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Curriculum Development for FAIR Data Stewardship

Data Intelligence 2022年第4期4卷 991-1012,1033页

作者： Francisca Oladipo Sakinat Folorunso Ezekiel Ogundepo obinna osigwe Akinyinka Tosin Akindele Directorate of Research InnovationsConsultancy and ExtensionKampala International University10102Uganda Virus Over Data Network(VODAN)-Africa and Asia Federal University Lokoja 260101Nigeria Department of Mathematical Sciences Olabisi Onabanjo UniversityP.M.B 2002Ago-IwoyeOgun State120005Nigeria Data Science Nigeria Lagos 105102Nigeria School of eLearning Projects Kampala International UniversityP.M.B 4000OgbomosoOyo stateNigeriaUganda

The FAIR Guidelines attempts to make digital data Findable, Accessible, Interoperable, and Reusable(FAIR). To prepare FAIR data, a new data science discipline known as data stewardship is emerging and, as the FAIR Guidelines gain more acceptance, an increase in the demand for data stewards is expected. Consequently, there is a need to develop curricula to foster professional skills in data stewardship through effective knowledge communication. There have been a number of initiatives aimed at bridging the gap in FAIR data management training through both formal and informal programmes. This article describes the experience of developing a digital initiative for FAIR data management training under the Digital Innovations and Skills Hub(DISH) project. The FAIR Data Management course offers 6 short on-demand certificate modules over 12 weeks. The modules are divided into two sets: FAIR data and data science. The core subjects cover elementary topics in data science, regulatory frameworks, FAIR data management, intermediate to advanced topics in FAIR Data Point installation, and FAIR data in the management of healthcare and semantic data. Each week, participants are required to devote 7–8 hours of self-study to the modules, based on the resources provided. Once they have satisfied all requirements, students are certified as FAIR data scientists and qualified to serve as both FAIR data stewards and analysts. It is expected that in-depth and focused curricula development with diverse participants will build a core of FAIR data scientists for Data Competence Centres and encourage the rapid adoption of the FAIR Guidelines for research and development.

关键词： Data steward Data science FAIR Guidelines FAIR Digital technology FDP installation FAIR Data Trains Semantic web Personal Health Train

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Incomplete COVID-19 Data: The Curation of Medical Health Data by the Virus Outbreak Data Network-Africa

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Data Intelligence 2022年第4期4卷 673-697,1033-1034,1036,1039-1042,1045-1051,1053页

作者： Mirjam Van Reisen Francisca Onaolapo Oladipo Mouhamed Mpezamihigo Ruduan Plug Mariam Basajja Aliya Aktau Putu Hadi Purnama Jati Reginald Nalugala Sakinat Folorunso Samson Yohannes Amare Ibrahim Abdulahi Oluwole Olumuyiwa Afolabi Ezra Mwesigwa Getu Tadele Taye Abdulahi Kawu Mariem Ghardallou Yan Liang obinna osigwe Araya Abrha Medhanyie Munyaradzi Mawere Leiden University Medical Centre 1310the Netherlands Leiden University 1310the Netherlands Tilburg University School of Humanities and Digital Sciences 1310the Netherlands VODAN-Africa 260101 Kampala International University P.O.Box 20000Uganda Federal University Lokoja Nigeria Central Bureau of Statistics 81119Indonesia Tangaza University College P.O.Box 15055Karen Nairobi Code 00509Kenya Olabisi Onabanjo University P.M.B 2002Ago-IwoyeOgun StateNigeria 120005Nigeria Mekelle University P.O.Box 231Ethiopia Ibrahim Badamasi Babangida University 911101Nigeria Makerere University P.O.Box 7062 KampalaUganda Universitéde Sousse 4002 SousseTunisia Great Zimbabwe University P.O.Box 1235 MasvingoZimbabwe

The incompleteness of patient health data is a threat to the management of COVID-19 in Africa and *** has become particularly clear with the recent emergence of new variants of *** Virus Outbreak Data Network(VODAN)-Africa has studied the curation of patient health data in selected African countries and identified that health information flows often do not involve the use of health data at the point of care,which renders data production largely meaningless to those producing *** modus operandi leads to disfranchisement over the control of health data,which is extracted to be processed *** response to this problem,VODAN-Africa studied whether or not a design that makes local ownership and repositing of data central to the data curation process,would have a greater chance of being *** design team based their work on the legal requirements of the European Union’s General Data Protection Regulation(GDPR);the FAIR Guidelines on curating data as Findable,Accessible(under well-defined conditions),Interoperable and Reusable(FAIR);and national regulations applying in the context where the data is *** study concluded that the visiting of data curated as machine actionable and reposited in the locale where the data is produced and renders services has great potential for access to a wider variety of data.A condition of such innovation is that the innovation team is intradisciplinary,involving stakeholders and experts from all of the places where the innovation is designed,and employs a methodology of co-creation and capacity-building.

关键词： FAIR Guidelines FAIR Equivalency Federated data Digital health GDPR VODAN-Africa

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Biochemical and Haematological Effects of the Leaf Extract of <i>Newbouldia laevis</i>in Alloxan-Induced Diabetic Rats

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Journal of Biosciences and Medicines 2017年第6期5卷 18-36页

作者： Chinyelu Clementina osigwe Peter Achunike Akah Chukwuemeka Sylvester Nworu Department of Pharmacology and Toxicology Faculty of Pharmaceutical Sciences University of Nigeria Nsukka Nigeria

Dichloromethane-methanol (1:1) extract (DME) of N. laevis leaves was prepared by cold maceration. The effects of the extract on the haematological and some biochemical parameters of alloxan-induced diabetic rats were investigated. The results showed that the oral administration of the extract (250, 500, 1000 mg/kg) caused a significant (P < 0.5) and dose-dependent increase in red blood cell count (RBC) and its indices, as well as a significant (p 0.05) and dose-dependent reduction in the platelet count and the white blood cells (WBC). The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were significantly (p 0.05) decreased. This effect was not dose related. The serum levels of total bilirubin, urea and creatinine were significantly (p 0.05) decreased. The serum total protein and total antioxidant status (TAS) significantly (p 0.05) increased dose dependently. Overall, administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological alterations in diabetes and this may be of immense benefits in the management of diabetes and its associated haematological complications. Improved liver and kidney functions as well as improved antioxidant status are beneficial in the management of chronic diseases such as diabetes.

关键词： Haematological Biochemical Newbouldia laevis Diabetes Anti-Oxidant

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Structural and Conceptual Design Analysis of an Axial Compressor for a 100 MW Industrial Gas Turbine (IND100)

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World Journal of Mechanics 2014年第11期4卷 332-347页

作者： D. S. Aziaka E. O. osigwe B. T. Lebele-Alawa Department of Power and Propulsion Cranfield University Cranfield UK Department of Mechanical Engineering Rivers State University of Science and Technology Port Harcourt Nigeria

The structural design of the IND100 axial compressor requires a multistage interrelationship between the thermodynamic, aerodynamic, mechanical design and structural integrity analysis of the component. These design criteria, sometimes act in opposition, hence engineering balance is employed within the specified design performance limits. This paper presents the structural and conceptual design of a sixteen stage single shaft high pressure compressor of IND100 with an overall pressure ratio of 12 and mass flow of 310 kg/s at ISOSLS conditions. Furthermore, in order to evaluate the conceptual design analysis, basic parameters like compressor sizing, load and blade mass, disc stress analysis, bearings and material selections, conceptual disc design and rotor dynamics are considered using existing tools and analytical technique. These techniques employed the basic thermodynamic and aerodynamic theory of axial flow compressors to determine the temperature and pressure for all stages, geometrical parameters, velocity triangle, and weight and stress calculations of the compressor disc using Sagerser Empirical Weight Estimation. The result analysis shows a constant hub diameter annulus configuration with compressor overall axial length of 3.75 m, tip blade speed of 301 m/s, maximum blade centrifugal force stress of 170 MPa, with major emphasis on industrial application for the structural component design selections.

关键词： Gas-Turbine Structural Design Conceptual Design Analysis Axial Compressor Mechanical Integrity

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Antihyperglycemic Studies on the Leaf Extract and Active Fractions of <i>Newbouldia laevis</i>(Bignoniaceae)

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Pharmacology & Pharmacy 2015年第11期6卷 518-532页

作者： Chinyelu C. osigwe Peter A. Akah Chukwuemeka S. Nworu Theophine C. Okoye Michel K. Tchimene Department of Pharmacology and Toxicology Faculty of Pharmaceutical Sciences University of Nigeria Nsukka Nigeria International Centre for Ethnomedicine and Drug Development Nsukka Nigeria

Optimal control of chronic hyperglycemia prevents both micro and macro vascular complications—a leading cause of morbidity and mortality in diabetic subjects. This study was undertaken to give credence to the traditional use of Newbouldia laevis leaves in the treatment of diabetes mellitus (DM). Dichloromethane-methanol (1:1) extract (DME) of N. laevis leaves was prepared by cold maceration. Separation of DME into column chromatographic fractions yielded the n-hexane fraction (HF), ethylacetate fraction (EF) and methanol fraction (MF). The extract and fractions were evaluated for antihyperglycemic activity in alloxanized diabetic rats. The results showed that the oral administration of extract and fractions (250, 500, 1000 mg/kg) caused a significant (P DME (dichloromethane/methanol extract;36.19%) > EF (ethylacetate fraction;20.70%) > HF (n-hexane fraction;10.09. The methanol fraction, which showed the highest potency in oral glucose tolerance test (OGTT), was further separated into column chromatographic sub-fractions—F1, F2, F3 and F4 fractions. These sub-fractions were evaluated for antihyperglycemic activity. Sub-fractions F1, F2 and F3 (1000 mg/kg) did produce significant (P > 0.05) reduction in blood glucose level after 24 h. Sub-fraction F4 (50, 100, 200 mg/kg), however caused a significant (P < 0.05) and dose-dependent reduction in blood glucose level. The reduction at 200 mg/kg dose of F4 (74.57%) was significantly (P < 0.05) higher than that of glibenclamide (58.04%). These findings suggest that leaf extract and fractions of Newbouldia laevis possess antihyperglycemic activities and can be the basis for the folk use N. laevis in management of diabetes mellitus.

关键词： Newbouldia Laevis Antihyperglycemic Diabetes Mellitus Blood Glucose Alloxan Hypoglycemia

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