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Selection of Bacillus thuringiensis strains in citrus and their pathogenicity to Diaphorina citri (Hemiptera: Liviidae) nymphs

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Insect Science 2020年第3期27卷 519-530页

作者： Silvia de Oliveira Dorta Juliana Balbinotte Rose Monnerat Joao Roberto Spotti Lopes Tatiane da Cunha odimar zanuzo zanardi Marcelo Pedreira de Miranda Marcos Antonio Machado Juliana de Freitas-Astua Programs de Pos-Graduagao em Microbiologia Agricola Escola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Laboratorio de Biotecnologia Centro de Citricultura Sylvio MoreiraInstituto Agronomico de CampinasCordeiropolisSPBrazil Laboratorio de Insetos Vetores de Fitopatdgenos Departamento de Entomologia e AcarologiaEscola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Embrapa Recursos Geneticos e Biotecnologia BrasiliaDFBrazil Fundo de Defesa da Citricultura(Fundecitrus) AraraquaraSPBrazil Embrapa Mandioca e Fruticultura Cruz das AlmasBABrazil Laboratdrio de Bioquimica Fitopatoldgica Instituto BioldgicoSao PauloSPBrazil

Bacillus thuringiensis(Bt)toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic *** discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap‐sucking insects,such as the Asian citrus psyllid Diaphorina citri Kuwayama(Hemiptera:Liviidae),a vector of“Candidatus Liberibacter spp.,”associated with citrus huanglongbing(HLB).In this study,translocation of endophytic Bt strains in citrus seedlings inoculated with Bt suspension delivered by soil‐drench,and their systemic pathogenicity to *** nymphs were *** pathogenicity of three wild‐type Bt strains against *** third‐instar nymphs was *** the 10 recombinant strains tested(each of them harboring a single cry or cyt gene),3 can be highlighted,causing 42%–77%and 66%–90%nymphal mortality at 2 and 5 d after inoculation,*** isolation of Bt cells from young citrus shoots and dead nymphs,and PCR performed with specific primers,confirmed the involvement of the Bt strains in the psyllid *** is the first report showing the translocation of Bt strains from citrus seedling roots to shoots and their potential to control *** nymphs that fed on these soil‐drench inoculated *** Bt strains that caused the highest mortality rates have the potential to be used as bioinsecticides to control *** and the identified genes can be used for the production of transgenic Bt citrus.

关键词： Asian citrus psyllid Citrus sinensis Cry toxins endophytic Bt huanglongbing young shoots

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The orthodox therapy of cardiovascular diseases integrated by ozone-therapy is able to normalize the redox system

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World Journal of Cardiovascular Diseases 2013年第3期3卷 308-311页

作者： Velio Bocci Emma Borrelli Iacopo zanardi Valter Travagli Dipartimento di Biotecnologie Mediche Università degli Studi di Siena Siena Italy Dipartimento di Biotecnologie Chimica e Farmacia Università degli Studi di Siena Siena Italy Dipartimento di Fisiologia Università degli Studi di Siena Siena Italy

Cardiovascular diseases such as chronic limb ischemia, cardiomyopathies and stroke represent the first cause of death. Moreover, type-II diabetes, chronic obstructive pulmonary disease and age-related macular degeneration are also progressive pathologies complicated by a chronic inflammation that might be able to maintain progressive chronic oxidative stress. Orthodox medicine has provided excellent drugs which slow down the progression of these diseases but minimally reverse the oxidative stress conditions. Administration of antioxidants is unable to balance the oxidant excess. Today, all the biochemical and molecular mechanisms of ozone therapy have been clarified and it has been demonstrated that ozone therapy can reactivate the fundamental Nrf2 system and be able to restore the innate antioxidant defense mechanisms composed of several highly protective enzymes. This paper proposes to integrate the orthodox treatment with ozone therapy for improving clinical results.

关键词： Chronic Oxidative Stress Ozone-Therapy Nrf2-Keap1 Antioxidant Response Integrative Medicine

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Si/Ga埃尼碳硅酸盐的合成与表征（英文）

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催化学报 2015年第6期36卷 813-819页

作者： Giuseppe Bellussi Angela Carati Stefania Guidetti Caterina Rizzo Roberto Millini Stefano zanardi Erica Montanari Wallace O'Neil Parker Jr. Michela Bellettato Eni s.p.a. Development Operations & Technology Downstream R&D

Phenylene-gallosilicates were prepared with the same crystalline structure as their aluminum analogues. The new Ga-Eni Carbon Silicates(Ga-ECS) phases were investigated by X-ray diffraction, scanning electron microscopy, nuclear magnetic resonance and thermogravimetric analysis, which demonstrated that gallium isomorphously replaced aluminum in the framework of the organic-inorganic hybrids similar to the case of classical zeolites. Hybrid ECS materials were obtained with different types of bridged silsesquioxane precursors that maintained the aluminum-silicate nature of the inorganic moiety. This work confirms a new level of crystal chemistry versatility for this class of materials, and demonstrates the possibility to tailor also the inorganic part of the framework by changing the nature of the trivalent heteroatom.

关键词：硅酸盐扫描电子显微镜 Si 合成表征 GA 碳 X射线衍射

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桡骨远段定量超声能有效地预测骨质疏松病人的骨折危险性吗?

桡骨远段定量超声能有效地预测骨质疏松病人的骨折危险性吗?

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第三届国际骨质疏松研讨会

作者： N.Malavolta M.Veronesi M.zanardi 波伦亚大学临床医学及应用生物技术部内科

＜正＞迄今只有几项纵向研究评估了定量超声能否预测骨质疏松者的骨折危险性。事实上,必须进行纵向观察以评估真正的骨折危险性;这种危险性只近似于横断面观察的比数比,而横断面观察由于骨折后骨状态的改变而有偏性。在本次中期报告中,... 详细信息

＜正＞迄今只有几项纵向研究评估了定量超声能否预测骨质疏松者的骨折危险性。事实上,必须进行纵向观察以评估真正的骨折危险性;这种危险性只近似于横断面观察的比数比,而横断面观察由于骨折后骨状态的改变而有偏性。在本次中期报告中,我们估计了定量超声预测骨折危险性的可能性。我们用骨技术仪器Signet对294名白种妇女的髌骨进行定量超声检查

关键词：定量超声骨折骨质疏松桡骨远段相对危险性

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阿仑膦酸钠及维生素D3联合治疗髋骨修复术患者

阿仑膦酸钠及维生素D3联合治疗髋骨修复术患者

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第三届国际骨质疏松研讨会

作者： Nazzarena Malavolta Maddalena Veronesi Melissa zanardi Claudio Ripamonti Saverio Gnudi Divisione di Medicina Interna-Dipartimento di Medicina Clinicae Biotecnologia Applicata "D.Campanacci"-Universita di Bologna-Istituti Ortopedici Rizzoli-Bologna-（意大利）

＜正＞髋骨修复术的失败主要由于骨植入后骨负重改建所致的,高骨转换或细胞因子的活性增强。假若药物干预可以持续性地减少骨丢失,便可使修复骨保持稳定。基于这一目的,我们研究了24名因骨关节病而接受了髋骨修复术的妇女。其中12名在... 详细信息

＜正＞髋骨修复术的失败主要由于骨植入后骨负重改建所致的,高骨转换或细胞因子的活性增强。假若药物干预可以持续性地减少骨丢失,便可使修复骨保持稳定。基于这一目的,我们研究了24名因骨关节病而接受了髋骨修复术的妇女。其中12名在术后三月始服用阿仑膦酸

关键词：髌骨修复术骨丢失骨痂阿仑膦酸钠骨密度测定

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不同形式和水平的硫酸铜对仔猪肝脏、血浆、粪便中铜含量的影响

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饲料与畜牧（新饲料） 2014年第7期 54-57页

作者：张继杰罗小荣杨帆吴兵 G.Pastorelli R.Rossi E.zanardi 吉隆达集团四川广汉618300

为评估不同形式硫酸铜对肝脏、血浆和粪便铜含量的影响,选取150头、26±2d断奶的杂交猪,试验35d。仔猪被随机分配到5个饲粮组,饲粮中铜含量(保护、未保护)逐渐递增:0mg/kg(CON),75mg/kg未保护硫酸铜组(Cu75UNP),75mg/kg保护硫酸铜组(Cu ... 详细信息

为评估不同形式硫酸铜对肝脏、血浆和粪便铜含量的影响,选取150头、26±2d断奶的杂交猪,试验35d。仔猪被随机分配到5个饲粮组,饲粮中铜含量(保护、未保护)逐渐递增:0mg/kg(CON),75mg/kg未保护硫酸铜组(Cu75UNP),75mg/kg保护硫酸铜组(Cu 75P),150mg/kg未保护硫酸铜组(Cu 150UNP),150mg/kg保护硫酸铜组(Cu 150p)。试验18d后,选取30头仔猪处死,分别检测肝脏和血浆中的铜含量;试验第35d,收集粪便样本并检测粪铜含量。结果发现,Cu 150UNP组肝铜含量极显著高于其他组(P<0.001),Cu 150p组血浆铜含量显著高于CON组(P<0.05),无论硫酸铜是否经过保护处理,Cu 150组粪铜含量均高于CON组和Cu 75组。铜的保护处理对Cu 75的生物学利用率没有负面影响。

关键词：仔猪硫酸铜肝脏血液粪便

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Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases

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Journal of Molecular Cell Biology 2022年第11期14卷 36-49页

作者： Luca Varinelli Marcello Guaglio Silvia Brich Susanna Zanutto Antonino Belfiore Federica zanardi Fabio Iannelli Amanda Oldani Elisa Costa Matteo Chighizola Ewelina Lorenc Simone P.Minardi Stefano Fortuzzi Martina Filugelli Giovanna Garzone Federica Pisati Manuela Vecchi Giancarlo Pruneri Shigeki Kusamura Dario Baratti Laura Cattaneo Dario Parazzoli Alessandro Podestà Massimo Milione Marcello Deraco Marco A.Pierotti Manuela Gariboldi Department of Research Fondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly Peritoneal Surface Malignancies Unit Colon and Rectal SurgeryFondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly Department of Pathology and Laboratory Medicine Clinical Research lABoratory(CRAB)Fondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly Bioinformatics Core Unit IFOM ETSThe AIRC Institute of Molecular Oncologyvia Adamello 1620139 MilanItaly Imaging Technological Development Unit IFOM ETSThe AIRC Institute of Molecular Oncologyvia Adamello 1620139 MilanItaly C.I.Ma.I.Na.and Dipartimento di Fisica‘Aldo Pontremoli’ Universitàdegli Studi di Milanovia G.Celoria 1620133 MilanItaly Cogentech Ltd Benefit Corporation with a Sole Shareholder via Adamello 1620139 MilanItaly Pathology and Laboratory Medicine Department Fondazione IRCCS Istituto Nazionale dei Tumorivia G.Venezian 120133 MilanItaly

Peritoneal metastases (PM) from colorectal cancer (CRC) are associated with poor survival. The extracellular matrix (ECM) plays a fundamental role in modulating the homing of CRC metastases to the peritoneum. The mechanisms underlying the interactions between metastatic cells and the ECM, however, remain poorly understood, and the number of in vitro models available for the study of the peritoneal metastatic process is limited. Here, we show that decellularized ECM of the peritoneal cavity allows the growth of organoids obtained from PM, favoring the development of three-dimensional (3D) nodules that maintain the characteristics of in vivo PM. Organoids preferentially grow on scaffolds obtained from neoplastic peritoneum, which are characterized by greater stiffness than normal scaffolds. A gene expression analysis of organoids grown on different substrates reflected faithfully the clinical and biological characteristics of the organoids. An impact of the ECM on the response to standard chemotherapy treatment for PM was also observed. The ex vivo 3D model, obtained by combining patient-derived decellularized ECM with organoids to mimic the metastatic niche, could be an innovative tool to develop new therapeutic strategies in a biologically relevant context to personalize treatments.

关键词： colorectal cancer peritoneal metastasis organoids extracellular matrix(ECM) decellularized extracellular matrix engineered disease model ECM stiffness

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