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Annals of Eye Science 2019年第1期4卷 19-22页

作者： Bella J.Wolf Ji Won kwon Gabriel m.Rand Jimmy K.Lee Patrick K.Gore moonseong Heo Roy S.Chuck Department of ophthalmology and Visual ciences Montefiore Medical CenterAlbert Einstein College of MedicineNew YorkNYUSA Department of ophthalmology Myongji HospitalSeonam University College of MedicineGoyangKorea Lions Eye Institute for Transplant&Research TampaFloridaUSA Saving Sight Eye Bank Kansas CityMissouriUSA Department of Epidemiology and Population Health at Einstein Montefiore Medical CenterAlbert Einstein College of MedicineBronxNew YorkUSA

Background:To evaluate the association between corneal central endothelial cell count(CECC)with reactivity for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),human T-lymphotropic virus-1(HTLV1),and syphilis from an eye bank ***:Eye bank data included 19,159 donors and 38,318 corneas screened for HBV,HCV,HIV,HTLV1,and syphilis from July 2007-may *** and binary mixed effects models were used to determine the adjusted marginal effect a positive viral screening test had on CECC and morphology,*** models were adjusted for age,race,gender,lens status,and death to *** with missing data were excluded from the *** significance was defined as P valuesotal of 18,097 donors and 35,136 corneas were included in the final *** CECC for eyes with negative viral screening was 2,597±436 while the average CECC for eyes screening positive for syphilis,HBV,HCV,HIV,and HTLV1 were 2,638±392(P=0.073),2,569±419(P=0.815),2,603±363(P=0.207),2,615±360(P=0.733),and 2,625±436(P=0.362)***:The presence of HBV,HCV,HIV,HTLV1,and syphilis display no association with a statistically significant difference in CECC when compared to normal non-diseased donors.

关键词： Eye bank endothelial cell count infectious reactivity hepatitis B virus(HBV) syphilis

Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtm204I mutations

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World Journal of Gastroenterology 2019年第33期25卷 4985-4998页

作者： Won Hyeok Choe Kijeong Kim So-Young Lee Yu-min Choi So Young kwon Jeong Han Kim Bum-Joon Kim Department of Internal medicine Konkuk University School of MedicineSeoul 05030South Korea Department of microbiology College of MedicineChung-Ang UniversitySeoul 06974South Korea Department of Biomedical Sciences Microbiology and ImmunologyLiver Research InstituteCancer Research Institute and SNUMRCCollege of MedicineSeoul National UniversitySeoul 03080South Korea

BACKGRoUND Hepatitis B virus(HBV) DNA polymerase mutations usually occur to long term use of nucleos(t)ide analogues(NAs), but they can occur spontaneously in treatment-na?ve chronic hepatitis B(CHB) patients. The naturally occurring HBV DNA polymerase mutations might complicate antiviral therapy with NAs,leading to the generation of drug-resistant viral mutants and disease *** most common substitutions are known to be YmDD-motif mutations, but their prevalence and the influence on antiviral therapy is *** To investigate prevalence of the naturally occurring rtm204I mutations in treatment-na?ve CHB genotype C2 patients and their influence on antiviral *** A total of 410 treatment-na?ve CHB patients infected with HBV genotype C2 strains were enrolled in this retrospective study. Among the 410 patients, 232 were treated with NAs for at least 12 mo. Significant fibrosis was defined as fibrosis-4 index > 3.25 or aspartate aminotransferase to platelet ratio index > *** viral response(CVR) during NAs was defined as undetectable serum HBV DNA(m L). The rtm204I variants were analyzed by a newly developed locked nucleotide probe(LNA probe) based real-time PCR(LNA-RTPCR) *** The LNA-RT-PCR could discriminate rtm204I mutant-type(17 patients, 4.2%)from rt m204 wild-type(386 patients, 95.8%) in 403 of 410 patients(98.3%sensitivity). multivariate analysis showed that naturally occurring rtm204I variants were more frequently detected in patients with significant fibrosis [oddratio(oR) 3.397, 95% confidence-interval(CI) 1.119-10.319, P = 0.031]. of 232 patients receiving NAs, multivariate analysis revealed that achievement of CVR was reversely associated with naturally occurring rtm204I variants prior to NAs treatment(oR 0.014, 95%CI 0.002-0.096, P most patients receiving tenofovir achieved CVR at 12 mo of tenofovir, irrespective of pre-existence of naturally occurring rtm204I mutations(CVR rates: patients with

关键词： Chronic hepatitis B Entecavir Hepatitis B virus Liver fibrosis mutation Tenofovir

Gain enhancement of perovskite nanosheets by a patterned waveguide:excitation and temperature dependence of gain saturation

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Light(Science & Applications) 2023年第12期12卷 2688-2699页

作者： Inhong Kim Ga Eul Choi ming mei min Woo Kim minju Kim Young Woo kwon Tae-In Jeong Seungchul Kim Suck Won Hong Kwangseuk Kyhm Robert A.Taylor Department of opto&Cogno mechatronics Engineering RCDAMPPusan National UniversityBusan 46241Republic of Korea Department of Nano-Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Clarendon Laboratory Department of PhysicsUniversity of OxfordOxford OX13PUUK

optical gain enhancement of two-dimensional CsPbBr3 nanosheets was studied when the amplified spontaneous emission is guided by a patterned structure of *** the uncertainties and pitfalls in retrieving a gain coefficient from the variable stripe length method,a gain contour g((h))ω.x)was obtained in the plane of spectrum energy(hω)and stripe length(x),whereby an average gain was obtained,and gain saturation was *** and temperature dependence of the gain contour show that the waveguide enhances both gain and thermal stability due to the increased optical confinement and heat dissipation,and the gain origins were attributed to the two-dimensional excitons and the localized states.

关键词： waveguide saturation contour

Estimation of exposure dose for decontamination workers from contaminated soil at a nuclear decommissioning site in Korea

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辐射防护 2020年第6期40卷 619-624页

作者： Sohyeon Lee Dong-kwon Keum Hyo-Joon Jeong In Jun Kwang-muk Lim and Yong-Ho Choi Korea Atomic Energy Research Institute 989-111 Daedeok-daeroYuseong-guDaejeonRepublic of Korea

Assessment of the exposure dose for workers is crucial to protecting workers from the radiological *** preliminary study estimates the potential radiological exposure for a soil remediation worker at a nuclear decommissioning site contaminated with Cs-137 in Korea,and then calculates the maximum workable soil concentration to comply with the occupational dose constraint of 20 mSv per *** Korean characteristic data,detailed exposure scenarios for workers by the type of work,and relevant exposure pathways were used in the dose *** a result,the most severe exposure-induced work type was identified as the excavator operation with an annual individual dose of 5.92×10^-5 mSv for a unit concentration of soil,from which the derived maximum workable soil concentration was 3.38×105 Bq/***,dose contribution by each exposure pathway was found to be decreased in the following order:external radiation exposure,soil ingestion,dust inhalation,and skin *** results of this study are expected to be used effectively to optimize radiation protection for workers and establish appropriate work procedures for future site remediation.

关键词： nuclear decommissioning decontamination site remediation dose assessment radiological risk radiological environmental impact assessment radiation protection

microsphere-assisted hyperspectral imaging:super-resolution,non-destructive metrology for semiconductor devices

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Light(Science & Applications) 2024年第6期13卷 1098-1111页

作者： Jangryul Park Youngsun Choi Soonyang kwon Youngjun Lee Jiwoong Kim Jae-joon Kim Jihye Lee Jeongho Ahn Hidong Kwak Yusin Yang Taeyong Jo myungjun Lee Kwangrak Kim metrology and Inspection Equipment R&D Team Mechatronics ResearchSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department DRAM Process Development TeamSemiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department Semiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea

As semiconductor devices shrink and their manufacturing processes advance,accurately measuring in-cell critical dimensions(CD)becomes increasingly *** test element group(TEG)measurements are becoming inadequate for representing the fine,repetitive patterns in cell *** non-destructive metrology technologies like optical critical dimension(oCD)are limited due to their large spot diameter of approximately 25μm,which impedes their efficacy for detailed in-cell structural ***,there is a pressing need for small-spot and non-destructive metrology *** address this limitation,we demonstrate a microsphere-assisted hyperspectral imaging(mAHSI)system,specifically designed for small spot optical metrology with *** microsphere-assisted super-resolution imaging,this system achieves an optical resolution of 66 nm within a field of view of 5.6μm×5.6μ*** approach effectively breaks the diffraction limit,significantly enhancing the magnification of the *** mAHSI system incorporating hyperspectral imaging with a wavelength range of 400–790 nm,enables the capture of the reflection spectrum at each camera *** achieved pixel resolution,which is equivalent to the measuring spot size,is 14.4 nm/pixel and the magnification is *** mAHSI system enables measurement of local uniformity in critical areas like corners and edges of DRAm cell blocks,areas previously challenging to inspect with conventional oCD *** our knowledge,this approach represents the first global implementation of microsphere-assisted hyperspectral imaging to address the metrology challenges in complex 3D structures of semiconductor devices.

关键词： metrology resolution enable

Regeneration-associated macrophages： a novel approach to boost intrinsic regenerative capacity for axon regeneration

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Neural Regeneration Research 2016年第9期11卷 1368-1371页

作者： min Jung kwon Hyuk Jun Yoon Byung Gon Kim Department of Brain Science Ajou University School of Medicine Suwon Republic of Korea Department of Neurology Ajou University School of Medicine Suwon Republic of Korea Neuroscience Graduate Program Department of Biomedical Sciences Ajou University Graduate School of Medicine Suwon Republic of Korea

Axons in central nervous system （CNS） do not regenerate spontaneously after injuries such as stroke and traumatic spinal cord iniury. Both intrinsic and extrinsic factors are responsible for the regeneration fail- ure, Although intensive research efforts have been invested on extrinsic regeneration inhibitors, the extent to which glial inhibitors contribute to the regeneration failure in viva still remains elusive. Recent exper- imental evidence has rekindled interests in intrinsic factors for the regulation of regeneration capacity in adult mammals. In this review, we propose that activating macrophages with pro-regenerative molecular signatures could be a novel approach for boosting intrinsic regenerative capacity of CNS neurons. Using a conditioning injury model in which regeneration of central branches of dorsal root ganglia sensory neu- rons is enhanced by a preceding injury to the peripheral branches, we have demonstrated that perineuronal macrophages surrounding dorsal root ganglia neurons are critically involved in the maintenance of en- hanced regeneration capacity. Neuron-derived chemokine （C-C motif） ligand 2 （CCL2） seems to mediate neuron-macrophage interactions conveying injury signals to perineuronal macrophages taking on a soley pro-regenerative phenotype, which we designate as regeneration-associated macrophages （RAms）. ma- nipulation of the CCL2 signaling could boost regeneration potential mimicking the conditioning injury, suggesting that the chemokine-mediated RAm activation could be utilized as a regenerative therapeutic strategy for CNS injuries.

关键词： axon regeneration conditioning injury neuron-macrophage interaction regeneration-associatedmacrophage cAmP CCL2 m2 polarization spinal cord injury

Runaway Electron Suppression by ECRH and RmP in KSTAR

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Plasma Science and Technology 2013年第2期15卷 119-122页

作者： A. C. ENGLAND Z. Y. CHEN D. C. SEo J. CHUNG Y. S. LEEV J. W. Yoo W. C. KIm Y. S. BAE Y. m. JEoNV J. G. KWAK m. kwon KSTAR Team National Fusion Research Institute Daejeon Republic of Korea Huazhong University of Science and Technology National Fusion Research Institute Daejeon Republic of Korea

We have observed reduction of the runaway electron synchrotron radiation, hard X-ray （HXR） intensity, and HXR energy after applying 110 GHz 2nd harmonic electron cyclotron resonant heating （ECRH） during runaway electron （RE） discharges at low density with startup runaway electrons. However, we did not see a significant reduction of X-rays from 170 GHz 2nd harmonic ECRH at a higher field. A recently installed IR TV camera was used to observe the forward cone of synchrotron radiation from high energy REs in KSTAR. We have observed changes to the synchrotron images and reduction of the HXR by application of resonant magnetic perturbations （RmP） from in-vessel control coils （IVCC） installed inside KSTAR in the n----1 configuration.

关键词： tokamak runaway electron suppression X-ray synchrotron radiation

Inhibition of mammalian target of rapamycin induces phenotypic reversion in three-dimensional cultures of malignant breast epithelial cells

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Journal of Biomedical Science and Engineering 2010年第5期3卷 476-483页

作者： Ross Booth Soonjo kwon Eric monson 不详

Inhibition of mammalian target of rapamycin (m- ToR) is a potential method for cancer treatment. Effects of rapamycin (RAP) on the reversion of malignant breast epithelial cells were investigated on three-dimensional (3D) basement membrane extract (BmE) cultures. Through continuous exposure to 20 nm of RAP, cell colony size was significantly reduced in 3D BmE cultures of malignant breast epithelial cells, while normal cell colony size appeared unaffected. In unfixed 3D BmE cultures of normal and RAP-treated malignant breast epithelial cells, the presence of luminal cell death was confirmed by ethidium bromide and propidium iodide labeling. Increased structural organization was observed by im- munofluorescence staining of F-actin and β-catenin in RAP-treated malignant breast epithelial cells. In monolayer cultures of normal and malignant breast epithelial cells, continuous exposure to 20 nm of RAP increased caspase 3/7 activity and decreased proliferation. Reverse transcriptase polymerase ch- ain reaction (RT-PCR) array analysis indicated a fold increase in the expression of a number of proteins related to polarity, cell-cell adhesion, and cell-matrix adhesion in the presence of RAP. our data showed that phenotypic reversion of malignancy can be ach- ieved through RAP exposure on 3D BmE cultures. This 3D BmE culture system will provide correct microenvironments for observing the effects of other mToR inhibitors on phenotypic reversion of malignant breast epithelial cells.

关键词： Rapamycin Three-Dimensional Culture Breast Cancer Reversion Basement membrane Extract mToR Inhibitors

Advances in Liquid Chromatography-mass Spectrometry-Based Lipidomics: A Look Ahead

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Journal of Analysis and Testing 2020年第3期4卷 183-197页

作者： Nguyen Phuoc Long Seongoh Park Nguyen Hoang Anh Sun Jo Kim Hyung min Kim Sang Jun Yoon Johan Lim Sung Won kwon College of Pharmacy Seoul National UniversitySeoul 08826Republic of Korea Department of Statistics Seoul National UniversitySeoul 08826Republic of Korea

Lipidomics is a subfield of metabolic phenotyping that focuses on high-throughput profiling and quantification of *** roles of lipidomics in translational and clinical research have emerged,especially over the past *** lipidomic pipelines have been developed using mass spectrometry(mS)-based *** of the complexity of the data,generally,computational demands are much higher in untargeted lipidomic *** the current paper,we primarily discussed the recent advances in untargeted liquid chromatography-mass spectrometry-based lipidomics,covering various facets from analytical strategies to functional *** current practice of tandem mS-based lipid annotation in untargeted lipidomics studies was ***,we highlighted the essential characteristics of machine learning models,together with a data partitioning strategy,to facilitate appropriate modeling and validation in metabolic phenotyping *** aspects of data sharing were briefly ***,certain recommendations were suggested toward more standardized and sustainable lipidomics analysis strategies as independent platforms,and as members of the omics family.

关键词： metabolic phenotyping Lipidomics mass spectrometry Biochemical analysis machine learning

Assimilating oSTIA SST into regional modeling systems for the Yellow Sea using ensemble methods

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Acta oceanologica Sinica 2017年第3期36卷 37-51页

作者： JI Xuanliang kwon Kyung man CHoI Byoung-Ju LIU Guimei PARK Kwang-Soon WANG Hui BYUN Do-Seong LI Yun JI Qiyan ZHU Xueming National marine Environmental Forecasting Center State Oceanic AdminstrationBeijing 100081China Key Laboratory of Research on marine Hazards Forecasting National Marine Environmental Forecasting CenterState Oceanic AdminstrationBeijing 100081China Department of oceanography Kunsan National UniversityGunsan 54150Republic of Korea Department of oceanography Chonnam National UniversityGwangju 61186Republic of Korea Korea Institute of ocean Science and Technology Ansan 15627Republic of Korea Korea Hydrographic and oceanographic Agency Busan 49111Republic of Korea marine Acoustics and Remote Sensing Laboratory Zhejiang Ocean UniversityZhoushan 316000China

The effects of sea surface temperature（SST） data assimilation in two regional ocean modeling systems were examined for the Yellow Sea（YS）. The SST data from the operational Sea Surface Temperature and Sea Ice Analysis（oSTIA） were assimilated. The National marine Environmental Forecasting Center（NmEFC） modeling system uses the ensemble optimal interpolation method for ocean data assimilation and the Kunsan National University（KNU） modeling system uses the ensemble Kalman filter. Without data assimilation, the NmEFC modeling system was better in simulating the subsurface temperature while the KNU modeling system was better in simulating SST. The disparity between both modeling systems might be related to differences in calculating the surface heat flux, horizontal grid spacing, and atmospheric forcing data. The data assimilation reduced the root mean square error（RmSE） of the SST from 1.78°C（1.46°C） to 1.30°C（1.21°C） for the NmEFC（KNU） modeling system when the simulated temperature was compared to optimum Interpolation Sea Surface Temperature（oISST） SST dataset. A comparison with the buoy SST data indicated a 41%（31%） decrease in the SST error for the NmEFC（KNU） modeling system by the data assimilation. In both data assimilative systems, the RmSE of the temperature was less than 1.5°C in the upper 20 m and approximately 3.1°C in the lower layer in october. In contrast, it was less than 1.0°C throughout the water column in February. This study suggests that assimilations of the observed temperature profiles are necessary in order to correct the lower layer temperature during the stratified season and an ocean modeling system with small grid spacing and optimal data assimilation method is preferable to ensure accurate predictions of the coastal ocean in the YS.

关键词： ensemble optimal interpolation ensemble Kalman filter SST Yellow Sea assimilation