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Vitamin D<sub>3</sub>Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor Function in –D<sub>2</sub>R Tardive Dyskinesia Mice Model

引用

Journal of Biomedical Science and Engineering 2015年第8期8卷 520-530页

作者： Oluwamolakun O. Bankole Babafemi J. Laoye Mujittapha U. Sirjao Azeez O. Ishola Damilola E. Oyeleke Wasiu G. Balogun Amin Abdulbasit Ansa E. Cobham Ibukun D. Akinrinade olalekan M. Ogundele Department of Biological Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Health Sciences University of Ilorin Ilorin Nigeria Department of Physiology College of Health Sciences University of Ilorin Ilorin Nigeria Department of Anatomy College of Medicine University of Calabar Calabar Nigeria Instituto Gulbenkian de Ciencia Oerias Portugal Department of Anatomy Bingham University College of Medicine Karu Nigeria

Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of dopamine receptive sites on D2-receptor (D2R). As a result of D2R inhibition, calcium-linked neural activity is affected and seen as a decline in mo-tor-cognitive function after prolonged haloperidol use in the treatment of psychotic disorders. In this study, we have elucidated the relationship between haloperidol-induced tardive dyskinesia and the neural activity in motor cortex (M1), basal nucleus (CPu), prefrontal cortex (PFC) and hippocampus (CA1). Also, we explored the role of Vitamin D3 receptor (VD3R) activation as a therapeutic target in improving motor-cognitive functions in dyskinetic mice. Dyskinesia was induced in adult BALB/c mice after 28 days of haloperidol treatment (10 mg/Kg;intraperitoneal). We established the presence of abnormal involuntary movements (AIMs) in the haloperidol treated mice (-D2) through assessment of the threshold and amplitude of abnormal involuntary movements (AIMs) for the Limbs (Li) and Orolingual (Ol) area (Li and Ol AIMs). As a confirmatory test, the dyskinetic mice (-D2) showed high global AIMs score when compared with the VD3RA intervention group (-D2/+VDR) for Li and Ol AIMs. Furthermore, in the behavioral tests, the dyskinetic mice exhibited a decrease in latency of fall (LOF;Rotarod-P 2/+VDR), 100 mg/Kg for 7 days, CPu-CA1 burst activity was restored leading to a decrease in abnormal movement, and an increase in motor function. Ultimately, we deduced that VD3RA activation reduced the threshold of abnormal movement in haloperidol induced dyskinesia.

关键词： Haloperidol VD3R Dyskinesia D2R Neural Activity Corticostriatal

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Natural toxins and One Health:a review

Science in One Health

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Science in One Health 2022年第1期1卷 44-56页

作者： Azubuike Raphael Nwaji Onikisateinba Arieri Annabel Sharon Anyang Kaze Nguedia Etomi Barbara Abiade Gilead Ebiegberi Forcados Olusola olalekan Oladipo Sunday Makama Ishaku Leo Elisha Nonyelim Ozele Jurbe Gofwan Gotep Department of Physiology Faculty of Basic Medical SciencesAlex Ekwueme Federal UniversityNdufu-AlikeEbonyi StateNigeria Department of Industrial Chemistry and Petrochemical Technology Faculty of Science LaboratoryUniversity of PortharcourtNigeria Faculty of Veterinary Medicine University of AbujaNigeria Department of Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of Yaounde ICameroon Faculty of Pharmaceutical Science University of JosPlateau StateNigeria Biochemistry Division National Veterinary Research InstituteVomPlateau StateNigeria Drug Development Division National Veterinary Research InstituteVomPlateau StateNigeria

Background:The One Health concept considers the interconnectivity,interactions and interdependence of humans,animals and the ***,animals and other organisms are constantly exposed to a wide range of natural toxins present in the ***,there is growing concern about the potential detrimental effects that natural toxins could pose to achieve One ***,alkaloids,steroids and bioactive peptides obtained from natural toxins could be used for the development of therapeutic ***:Our literature search focused on the following keywords;toxins,One Health,microbial toxins,mycotoxins,phytotoxins,phycotoxins,insect toxins and toxin *** Scholar,Science Direct,PubMed and Web of Science were the search engines used to obtain primary *** chose relevant full-text articles and review papers published in English language *** research was done between July 2022 and January ***:Natural toxins are poisonous substances comprising bioactive compounds produced by microorganisms,invertebrates,plants and *** compounds possess diverse structures and differ in biological function and toxicity,posing risks to human and animal health through the contamination of the environment,causing disease or death in certain *** from the articles reviewed revealed that effects of natural toxins on animals and humans gained more attention than the impact of natural toxins on the environment and lower organisms,irrespective of the significant roles that lower organisms play to maintain ecosystem ***,systematic approaches for toxin control in the environment and utilization for beneficial purposes are inadequate in many ***,bioactive compounds present in natural toxins have potential for the development of therapeutic *** findings suggest that global,comprehensive and coordinated efforts are required for improved management of natural toxins through an interdisciplinar

关键词： One Health Mycotoxins Phytotoxins Phycotoxins Insect toxins Aqua toxins

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