan Crivellaro Dominique Arseneault Mike Baillie David Barclay.Mauro Bernabei Jarno Bontadi Gretel Boswijk David Brown Duncan A.Christie olga V.Churakova Edward R.Cook Rosanne D’Arrigo Nicole Davi Jan Esper patrick Fonti Ciara Greaves Rashit M.Hantemirov Malcolm K.Hughes Alexander V.Kirdy.nov paul J.Krusic Carlos Le Quesne Fredrik C.Ljungqvist Michael Mc.Cormick Vladimir S.My.lan Kurt Nicolussi Clive Oppenheimer Jonathan palmer Chun Qin Frederick Reinig Matthew Salzer Markus Stoffel Max Torbenson Mirek Trnka Ricardo Villalba Nick Wiesenberg Greg Wiles Bao y.ng Alma piermattei Department of Geography University of CambridgeCambridge CB23ENUK Swiss Federal Research Institute(WSL) Birmensdorf 8903Switzerland Global Change Research Centre(CzechGlobe) Brno 60300Czech Republic Department of Geography Faculty of ScienceMasaryk UniversityBrno 61300Czech Republic Forest Biometrics Laboratory Faculty of Forestry“Stefan cel Mare”University of SuceavaSuceava 720229Romania Department of Biology Chemistry and GeographyUniversity of Quebec in RimouskiRimouski Qc.G5L 3A1Canada Archaeology.palaeoecology School of Natural and Built EnvironmentQueen’s University BelfastBelfast BT71NNUK Department of Geology State University of New York at CortlandCortland NY 13045USA CNR-IBE Institute of BioEconomyNational Research CouncilTrento 38121Italy School of Environment The University of AucklandAuckland 1010New Zealand Laboratorio de Dendrocronología y.Cambio Global Universidad Austral de ChileValdivia 509000Chile Center for Climate and Resilience Research(CR) Santiago 8370449Chile Cape Horn International Center(CHIC) Punta Arenas 6200000Chile Institute of Ecology.and Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Tree-Ring Laboratory Lamont-Doherty Earth ObservatoryColumbia UniversityPalisades NY 10964USA Department of Environmental Science William Paterson UniversityWayne NJ 07470USA Department of Geography Johannes Gutenberg UniversityMainz 55099Germany Institute of plant and Animal Ecology Ural BranchRussian Academy of SciencesYekaterinburg 620144Russia Ural Institute of Humanities Ural Federal UniversityYekaterinburg 620002Russia Laboratory.of Tree-Ring Research University of ArizonaTucson AZ 85721USA Sukachev Institute of Forest SB RAS Krasnoyarsk 660036Russia Department of phy.ical Geography Bolin Centre for Climate ResearchStockholm UniversityStockholm 10691Sweden Department of History Stockholm UniversityStockholm 10691Sweden Bolin Centre for Climate Research Stockholm UniversityStockholm 10691Sweden Swedish Collegium for Advanced Study

Linked to major volcanic eruptions around 536 and 540 CE, the onset of the Late Antique Little Ice Age has been described as the coldest period of the past two millennia. The exact timing and spatial extent of this exceptional cold phase are, however, still under debate because of the limited resolution and geographical distribution of the available proxy.archives. Here, we use 106 wood anatomical thin sections from 23forest sites and 20 tree species in both hemispheres to search for cell-level fingerprints of ephemeral summer cooling between 530 and 550 CE. After cross-dating and double-staining, we identified 89Blue Rings(lack of cell wall lignification), nine Frost Rings(cell deformation and collapse), and 93Light Rings(reduced cell wall thickening) in the Northern Hemisphere. Our network reveals evidence for the strongest temperature depression between mid-July.and early.August 536 CE across North America and Eurasia, whereas more localised cold spells occurred in the summers of 532, 540–43, and548 CE. The lack of anatomical signatures in the austral trees suggests limited incursion of stratospheric volcanic aerosol into the Southern Hemisphere extra-tropics, that any.forcing was mitigated by.atmosphere-ocean dy.amical responses and/or concentrated outside the growing season, or a combination of factors. Our findings demonstrate the advantage of wood anatomical investigations over traditional dendrochronological measurements, provide a benchmark for Earth sy.tem models, support cross-disciplinary.studies into the entanglements of climate and history. and question the relevance of global climate averages.

关键词： Blue Rings Climate extremes Dendrochronology Late Antiquity Tree rings Volcanic eruptions

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降低哈德逊混输管道段塞影响的模拟研究和现场测试

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国外油田工程 2001年第8期17卷 64-67页

作者： Z G XU p GAy.ON 韩方勇大庆油田设计院

对哈德逊混输管道由段塞引起停输的模拟研究和现场测试 ,研究段塞对管输的影响规律和降低段塞影响的方法。其目的有两个 :一是验证模拟工具能否准确地预测段塞特性 ;二是为设计降低段塞影响的方法提供基础数据。模拟工具为瞬态多相流模... 详细信息

对哈德逊混输管道由段塞引起停输的模拟研究和现场测试 ,研究段塞对管输的影响规律和降低段塞影响的方法。其目的有两个 :一是验证模拟工具能否准确地预测段塞特性 ;二是为设计降低段塞影响的方法提供基础数据。模拟工具为瞬态多相流模拟器olga。现场测试和模拟结果表明 :段塞不是由立管引起的 ,而是由于管道操作条件处于水力段塞流的范围内引起的 ;由olga计算出的段塞分布同测试结果非常一致 ;还可以通过改进液位控制的方法来消除段塞引起的停输 ,这一点在其后的生产中得到验证。

关键词：管道输送多相流油气水段塞流模型现场测试 Hudson油田混输管道

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A pILOT STUDy.OF ACUpUNCTURE IN TREATING BORTEZOMIB-INDUCED pERIpHERAL NEUROpATHy.IN MULTIpLE My.LOMA pATIENTS

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Journal of Integrative Medicine 2014年第3期 301-301页

作者： Ting Bao olga Goloubeva Colleen pelser Neil porter porter James primrose Lisa Hester Hester Mariola Sadowska Rena Lapidus Michelle Medeiros Lixing Lao Susan Dorsey.Ashraf Badros The University.of Mary.and School of Medicine Marlene and Stewart Greenebaum Cancer Center The University.of Mary.and School of Medicine Department of Neurology The University.of Mary.and School of Medicine School of Chinese Medicine the University.of Hong Kong The University.of Mary.and School of Nursing

Background: peripheral neuropathy.is the dose-limiting toxicity.of bortezomib in multiple my.loma(MM) ***: To examine the safety. feasibility.and efficacy.of acu-puncture in reducing bortezomib-induced peripheral neuropathy.BIpN) ***: MM patients experiencing persistent BIpN ≥ grade 2 despite adequate medical intervention and discontinuation of bortezomib received 10 acupuncture treatments for 10 weeks(2/week for 2 weeks, 1/week for 4 weeks, and then biweekly.for 4 weeks).Responses were assessed by.the Clinical Total Neuropathy.Score(TNSc), the Functional Assessment of Cancer Therapy.Gy.ecologic Oncology.Group-Neurotoxicity.FACT/GOG-Ntx) questionnaire and the Neuropathy.pain Scale(NpS).TNSc was evaluated by.a trained research nurse who used both subjective and objective *** measures analy.is of variance was used to test for monotonic decline in scores on each of the *** serum levels of pro-inflammatory.and neurotrophic cy.okines were obtained at baseline and weeks 1, 2, 4, 8, and ***: Twenty.seven MM patients were enrolled in the *** were no adverse events associated with the acupuncture *** weeks 10 and 14, TNSc, FACT/GOG-Ntx and NpS all showed significant reduction which suggested decreased pain, improved function and improved objective neuropathy.measurement(p-values were 0.02 and 0.03 for TNSc at weeks 10 and 14, respectively. ppS at weeks 10 and 14).However, nerve conduction studies did not significantly.change from baseline assessment to the end of *** was no correlation in serum cy.okines for responder versus none ***: Acupuncture is safe, feasible and produces subjective and objective improvements in patients’ sy.ptoms.A follow-up randomized controlled trial is warranted.

关键词： A pILOT STUDy.OF ACUpUNCTURE IN TREATING BORTEZOMIB-INDUCED pERIpHERAL NEUROpATHy.IN MULTIpLE My.LOMA pATIENTS NpS

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Common surgical complications in degenerative spinal surgery

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World Journal of Orthopedics 2013年第2期4卷 62-66页

作者： Michael papadakis Lianou Aggeliki Elias C papadopoulos Federico p Girardi Resident in Orthopedic Surgery University of Athens School of Medicine 10676 Athens Greece Resident in Radiology St. Olga Hospital 10676 Athens Greece Spine Service School of Medicine University of Athens 10676 Athens Greece Attending Spine Service Hospital for Special Surgery New York NY 10021 United States

The rapid growth of spine degenerative surgery.has led to unrelenting efforts to define and prevent possible complications, the incidence of which is probably.higher than that reported and varies according to the region of the spine involved(cervical and thoracolumbar) and the severity.of the surgery. Several issues are becoming progressively.clearer, such as complication rates in primary.versus revision spinal surgery. complications in the elderly. the contribution of minimally.invasive surgery.to the reduction of complication rate. In this paper the most common surgical complications in degenerative spinal surgery.are outlined and discussed.

关键词： Spine surgery Complication Failed back surgery Instability Disc herniation

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