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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

Neural Regeneration Research 2025年第7期20卷 1957-1970页

作者： Bridget Martinez Philip v.Peplow department of Pharmacology University of Nevada-RenoRenoNVUSA department of Medicine University of Nevada-RenoRenoNVUSA department of Anatomy University of OtagoDunedinNew Zealand

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSd)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to december *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSd subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSd and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.P.Sakamuri Anil Sakamuri department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;dal-valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Computer simulation of W-C-Co-v system diffusion couples

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Rare Metals 2007年第5期26卷 492-497页

作者： HE Yanlin LI Lin HUANG Shuigen Jef vleugels omer van der biest School of Material Science ＆ Engineering Shanghai University Shanghai 200072 China department of Metallurgy and Materials Engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 44 Heverlee B-3001 Belgium

diffusion couples,WC/Co-1at.%C,v8C7/Co,and WC/Co-0.3wt.%v8C7 were constructed and annealed at temperatures ranging from 1100 to 1300℃. The concentration profile of v and W atoms in these couples were measured by EPMA. Aided by Thermo-calc ＆ dICTRA software package,the concentration profiles of W and v in established diffusion couples were calculated by the moving boundary model according to revised dynamic parameters and MoB database,respectively. Then the concentration profile of W in Co binder during sintering WC-Co cemented carbide was simulated by the Cell model. It can provide reference for composition and sintering process design of cemented carbides with high performance. Meanwhile,the validity of revised dynamic parameters of the W-C-Co-v system is verified by the comparison of experimental and simulated results.

关键词： material science W-C-Co-v system Thermo-calc and dICTRA software package dynamic parameters

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High-Q surface electromagnetic wave resonance excitation in magnetophotonic crystals for supersensitive detection of weak light absorption in the near-infrared

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Photonics Research 2020年第1期8卷 57-64页

作者： o.v.BoRovKovA d.o.IGNATYEvA S.K.SEKATSKII A.KARABCHEvSKY v.I.BELoTELov Russian Quantum Center SkolkovoMoscow 143025Russia Lomonosov Moscow State University Moscow 119991Russia Laboratoire de Physique de la Matiere vivante IPHYSEPFL1015 LausanneSwitzerland School of Electrical and Computer Engineering Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

The mid-infrared spectrum can be recorded from almost any material,making mid-infrared spectroscopy an extremely important and widely used sample characterization and analysis ***,sensitive photoconductive detectors operate primarily in the near-infrared(NIR),but not in the mid-infrared,making the NIR more favorable for accurate spectral *** the absorption cross section of vibrational modes in the NIR is orders of magnitude smaller compared to the fundamental vibrations in the mid-infrared,different concepts have been proposed to increase the detectability of weak molecular transitions ***,the contribution of magnetophotonic structures in the NIR absorption effect has never been explored so *** we propose high-Q magnetophotonic structures for a supersensitive detection of weak absorption resonances in the *** analyze the contributions of both magnetic and nonmagnetic photonic crystal configurations to the detection of weak molecular transitions *** results constitute an important step towards the development of highly sensitive spectroscopic tools based on high-Q magnetophotonic sensors.

关键词： absorption magneto resonance

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/Cd73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Influence of Zr and Mn additions on microstructure and properties of Mg-2.5wt%Cu-Xwt%Zn(X=2.5,5 and 6.5)alloys

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International Journal of Minerals,Metallurgy and Materials 2022年第9期29卷 1733-1745页

作者： A.v.Koltygin v.E.Bazhenov I.v.Plisetskaya v.A.Bautin A.I.Bazlov N.Y.Tabachkova o.o.voropaeva A.A.Komissarov v.d.Belov Foundry department National University of Science and Technology(MISiS)Moscow 119049Russia department of Metallurgy Steel New Production Technologies and Protection of MetalsNational University of Science and Technology(MISiS)Moscow 119049Russia Laboratory of Advanced Green Materials National University of Science and Technology(MISiS)Moscow 119049Russia department of Materials Science of Semiconductors and dielectrics National University of Science and Technology(MISiS)Moscow 119049Russia Fianit Laboratory(Laser Materials and Technology Research Center at GPI) Prokhorov General Physics Institute RASMoscow 119991Russia Laboratory of Hybrid Nanostructured Materials National University of Science and Technology(MISiS)Moscow 119049Russia Laboratory of Medical Bioresorption and Bioresistance Moscow State University of Medicine and DentistryMoscow 127473Russia

This work studied the effects of adding Zr and Mn in amounts less than 1wt%on the microstructure,mechanical properties,casting properties,and corrosion resistance of Mg-Zn-Cu alloys containing 2.5wt%Cu and 2.5wt%-6.5wt%*** hardness and electrical conductivity measurements were used to find an optimal heat treatment schedule with the best mechanical *** has been established that Zr significantly increases the yield strength of the alloys due to a strong grain refinement ***,the presence of Mn and Zr has a detrimental effect on alloy’s elongation at *** was shown that the precipitation of the Mg_(2)Cu cathodic phase in the alloy structure negatively affects the corrosion ***,the addition of Mn decreases the corrosion rate of the investigated *** best combination of the mechanical,casting,and corrosion properties were achieved in the alloys containing 2.5wt%Cu and 5wt%***,the Mn or Zr addition can improve the properties of the alloys;for example,the addition of Mn or Zr increases the fluidity of the alloys.

关键词： magnesium alloy Mg-Zn-Cu casting alloy Mn addition Zr addition

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Experience gained in analyzing severe accidents for WWER RP using CC SoCRAT

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Frontiers in Energy 2021年第4期15卷 872-886页

作者： S.I.PANTYUSHIN А.v.LITYSHEv A.v.NIKoLAEvA o.v.AULovA d.L.GASPARov v.v.ASTAKHov M.A.BYKov Non-stationary Thermohydraulics department OKB Gidropress JSC 142103PodolskRussia

The current Russian regulatory documents on the safety of nuclear power plant(NPP)specify the requirements regarding design basis accidents(dBAs)and beyond design basis accidents(BdBAs),including severe accidents(SAs)with core meltdown,in NPP design(NP-001-15,NP-082-07,and others).For a rigorous calculational justification of BdBAs and SAs,it is necessary to develop an integral CC that will be in line with the requirements of regulatory documents on verification and certification(Rd-03-33-2008,Rd-03-34-2000)and will allow for determining the amount of data required to provide information within the scope stipulated by the requirements for the structure of the safety analysis report(SAR)(NP-006-16).The system of codes for realistic analysis of severe accidents(SoCRAT)(formerly,thermohydraulics(RATEG)/coupled physical and chemical processes(SvECHA)/behavior of core materials relocated into the reactor lower plenum(HEFEST))was developed in Russia to analyze a wide range of SAs at NPP with water-cooled water-moderated power-generating reactor(WWER)at all stages of the *** to the code and broadening of its applicability are continually being pursued by the code developers(Nuclear Safety Institute of the Russian Academy of Sciences(IBRAE RAN))with oKB Gidropress JSC and other ***,the SoCRAT/В1 code can be used as a base tool to obtain realistic estimates for all parameters important for computational justification of the reactor plant(RP)safety at the in-vessel stage of SAs with fuel *** perform analyses using CC SoCRAT/В1,the experience gained during execution of thermohydraulic codes is applied,which allows for minimizing the uncertainties in the results at the early stage of an accident *** study presents the results of the work performed in 2010–2020 in oKB Gidropress JSC using the CC SoCRAT/В*** have been considered to develop calculational models and analyze SAs using CC *** process,which is cle

关键词： system of codes for realistic analysis of severe accidents(SoCRAT) design basis accidents(dBAs) severe accidents(SAs) computer code(CC) nuclear power plant(NPP)design water-cooled water-moderated(WWER) modeling model safety requirements

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Effect of silica source on photocatalytic properties of Bi_(2)o_(3)/Bi_(2)Sio_(5) heterostructure

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Journal of Bioresources and Bioproducts 2023年第2期8卷 176-186页

作者： o.d.Arefieva M.S.vasilyeva L.A.Zemnukhova d.P.opra d.A.Nikolaeva v.v.Tkachev d.H.Shlyk Far Eastern Federal University Vladivostok 690922Russian Federation Institute of Chemistry Far-Eastern BranchRussian Academy of SciencesVladivostok 690922Russian Federation

The Bi_(2)o_(3)/Bi_(2)Sio_(5) heterostructures were obtained with various samples of silica as a precursor:on the basis of biogenic silica isolated from rice husk and rice straw and the silica of mineral ori-gin.A mixture of Bi(No_(3))_(3) and Sio_(2) with a mass content of 15%was used for synthesizing all the *** transform infrared(FT-IR)spectroscopy,scanning electron microscope(SEM),X-ray phase,X-ray fluorescence,and ultraviolet-visible diffused reflectance spectroscopy(Uv-vis dRS)were used to systematically characterize as-obtained *** of methyl orange in neutral aqueous solutions(pH=6.8)under Uv irradiation was studied to evaluate their photocatalytic ***,bandgaps,the value of the zero charge point,and photo-catalytic activity of the samples depended on the characteristics of the original *** degree of methyl orange degradation reached the maximum values(81%−85%)for samples based on precipitated silica from rice husks,straw,and the minimum value(16%)for a composite with thermal silica from rice *** based on thermal silica from rice husks and reagents from mineral raw materials did not statistically differ from each other in the degree of methyl orange degradation(67%−74%).

关键词： Biogenic silica Heterostructures Photocatalysis Rice husk Rice straw

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Coercivity kinetics upon step annealing of sintered Sm(Co0.88-xFexCu0.09Zr0.03)7 magnets

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Journal of Rare Earths 2019年第10期37卷 1059-1065页

作者： A.G.Popov o.A.Golovnia A.v.Protasov v.S.Gaviko d.A.Kolodkin R.Gopalan M.N.Miheev Institute of Metal Physics of Ural Branch of Russian Academy of Sciences Str.S.Kovalevskoy18Ekaterinburg620990Russia Institute of Natural Sciences and Mathematics Ural Federal Universitypr.MiraEkaterinburg19620002Russia International Advanced Research Centre for Powder Metallurgy and New Materials(ARCI) IITM Research ParkChennai 600113India

Behavior of the coercivity of the high-temperature Sm(Co0.88-xFexCu0.09Zr0.03)7 magnets depending on the temperature and time of annealing with the temperature decreasing stepwise from 700 to 400℃ was *** is shown that the growth rate of coercivity abruptly increases at the initial stage of annealing in the vicinity of the Curie temperature of the SmCo5 *** origin of the effect is the counter diffusion of Cu and Co atoms through dislocation tubes,which form because of enhanced stresses and a partial breakage of coherent coupling at the interface of the Sm2 Co17 and SmCo5 *** enrichment of the SmCo5 phase in Cu close to the interface with Sm2 Co17 leads to relaxation of stresses and increases in the gradient of the magnetic domain-wall energy and coercivity.

关键词： Sm-Co-Fe-Cu-Zr Permanent magnet Sm2Co17 SmCo5 Coercivity kinetics

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