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结核病治疗过程中乙型肝炎病毒感染能预测肝毒性吗?制定一个初步的预测规律

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国际结核病与肺部疾病杂志 2010年第3期5卷 332-340页

作者： L.de castro P.E.A.A.do Brasll T.P.monteiro V.c.Rolla 韩喜琴刘宇红 Instituto de Pesquisa clinica Evandro chagas Fundao Oswaldo CruzRio de JaneiroRio de JaneiroBrazil

背景:结核病治疗过程中肝毒性的出现常常导致抗结核治疗的中断,或调整为较弱的治疗方案。目的:评估乙型肝炎病毒(HBV)感染者和未感染者在接受抗结核治疗过程中出现肝毒性的风险,从而制定出一套临床可遵循的预测规律。设计:采用前瞻性观... 详细信息

背景:结核病治疗过程中肝毒性的出现常常导致抗结核治疗的中断,或调整为较弱的治疗方案。目的:评估乙型肝炎病毒(HBV)感染者和未感染者在接受抗结核治疗过程中出现肝毒性的风险,从而制定出一套临床可遵循的预测规律。设计:采用前瞻性观察随访的研究方法。对接受抗结核治疗的154例患者的临床资料进行分析,采用粗风险比率估算并应用cox比例风险模型分析。结果:平均随访日为187 d,粗风险比率显示种族、人类免疫缺陷病毒感染(HIV)、多个性伴侣、高效联合抗病毒治疗以及结核病的临床类型可摘要能是出现肝毒性的预测因子。虽然无统计学意义,但HBV感染和其他性传播疾病仍显示为相当大的相对危险度。cox风险比例模型显示以下为出现肝毒性的高危因素:白种人、多个性伴侣、基础谷丙转氨酶升高以及结核病的临床类型。虽然缺乏精确的证据,但通过HBV表面抗原检测证实为活动性乙型肝炎的患者,仍预示可能出现肝毒性。结论:通过以上信息,我们可以根据分值绘制出列线图来估算每一个患者的生存概率和事件发生的中位时间。

关键词：结核乙型肝炎病毒抗结核药物药物毒性列线图 HIV

cystic fibrosis and the relevance of the whole-body vibration exercises in oscillating platforms: a short review

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Health 2011年第10期3卷 656-662页

作者： Adalgisa Ieda Maiworm Milena B.monteiro Sebastiao D.Santos-Filho Agnaldo J.Lopes Leandro Azeredo Sotiris Missailidis Pedro J.Marin Mario Bernardo-Filho Hospital Universitario Pedro Ernesto Setor de FisioterapiaUniversidade do Estado do Rio de JaneiroRio de JaneiroBrazil clinica de Fisioterapia e Biomedicina Rio de JaneiroBrazil Universidade do Estado do Rio de Janeiro Instituto de Biologia Roberto Alcantara GomesDepartamento de Biofisica e BiometriaRio de JaneiroBrazil Departamento de Pneumologia e coordenacao do centro de Referencia de Fibrose cistica em Adultos do Estado do Rio de Janeiro Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Hospital da Policia Militar NiteroiBrazil The open University Milton KeynesUK Laboratory of Physiology European University Miguel de CervantesValladolidSpain Research center on Physical Disability ASPAYMCastilla y LeonSpain coordenadoria de Pesquisa Instituto Nacional do CancerINCaRio de Janeiro Brazil.

objective: The aim is to present a review about the whole-body vibration (WBV) exercises in the management of cystic fibrosis (cF). Methods: computerized literature searches were performed using the PubMed databases. Results: A strong interest in studies, considering the number of publications, involving cF and lung was found. Although, the exercises and physical activities seem to have a high relevance in the management of the patients with cF, the number of publications involving these procedures is limited. Moreover, a modality of exercise involving WBV seems to be poorly utilized by the patients with cF and only two papers were found with positive actions. conclusion: oscillating platform is a promising technique to manage patients with cF. Moreover, as (i) the use of the oscillating platforms is inexpensive, (ii) the vibration exercise requires less technical abilities as compared to the performance of conventional resistance training and (iii) positive clinical findings have been noticed with the use of WBV in cF, it is suggested to implement the studies involving the application of the exercises with WBV in oscillating platforms to manage the patients with cF.

关键词： cystic fibrosis whole body vibration PubMed

Time-dependent impact of a high-fat diet on the intestinal barrier of male mice

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World Journal of Methodology 2024年第1期14卷 114-123页

作者： carolline Santos Miranda Daiana Araujo Santana-oliveira Isabela Lopes Vasques-monteiro Nathan Soares Dantas-Miranda Jade Sancha de oliveira Glauser Flavia Maria Silva-Veiga Vanessa Souza-Mello Department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil

BAcKGRoUND Excessive saturated fat intake compromises the integrity of the intestinal mucosa,leading to low-grade inflammation,impaired mucosal integrity,and increased intestinal permeability,resulting in the migration of lipopolysaccharide(LPS)to other *** To evaluate the chronic effects(at 10 and 16 wk)of a high-fat diet(HFD)(with 50%energy as fat)on the phylogenetic gut microbiota distribution and intestinal barrier structure and protection in c57BL/6 *** Forty adult male mice were divided into four nutritional groups,where the letters refer to the type of diet(control and HFD or HF)and the numbers refer to the period(in weeks)of diet administration:control diet for 10 wk,HFD for 10 wk,control diet for 16 wk,and HFD for 16 *** sacrifice,biochemical,molecular,and stereological analyses were *** The HF groups were overweight,had gut dysbiosis,had a progressive decrease in occludin immunostaining,and had increased LPS *** progression reduced the number of goblet cells per large intestine area and Mucin2 expression in the HF16 group,consistent with a completely disarranged intestinal ultrastructure after 16 wk of HFD *** chronic HFD intake causes overweight,gut dysbiosis,and morphological and functional alterations of the intestinal barrier after 10 or 16 ***-dependent reductions in goblet cell numerical density and mucus production have emerged as targets for countering obesity-driven intestinal damage.

关键词： High-fat diet Intestine Ultrastructure Goblet cells Gut microbiota

Notes for genera:Ascomycota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman c.Rajeshkumar David L.Hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree V.Singh Pedro W.crous Martin Kukwa Robert Lücking cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura Selbmann Monika c.Dayarathne Gothamie Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael F.castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová Lorenzo Lombard Belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati o.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb Marcela E.S.caceres Sergio Perez-ortega Patrícia o.Fiuza Josiane Santana monteiro Larissa N.Vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh Fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena oset Mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil c.Senanayake Subashini c.Jayasiri Milan c.Samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma Luis F.P.Gusmao Darshani Weerahewa Samantha c.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal culture collection of India(NFccI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSMZ-German collection of Microorganisms and cell cultures Inhoffenstraße 7B38124 BrunswickGermany Farlow Reference Library and Herbarium of cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of organismic and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature committee for Fungi(NcF).The previously invalidly published generic names Barriopsis,collophora(as collophorina),cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 classification one name Pleomorphic fungi Taxonomy

国际糖尿病足工作组:指南的制定和方法学(2023)——《国际糖尿病足工作组:糖尿病相关的足病预防与管理指南(2023)》的一部分

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感染、炎症、修复 2024年第1期25卷 72-79页

作者： Sicco A.Bus Matilde monteiro-Soares Fran Game Jaap J.van Netten Jan Apelqvist Robert Fitridge Eric Senneville Nicolaas c.Schaper on behalf of the IWGDF Editorial Board 朱虹何洁(译) 刘芳(审校) Amsterdam UMc University of AmsterdamDepartment of Rehabilitation MedicineAmsterdamthe Netherlands Amsterdam Movement Sciences program Rehabilitation&DevelopmentAmsterdamthe Netherlands Higher School of Health of the Portuguese Red cross LisbonPortugal Department of community Medicine Information and Health Decision Sciences(MEDCIDS)Faculty of MedicineUniversity of PortoPortoPortugal RISE@cINTESIS Faculty of MedicineOporto UniversityPortoPortugal Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Endocrinology University Hospital of MalmöSweden Discipline of Surgery The University of Adelaide and Vascular and Endovascular ServiceRoyal Adelaide HospitalAustralia Department of Infectious Diseases Gustave Dron HospitalTourcoingFrance Division of Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtthe Netherlands 不详温州医科大学附属第一医院内分泌科浙江温州325000 上海交通大学医学院附属第一医院内分泌代谢科上海200080

糖尿病相关的足病是造成糖尿病患者经济负担和增加社会成本的主要原因之一。本指南以主要目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病相关的足病指南对于减轻患者经济负担和社会成本有着重要影响。国际糖尿病足... 详细信息

糖尿病相关的足病是造成糖尿病患者经济负担和增加社会成本的主要原因之一。本指南以主要目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病相关的足病指南对于减轻患者经济负担和社会成本有着重要影响。国际糖尿病足工作组(IWGDF)从1999年起开始发布并随后更新国际指南。2023年更新版指南相关推荐均基于推荐、评估、发展和评价分级(GRADE)系统,包括制定相关临床问题和重要结局,完成系统的文献系统综述和荟萃分析,完成评判表汇总,并且给予具体、明确、操作性强的推荐以及理论依据。本文阐述了《国际糖尿病足工作组:糖尿病相关的足病预防和管理指南(2023版)》(以下简称为指南)的制定过程。指南由7个部分组成,包括预防、糖尿病相关的足溃疡分类、减压、周围动脉病变、感染、创面愈合干预以及活动性夏科神经骨关节病,分别由7个独立的国际专家工作组编写。IWGDF编辑委员会对7个章节进行了整合和简化,形成IWGDF实践指南。指南中的每条推荐均经过IWGDF编辑委员会成员和相关领域的独立的国际专家审阅通过。本文是IWGDF指南的制定和方法学。我们相信,医务人员、公共卫生机构和政策制定者采用和实施2023年IWGDF指南,将会改善糖尿病相关的足病的预防和管理水平,从而减少全球该疾病患者和减轻该疾病引起的全球社会负担。

关键词：指南糖尿病糖尿病相关的足病方法学国际糖尿病足工作组

软X射线光谱显微技术研究cacl2对c3S水化产物的影响(英文)

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软X射线光谱显微技术研究CaCl2对C3S水化产物的影响(英文)

Body Shape and coloration of Silkworm Larvae Are Influenced by a Novel cuticular Protein

中国硅酸盐学会混凝土与水泥制品分会第九届理事会成立大会暨第十一届全国高性能混凝土学术研讨会

作者：李琴飞葛勇耿国庆 Sungchul Bae Paulo J.M.monteiro 哈尔滨工业大学交通科学与工程学院 University of california-Berkeley Department of Civil Environmental and Enginecring

氯化钙作为一种极为有效的早强剂,能够极大程度上加速cS和水泥的水化反应,本文为了深入研究氯化钙对硅酸三钙的水化产物微观结构的影响,分别采用扫描透射X射线显微技术(STXM)和近边X射线吸收精细结构(NEXAFS)来进行研究。ca L-edge NEX... 详细信息

氯化钙作为一种极为有效的早强剂,能够极大程度上加速cS和水泥的水化反应,本文为了深入研究氯化钙对硅酸三钙的水化产物微观结构的影响,分别采用扫描透射X射线显微技术(STXM)和近边X射线吸收精细结构(NEXAFS)来进行研究。ca L-edge NEXAFS研究结果表明氯化钙在加速cS水化反应过程中,并未改变水化产物c-S-H微观结构中ca的配位环境,而oK-edge NEXAFS和化学组分分布能够有效区分cS水化产物的化学组成,是一种研究水泥基材料的高效先进的技术手段。

关键词：加速作用水化反应同步辐射 c-S-H ca3Sio5

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Body Shape and Coloration of Silkworm Larvae Are Influenced ...

Body shape and coloration of silkworm larvae are influenced by a novel cuticular protein

中国蚕学会第十届青年学术研讨会

作者： Gao Xiong Xiaoling Tong Tingting Gai chunlin Li Liang Qiao Antónia monteiro Hai Hu Minjin Han Xin Ding Songyuan Wu Zhonghuai Xiang cheng Lu Fangyin Dai State Key Laboratory of Silkworm Genome Biology Southwest University Key Laboratory of Sericultural Biology and Genetic Breeding Ministry of AgricultureCollege of BiotechnologySouthwest University Institute of Entomology and Molecular Biology College of Life SciencesChongqing Normal University Department of Biological Sciences National University of Singapore Yale-NUS college

The genetic basis of body shape and coloration patterns on caterpillars is often assumed to be regulated separately,but it is possible that common molecules affect both types of trait *** we examine the genetic basis of a spontaneous cuticle defect in silkworm,where larvae exhibit a bamboo-like body shape and decreased *** performed linkage mapping and mutation screening to determine the gene product that affects body shape and coloration *** these mutant larvae we identified a null mutation in BmorcPH24,a gene encoding a cuticular protein with low complexity *** expression analyses showed that BmorcPH24 is expressed in the larval epidermis ***-mediated knockdown and cRISPR/cas9-mediated knockout of BmorcPH24 produced the abnormal body shape and the inhibited pigment typical of the mutant *** addition,our results showed that BmorcPH24 may be involved in the synthesis of endocuticle and its disruption-induced apoptosis of epidermal cells that accompanied the reduced expression of R＆R-type larval cuticle protein genes and pigmentation gene Wnt1 Strikingly,BmorcPH24,a fast-evolving gene,has evolved a new function responsible for the assembly of silkworm larval cuticle and has evolved to be an indispensable factor maintaining the larval body shape and its coloration *** is the first study to identify a molecule whose pleiotropic function affects the development of body shape and color patterns in insect larvae.

关键词： apoptosis body shape color patterns cuticular protein novel gene

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Body shape and coloration of silkworm larvae are influenced ...

国际糖尿病足工作组:糖尿病足溃疡预防指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分

中国蚕学会第九届青年学术研讨会

The genetic basis of body shape and coloration patterns on caterpillars is often assumed to be regulated separately,but it is possible that common molecules affect both types of trait *** we examine the genetic basis of a spontaneous cuticle defect in silkworm,where larvae exhibit a bamboo-like body shape and also decreased *** performed linkage mapping and mutation screening to determine the gene product that affects body shape and coloration *** these mutant larvae we identified a null mutation in BmorcPH24,a gene encoding a cuticular protein with low complexity *** expression analyses showed that BmorcPH24 is expressed in the larval epidermis ***-mediated knockdown and cRISPR/cas9-mediated knockout of BmorcPH24 produced the abnormal body shape and the inhibited pigment typical of the mutant *** addition,our results showed that BmorcPH24 may be involved in the synthesis of endocuticle and its disruption induced apoptosis of epidermal cells which accompanied the reduced expression of R＆R-type larval cuticle protein genes and pigmentation gene ***,BmorcPH24,a fast-evolving gene,has evolved a new function responsible for the assembly of silkworm larval cuticle and has evolved to be an indispensable factor maintaining the larval body shape and its coloration *** is the first study to identify a molecule whose pleiotropic function affects the development of body shape and color patterns in insect larvae.

关键词： body shape color patterns cuticular protein apoptosis novel gene

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感染．炎症．修复 2019年第3期20卷 140-157页

作者： Sicco A.Bus Larry A.Lavery Matilde monteiro-Soares Anne Rasmussen Anita Raspovic Isabel c.N.Sacco Jaap J.van Netten 无罗颖琪李炳辉(译) 许樟荣(审校) Amsterdam UMc Department of Rehabilitation MedicineAcademic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Department of Plastic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA MEDcIDES:Departamento de Medicina da comunidade Informacao e Decisao em Saude&cINTESIS–center for Health Technology and Services Research Faculdade de Medicina da Universidade do PortoPortoPortugal Steno Diabetes center copenhagen GentofteDenmark Discipline of Podiatry School of Allied HealthHuman Services and SportLa Trobe UniversityMelbourneVictoriaAustralia Physical Therapy Speech and Occupational Therapy DepartmentSchool of MedicineUniversity of Sao PauloSao PauloBrazil School of clinical Sciences Queensland University of TechnologyBrisbaneAustralia Diabetic Foot clinic Department of SurgeryZiekenhuisgroep TwenteAlmelo and HengeloThe Netherlands International Working Group on the Diabetic Foot(IWGDF) 华中科技大学同济医学院附属梨园医院湖北武汉430077

国际糖尿病足工作组(IWGDF)1999年发布了关于预防和管理糖尿病足病的循证指南。该指南旨在预防糖尿病患者的足部溃疡,并在2015年,IWGDF对预防指南进行了更新。我们遵循GRADE(grading of recommendations assessment development and eva... 详细信息

国际糖尿病足工作组(IWGDF)1999年发布了关于预防和管理糖尿病足病的循证指南。该指南旨在预防糖尿病患者的足部溃疡,并在2015年,IWGDF对预防指南进行了更新。我们遵循GRADE(grading of recommendations assessment development and evaluation)的评分方法,采用以患者为观察对象、有干预措施、与对照组进行比较、观察结局(patient-intervention-comparison-outcome,PIco)的方法来设计临床问题和关键成果,对医学科学文献进行系统评价,并撰写推荐意见及其理由。这些推荐基于系统评价中发现的证据质量、专家意见,以及益处及危害的权重、患者偏好、可行性和适用性以及与干预相关成本的权衡。我们建议对处于极低溃疡风险的患者每年做一次筛查,了解其是否有周围神经病变和外周血管病变,对高风险人群检查的频率要更高,以筛查其他危险因素。为了预防足溃疡,要对有危险因素的患者进行健康教育,教育患者适当地对足部进行自我护理以及对溃疡前症状进行有效治疗。指导中高危患者穿着合适的治疗鞋,并对其足部皮肤温度进行监测。处方治疗鞋在行走过程中具有明显的减轻足底压力的效果,能够防止足底溃疡复发。急性足溃疡或即将发生的足溃疡保守治疗失败,应考虑手术干预。我们不建议使用神经松解减压术。对高危患者给予综合足部医疗护理,以防溃疡复发。贯彻这些推荐将有助于医疗专业人员对有足溃疡风险的糖尿病患者提供更好的护理,降低糖尿病足溃疡的发生率,使足部健康维持更长的时间即增加无足病的天数,显著减少糖尿病患者和医疗机构的负担。

关键词：糖尿病足足溃疡指南预防鞋具自我护理自我管理教育