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C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

Nano Research 2017年第2期10卷 652-671页

作者： Svitlana Prylutska Rostyslav Panchuk Grzegorz Golunski Larysa Skivka Yuriy Prylutskyy Vasyl Hurmach Nadya Skorohyd Agnieszka Borowik Anna Woziwodzka Jacek Piosik olena Kyzyma Vasil Garamus Leonid Bulavin Maxim Evstigneev Anatoly Buchelnikov Rostyslav Stoika Walter Berger Uwe Ritter Peter Scharff Taras Shevchenko National University of Kyiv 64 Volodymyrska Str. 01601 Kyiv Ukraine Institute of Cell Biology NAS of Ukraine 14-16 Drahomanov 5tr. 79005 Lviv Ukraine Laboratory of Biophysics Intercollegiate Faculty ofBiotechnology UG-MUG Abrahama 58 80-307 Gdansk Poland Joint Institute for Nuclear Research 6 Joliot-Curie Str. 141980 Dubna Moscow reg. Russia Helmholtz-Zentrum Geesthacht: Centre for Materials and Coastal Research 1 Max-Planck Str. 21502 Geesthacht Germany Belgorod State University 85 Pobedy Str. 308015 Belgorod Russia Institute of Cancer Research and Comprehensive Cancer Center Medical University Vienna 1090 8A Borschkegasse Vienna Austria Institute of Chemistry and Biotechnology Technical University ofllmenau 25 Weimarer Str. 98693 Ilmenau Germany

We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin （Cis） with C60 fullerene （C60＋Cis complex） and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone. The highest toxicity of the complex was observed in HL-60/adr and HL-60/vinc chemotherapy- resistant human leukemia cell sublines （resistant to Adriamycin and Vinculin, respectively）. We discovered that the action of the C60＋Cis complex is associated with overcoming the drug resistance of the tumor cell lines through observing an increased number of apoptotic cells in the Annexin V/PI assay. Moreover, in vivo assays with Lewis lung carcinoma （LLC） C57BL/6J male mice showed that the C60＋Cis complex increases tumor growth inhibition, when compared to Cis or C60 fullerenes alone. Simultaneously, we conducted a molecular docking study and performed an Ames test. Molecular docking specifies the capability of a C60 fullerene to form van der Waals interactions with potential binding sites on P-glycoprotein （P-gp）, multidrug resistance protein 1 （MRP-1）, and multidrug resistance protein 2 （MRP-2） molecules. The observed phenomenon revealed a possible mechanism to bypass tumor cell drug resistance by the C60＋Cis complex. Additionally, the results of the Ames test show that the formation of such a complex diminishes the Cis mutagenic activity and may reduce the probability of secondary neoplasm formation. In conclusion, the C60＋Cis complex effectively induced tumor cell death in vitro and inhibited tumor growth in vivo, overcoming drug resistance likely by the potential of the C60 fullerene to interact with P-gp, MRP-1, and MRP-2 molecules. Thus, the C60＋Cis complex might be a potential novel chemotherapy modification.

关键词： molecular docking,small-angle X-ray scattering,apoptosis,mutagenic activity lung carcinoma (LLC),cytotoxicity

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Cortical Arousal Strategies in Left-Handers during the Aural Perception and Manual Playback of Mono-and Polyphonic Rhythmical Patterns

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Journal of Life Sciences 2012年第12期6卷 1408-1413页

作者： Pavlovych olga Sergiyivna Morenko Alevtyna Grigorivna Kotyk olena Adamivna Vlasjuk Svitlana Sergiyivna Lesia Ukrainka Volyn National University Lutsk *** Ukraine

The actual purpose of this study is to establish the cortical arousal strategies （according to the power of the EEG （electroencephalogram） a-oscillations） during the aural perception as well as manual playback of mono- and polyphonic rhythmical patterns in men with left profile. The study involved 35 men from 19 to 21 years old with the left profile of the manual and aural asymmetries. EEG was recorded in the functional status of rest： during the aural perception and playback of mono- and polyphonic rhythmical patterns with the left and right hand fingers. The monophony in the rhythmical pattern sounding relative to monophonic patterns is followed by more expressed and widespread cortical processes of the EEG a-oscillation depression. Given patterns indicate a greater intensity of ascending nonspecific arousal strategies of data processing by men on conditions of the sound and harmonious complications of the pattern structure. The aural perception and playback of rhythmical patterns with both hands were accompanied by the increased significance of arousal processes in the right hemisphere. This may be due to the dominant role of the hemisphere during the formation of the innervation impacts on the left-hander＇s neuro-motor apparatus. More differentiated changes in the cerebral cortex were installed during the left hand activation.

关键词： Left-handers mono- and polyphonic sounding alpha rhythm rhythmic sense.

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基于卷积神经网络的联合彩色图像和超分辨率的深度图

基于卷积神经网络的联合彩色图像和超分辨率的深度图

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作者：阿廖娜（PIDBEREZNA olena）哈尔滨工业大学

学位级别：硕士

提高图像分辨率是当前数字图像处理领域的研究热点之一。超分辨率(SR)方法是一组信号处理算法,它允许从同一场景的单个或多个低分辨率(LR)图像生成高分辨率(HR)图像。不久前,深度神经网络(DNN)被引入到计算机视觉、机器翻译、自然语言... 详细信息

提高图像分辨率是当前数字图像处理领域的研究热点之一。超分辨率(SR)方法是一组信号处理算法,它允许从同一场景的单个或多个低分辨率(LR)图像生成高分辨率(HR)图像。不久前,深度神经网络(DNN)被引入到计算机视觉、机器翻译、自然语言处理、语音和音频识别、社会网络分析、生物信息学、医学图像分析和材料检验等领域。卷积神经网络(CNN)也被广泛应用于彩色图像和深度图的超分辨率问题,在相同场景的额外HR或LR彩色图像的引导下,可以从LR深度图中恢复高分辨率的深度图。本文提出了一种通过联合LR深度图和相应的LR强度图像重建HR深度图的算法。为解决图像超分辨率问题,提出了一种多尺度上采样的联合双分支网络(JDBNet)概念。该方法可以显著提高恢复的HR深度图像的质量。网络又细分为两个独立的网络—JDBNet1和JDBNet2。JDBNet1和JDBNet2的主要区别在于,JDBNet2有两个均方误差损失函数作为强度Y分支的最后一个输出层和深度映射D分支的最后一个输出层。这进而使得JDBNet2的性能优于JDBNet1。同一场景的低分辨率强度图像和低分辨率深度图是训练网络的输入数据。系统输出数据为高分辨率深度图。这些网络分别训练为2×,4×,8×和16×的上标因子。我们用均方根误差(RMSE)对所表示方法的性能进行了评价,实验表明,提出的网络比其他作者提出的深度图像超分辨率方法具有更好的性能。

关键词：超分辨率深度图彩色图像卷积神经网络多尺度上采样

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ontogenetic Approach to the Study of Mechanisms of Copper-Induced Liver Fibrosis

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Advances in Aging Research 2017年第3期6卷 39-54页

作者： Anatoliy I. Bozhkov olena M. Klimova Yuriy V. Nikitchenko Natalia I. Kurguzova olena S. Linkevych Katherine M. Lebid olena S. Protsenko Natalya A. Remneva Ali M. M. Al-Bahadly Mohammad A. Y. Al-Begai Research Institute of Biology of V.N. Karazin Kharkov National University Kharkov Ukraine SI “Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine” Kharkov Ukraine Medical Department of V.N. Karazin Kharkov National University Kharkov Ukraine

on the model of Cu-induced liver fibrosis, the relationship between the activity of prooxidant-antioxidant system, immune system parameters, liver morphology and several physiological parameters (body temperature and performance ability of the animals, taking into account their ages) was investigated. Classical biochemical, immunological, histological and physiological methods of investigation were used. The subjects of the study were male Wistar rats of 3-month (young) and 20-month (old) age. For the induction of liver fibrosis, experimental animals were successively injected with copper sulfate (three times at intervals of 24 hours at a dose corresponding to 33% of the lethal one). It was shown that after five days of sulfate copper administration inflammatory reactions in the liver, damage of the vessel epithelium, an increase in collagen content, and other morphological changes were detected. At this time, the content of lipid hydroperoxides in the liver and blood serum was increased, the activity of a number of antioxidant enzymes was reduced, and the activity of aconitase was two times less compared to values in the control group. These changes correlated with a decrease in the amount and activity of phagocytic cells in the blood of experimental animals. Inhibition of the general metabolism was accompanied by a decrease in body temperature, loss of body weight and performance ability. The relationship between a specific metabolic pattern in animals with Cu-induced fibrosis was age-dependent. The formed specific adaptive metabolic pattern is unstable, and in the future it can be realized in one of three possible adaptive strategies, the choice of which is influenced by age.

关键词： Lipid Hydroperoxides Glutathione Peroxidase Aconitase Liver Fibrosis ontogenesis

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Intra-urban variation in tuberculosis and community socioeconomic deprivation in Lisbon metropolitan area:a Bayesian approach

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Infectious Diseases of Poverty 2022年第2期11卷 92-92页

作者： olena oliveira Ana Isabel Ribeiro Raquel Duarte Margarida Correia‑Neves Teresa Rito Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of Minho4710‑057 BragaPortugal 不详

Background:Multidrug resistant tuberculosis(MDR-TB)is a recognized threat to global eforts to TB control and remains a priority of the National Tuberculosis ***,social determinants and socioeconomic dep‑rivation have since long been associated with worse health and perceived as important risk factors for *** study aimed to analyze the spatial distribution of non-MDR-TB and MDR-TB across parishes of the Lisbon metropolitan area of Portugal and to estimate the association between non-MDR-TB and MDR-TB and socioeconomic ***:In this study,we used hierarchical Bayesian spatial models to analyze the spatial distribution of notifcation of non-MDR-TB and MDR-TB cases for the period from 2000 to 2016 across 127 parishes of the seven municipalities of the Lisbon metropolitan area(Almada,Amadora,Lisboa,Loures,odivelas,oeiras,Sintra),using the Portuguese TB Surveillance System(SVIG-TB).In order to characterise the populations,we used the European Deprivation Index for Portugal(EDI-PT)as an indicator of poverty and estimated the association between non-MDR-TB and MDR-TB and socioeconomic ***:The notifcation rates per 10,000 population of non-MDR TB ranged from 18.95 to 217.49 notifcations and that of MDR TB ranged from 0.83 to *** identifed 54 high-risk areas for non-MDR-TB and 13 high-risk areas for *** in the third[relative risk(RR)=1.281,95% credible interval(CrI):1.021-1.606],fourth(RR=1.786,95%CrI:1.420-2.241)and ffth(RR=1.935,95%CrI:1.536-2.438)quintile of socioeconomic deprivation presented higher non-MDR-TB notifcations *** in the fourth(RR=2.246,95%CrI:1.374-3.684)and ffth(RR=1.828,95%CrI:1.049-3.155)quintile of socioeconomic deprivation also presented higher MDR-TB notifcations ***:We demonstrated signifcant heterogeneity in the spatial distribution of both non-MDR-TB and MDRTB at the parish level and we found that socioeconomically disadvantaged parishes are disproportionall

关键词： Tuberculosis Multidrug-resistant tuberculosis Bayesian Spatial analysis Socioeconomic deprivation

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Essential variables for air quality estimation

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International Journal of Digital Earth 2020年第2期13卷 278-298页

作者： Andrii Shelestov Andrii Kolotii Tatiana Borisova olena Turos Gennadi Milinevsky Igor Gomilko Tatyana Bulanay oleg Fedorov Leonid Shumilo Liudmyla Pidgorodetska Liudmyla Kolos Arsenii Borysov Natalia Pozdnyakova Alexander Chunikhin Marina Dudarenko Arina Petrosian Vassyl Danylevsky Natalia Miatselskayak Vasyl Choliy Department of Information Security National Technical University“Igor Sikorsky Kyiv Polytechnic Institute”KyivUkraine Department of Information Technologies Space Research Institute NASU-SSAUKyivUkraine Department of Neurochemistry Palladin Institute of BiochemistryNational Academy of Sciences of UkraineKyivUkraine Laboratory of Air Quality Marzeiev Institute for Public HealthNational Academy of Medical Science of UkraineKyivUkraine Department of Astronomy and Space Physics Taras Shevchenko National University of KyivKyivUkraine Department for Atmospheric optics and Instrumentation Main Astronomical Observatory of National Academy of Science of UkraineKyivUkraine Dnipro Noosphere Engineering School DniproUkraine Department of Microgravity Sciences Space Research Institute NASU-SSAUKyivUkraine Department of Remote Sensing Methods and Advanced Instrumentation Space Research Institute NASU-SSAUKyivUkraine Astronomical observatory Taras Shevchenko National University of KyivKyivUkraine Physical optics Laboratory Stepanov Institute of Physics of the NAS of BelarusMinskBelarus

Within this survey we describe the conceptual architecture of the infrastructure to measure PM2.5/PM10 concentration in the atmosphere over the Kyiv city using modern monitoring *** define the requirements for information tools and network for informing Kyiv city community on the state of PM pollutions that will be *** infrastructure will provide long-term PM2.5/PM10 observations that could be included in the AirBase *** comprehensive review of in-situ and satellite measurements of PM2.5/PM10 is provided as well as the description current state-of-the-art for Air Quality monitoring with intelligent sensors and systems in Ukraine as-awhole and in Kyiv in *** is proposed to apply the concept of essential variables(EVs)used in Earth observation to identify the variables that should be measured in priority when designing,deploying and maintaining observation *** this study we use and validate the global air quality products from Copernicus Atmosphere Monitoring Service obtained from modeling by GEoS-Chem model and other *** influence of PM and aerosols on a human health is estimated in terms of possible diseases and dangerous concentrations.

关键词： Essential variable sustainable development goal air quality remote sensing

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Impact of In^(3+) cations on structure and electromagnetic state of M-type hexaferrites

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Journal of Energy Chemistry 2022年第6期31卷 667-676,I0018页

作者： Vitalii Alexandrovich Turchenko Sergei Valentnovich Trukhanov Vladmir Grigor'evich Kostishin Francua Damay Florance Porcher Denis Sergeevich Klygach Maxim Grigor'evich Vakhitov Lyudmila Yur'evna Matzui olena Sergeevna Yakovenko Bernat Bozzo Ignasi Fina Munirah Abdullah Almessiere Yassine Slimani Abdulhadi Baykal Di Zhou Alex Valentinovich Trukhanov Joint Institute for Nuclear Research 6 Joliot-Curie Str.Dubna 141980Russia South Ural State University 76Lenin Av.Chelyabinsk 454080Russia Donetsk Institute of Physics and Technology named after o.o.Galkin of the NASU 46 Nauki Av.Kiev 03680Ukraine SSPA“Scientific and Practical Materials Research Centre of NAS of Belarus” 19 P.Brovki str.Minsk 220072Belarus National University of Science and Technology“MISiS” Leninsky av.4Moscow 119049Russia Laboratoire Leon Brillouin UMR12 CEA-CNRSB̂at.563 CEA SaclayGif sur YvetteCedex 91191France Ural Federal University named after the First President of Russia B.N.Yeltsin Yekaterinburg 620002Russia Taras Shevchenko National University of Kyiv Volodymyrs’ka str.64/13Kyiv 01601Ukraine Institut de Ciencia de Materials de Barcelona-CSIC Campus de la UABBellaterraBarcelona 08193Spain Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Department of Nanomedicine Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi'an 710049ShannxiChina Department of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia

The solid solutions of In^(3+) doped M-type strontium hexaferrites were produced using a conventional solid-state reaction method,and Rietveld analysis of the neutron diffraction patterns was ***^(3+) cations occupy octahedral (4f_(Ⅵ)and 12 k) and tetrahedral (4f_(Ⅳ)) positions (SG=P6_(3)/mmc(No.194)).The average particle size is 837–650 *** tempearature (T_(C)) of the compounds monotonically decreased down to~520 K with increasing x.A frustrated magnetic state was detected from ZFC and FC *** magnetization (M_(s)) and effective magnetocrystalline anisotropy coefficient (k_(eff)) were determined using the law of approach to saturation.A real permittivity (ε″) maximum of~3.3 at~45.5 GHz and an imaginary permittivity (ε′) of~1.6 at~42.3 GHz were observed for x=0.1.A real permeability (μ′) maximum of~1.5 at~36.2 GHz was observed for x=0.Aμ″imaginary permeability maximum of~0.8 at~38.3 GHz was observed for x=*** interpretation of the results is based on the type of dielectric polarization and the natural ferromagnetic resonance features.

关键词： Doped strontium hexaferrites Neutron powder diffraction Magnetic properties Permittivity Permeability

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乌克兰对中国投资吸引力相关问题研究

乌克兰对中国投资吸引力相关问题研究

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作者：奥列娜（olena BALABAS）哈尔滨工业大学

学位级别：硕士

目前,国家经济发展的重要因素之一是投资资金的可用性。乌克兰具有相当大的投资潜力,充足的自然资源,人力资源,工业和农业潜力以及优越的地理条件,这些条件吸引外国投资者来乌克兰投资,即中国投资者。乌克兰吸引中国投资者投资的另一个... 详细信息

目前,国家经济发展的重要因素之一是投资资金的可用性。乌克兰具有相当大的投资潜力,充足的自然资源,人力资源,工业和农业潜力以及优越的地理条件,这些条件吸引外国投资者来乌克兰投资,即中国投资者。乌克兰吸引中国投资者投资的另一个重要因素是,乌克兰——中国战略性友好合作关系的建立。中国与1991年12月27日承认乌克兰独立,是第一个承认乌克兰独立的国家,乌克兰——中国双边合作关系包括290多份法律文件。在2011年6月20日,乌克兰和中国成立乌克兰和中国之间的战略合作伙伴联合声明。乌克兰主动参与中国的“一带一路”和《TRACECA》。乌克兰位于欧盟的边境,这样的条件使得基礎投资机会和高技术的人力资本(乌克兰识字率高达99.7%)。乌克兰地理位置距离欧盟较近,但是较欧盟相比,生产成本较低,同时更接近主要市场,是位于欧洲和亚洲的交界处的制造和贸易中心。其信息技术业、农业、航空航天业、教育和自然资源都具有较大的吸引力。乌克兰的欧洲一体化进程:最近两年,乌克兰的政治正在向欧洲一体化发展,这促进了乌克兰的政治改革,也对乌克兰和欧盟于2014年6月27日签订的欧盟——乌克兰联合协定(AA)框架产生了积极的作用。与此同时,2016年4月,IMF的世界经济展望数据库的宏观指标表明乌克兰的经济在2016年至2021年将取得重要的发展。但是,尽管投资乌克兰有诸多优点,不可否认的是,投资仍然存在风险,包括政治风险、经济风险和社会风险。通过Charles ***、*** ***和***提出的方法计算乌克兰政治风险强度,包括政治(政治制度类型、权力的分离程度、政府的问责制、政府腐败情况、法律传统与一般整体重量)、经济(经济的自由化程度、参与多边投资担保机构的积极性、经济对社会发展的促进作用、金属的储存量、宏观经济政策等)、社会(识字率、基尼系数、中期教育情况、全球人类发展评分、平均预期寿命水平等),很容易得到一个结论,上述提到的指标数量的41%决定了政治风险强度(Cr)的由低到高。根据***和***两位教授在《Methodic ways of investment attractiveness valuation of states for foreign companies》一文中的方法的计算公式数据来源于2015年失败国家指数,选取指标DP(人口压力)、GR(集团不满)、CR(國家合法性)、HR(人权和法治)、EL(派别精英)、SEC(安全机构数量)、INT(外部干預)。根据公式计算可得乌克兰的?指标0.0143266476。较俄罗斯和白俄罗斯低,但是高于美国、英国和芬兰。在投资前,分析乌克兰的相关法规是非常重要的,对于立法的不稳定行、税收制度的缺陷、银行系统的不可靠性、对于投资者的知识产权等方面法律保护制度的不健全等问题,都是需要投资者预先分析了解的。现如今,国家权利、国家义务以及投资者的概念都在发展。因此,在投资领域,如何平衡自由化和固定的法律法规成为目前较难解决的问题之一。协调国际国内投资政策和其他领域(如政治、经济、社会、法律等)政策是非常重要的。在世界经济全球化条件下,国家的发展水平取决于如何的状态有效地利用国际市场,特别是资本市场。对于外国投资对乌克兰的影响,既有学者认为影响是积极的,也有学者认为影响是消极的。研究结果的不同是不仅由于研究的复杂性,也因为研究尚不充足,因为要涉及政治、经济、社会、法律等诸多方面。因此,形成并且实现政治、经济、社会和法律部门等领域规范化是改善投资环境的关键因素。这是可以确定法规的下一个方法:在政治领域(建立有效运作的乌克兰和中国的非政府组织,将会使乌克兰和中国合作达到一个新高度),建立乌克兰——中国商业间的高层次对话,以满足政治领导人参与峰会的需求,专门建立乌克兰——中国政府间的委员会,为优先发展两国之间的合作提出建议。2015年3月28日由中国商务部、国务院批准,中国发改委、外交部颁布《推动共建丝绸之路经济带和21世纪海上丝绸之路的愿景与行动》,在政治、经济、文化、生态、IT等多领域推动了乌克兰——中国在《一带一路》中的合作,在反腐效果、司法体制和政治管理等多方面,中国和乌克兰交换了经验和思想政策,特别是,通过《一带一路》的带动以及双方合作项目的开展(在经济领域。外国投资的结构分布流的平衡,通过技术水平的提高增加了外国投资者的参与度,同时也提高了部分外国投资在乌克兰经济和生产领域的地位。增加外国投资在乌克兰长期投资的项目数量可以促进乌克兰的劳动生产率和就业率。改善国际投资头寸及其比例,简化非乌克兰居民财产登记程序,改善国内基础设施,优化交通系统,深化国际运输系统的发展,改善乌克兰税收制度存在的问题。特别是,鉴于过去几年

关键词： Ukraine China investments investment relations investment attractiveness risks ways of solution

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Fetal stem cells are effective in the treatment of Grade Ⅰ and Ⅱrespiratory failure in amyotrophic lateral sclerosis and muscular dystrophy

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Translational Neuroscience and Clinics 2015年第1期1卷 10-16页

作者： Nataliia.S..Sych olena.V..Ivankova Mariya.o..Klunnyk Iryna.G..Matiyashchuk Andrey.A..Sinelnyk Mariya.P..Demchyk Maryna.V..Skalozyb Dario.Siniscalco Department of Clinical Cell Therapy Center Em Cell Department of Skalozyb‐Biotechnology Cell Therapy Center Em Cell Department of Experimental Medicine Second University of Naples via S.Maria di Costantinopoli 16

objectives: To study the effect of fetal stem cell(FSC) therapy on Grade Ⅰ and Ⅱrespiratory failure in patients with amyotrophic lateral sclerosis(ALS) and muscular dystrophy(MD). Methods: A comparative study was conducted on 41 patients with Grade Ⅰ or Ⅱrespiratory failure(RF) resulting from ALS or MD. The patients were divided into 4 groups according to the underlying disease and the degree of RF. Patients underwent combined treatment, including the experimental application of FSC therapy, and were examined before FSC treatment, and 6 months and 12 months after treatment. Results: FSC treatment improved both subjective and objective breathing parameters as early as 6 months post‐treatment. A significant increase in the forced vital capacity(FVC) and forced expiratory volume in 1 second(FEV1) was reported by all patients with grade Ⅰ RF linked to ALS and MD compared to baseline. Patient respiratory improvement was maintained over the next 6 months. Grade Ⅱ RF patients with MD reported a significant improvement in FVC 12 months after treatment. Conclusions: Evidence for respiratory improvement was observed as early as 6 months in all patients after combined treatment including FSC therapy, and this was maintained for a further 6 months after therapy. In MD patients with Grade Ⅱ RF, treatment resulted in a significant FVC and FEV1 increase within 6 months and downgrading to Grade Ⅰ RF within a year after FSC treatment.

关键词： respiratory failure amyotrophic lateral sclerosis muscular dystrophy fetal stem cells forced vital capacity forced expiratory volume

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Protective Effect of Ubiquinone and Precursors of ItsSynthesis on Mitochondrial Respiratory Chain andActivity of Matrix Metalloproteinases in Animal Tissuesunder Effect of Doxorubicin

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Journal of Pharmacy and Pharmacology 2015年第3期3卷 116-127页

作者： Anatoliy Burlaka olena Kuchmenko Dmytro Petukhov Iryna Ganusevych Sergiy Lukin Evgeniya Lukyanchuk Evgen Sydoryk Georgiy Donchenko Department of Microenvironment of Tumor Cells Kavetsky Institute of Experimental Pathology Oncology and Radiobiology ofthe National Academy of Sciences of Ukraine Kyiv 03022 Ukraine Laboratory of Molecular Biochemistry Department of Fundamental Research National Scientific Centre "Strazhesko Institute ofCardiology" of the National Academy of Medical Sciences of Ukraine Kyiv 03680 Ukraine Laboratory of Cell Signaling Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine Kyiv 01601Ukraine Department of Vitamin and Coenzyme Biochemistry PaUadin Institute of Biochemistry of the National Academy of Sciences ofUkraine Kyiv 01601 Ukraine

Mitochondrial dysfunction, oxidative stress, and their regulation are important fields of study in modem clinical *** CoQ is an efficient therapeutic agent, yet its application has leads to continued suppression of endogenous CoQ synthesis,which limits CoQ applicability. our aim was to study the state of mitochondrial electron transport chain components, CoQ contentand redox state, superoxide anion radicals and No production rates, and active MMP-2 and MMP-9 content in rat liver and heartunder treatment with Doxorubicin, CoQ10, and complex preparation of modulators and precursors of CoQ biosynthesis （EPMcomplex）. The results demonstrate that treatment with EPM complex and CoQ10 in addition to Doxorubicin administration exertsprotective effect on liver and heart mitochondria, evidenced by restoration of electron transport in respiratory chain, which isexpressed as decreased nitrile complexes formation with Fe-S-proteins and increased ubisemiquinone content. The protective effectsof EPM complex on mitochondrial electron transport chain under Doxorubicin administration is on par with those of CoQ10, anddecreased MMP2 and MMP9 activities signify lessened extracellular matrix destruction. These results demonstrate the viability ofapproaches to correct adverse effects of Doxorubicin by treatment with CoQ10 and e complex of precursors and modulators of itsbiosynthesis.

关键词： Ubiquinone, mitochondrion, matrix metalloproteinases, doxorubicin.

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