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Phosphoinositide and Inositolpolyphosphate Signalling in Defense Responses of Arabidopsis thaliana Challenged by Mechanical Wounding

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Molecular Plant 2008年第2期1卷 249-261页

作者： Alina Mosblech Sabine Konig Irene stenzel Peter Grzeganek Ivo Feussner Ingo Heilmann Department of Plant Biochemistry Albrecht-yon-Hailer-Institute for Plant Sciences Georg-August-University G6ttingen Justus-von-Liebig-Weg 1137077 G6ttingen Germany

Various biochemical signals are implicated in Arabidopsis wound signalling, including jasmonic acid （JA）, salicylic acid, auxin, and Ca^2＋. Here, we report on cross-talk of phytohormones with phosphoinositide signals not previously implicated in plant wound responses. Within 30 min of mechanical wounding of Arabidopsis rosette-leaves, the levels of the lipid-derived soluble inositolpolyphosphate, inositol 1,4,5-trisphosphate （InsP3）, increased four to five-fold. Concom- itantly, the precursor lipids, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol transiently depleted, followed by re-synthesis after 30-60 min of stimulation. Increased InsP3 levels with wounding coincided with JA increases over the first hours of stimulation. In dde2-2-mutant plants deficient in JA biosynthesis, no InsP3 increase was observed upon wounding, indicating that JA was required for InsP3 formation, and InsP3 levels increased in wild-type plants challenged with sorbitol, increasing endogenous JA levels. In InsP 5-ptase plants with attenuated phosphoinositide signalling, the induction of wounding-inducible genes was diminished compared with wildtype plants, suggesting a role for phosphoinositide signalling in mediating plant wound responses. The gene-expression patterns suggest that phosphoinositides contribute to both JA-dependent and JA-independent aspects of wound signalling. Weight gain of Plutella xylostella caterpillars feeding on InsP 5-ptase plants was increased compared with that of caterpillars feeding on wild-type plants. The ecophysiological relevance of phosphoinositide signals in plant defense responses to herbivory is discussed in light of recent findings of inositolpolyphosphate involvement in phytohormone-receptor function.

关键词： .Wild-type Increases Defense Responses Mechanical Wounding Heilmann wound signalling InsP levels InsP ptase

Magnetic resonance imaging in children and adolescents with chronic inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1180-1191页

作者： Hans-Joachim Mentzel Steffen Reinsch Monika Kurzai Martin stenzel Section of Pediatric Radiology Department of Radiology University Hospital Jena- Friedrich-Schiller-University Jena Section of Pediatric Gastro-enterology Department of Pediatrics University Hospital Jena Friedrich-Schiller-University Jena

Inflammatory bowel diseases(IBD) represent challenges, both from a diagnostic, and therapeutic point of view. Deep-seated anatomic structures are difficult to assess by ultrasound technique alone. As radiation-free alternative cross-sectional imaging method, magnetic resonance imaging of the intestinal structures is costly and time-consuming. Examination of pediatric patients imply additional considerations: reduction of body motions in younger children and consideration of the most appropriate preparation, and examination technique. The demanding Sellink technique is the only means for appropriately distending the lesser intestine in order to detect small bowel strictures. Oral intake of contrast medium(CM) alone shows its limitations regarding distensibility. The need for intravenous contrast media application needs to be considered, too. Active inflammation of both intestinal wall, and mesentery can be demonstrated accurately. Nevertheless, viable alternatives to CM application is desirable, considering non-negligible adverse reactions. Recent data suggest diffusion weighted imaging might fill this diagnostic gap. Irrespective of sequence technique chosen, bowel movement remains a major obstacle. Antispasmolytics in their function as smooth muscle relaxants help in improving image quality, however, their use in children might be off-label. Optimal preparation for the examination and appropriate imaging technique allow for diagnosing typical patterns of changes in IBD, such as bowel wall thickening, ulcers, mural stratification, strictures, creeping fat, and comb sign, and lymphadenopathy. The article gives a detailed overview of current significance of magnetic resonance imaging pediatric patients suffering from IBD, considering indications, limitations, and safety aspects.

关键词： Children, Adolescents, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Magnetic resonance imaging, Enterography

A hybrid algorithm for reengineering the refractive index profile of inhomogeneous coatings from optical in-situ broadband monitoring data

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光学精密工程 2005年第4期13卷 487-491页

作者： S. Wilbrandt O. stenzel D. Gbler N. Kaiser Friedrich-Schiller-Universitt Jena Institut für Angewandte Physik Max-Wien-Platz 1 07743 Jena GermanyFraunhofer-Institut für Angewandte Optik und Feinmechanik Albert-Einstein-Str. 7 D-07745 Jena GermanyFraunhofer-Institut für Angewandte Optik und Feinmechanik Albert-Einstein-Str. 7 D-07745 Jena GermanyFraunhofer-Institut für Angewandte Optik und Feinmechanik Albert-Einstein-Str. 7 D-07745 Jena Germany

Reengineering the refractive index profile of inhomogeneous coatings is a troublesome task. Multiplicity of solutions may significantly reduced by providing additional information. For this reason an in-situ broadband monitoring system was developed to measure the transmittance of the growing film directly at the rotating substrate. For characterization of these coatings, a new model was developed, which significantly reduces the number of parameters. The refractive index profile may be described by a proper number of equally spaced volume fraction values using the Bruggeman effective media approach. A good initial approximation of the refractive index profile can be generated based on deposition rates for both materials recorded with quartz crystal monitor during manufacturing. During the optimization process, a second order minimization algorithm was used to vary the refractive index profile of the whole coating and film thickness of the intermediate stages. Finally, a significantly improved accuracy of the modelled transmittance was achieved.

关键词：光学涂覆技术折射率宽带混合模型管理方式

Manipulating endogenous exosome biodistribution for therapy

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SmartMat 2021年第2期2卷 127-130页

作者： Zhiwei Sun Yanyan Jiang Martina stenzel Key Laboratory for Liquid−Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinanChina School of Chemistry Centre for Advanced Macromolecular Design(CAMD)University of New South WalesSydneyNew South WalesAustralia

Exosomes have been recognized as extracellular vesicles that mediate systemic information exchange and long-distance interactions between cells.1 Their functions are all highly reliant on systemic biological distribution so that it is possible to promote the biological effects for therapy by accurately manipulating exosome ***,given that the mechanisms for regulating the exosome biodistribution are unclear,it is challengeable to achieve the manipulation of exosome biodistribution by regulating molecular ***,Liu et al.2 reported a vesicle shuttle(VS),which was composed of a ferroferric oxide core,a silica shell,and a stimuli-cleavable poly(ethylene glycol)corona conjugated to two types of antibody(one against antigens on the exosomes of interest,and the other targeted to the recipient injured cells).2 They showed that the VS could effectively collect,transport,and release circulating exosomes to the designated areas inside the organism.

关键词： exosome endogenous distribution

Functional Cooperativity of Enzymes of Phosphoinositide Conversion According to Synergistic Effects on Pectin Secretion in Tobacco Pollen Tubes

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Molecular Plant 2010年第5期3卷 870-881页

作者： Till Ischebeck Linh Hai Vu Xu Jin Irene stenzel Christian Lofke Ingo Heilmann Department of Plant Biochemistry Albrecht-von-Haller-lnstitute for Plant Sciences Georg-August-University Gottingen Justus-von-Liebig-Weg 11 37077 Guttingen Germany Present address: Center for Biochemistry Cologne University Joseph-Stelzmann-Straβe 52 50931 Cologne Germany Present address: Department of Forest Botany Georg-August-University Gottingen Busgenweg 2 37077 Gottingen Germany Present address: Department of Plant Cell Biology Albrecht-von-Haller-lnstitute for Plant Sciences Georg-August-University Gottingen Untere Karspule 2 37073 Gottingen Germany

The Arabidopsis phosphoinositide kinases PI4Kβ1 and PIP5K5 have been implicated in the control of directional vesicle trafficking underlying polar tip growth in pollen tubes. PI4Kβ1 and PIP5K5 catalyze key consecutive steps of phosphoinositide conversion, and it appears obvious that phosphatidylinositol-4-phosphate formed by PI4Kβ1 might act as a substrate for phosphatidylinositol-4,5-bisphosphate formation by PIP5K5. However, this hypothesis has not been experimentally addressed and distinct localization patterns of PI4Kβ1, PIP5K5, and also PI-synthases （PIS） generating phosphatidylinositol suggest additional complexity. Here, the synergistic functionality of enzymes of phosphoinositide conversion was assessed. In tobacco and Arabidopsis pollen tubes, phosphoinositides influence the apical secretion of pectin, and increased pectin deposition results in characteristic morphological alterations. Catalytically active and dominant negative variants of PI4Kβ1 and PIP5K5 were systematically co-expressed in tobacco pollen tubes and the incidence of morphologies related to enhanced pectin secretion was evaluated. The data support a proposed functional interplay of PI4Kβ1 and PIP5K5 at the trans-Golgi network, mediating directional vesicle trafficking. Co-expression experiments additionally including PIS isoforms, PIS1 or PIS2, indicate that pectin secretion is synergistically mediated by PI4Kβ1 and PIPSK5 acting on Ptdlns formed by PIS2 rather than PIS1. Possible ramifications for the preferential channeling of phosphoinositide intermediates between particular isoforms of PI pathway enzymes are discussed.

关键词： Phosphatidylinositol synthase phosphatidylinositol 4-kinase phosphatidylinositol-4-phosphate 5-kinase cooperativity pectin secretion pollen tubes.

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故障分量发电机定子单相接地保护应用研究

电力系统自动化 2005年第17期29卷 59-63页

作者：邰能灵 Ing.J.stenzel 上海交通大学电子信息与电气工程学院上海市200030 Darmstadt工业大学电气工程系 darmstadt德国64283

简要分析了发电机发生定子单相接地故障后,机端和中性点侧零序电压变化的特性,并对基波和3次谐波电压原理的发电机定子接地保护方案的灵敏度进行比较。研究表明,发电机绕组中部接地时电压增量相对较小,不利于保护灵敏度的提高。在此基础... 详细信息

简要分析了发电机发生定子单相接地故障后,机端和中性点侧零序电压变化的特性,并对基波和3次谐波电压原理的发电机定子接地保护方案的灵敏度进行比较。研究表明,发电机绕组中部接地时电压增量相对较小,不利于保护灵敏度的提高。在此基础上,提出改进的利用基波和3次谐波零序电压综合信息量的差动保护判据。该判据忽略基波零序电压增量的影响,减少了调试和整定环节,能有效提高保护灵敏度。理论分析以及实验研究均表明其优越性。

关键词：发电机定子接地保护故障分量 3次谐波零序电压基波零序电压

Fabrication and characterization of rugate structures composed of SiO_(2) and Nb_(2)O_(5)

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光学精密工程 2005年第4期13卷 505-511页

作者： R.Leitel O.stenzel S.Wilbrandt D.Gäbler V.Janicki N.Kaiser Institut für Angewandte Physik Friedrich Schiller University JenaMax-Wien-Platz 107743 JenaGermany Optical Coatings Department Fraunhofer Institut für Angewandte Optik und FeinmechanikAlbert-Einstein-Str.7D-07745 JenaGermany Institute Ruder Boskovic Bijenicka 5410000 ZagrebCroatia

Gradient index layers and rugate structures were fabricated on a Leybold Syrus pro deposition system by plasma-assisted coevaporation of the low index material silica and the high index material niobium *** obtain information about the compositional profiles of the produced layers,cross sectional transmission electron microscopy was used in assistance to deposition rate data recorded by two independent crystal monitors during the film *** depth dependent concentration profiles were transformed to refractive index gradients by means of effective medium *** on the refractive index gradients the corresponding samples`transmission and reflection spectra could be calculated by utilizing matrix *** relevance of the established refractive index profiles could be verified by comparison of the calculated spectra with the measured ones.

关键词： physical vapor deposition effective medium approximation rugate structure

通过品质展会深入俄罗斯市场——访杜塞尔多夫展览公司莫斯科公司董事总经理Thomas stenzel

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出展世界（中英文版） 2015年第6期 34-37页

作者：夏雪 Thomas stenzel 不详杜塞尔多夫展览公司莫斯科公司

记者:杜塞尔多夫展览公司进入俄罗斯市场五十多年了,请您介绍一下业务开展情况。stenzel:杜塞尔多夫展览公司莫斯科公司进入俄罗斯会展市场已经有50多年的历史。我们是在俄罗斯开展会展业务比较早的德国公司。现在,我们的展会项目涵盖... 详细信息

记者:杜塞尔多夫展览公司进入俄罗斯市场五十多年了,请您介绍一下业务开展情况。stenzel:杜塞尔多夫展览公司莫斯科公司进入俄罗斯会展市场已经有50多年的历史。我们是在俄罗斯开展会展业务比较早的德国公司。现在,我们的展会项目涵盖了俄罗斯大部分经济支柱产业,包括石油化学、冶金、管线、煤、供暖、包装、针对身体残疾人士的康复设备与技术、医药等。在俄罗斯,我们还举办欧洲最大的时尚展(CPM Moscow)o我们所有的展会都有数千名来自俄罗斯和其他国家的商业人士。杜塞尔多夫展览公司莫斯科公司与我们在德国的母公司——杜塞尔多夫展览公司一样,实践“打造商务要素”的信条,深刻了解展商和买家的需求并满足这些需求。

关键词：经济支柱产业业务开展情况设备与技术母公司残疾人士杜塞尔多夫石油化学商业人士

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Genes & Diseases 2022年第6期9卷 1506-1520页

作者： Jon Christiansen Anne-Katrin Guttsches Ulrike Schara-Schmidt Matthias Vorgerd Christoph Heute Corinna Preusse Werner stenzel Andreas Roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e Universitatsmedizin Berlin Freie Universitat Berlin10117 BerlinGermany Humboldt-Universitat zu Berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s Hospital of Eastern Ontario Research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MRI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LGMDR12 MMD3 Muscle inflammation Muscle MRI