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β-Glucan Contents and Anti-wrinkling Effects of Brown Rice Pbellinus linteus mycelium Extracts Fermented with Lactobacillus plantarum

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北京日化 2016年第4期 56-64页

作者： Jae-Won Kim Jung-mo Ahn o-Jun kwon Seon Hee Kim Cosmetology Research Center MJ Co. Ltd. Jeju Korea Research Center Incheon Technopark Incheon Korea Gyeongbuk Institute for Regional Program Evaluation Gyeongsan-si Gyeongsangbuk-do Korea

Application of 3D bioprinting in the prevention and the therapy for human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1681-1697页

作者： Hee-Gyeong Yi Hyeonji Kim Junyoung kwon Yeong-Jin Choi Jinah Jang Dong-Woo Cho Department of Rural and Biosystems Engineering College of Agriculture and Life SciencesChonnam National University77 Yongbong-RoGwangju 61186Korea Department of mechanical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-RoPohangKyungbuk 37673Korea Department of Advanced Biomaterials Research Korea Institute of Materials Science(KIMS)797 ChangwondaeroChangwonKyungnam 51508Korea Department of Convergence IT Engineering POSTECH77 Cheongam-RoPohangKyungbuk 37673Korea Institute of Convergence Science Yonsei University50 Yonsei-RoSeoul 03722Korea

Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious *** speed up the drug discovery process,the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery *** this regard,layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease *** addition,the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines,therapeutics,and relevant delivery ***,we discuss the potential of 3D bioprinting technologies for the control of infectious *** also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

关键词： printing prevention introducing

Classifying extrahepatic bile duct metachronous carcinoma by de novo neoplasia site

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World Journal of Gastroenterology 2014年第11期20卷 3050-3055页

作者： Hyung Jun kwon Sang Geol Kim Jae min Chun Yoon Jin Hwang Department of Surgery Kyungpook National University Medical CenterDaegu 702-210South Korea

Extrahepatic bile duct(EHBD)cancer may occur metachronously,and these cancers are resectable with a favorable *** aimed to identify the pattern of metachronous EHBD *** classified the cases of metachronous EHBD cancer reported in the literature thus far and investigated two new cases of metachronous EHBD cancer.A 70-year-old female underwent R0 bile duct resection for a type 1 Klatskin tumor(pT-1N0m0).A 70-year-old male patient underwent R0 bile duct resection for a middle bile duct cancer(pT2N1m0).Imaging studies of both patients taken at 14 and 24mo after first surgery respectively revealed a metachronous cholangiocarcinoma that required pancreaticoduodenectomy(PD).Histopathology of the both tumors after PD revealed cholangiocarcinoma invading the pancreas(pT3N0m0).Both patients have been free from recurrence for 6 years and 16 mo respectively after the second *** a review of the literature on these cases,we classified the pattern of metachronous EHBD cancer according to the site of de novo *** proximal remnant bile duct was most commonly *** EHBD cancer should be distinguished from an unresectable recurrent *** metachronous EHBD cancer may be helpful in identifying rare metachronous tumors.

关键词： metachronous Extrahepatic bile duct Cancer Prognosis Recurrence

microstructure of stir zone in dissimilar friction stir welds of AA6061-T6 and AZ31 alloy sheets

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Transactions of Nonferrous metals Society of China 2014年第7期24卷 2374-2379页

作者： Kwang-Jin LEE Eui-Pyo kwon Convergence Components & Agricultural machinery Application Center Korea Institute of Industrial Technology

This study was performed to investigate microstructure of dissimilar friction stir welds manufactured with AA6061-T6 and AZ31 alloy sheets. Dissimilar butt joints were fabricated under the ＇off-set＇ condition that tool plunge position shifted toward AZ31 from the interface between AA6061-T6 and AZ31. optimized tool rotating speed and its traveling speed were selected through a lot of preliminary experiments. Electron back-scatter diffraction （EBSD） technique was applied to measure texture in the stir zone （SZ）. Grain size distribution and misorientation angle distribution were also obtained. A remarkably fine-grained microstructure was observed in the SZ. Randomized or weaker plane orientations were formed in the SZ of AA6061-T6, while rotated basal plane orientations were concentrated in the SZ of AZ31. Average size of recrystallized grains was measured as just 2.5—4.5 μm. The fraction of high-angle boundary in the SZ of AA6061-T6 increased and that of low-angle boundary in the SZ of AZ31 decreased compared with the base metals.

关键词： AA6061-T6 alloy AZ31 alloy friction stir welding microstructure

Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERKl/2 aggravates cancer-induced bone destruction

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Bone Research 2021年第4期9卷 557-570页

作者： Jungho Back minh Nam Nguyen Lu Li Saelim Lee Inkyu Lee Fancheng Chen Lauren Gillinov Yeon-Ho Chung Kareme D.Alder Hyuk-kwon kwon Kristin E.Yu Christopher m.Dussik Ziehen Hao michael J.Flores Yoseph Kim Izuchukwu K.Ibe Alana m.munger Sung Wook Seo Francis Y.Lee Department of orthopaedics&Rehabilitation Yale UniversitySchool of MedicineNew HavenCTUSA Research Center for Genetics and Reproductive Health School of MedicineVietnam National University Ho Chi Minh CityLinh Trung WardThu Due DistrictHo Chi Minh CityVietnam Department of Rehabilitation medicine Renji HospitalSchool of MedicineShanghai JiaoTong UniversityShanghaiChina College of medicine Dankook UniversityCheonanRepublic of Korea Department of Life Science Chung-Ang UniversitySeoulRepublic of Korea Shanghai medical College Fudan UniversityShanghai CityChina Department of Emergency&Trauma Changhai HospitalNavy Medical UniversityShanghaiChina Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Department of orthopedic Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulGangnam-guRepublic of Korea

Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation,thereby predisposing patients to pathological fracture and cancer *** of osteoblast function induces skeletal diseases due to the disruption of bone *** observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer *** confirmed that osteolytic breast cancers with high expression of pERK1/2 disrupt bone homeostasis via osteoblastic ERK1/2 activation at the bone-breast cancer *** process of inflammatory osteolysis modulates ERK1/2 activation in osteoblasts and breast cancer cells through dominant-negative mEK1 expression and constitutively active mEK1 expression to promote cancer growth within ***,an FDA-approved mEK inhibitor,not only reduced breast cancer-induced bone destruction but also dramatically reduced cancer growth in bone by inhibiting the inflammatory skeletal *** together,these findings suggest that ERK1/2 activation in both breast cancer cells and osteoblasts is required for osteolytic breast cancer-induced inflammatory osteolysis and that ERK1/2 pathway inhibitors may represent a promising adjuvant therapy for patients with aggressive osteolytic breast cancers by altering the shared cancer and bone microenvironment.

关键词： pERK1/2 breast homeostasis

Design and performance simulation of a molecular Doppler wind lidar

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Chinese optics Letters 2009年第7期7卷 593-597页

作者：沈法华 Hyunki Cha 董吉辉 Dukhyeon Kim 孙东松 Sung ok kwon Anhui Institute of optics and Fine mechanics Chinese Academy of Sciences Korea Atomic Energy Research Institute Hanbat National University

A mobile molecular Doppler wind lidar at an eye-safe wavelength of 355 nm based on double-edge technique is being built in Hefei （China） for wind measurement from 10-to 40-km altitude. The structure of this lidar system is described. A triple Fabry-Perot etalon is employed as a frequency discriminator whose parameters are optimized. The receiver system is designed to achieve compactness and stability by putting in a standard 19-inch socket bench. Simulation results show that within the wind speed dynamic range of ±100 m/s, the horizontal wind errors due to noise are less than 1 m/s bdow 20-km altitude for 100-m vertical resolution, and less than 5.5 m/s from 20 km up to 40 km for 500-m vertical resolution with 400-mJ laser energy, 30-min temporal resolution, and a 45-cm aperture telescooe.

关键词： optical radar

Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.m.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun kwon You‑Jin Jeon Department of marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(mNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing mNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 marine natural products Drug targets Inhibitors

High-resolution circulation forecasting of the maenggol Channel, south coast of Korea

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Acta oceanologica Sinica 2015年第12期34卷 11-18页

作者： CHoI Jinyong JUN Kicheon CHoI Youngkwang CHo Kyoungho kwon Jae-Il PARK Jinsoon PARK Kwangsoon operational oceanography Research Center Korea Institute of Ocean Science and Technology Task Force for Construction of RV ISABU Support Facility Korea Institute of Ocean Science and Technology Division of Polar ocean Environment Korea Polar Research Institute China-Korea Joint ocean Research Center Coastal Development Research Center Korea Institute of Ocean Science and Technology

The maenggol Channel and Uldolmok Strait, located on the south-west coast of Korea, have notably strong and complex currents due to tidal effects and to local geological factors. In these areas, electric power has been generated using strong tidal currents, the speed of which is more than 3 m/s during spring tides. The region also provides a shortcut for navigation. These tidal conditions are therefore sometimes useful, but may also cause terrible accidents or severe economic damage, in the absence of accurate information regarding ocean conditions. In April 2014, the passenger ferry mV Sewol capsized in the maenggol Channel, with 295 passengers killed and 9 still missing. While this was unquestionably a man-made disaster, strong currents were one of the contributing causes. It was also difficult to conduct scuba diving rescue operations given strong current speeds,and accurate prediction of the time when the tide would turn was thus critically needed. In this research, we used the high-resolution coastal circulation forecasting system of KooS（Korea operational oceanographic System） for analysis and simulation of strong tidal currents in such areas with many small islands, using measurements and modeling from this research area. For accurate prediction of tidal currents, small grid size-modeling was needed,and in this study, we identified a suitable grid size that offers efficiency as well as accuracy.

关键词： maenggol Channel Sewol ferry accident circulation forecasting

Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFemnNi high-entropy alloys

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Rare metals 2024年第8期43卷 3893-3903页

作者： Jaesoung Lee Seulgi Kim Taehyun kwon Young II Kim Suyeon Kim Sung Ho Song Bin Lee Dongju Lee Department of Urban Energyand Environmental EngineeringChungbuk National UniversityCheongju 28644Republic of Korea Division of Advanced materials Engineering Kongju National UniversityChungnam 330-717Republic of Korea Department of Advanced materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYongin17104Republic of Korea

The CoCrFemnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 mPa and elongation of 19.64%.This strength value represents an~41% increase compared with the sample that displayed a fine single microstructure(347.08 mPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFemoNi Bimodal Gas atomization mechanical properties