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A pilot study of the relative number of circulating tumor cells and leukocytes containing actin-binding proteins in head and neck cancer patients

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The Journal of Biomedical Research 2023年第3期37卷 213-224页

作者： Gelena Kakurina Marina Stakheeva Elena Sereda Evgenia Sidenko olga cheremisina Evgeny Choinzonov Irina Kondakova Cancer Research Institute Tomsk National Research Medical CenterRussian Academy of SciencesTomsk 634009Russia Department of Biochemistry and Molecular Biology Faculty of Medicine and BiologySiberian State Medical UniversityTomsk 634050Russia.

Circulating tumor cells(CTCs)play an important role in tumor metastases,which is positively correlated with an increased risk of ***-binding proteins,including cofilin(CFL1),profilin 1(PFN1),and adenylate cyclase-associated protein 1(CAP1),are thought to be involved in tumor cell motility and metastasis,specifically in head and neck squamous cell carcinoma(HNSCC).However,currently,there are no published studies on CFL1,PFN1,and CAP1 in CTCs and leukocytes in HNSCC *** assessed serum levels of CFL1,PFN1,and CAP1 and the number of CTCs and leukocytes containing these proteins in blood from 31 HNSCC patients(T1-4N0-2M0).The analysis used flow cytometry and an enzyme-linked immunosorbent assay *** found that CAP1+CTCs and CAP1+leukocyte subpopulations were prevalent in these HNSCC patient samples,while the prevalence rates of CFL1+and PFN1+CTCs were relatively *** with stage T2-4N1-2M0 had CFL1+and PFN1+CTCs with an elevated PFN1 serum level,compared with the T1-3N0M0 *** summary,the PFN1 serum level and the relative number of PFN1+CD326+CTCs could be valuable prognostic markers for HNSCC *** current study is the first to obtain data regarding the contents of actin-binding proteins(ABPs)in CTCs,and leukocytes in blood from HNSCC *** is also the first to assess the relationship between the number of CTCs subgroups and disease characteristics.

关键词： head and neck squamous cell carcinoma metastasis circulating tumor cells actin-binding proteins adenylyl cyclase-associated protein 1

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