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Single intravenous injection of CoQ10reduces infarct size in a rat model of ischemia and reperfusion injury

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World Journal of Cardiovascular Diseases 2013年第5期3卷 1-7页

作者： Alexander Ivanov Evgenia Gorodetskaya Elena Kalenikova oleg Medvedev Department of Pharmacology Faculty of Basic Medicine M.V. Lomonosov Moscow State University Moscow Russia Department of Pharmacology Faculty of Basic Medicine M.V. Lomonosov Moscow State University Moscow Russia Russian Cardiology Research and Production Complex Moscow Russia Department of Pharmacology Faculty of Basic Medicine M.V. Lomonosov Moscow State University Moscow Russia Russian Cardiology Research and Production Complex Moscow Russia

Maintenance of mitochondrial activity and antioxidant features of coenzyme Q10 (CoQ10) could be an effective background for treatment of acute myocardial ischemia. Dietary uptake of CoQ10 is limited to only a few percent. In urgent cases, parenteral administration of CoQ10 could provide fast increase of its plasma and myocardial levels. The aim was to evaluate whether a single intravenous (i.v.) injection of solubilized CoQ10 before ischemia/reperfusion (IR) could lead to replenishment of its myocardial levels and limits subsequent myocardial IR injury. Methods: 30 min prior to coronary artery occlusion rats received i.v. solubilized CoQ10 (30 mg/kg) or saline (1 ml/kg). After 30 min of ischemia and 120 min of reperfusion, infarct zone of left ventricle (Lv) and quantity of CoQ10 in Lv were determined. Cardiac rhythm was monitored through the whole experiment. Results: At the beginning of reperfusion, arrhythmias were recorded in 8 (from 9) in saline and 2 (from 9) in CoQ10-treated rats. Arrhythmias in CoQ10-treated rats arose later (40 ± 8 sec) and had less duration (26 ± 14 sec);14 ± 13 sec and 52 ± 17 sec in saline treated rats respectively. At the end of reperfusion CoQ10 treated rats revealed: 2 fold higher CoQ10 content in Lv (p 10 were accompanied by less infarct size (r = ﹣0.77, p i.v. injection of CoQ10 effectively increased its myocardial levels and protected heart against IR injury by diminishing the size of the irreversibly damaged myocardium, decreasing frequency and duration of arrhythmias. The infarct zone inversely correlated with the quantity of CoQ10 in Lv.

关键词： Coenzyme Q10 Intravenous Injection Myocardial Ischemia Reperfusion Injury

Current Methods of Human and Animal Brucellosis Diagnostics

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Advances in Infectious Diseases 2013年第3期3卷 177-184页

作者： Ekaterina A. Smirnova Andrey v. vasin Nurlan T. Sandybaev Sergey A. Klotchenko Marina A. Plotnikova Olga v. Chervyakova Abylai R. Sansyzbay oleg I. Kiselev Laboratory of Structural and Functional Proteomics Research Institute of Influenza of the Ministry of Health of the Russian Federation St. Petersburg Russia

Brucellosis is an urgent infectious disease of livestock and wild animals and the commonest human zoonosis. Diagnosis of brucellosis is rather complicated and it has to be obligatorily confirmed by laboratory testing. Direct bacteriological and molecular methods and indirect serological tests are used for brucellosis diagnostics. The choice of the diagnostic tools depends on the overall epidemiological situation in the region and the objectives of the study: validation of the diagnosis, screening (monitoring), cross-sectional studies or confirmation of brucellosis-free status of the region. The review describes current bacteriological, serological and molecular methods, routinely used for the diagnosis of brucellosis in humans and animals. The perspectives of brucellosis diagnostics are also discussed.

关键词： Brucellosis Diagnostics Bacteriology Polymerase Chain Reaction Serology

Morphometric variability of Arctodiaptomus salinus （Copepoda） in the Mediterranean-Black Sea region

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Zoological Research 2015年第6期36卷 328-336页

作者： Elena v.ANUFRIIEvA Nickolai v.SHADRIN The AO Kovalevsky Institute of Marine Biological Research Russian Academy of Sciences

Inter-species variability in morphological traits creates a need to know the range of variability of characteristics in the species for taxonomic and ecological tasks. Copepoda Arctodiaptomus salinus, which inhabits water bodies across Eurasia and North Africa, plays a dominant role in plankton of different water bodies-from fresh to hypersaline. This work assesses the intra- and inter-population morphometric variability of A. sa/inus in the Mediterranean-Black Sea region and discusses some observed regularities. The variability of linear body parameters and proportions was studied. The impacts of salinity, temperature, and population density on morphological characteristics and their variability can manifest themselves in different ways at the intra- and inter-population levels. A significant effect of salinity, pH and temperature on the body proportions was not found. Their intra-population variability is dependent on temperature and salinity. Sexual dimorphism of A. salinus manifests in different linear parameters, proportions, and their variability. There were no effects of temperature, pH and salinity on the female/male parameter ratio. There were significant differences in the body proportions of males and females in different populations. The influence of temperature, salinity, and population density can be attributed to 80%-90% of intra-population variability of A. salinus. However, these factors can explain less than 40% of inter-population differences. Significant differences in the body proportions of males and females from different populations may suggest that some local populations ofA. salinus in the Mediterranean-Black Sea region are in the initial stages of differentiation.

关键词： Crustacea Differentiation Morphology Sex differences Environmental factors

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Improving sintering kinetics and compositional homogeneity of 625 superalloy open-cell foams made by suspension impregnation method

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Transactions of Nonferrous Metals Society of China 2021年

作者： oleg Smorygo vitali Mikutski Anastasia vazhnova viachaslau Hancharou Serguei Tikhov Janagam vinod Kumar Amol Anant Gokhale O.v.Roman Powder Metallurgy Institute Boreskov Institute of Catalysis， Siberian Branch， Russian Academy of Sciences Defence Metallurgical Research Laboratory Indian Institute of Technology Bombay

Open-cell IN 625 superalloy foams were prepared by suspension impregnation method which involves replication of pure nickel foam ligaments with a mixed powder suspension and subsequent heat treatments. The objective of the present study is to find a suitable method ensuring complete densification of the superalloy foam ligaments without using low-melting additives and achieving uniform chemical composition at moderate sintering temperatures. Forms prepared using the above methodology were evaluated for the microstructure and compositional variation across the foam ligaments by Scanning Electron Microscopy （SEM） coupled with Electron Dispersive Spectroscopy （EDS）. Quasi-static compressive properties of the foams were evaluated. It is shown that if elemental powders of Cr， Mo and Ni are used as additives to the superalloy powder suspension， high ligament density with uniform chemical composition conforming to the IN 625 specification are achieved at moderate sintering temperatures. These results are attributed to the formation of low melting eutectics and to acceleration of the diffusion kinetics due to the non-equilibrium thermodynamic conditions created by large compositional gradients in the presence of elemental powders.

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Improving sintering kinetics and compositional homogeneity of Inconel 625 superalloy open-cell foams made by suspension impregnation method

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Transactions of Nonferrous Metals Society of China 2021年第8期31卷 2388-2401页

作者： oleg SMORYGO vitali MIKUTSKI Anastasia vAZHNOvA viachaslau HANCHAROU Serguei TIKHOv vinod Kumar JANAGAM Amol Anant GOKHALE O.v Roman Powder Metallurgy Institute 41Platonov str.Minsk 220005Belarus Boreskov Institute of Catalysis Siberian BranchRussian Academy of Sciences5pr.LavrentievaNovosibirsk 630090Russia Defence Metallurgical Research Laboratory KanchanbaghHyderabad 500058India Indian Institute of Technology Bombay PowaiMumbai 400076India

Open-cell Inconel 625 superalloy foams were prepared by suspension impregnation method which involves replication of pure nickel foam ligaments with a mixed powder suspension and subsequent heat *** objective of the present study is to find a suitable method ensuring complete densification of the superalloy foam ligaments without using low-melting additives and achieving uniform chemical composition at moderate sintering *** prepared using the above methodology were evaluated for the microstructure and compositional variation across the foam ligaments by scanning electron microscopy(SEM)coupled with electron dispersive spectroscopy(EDS).Quasi-static compressive properties of the foams were *** is shown that if elemental powders of Cr,Mo and Ni are used as additives to the superalloy powder suspension,high ligament density with uniform chemical composition conforming to the Inconel 625 specification is achieved at moderate sintering *** results are attributed to the formation of low melting eutectics and to acceleration of the diffusion kinetics due to the non-equilibrium thermodynamic conditions created by large compositional gradients in the presence of elemental powders.

关键词： superalloy foam suspension replication sintering diffusion microstructure

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Possibility for Recognition of Psychic Brain Activity with Continuous Wavelet Analysis of EEG

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Journal of Behavioral and Brain Science 2019年第3期9卷 67-77页

作者： Evgeny A. Yumatov Alexandr E. Hramov vadim v. Grubov oleg S. Glazachev Elena N. Dudnik Nikolay A. Karatygin P.K. Anokhin Research Institute of Normal Physiology Moscow Russia Yuri Gagarin State Technical University of Saratov Saratov Russia First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) Moscow Russia

The brain is a unique organization in nature, possessing the ability for psychic activity, which manifests itself in thoughts, feelings and emotions. In present days, numbers of mathematical methods for analysis of electroencephalogram (EEG) were developed with continuous wavelet transform being one of the most successive approaches for studying of brain activity. This paper is aimed to develop methods for investigation of psychic brain activity with help of continuous wavelet analysis of EEG. Ability of human to realize semantic content of the image presented on the screen was tested. Experiment was accompanied with simultaneous EEG recording, which was held with developed software and PC-based experimental setup. The information capabilities of continuous wavelet transform-based method for EEG analysis were improved for the recognition of specific patterns in human brain activity. Comparative wavelet analysis was carried out for EEG recordings at the moment of awareness of the semantic content of the image and for EEG recordings in the absence of conscious (subjective) perception of the semantic content of the image. Significant differences were shown in the alpha rhythm of EEG for the moments of awareness of the semantic content of the image and for the moments of absence of conscious perception. Continuous wavelet analysis of EEG showed that the alpha rhythm is the main EEG rhythm, which can be used to estimate the presence of subjective perception of the visual image. Significant differences were shown in the alpha rhythm of EEG for the moments of awareness of the semantic content of the image and for the moments of absence of conscious perception. Conducted studies allow to conclude that revealing of brain activity related to visual image awareness is possible through analysis of EEG.

关键词： Brain Psychic Consciousness Electroencephalogram Continuous Wavelet Analysis

Modelling One-Pot Method for Synthesis of 2,3-Dihydro-1H-pyrrolo[2,1-c][1,4]benzothiazine 5,5-Dioxides and Their Homologues

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International Journal of Organic Chemistry 2013年第2期3卷 125-135页

作者： Oleksandr Yu Grevtsov oleg v. Zaremba Anna B. Bondarenko Oleksandr G. Drushlyak Sergiy M. Kovalenko valentyn P. Chernykh National University of Pharmacy Kharkiv Ukraine

A facile method for synthesis of 2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzothiazines by interaction of methylenactive (2-fluorophenyl)sulfones with homologues of either 5-methoxy-3,4-dihydro-2H-pyrrole or 5-(methylthio)-... 详细信息

关键词： Sulfones Lactims Cyclization Heterocycles Nucleophilic Aromatic Substitution

A Comparative Study on Pharmacokinetics of Tricin, a Flavone from Gramineous Plants with Antiviral Activity

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Journal of Biosciences and Medicines 2021年第2期9卷 76-91页

作者： Galina I. Solyanik oleg S. Zulphigarov Iryna v. Prokhorova Olga N. Pyaskovskaya Denis L. Kolesnik viktor P. Atamanyuk Laboratory of Molecular and Cellular Mechanisms of Metastasis R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology of NASU Kyiv Ukraine SMC Ecopharm Ltd. Kyiv Ukraine

Tricin (and tricin containing plant extracts) has been shown to exert a pronounced antiviral activity, high radical scavenging activity and is favored for its safety profile. In the present study we have analyzed the pharmacokinetics of tricin after a single intravenous and oral administration to Wistar rats of an ethanol extract of Calamagrostis Adans and Deschampsia Beauv plants (test agent) at different doses. Tricin concentrations in blood plasma and blood cells were measured at different time points. Two-compartment (for intravenous injection) and one compartment (for oral administration) models were used for the analysis of tricin pharmacokinetics. The results showed that the pharmacokinetics of tricin after intravenous injection of test agent has a pronounced biphasic character, is well described by a two-compartment pharmacokinetic model, and is characterized by non-linear dose-dependence. The pharmacokinetics of tricin administered orally is characterized by a high rate of absorption from the gastrointestinal tract into the blood and rather slow elimination, which leads to a large volume of distribution in the body and a fairly high bioavailability. The obtained results indicate the advantages of the oral route of administration over the intravenous route.

关键词： Polyphenolic Compounds Tricin Pharmacokinetics Bioavailability

2020 Roadmap on gas-involved photo-and electro-catalysis

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Chinese Chemical Letters 2019年第12期30卷 2089-2109页

作者： Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev oleg v.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew v.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma School of Physics and Electronics Hunan UniversityChangsha 410082China College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332United States College of Engineering and Applied Sciences and School of Energy ResourcesUniversity of WyomingLaramieWY 82071United States Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNSW 2522Australia Laboratory of Advanced Materials Department of ChemistryFudan UniversityShanghai 200438China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China Institute of Chemistry St.Petersburg State University7/9 Universitetskaya emb.St.Petersburg 199034Russian Federation Department of Chemical Engineering University of PatrasPatras 26500Greece School of Environmental Science and Engineering Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation TechnologySun Yat-sen UniversityGuangzhou 510275China School of Materials Science and Engineering Nankai UniversityTianjin 300350China Department of Chemistry Chinese University of Hong KongHong KongChina Institute of Nanoscience and Nanotechnology NCSR"Demokritos"Athens 15341Greece State Key Laboratory of School of Radiation Medicine and Protection and School for Radiological and interdisciplinary Sciences(RAD-X) Soochow UniversitySuzhou 215123China State Key Laboratory of High Performance Ceramics and Superf

Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal ***-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright ***,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) *** can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction ***,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction ***,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble *** reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted *** them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of ***,the cost,synthetic methods of catalysts should also be ***,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so *** extremely active fields,we should pay attention to *** the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’.

关键词： H2 evolution reaction O2 reduction reaction O2 evolution reaction CO2 reduction reaction N2 reduction reaction Electrocatalysis Photocatalysis Photoelectrocatalysis

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