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Macrofossil Assemblages in the Ryazanian Stage (Lower Cretaceous) of the Stratotype Region

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Open Journal of Geology 2019年第10期9卷 558-561页

作者： Olga S. Urman Boris N. Shurygin oksana S. Dzyuba Trofimuk Institute of Petroleum Geology and Geophysics Siberian Branch Russian Academy of Sciences Novosibirsk Russia Novosibirsk National Research State University Novosibirsk Russia

The stratotype region of the Ryazanian stage is located in the Oka River Basin near Ryazan, Central Russia. Since ammonites are very well studied here, we investigated other groups of macrofossils. We report a large number of bivalve genera: Arctica, Astarte, Buchia, Camptonectes, Chlamys, Ctenostreon, Entolium, Gomomya, Gresslya, Hartwellia, Lima, Meleagrinella, Modiolus, Oxytoma, and Pleuromya. The belemnites are represented by two cylindroteuthidid genera, Acroteuthis and Liobelus. In addition, brachiopods (Rhynchonellidae and Terebratulidae) and unidentifiable gastropod fragments have been revealed. The highest taxonomic diversity of macrofauna is observed in the Surites spasskensis ammonite Zone.

关键词： Fossil Mollusks Brachiopods Ryazanian Central Russia

Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells

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World Journal of Gastroenterology 2006年第35期12卷 5628-5634页

作者： William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar oksana Holian Department of Medicine Division of Gastroenterology John H. Stroger Hospital of Cook County Chicago IL 60612 United States

AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells.

关键词：白藜芦醇胃癌肿瘤细胞治疗

Glass-Reinforced Plastic Filled by Multiwall Carbon Nanotubes and Their Modified Forms

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Journal of Materials Science and Chemical Engineering 2019年第7期7卷 26-35页

作者： Yurii Sementsov oksana Cherniuk Galyna Dovbeshko Serhii Zhuravskyi Stanislav Makhno Bo Wang Mykola Kartel Transportation and Logistics College Ningbo University of Technology Ningbo China Department of Nanoporous and Nanosized Carbon Materials Chuiko Institute of Surface Chemistry NAS of Ukraine Kyiv Ukraine Department of Physics of Biological Systems Institute of Physics NAS of Ukraine Kyiv Ukraine

The effect of modifying the surface of multiwall carbon nanotubes (CNT’s) by oxygen and nitrogen on the strength characteristics of the fiberglass filled with them was investigated by testing for tension and bending. The method of obtaining nitrogen-containing nanostructures is developed. It was shown that in the epoxide system LR285-LH286 hydrophobic CNT’s (outgoing) at introducing into the catalyst polymerization of LH286, increase the strength with respect to unreinforced CNT’s by 48% - 54%. Oxidized CNT’s (200 A?h/kg) introduced into the resin LR285 increase the strength by 59%. The distribution of the filler particles in size, both in the epoxy resin and in the catalyst, depends on their concentration nonlinear, and correlates with the strength characteristics of the composite.

关键词： Fiberglass Multiwall Carbon Nanotubes Polymer Composite Materials

Distribution of serotonin and FMRF-amide in the brain of Lymnaea stagnalis with respect to the visual system

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Zoological Research 2012年第3期33卷 1-12页

作者： oksana P.TUCHINA Valery V.ZHUKOV Victor B.MEYER-ROCHOW School of Engineering and Science Jacobs UniversityBremen D-28759Germany Department of Agricultural and Soil Ecology Faculty of Bioresources and Natural UsageKaliningrad State Technical UniversityKaliningrad 236000Russia Department of Biology Oulu UniversityOuluSF 90300 Finland

Despite serotonin’s and FMRF-amide’s wide distribution in the nervous system of invertebrates and their importance as neurotransmitters,the exact roles they play in neuronal networks leaves many *** mapped the presence of serotonin and FMRF-amide-immunoreactivity in the central nervous system and eyes of the pond snail Lymnaea stagnalis and interpreted the results in connection with our earlier findings on the central projections of different peripheral *** the chemical nature of the intercellular connections in the retina of *** is still largely unknown,we paid special attention to clarifying the role of serotonin and FMRF-amide in the visual system of this snail and compared our findings with those reported from other *** least one serotonin-and one FMRF-amidergic fibre were labeled in each optic nerve,and since no cell bodies in the eye showed immunoreactivity to these neurotransmitters,we believe that efferent fibres with somata located in the central ganglia branch at the base of the eye and probably release 5HT and FMRF-amide as *** labelling revealed retrograde transport of neurobiotin through the optic nerve,allowing us to conclude that the central pathways and serotonin-and FMRF-amide-immunoreactive cells and fibres have different locations in the CNS in *** chemical nature of the fibres,which connect the two eyes in ***,is neither serotoninergic nor FMRF-amidergic.

关键词： Gastropoda Nervous system Retina Visual projections Retrograde transport Immunocytochemistry Neurotransmitters

Implementation of the FAIR Data Principles for Exploratory Biomarker Data from Clinical Trials

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Data Intelligence 2021年第4期3卷 630-661页

作者： Alexander Arefolov Laura Adam Shoshana Brown Yelena Budovskaya Cong Chen Diya Das Chen Farhy Rebecca Ferguson Hongmei Huang Kimberly Kanigel Christina Lu oksana Polesskaya Tracy Staton Rajeev Tajhya Maryann Whitley Jee-Yeon Wong Xiangpei Zeng Mark McCreary Rancho BioSciences LLC. San DiegoCA 92127USA Development Sciences Informatics Genentech Inc.South San FranciscoCA 94080-4990USA Development Sciences OMNI-Biomarker Development Genentech Inc.South San FranciscoCA 94080-4990USA

The FAIR data guiding principles have been recently developed and widely adopted to improve the Findability,Accessibility,Interoperability,and Reuse of digital assets in the face of an exponential increase of data volume and *** FAIR data principles have been formulated on a general level and the technological implementation of these principles remains up to the industries and organizations working on maximizing the value of their ***,we describe the data management and curation methodologies and best practices developed for FAIRification of clinical exploratory biomarker data collected from over 250 clinical *** discuss the data curation effort involved,the resulting output,and the business and scientific impact of our ***,we propose prospective planning for FAIR data to optimize data management efforts and maximize data value.

关键词： Data management Data curation Clinical studies FAIR data Biomarkers Data model Metadata Data standards Data governance

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思维尔得罗夫思科地区的技术园区的运作研究

思维尔得罗夫思科地区的技术园区的运作研究

作者：奥克桑娜（oksana Akhmetzianova）哈尔滨工业大学

学位级别：硕士

在现代条件下,科学和技术发展已经成为经济领导力的主要目的。它是竞争性活动的重要工具并且可以带来可观的商业利益。国民经济的较高技术水平和智力资源的有效利用体系是促进高科技产品走向国际市场的现代化机制。技术园区是当代经济... 详细信息

在现代条件下,科学和技术发展已经成为经济领导力的主要目的。它是竞争性活动的重要工具并且可以带来可观的商业利益。国民经济的较高技术水平和智力资源的有效利用体系是促进高科技产品走向国际市场的现代化机制。技术园区是当代经济的一个重要组成要素。技术园区可以为小型企业提供支持,它的发展能使社会再生产达到一个全新水平。换句话说,技术园区是一个结构,它的目标是促进所在社区繁荣,增强创新过程文化,提高产出组织和商品的竞争能力。产出取决于技术园区内部驻地公司的商业定位。相反,驻地公司运行的商业模式定义技术园区。“商业模式”这一术语已经被学者讨论了约27年。“商业模式”用于公司展示商业特点,包括目标、战略、计划、基础设施、组织结构等等,的广泛的官方和运营说明。本研究基于斯维尔德洛夫斯克地区技术园区运营情况的相关成果,采用Osterwalder和Pigneur制定的CANVAS业务模式框架,对这些技术园区的活动执行进行分析。斯维尔德洛夫斯克地区技术园区的表现近来备受批评。根据相关研究,斯维尔德洛夫斯克地区50%以上的技术园区不能被定性为创新性基础设施,只能作为商业机构运营。尽管如此,创立技术园区的成本仍由国家预算支付。在这一点上,分析斯维尔德洛夫斯克地区技术园区的商业模式运作这一研究目标的重要性显而易见。本论文的总体目标是,按照对于居民和其他受益者的重要性,对斯维尔德洛夫斯克地区的技术园区进行分类(基于CANVAS业务模式框架)。本研究的理论意义在于,技术园区分类有助于区别技术园区作为创新性复杂对象的不同规格和支持水平。实践层面,建立一个新的商业模式能够吸引新的居民,改善与现有居民的合作政策,优化维持技术园区的公共开支,通过关注更高要求的服务来提高设施竞争力,以及提高与合作伙伴互动的效率。应用本研究得到的分类能够将目前以商业中心形式运营的很多技术园区转化为创新结构组织。应用CANVAS业务模式框架被认为是对以技术园区形式存在的公共部门进行创新的一种可能。在这一点上,创新是提高公共服务绩效的重要动力。最后,通过应用:CANVAS业务模式对斯维尔德洛夫斯克地区的技术园区进行分类,并且引入技术园区运行的创新发展要素,本论文的意义在于改善公共服务和提高公民生活质量。通过应用CANVAS业务模式框架,技术园区可以达到科学研究商业化进程以及发展的全新水平。对商业模式进行细致研究能够揭示技术园区的竞争优势和劣势。本论文基于斯维尔德洛夫斯克地区9个技术园区运行的相关研究成果。研究在CANVAS业务模式的9个关键领域进行,包括提供的基础设施和服务,公司居民,与合作伙伴(包括地区和联邦当局,科学和教育机构)的合作,技术园区的财务和经济指标。在经验数据的基础上,生成斯维尔德洛夫斯克地区技术园区运行的9个商业模式。为了分析斯维尔德洛夫斯克地区技术园区的表现,应用Osterwalder和Pigneur开发的CANVAS业务模式框架,本文将在框架中加入一些加工数据,这些数据是通过在线调查和访谈得到的。因此,本文的分析工具隶属定性研究方法,主要包括对技术园区代表进行访谈,对技术园区管理公司官员进行在线调查,方案实施(CANVAS业务模式)。此外,本文充分考虑参与者(代表和官员)的观点;在与参与者直接接触的过程中进行数据采集。本研究分为三个阶段:(1)对斯维尔德洛夫斯克地区技术园区管理公司官员进行在线调查。在线调查将在全俄非政府组织“俄罗斯青年科学家联合会”的支持下进行。在线调查问卷基于CANVAS业务模式框架设计。(2)对相关书籍、官方文件、近期学术期刊、学术会议论文集、学术论文摘要、年度报告和技术园区介绍等等内容进行分析。本阶段的分析目的在于:首先,研究陈述主题的理论基础及其专题领域;其次,获得在线调查不涉及的相关数据。(3)对技术园区代表进行访谈。访谈问题基于CANVAS业务模式框架,包括11个斯维尔德洛夫斯克地区技术园区运营的相关问题。表格中列出CANVAS业务模式框架在基础设施领域的应用。根据官方统计数据,将斯维尔德洛夫斯克地区技术园区结构的精确数量确定为9。根据对代表和官员进行的访谈,技术园区管理公司在线调查,以及使用CANVAS业务模式框架对技术园区进行的分类,应该注意到,“工业园区”形式在斯维尔德洛夫斯克地区占主导地位。目前,发展技术园区被视为支持中小型高科技企业的重要工具,包括国家技术倡议规划区域。在俄罗斯实体经济部门向现代生产组织模式过渡的条件下,只有那些能够有效管理产品生命周期并为消费者提供所需的质量水平和个性化服务的企业才会具有竞争力。考虑到这些要求,技术园区应该成为组织“开放式”合同服务和降低业务成本必需的基础设施,从而成为区域经济新的增长点。技术园区能为政府和个人创造经济利益。此外,园区也为驻地公司带来巨大收益。除了完备的工作场所和实现潜能的舒适条件之

关键词： CANVAS业务模式技术园区公共组织设计

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乌克兰学生汉字偏误分析及教学建议

乌克兰学生汉字偏误分析及教学建议

作者：齐若薇（Chypchyruk oksana）广东外语外贸大学

学位级别：硕士

汉字教学是汉语作为第二语言的教学中的一个重要环节。对于大多数汉语学习者来说,汉字是汉语学习中的一大难点,尤其对于母语文字是拼音文字的二语学习者而言,汉字是非常难记的。目前,有关汉字的本体研究、二语习得研究、二语教学研究虽... 详细信息

汉字教学是汉语作为第二语言的教学中的一个重要环节。对于大多数汉语学习者来说,汉字是汉语学习中的一大难点,尤其对于母语文字是拼音文字的二语学习者而言,汉字是非常难记的。目前,有关汉字的本体研究、二语习得研究、二语教学研究虽然较多,但是专门针对乌克兰学生汉字偏误分析及教学的研究还很少,相关文献资料十分缺乏。因此,本人对汉语水平处于不同阶段的128名乌克兰汉语学习者的汉字学习情况进行了相关调查,收集了大量汉字语料,分析了乌克兰汉语学习者在学习汉字时所产生的偏误类型和出现偏误的原因。本研究对收集到的汉字偏误类型进行统计分析后发现,乌克兰学生书写汉字时错字偏误比别字偏误多。在错字偏误中,笔画偏误最多,其次是部件偏误,结构偏误最少;在别字偏误中,形近字偏误最多,近音字、同音字偏误较少。乌克兰学生出现汉字偏误的原因主要有母语负迁移,目的语规则泛化,教学、教材不当。最后,本人还提出了一些具体的教学建议,以期对改进教师的汉字教学方式、提高汉字教学效率有一定的帮助。全文分为以下五个部分:第一章为绪论,包括选题缘由、目的与意义、研究综述、理论基础与研究方法。第二章为乌克兰学生汉字学习的偏误类型,主要包括汉字偏误预测、汉字语料收集、汉字偏误概况与偏误类型分析,此外还总结了乌克兰学生和菲律宾、俄罗斯、韩国、白俄罗斯学生在汉字偏误上的异同。第三章为乌克兰学生汉字偏误原因分析,主要有母语负迁移、目的语规则泛化、教学及教材不当等原因。第四章为针对乌克兰学生的汉字教学建议。第五章为结语,包括本研究的总结、不足与展望。

关键词：乌克兰汉语学习者汉字书写汉字偏误教学建议

A Mass Spectrometry Study of the Lipid Profile of Carotene-Containing Blakeslea trispora Biomass

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Journal of Pharmacy and Pharmacology 2014年第2期2卷 129-134页

作者： oksana V. Kalinkevich Aleksei N. Kalinkevich Valery I. Kindya Vadim D. Chivanov Radiation Biophysics Department Institute for Applied Physics NAS of Ukraine Sumy 40000 Ukraine Physiology and Pathophysiology Department Medical Institute of Sumy State University Sumy 40018 Ukraine

The work demonstrates an example of application of 252Cf PDMS (plasma desorption mass spectrometry) to analysis of lipid profile of carotene-containing Blakeslea trispora biomass. It was shown that this method allows identification of the individual components in the crude multicomponent mixtures not subjected to previous chromatographic separation or enrichment. Using a very simple pretreatment by different extractants permits to select preferable lipid fractions of microorganisms.

关键词：药剂学药理学药学药物分析药典

Impact of chemical elements on heart failure progression in coronary heart disease patients

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Health 2011年第5期3卷 263-270页

作者： Karaskov Alexander Kamenskaya oksana Levicheva Elena Loginova Irina Okuneva Galina Cherniavsky Aleksander Kliver Evgeni Volkov Alexander 不详

Background. The high prevalence, poor prog-nosis of patients with coronary heart disease with chronic heart failure determine the relevance of the study pathophysiological and molecular mechanisms of this pathology. Researches of the trace element metabolism in the myocardium are scarce. With this in mind, an attempt was made to analyze the relationship of macro and trace elements metabolism with the functional state of the myocardium in coronary heart disease patients against the background of chronic heart failure progression. Methods and Results. To study the content of the chemical elements (S, K, Ca, Cr, Fe, Ni, Cu, Zn, Se, Rb, Sr) in the myocardium of 43 patients with coronary heart disease, use was made of X-ray fluorescence with synchrotron radiation. While doing autopsy, 43 samples of left ventricle myocardium were taken off the cardiac callosity. Myocardium samples were subjected to histological examination. Dynamics of macro and trace elements content in the myocardium reflects the development of energy deficiency and disorders of myocardial microcirculation with a decrease of systolic myocardial function. Structural/functional disorders in the myocardium of the left ventricle of patients with coronary heart disease that accompany the progression of chronic heart failure are associated with profound changes of metabolic processes in heart muscle. Conclusions. The structural/ functional changes accompanying chronic heart failure progression are associated with wide variations of metabolic processes in the myocardium, which could be evaluated by the content of chemical elements in tissue.

关键词： Heart Failure Tissue Myocardium