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on Eccentric Connectivity Index and Connectivity

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Acta Mathematica Sinica,English Series 2019年第7期35卷 1205-1216页

作者： vivian MUKUNGUNUGWA Simon MUKWEMBI Department of Mathematics University of Zimbabwe

Let G be a finite connected graph. The eccentric connectivity index ξ^c(G) of G is defined as ξ^c(G)=∑v∈V(G)ec(υ)deg(υ), where ec(v) and deg(υ) denote the eccentricity and degree of a vertex v in G, respectively. In this paper, we give an asymptotically sharp upper bound on the eccentric connectivity index in terms of order and vertex-connectivity and in terms of order and edge-connectivity. We also improve the bounds for triangle-free graphs.

关键词： Extremal graph order diameter vertex-connectivity edge-connectivity

Cyst fluid glucose: An alternative to carcinoembryonic antigen for pancreatic mucinous cysts

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World Journal of gastroenterology 2019年第19期25卷 2271-2278页

作者： César vivian Lopes Department of gastroenterology and Digestive Endoscopy Santa Casa Hospital

Pancreatic cystic lesions(PCLs) have been increasingly recognized in clinical practice. Although inflammatory cysts(pseudocysts) are the most common PCLs detected by cross-sectional imaging modalities in symptomatic patients in a setting of acute or chronic pancreatitis, incidental pancreatic cysts with no symptoms or history of pancreatitis are usually neoplastic cysts. For these lesions,it is imperative to identify mucinous cysts(intraductal papillary mucinous neoplasms and mucinous cystic neoplasms) due to the risk of their progression to malignancy. However, no single imaging modality alone is sufficient for a definitive diagnosis of all PCLs. The cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration provides additional information for the differential diagnosis of PCLs. Current recommendations suggest sending cyst fluid for cytology evaluation and measurement of carcinoembryonic antigen(CEA) levels. Unfortunately, the sensitivity of cytology is greatly limited, and cyst fluid CEA has demonstrated insufficient accuracy as a predictor of mucinous cysts. More recently, cyst fluid glucose has emerged as an alternative to CEA for distinguishing between mucinous and nonmucinous lesions. Herein, the clinical utility of cyst fluid glucose and CEA for the differential diagnosis of PCLs was evaluated.

关键词： Carcinoembryonic antigen Differential diagnosis Fine-needle biopsy Glucose Pancreatic cyst Tumor marker

Antibodies and liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 184-185页

作者： vivian McAlister Department of Surgery University of Western OntarioLondonONCanada

A few years ago,I had an opportunity to collaborate with Professor Haitao Zhao and Dr Ruoyu Miao of the Peking Union Medical College Hospital(PUMCH).To witness their superior clinical and research programs would have been reward enough for a visit to Beijing,but I was also blessed to meet Professor Yilei *** I had observed him complete complex liver surgery at PUMCH,Professor Mao informed me of plans to start a new high quality journal dedicated to the science of liver disease and nutrition.I knew it would be a ***,I was greatly honored to be invited to guest-edit a special issue of the journal.

关键词： journal enough opportunity

Pore pressure prediction in offshore Niger delta using data-driven approach: Implications on drilling and reservoir quality

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Energy Geoscience 2023年第3期4卷 252-265页

作者： Joshua Pwavodi Ibekwe N.Kelechi Perekebina Angalabiri Sharon Chioma Emeremgini vivian o.oguadinma Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIRDUGEISTerre38000GrenobleFrance TotalEnergies SA CSTJF Avenue Larribau64000PauFrance Centre of Excellence in Petroleum Geoscience and Engineering University of BeninBenin CityEdo StateNigeria Univ.Lille CNRSUniv.Littoral Cote d’OpaleUMR 8187LOGLaboratoire d’Oceanologie et de Geosciences59000LilleFrance

Despite exploration and production success in Niger Delta,several failed wells have been encountered due to ***,it is very essential to understand the spatial distribution of pore pressure and the generating mechanisms in order to mitigate the pitfalls that might arise during *** research provides estimates of pore pressure along three offshore wells using the Eaton's transit time method,multi-layer perceptron artificial neural network(MLP-ANN)and random forest regression(RFR)*** results show that there are three pressure magnitude regimes:normal pressure zone(hydrostatic pressure),transition pressure zone(slightly above hydrostatic pressure),and over pressured zone(significantly above hydrostatic pressure).The top of the geopressured zone(2873 mbRT or 9425.853 ft)averagely marks the onset of overpressurization with the excess pore pressure above hydrostatic pressure(P∗)varying averagely along the three wells between 1.06−24.75 *** results from the three methods are self-consistent with strong correlation between the Eaton's method and the two machine learning *** models have high accuracy of about>97%,low mean absolute percentage error(MAPEoefficient of determination(R2>0.98).our results have also shown that the principal generating mechanisms responsible for high pore pressure in the offshore Niger Delta are disequilibrium compaction,unloading(fluid expansion)and shale diagenesis.

关键词： Niger Delta Pore pressure Reservoir Fracturing pressure Artifidal neural network Machine leaming algorithm Random forest regression

Mitophagy:From the dark into the spotlight

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Molecular Plant 2023年第10期16卷 1487-1489页

作者： vivian Schmitt olivier Van Aken Department of Biology Lund UniversityLundSweden

Despite the generally placid appearance of plants,many dynamicprocesses take place inside a plant *** such process thathas garnered attention in recent years is termed"autophagy."While originally discovered in yeast,our understanding of autophagy in plants has improved *** is considered a cellular recycling system in which cellular components oreven entire organelles can be encapsulated by a membranestructure(autophagosome)and then transported to the vacuole(in plants)for degradation and re-use.

关键词： attention organelle spite

From conception to delivery: Managing the pregnant inflammatory bowel disease patient

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World Journal of gastroenterology 2014年第13期20卷 3495-3506页

作者： vivian W Huang Flavio M Habal Division of gastroenterology Department of MedicineUniversity of AlbertaEdmontonAlberta T6G 2X8Canada Division of gastroenterology Department of MedicineUniversity Health NetworkUniversity of TorontoToronto ON M5G 2C4Canada

Inflammatory bowel disease(IBD)typically affects patients during their adolescent and young adult *** these are the reproductive years,patients and physicians often have concerns regarding the interaction between IBD,medications and surgery used to treat IBD,and reproduction,pregnancy outcomes,and neonatal *** have shown a lack of knowledge among both patients and physicians regarding reproductive issues in *** the literature is constantly expanding regarding these very issues,with this review,we provide a comprehensive,updated overview of the literature on the management of the IBD patient from conception to delivery,and provide action tips to help guide the clinician in the management of the IBD patient during pregnancy.

关键词： Inflammatory bowel disease Pregnancy Biologics Neonatal outcomes

MiRNA as potential biomarkers and therapeutic targets for gastric cancer

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World Journal of gastroenterology 2014年第30期20卷 10432-10439页

作者： vivian Yvonne Shin Kent-Man Chu Department of Surgery The University of Hong KongQueen Mary Hospital

gastric cancer is one of the leading causes of cancer mortality in the world. Aberrant expression of microRNAs (miRNAs) is the hallmark of this disease. MiRNAs are endogenous non-coding RNAs that are involved in many biological processes (e.g., cell proliferation, differentiation, apoptosis, invasion and development) through gene repression. Deregulation of miRNA expression in gastric tumors and cancer cell lines have been documented to contribute in tumorigenesis, and the expression signature may correlate with different cancer types and clinicopathological features. Here, we summarized the updated gastric cancer-associated miRNAs and the downstream targets in the process of tumorigenesis. Recently, many researchers make use of the miRNA microarray platform to profile miRNA expression in gastric cancer and correlated with different clinical parameters. Its application on cancer diagnosis, prognosis and predicting treatment response rate are still underway and needs further investigation. Emerging roles of miRNAs with oncogenic or tumor suppressive properties in gastric tumorigenesis were discussed. Epigenetic silencing of miRNA by hypermethylation of promoter CpG island was also observed in gastric cancer. However, detailed mechanisms of how miRNAs regulate gene expression in gastric cancer has not been well studied. In this review, we highlight the up-to-date findings on the deregulated miRNAs in gastric cancer, and the potential use of miRNA in the clinical settings, such as diagnostic/prognostic markers and chemotherapeutic tools.

关键词： MicroRNA gastric cancer Biomarker Diagnosis Prognosis Clinical application

Fatal graft versus host hemolytic reaction from Rhesus compatible mismatched liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 186-188页

作者： Hemant Sharma vivian McAlister Department of Multiorgan Transplant Surgery Ochsner Medical CenterNew OrleansLAUSA Department of Surgery University of Western OntarioLondonONCanada

Matching for Rhesus(Rh)blood group is not part of organ allocation *** principle concern expressed in the literature is that Rh-negative recipients might become sensitized and produce anti-D antibody which would have consequences for them if transfusion with Rh-positive blood or a pregnancy were to occur *** Rh allosensitization is thought to occur in over 80%of Rh-negative recipients of Rh-positive blood,Starzl reported that it is less much less common in organ(liver,heart,lung)recipients even if they received Rh-positive blood during the operation(1).A more recent review of pediatric liver transplantation confirms the very low rate of allosensitization of Rh recipients of grafts from Rh-positive donors(2).In theory,there should be no risk of rejection if the combination is reversed—Rh-negative donor to a Rh-positive ***,it does not appear to be necessary to consider Rh status when allocating organs for transplantation.

关键词： organs transfusion liver

Anti-donor immunoglobulin G subclass in liver transplantation

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 125-128页

作者： vivian C.McAlister Department of Surgery University of Western OntarioLondonONCanada

Immunoglobulin G(IgG)subclasses in human health and immunity have only be sporadically studied in the half century since their *** patterns of IgG subclass production are seen if the immune response is deviated towards type 1 versus type *** current state of our knowledge of IgG subclasses in liver transplantation is reviewed *** several studies have been conducted in liver disease,only four relatively small studies have been undertaken in liver transplant *** IgG4 elevation in serum is related to sclerosing pancreatico-cholangiopathy that is sensitive to treatment with *** immunosuppressive regimes,especially with a combination of tacrolimus and sirolimus,reduce the production of all IgG subclasses after transplantation but it is not known if they deviate the immune *** of anti-donor IgG3 before transplantation,or its expansion after transplantation,has been associated with rejection and liver graft ***-GSTT1 IgG4 production after transplantation is associated with de-novo immune *** knowledge of anti-donor IgG subclass responses after transplantation will allow us tailor novel treatments for greater effect.

关键词： Anti-donor immunoglobulin G subclass liver transplantation