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Association of Erectile Dysfunction and Hypogonadism with Metabolic Syndrome in Men with Lower Urinary Tract Symptoms of Younger and older Age Groups

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Advances in Sexual Medicine 2014年第4期4卷 55-64页

作者： Elena novikova Vera Selyatitskaya Igor Mitrofanov Boris pinkhasov Ani Karapetyan Siberian Branch of Russian Academy Medical Sciences Scientific Centre of Clinical and Experimental Medicine Novosibirsk Russia Department of Urology Regional Medical and Diagnostic Center Novosibirsk Russia

The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and older (40 - 60 years old) age groups depending on the presence of metabolic syndrome (MetS). Triglycerides, glucose and high-density lipoprotein cholesterol, serum total testosterone (TT), sex hormone-binding globulin, prostate-specific antigen, pituitary hormones levels were measured in serum. Standardized criteria (2009) were used to determine the prevalence of MetS. patients were assessed based on the International prostate Symptom Score (IpSS) and the IpSS-Quality of Life (IpSS-QoL) for LUTSs and the International Index of Erectile Function (IIEF) for ED. Hypogonadism was determined in accordance with the ISA, ISSAM, EAU, EAA and ASA recommendations. In men with MetS in the younger age group the incidence of ED was 2.4 times higher, and that of low TT level and hypogonadism was 8.4 times higher compared to men without the syndrome. In the older age group, an increased incidence of ED and low TT level in men with MetS compared to men without the syndrome was on the trend level, but the incidence of hypogonadism was for sure higher (by 1.6 times). In conclusion, the study showed that ED and hypogonadism are associated with MetS by a high degree of certainty in young men with LUTSs. In men of the older age group with LUTSs, the presence of MetS is not so clearly associated with ED and hypogonadism due to the fact that the incidence of these urogenital diseases is also high in men without MetS.

关键词： Erectile Dysfunction Testosterone Hypogonadism Metabolic Syndrome Men of Younger and older Age Groups Lower Urinary Tract Symptoms

Essential problems of Russian Students' Educational Activities Style Evaluation

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Essential Problems of Russian Students' Educational Activiti...

地震预测CN算法对世界22个地区的预测效能

作者： Elena novikova Vitaly Ivlev Andrey Galukhin plekhanov Russian University of Economics (pRUE) National Research University Bauman Moscow State Technical University (BMSTU)

This paper presents the results of the interdisciplinary study of the relationship between teleological determinants, cognitive constituents and individual features of the student's activities within the framework of general educational process. We assume that heuristic educational programs should be developed on the basis of taking into account the alternative cognitive dispositions of students, their attitudes, preferences and styles. The study of students' cognitive styles is designed to reveal the possibilities of improving actual educational practices. This would enable to develop the most efficient learning and teaching strategies and to identify the prominent ways of forming personal attitudes towards education in accordance with social requirements and professional standards. Specifically, this paper considers the issue of how academic corporate culture influences the students' cognitive styles manifested in educational activities. The main constituents of academic corporate culture such as educational standards, values and beliefs play a significant role in framing the vision of the opportunities of the student'spersonal enhancement as a future professional. The stylistic features of Russian students' educational activities are mainly formed under the influence of professional career guidance and actual demands of the labor market. But this determination does not exclude factors that possibly could lead to the deformation of personal development.

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世界地震译丛 2000年第1期31卷 24-29页

作者： I.Rotwain o.novikova 王林瑛中国地震局地球物理研究所

评估了在世界22个地区利用地震预测CN算法进行的中期地震预测。区域的选择取决于可得到的地震目录的质量。由于CN算法的参量已事先确定并发表,因而对地震的预测完全可以重复。总的检验结果如下:在发布警报的26％的时间内,预测的24次地... 详细信息

评估了在世界22个地区利用地震预测CN算法进行的中期地震预测。区域的选择取决于可得到的地震目录的质量。由于CN算法的参量已事先确定并发表,因而对地震的预测完全可以重复。总的检验结果如下:在发布警报的26％的时间内,预测的24次地震中有11次确实发生了,占46％。预测的总误差可以用警报总时间和预报失误率之和R表征。我们得到R=0.26+(1-0.46)=0.8。该R值比对加州地区的回顾性预测的总误差高2倍。预测的统计显著性到目前为止为91％;如果以后几年预测质量仍保持不变的话,统计显著性将超过96％。

关键词：地震预测 CN算法预测效能震级

Fuel Cycle for Reactor SVBR-100

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材料科学与工程（中英文B版） 2011年第7期1卷 929-937页

作者： Zrodnikov Anatoly Toshinsky Georgy Komlev oleg Melnikov Kirill novikova Nataliya FSUE Institute for physics and power Engineering （IppE） 1 Bondarenko sq. Obninsk Kaluga rg 249033 Russia

The report presents a validated strategy of implementation of fast reactors SVBR-100 in nuclear power, which provides putting in operation the reactors using the mastered uranium oxide fuel with postponed reprocessing and changing over to the closed fuel cycle with use of the own spent fuel. By the end of the lifetime, a comparatively high core breeding ratio (~0.84) of reactor SVBR-100 using uranium oxide fuel for operation provides high content of plutonium in the spent nuclear fuel, which could be used in next fuel lifetimes while organizing the closed fuel cycle. That strategy is more economically efficient as the amount of reprocessing in terms of 1 t of plutonium is approximately 10 times less than the corresponding amount of plutonium extracted from the spent nuclear fuel of thermal reactors. Such approach to organization of the fuel cycle will reduce considerably the integral consumption of natural uranium and regarding to this, it will make Npps based on reactors SVBR-100 competitive with Npps based on thermal reactors. The report also reveals that in the closed nuclear fuel cycle instead of pile (depleted) uranium, the spent fuel of thermal reactors without separating of uranium, plutonium, minor actinides and fission products can be used as makeup fuel similarly to the DUpIC-technology for reactors CANDU.

关键词：核燃料循环热核反应堆热中子反应堆铀燃料核电厂循环利用循环使用 IC技术

Effect of prostate Inflammation on Ejaculate Indicators in Men of Various Ages from Infertility Couples

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Advances in Sexual Medicine 2023年第1期13卷 1-9页

作者： Elena G. novikova Vera G. Selyatitskaya Igor I. Tityaev Federal Research Centеr of Fundamental and Translational Medicine Novosibirsk Russia Regional Medical and Diagnostic Centre Ltd. Novosibirsk Russia State Budgetary Institution of Healthcare Novosibirsk’s Region City Hospital No. 1 Novosibirsk Russia

The question of the impact of chronic prostatitis on male fertility remains debatable. In our study, we proved that inflammation of the prostate affects the characteristics of a man’s ejaculate. The inflammatory process negatively affects the reproductive characteristics of men of all ages, however, in the older age group, its clinical and laboratory manifestations are most pronounced.

关键词： Spermatogenesis prostatitis Inflammation Male Infertility

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苏联军队全部撤出阿富汗以后的情况研究

苏联军队全部撤出阿富汗以后的情况研究

作者：拉娜（novikova Svetlana）中国石油大学（北京）

学位级别：硕士

苏联军队全部撤出阿富汗以后的情况研究是一个当代国际政治中最有现实意义的题目。20年多来,阿富汗一直处于兵荒马乱的战争状态,战乱使阿富汗成为世界最主要的毒品和武器走私、恐怖主义和极端主义的存在场所之一;塔利班推行极端伊斯兰路... 详细信息

苏联军队全部撤出阿富汗以后的情况研究是一个当代国际政治中最有现实意义的题目。20年多来,阿富汗一直处于兵荒马乱的战争状态,战乱使阿富汗成为世界最主要的毒品和武器走私、恐怖主义和极端主义的存在场所之一;塔利班推行极端伊斯兰路线,对南亚,中亚地区的稳定和安全构成严重威胁。因此,阿富汗问题引起国际社会的极大关注,并不断加大和平调解力度。中亚国家、俄罗斯、美国、中国和国际组织都全力支持国际社会共同努力解决阿富汗问题,认为没有国际社会的帮助,阿富汗无法自己解决问题。为了更清楚地研究阿富汗问题的原因、影响和结果,作者根据阿富汗历史用四章来分别研究在每个政权下阿富汗的政治、经济、社会情况和各种各样的问题,国际社会为解决阿富汗问题所作出的行动和影响。第一章,研究苏联撤离之后的阿富汗内部局势（1989-1992）:苏联队撤离之后的穆罕默德·纳吉布拉政权;沙阿纳瓦兹·塔奈的叛乱与反对派和政府的谈判进程;纳吉布拉政权垮台和分离的影响范围。第二章,研究塔利班的运动:阿富汗的塔利班政权（1996-2001）;国际恐怖主义和极端主义;毒品贩运的威胁和“大政策”;阿富汗的社会和经济状况;塔利班政权被推翻之后的阿富汗内部问题。第三章,研究阿富汗和国际社会:联合国,哈萨克斯坦,俄罗斯,美国和中国改善目前的状况。第四章,结论,作者在研究的课题作出一般性结论和为了解决阿富汗问题提出的建议。本文的重要意义在于,充分研究阿富汗的政治和军事行动的教训,总结出可供参考的经验,形成更为合理的阿富汗问题解决方案,并使我们能够充分地应对当今和未来的安全挑战。与此同时,我们必须考虑援助重建阿富汗的经济。因为全世界的安全与稳定取决于阿富汗问题的解决。

关键词：阿富汗问题毒品恐怖主义极端主义塔利班

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余华及其作品在俄罗斯的传播

余华及其作品在俄罗斯的传播

作者：罗小花（novikova Anna）华南理工大学

学位级别：硕士

现在俄罗斯的汉学家们普遍认为,中国当代文学在俄罗斯的外国文学市场中处于末端。为了找出造成这种情况的原因,并寻求解决的方法,本人选择余华作为案例来进行本次的研究。以前对中国文学的研究都是通过作品的内容来进行,现在本人希望从... 详细信息

现在俄罗斯的汉学家们普遍认为,中国当代文学在俄罗斯的外国文学市场中处于末端。为了找出造成这种情况的原因,并寻求解决的方法,本人选择余华作为案例来进行本次的研究。以前对中国文学的研究都是通过作品的内容来进行,现在本人希望从传播的角度切入研究,采取文献法、案例研究法和问卷调查法通过对社会背景、余华及其作品传播原因以及读者等方面的分析,加深对中国现当代文学在俄罗斯传播情况的了解,并创新性地分析余华及其作品在俄罗斯的传播原因,进而为中国现当代文学在俄罗斯更好地传播寻求可行之道。通过研究发现：1、大部分的俄罗斯读者了解的中国文学还都是古代文学和共产主义的文学。2、尽管读者认为余华的作品是很好理解的、有趣的以及值得看的,但依然会觉得外国作家写的有关中国题材的作品更易于理解。3、余华读者的年龄跨度较大,而且其中大部分的人都是跟中国有关联的人。4、余华在俄罗斯出名的主要原因是他的作品在中国被禁止这一卖点。5、因为大部分读者都是带着目的性去阅读关于中国的书籍,并希望从中获得对中国的相关知识,而不是单纯的去享受文学作品。余华的《十个词汇里的中国》这一作品正好符合了这一趋势。6、读者最感兴趣的是一些关于中国负面的、不好的方面。而在余华的作品中,关于“文化大革命”、“暴力”以及“山寨”这些方面的描写正好符合了读者的心态。7、由于读者对中国文学现状不了解,在描写关于中国的作品中,他们很难分辨出作品的真伪以及优劣。8、莫言的出名引发了俄罗斯读者对中国文学新一轮的热潮,这也使得余华的作品被更多俄罗斯读者所知。9、通过调查研究本人发现影响中国文学在俄罗斯传播的最大因素有两个：一是读者自身;二是媒体的不作为。大部分读者自己不会特意去关注搜寻关于中国文学的资料和作品,并且也没有一个确切的平台来提供这一方面的讯息。根据研究的结果,本人认为要改善目前的状况,可通过以下几种途径：增加作品的种类;媒体加大宣传力度;政府给予政策和资金的支持;加强两国之间的文化交流;建立一个全面的中国文学平台。

关键词：余华俄罗斯文学传播

Analytical philosophy of Education: Approaches and Russian Realities

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Functional reconstruction of bovine p450scc steroidogenic system in <i>Escherichia coli</i>

作者： Elena novikova Andrey Galukhin Vitaly Ivlev Marina L.Ivleva plekhanov Russian Economic University (REU) National Research University Bauman Moscow State Technical Universit (BMSTU) peoples' Friendship University of Russia

The article explores the constructive possibilities of developing theories and approaches in the field of higher school pedagogy based on the use of a system of concepts and methods of analytical philosophy. The methodological functions of analytical philosophy in relation to educational programs in higher education manifested themselves in the form of a fundamental focus on conceptual analysis, revealing substantial and variational aspects of the meaning of terms used for theoretical description and modeling of the educational process. The specifics of the methodology and the thematic profile of the analytical philosophy of education are revealed through the analysis of the concepts of R. peters and p. Hirst, representative for this direction, which consist in certain continuity and reflect both positive heuristics and limitations of the analytical approaches used in educational theory. Russian higher education paradigms cover the stages of formation in general, which are indicated in the analytical philosophy of education. However, the epistemological similarity is accompanied by an ontological difference in the basis for the development of programs, which in Russian schools are more relevant to the specifics of the socio-economic and cultural context.

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American Journal of Molecular Biology 2013年第4期3卷 173-182页

作者： Desislava S. Makeeva Dmitry V. Dovbnya Marina V. Donova Ludmila A. novikova Belozersky Institute of physico-Chemical Biology Lomonosov Moscow State University Moscow Russia Institute of Biochemistry & physiology of Microorganisms Russian Academy of Sciences Pushchino Russia

Mammalian cytochrome p450scc enzyme system catalyzes the initial step in steroid hormone biosynthesis—cholesterol hydroxylation followed by cleavage of the side-chain to yield pregnenolone. This system consists of three components—the cytochrome p450scc (CYp11A1), a flavoprotein (NADpH-adrenodoxin reductase, AdR) and an iron-sulfur protein (adrenodoxin, Adx). In this work, the three-component electron transport chain (AdR/Adx/CYp11A1) from bovine adrenal cortex has been implemented in Escherichia coli by co-expression of the corresponding coding sequences from a tricistronic plasmid. The cDNAs of AdR, Adx and CYp11A1 are situated in a single transcription unit and separated by ribosome binding sequences. The recombinant strain created was capable of synthesizing functional proteins identical to the bovine CYp11A1, AdR and Adx on molecular weights and immuno-specificity. The experiments in vivo showed pregnenolone production from cholesterol by the transformed bacteria. Maximal productivity of 0.42 ± 0.015 mg/l pregnenolone for 24 h has been reached for the induced cells in the presence of cholesterol solubilizing agent—methyl-β-cyclodextrin. Thus, a stable transgenic E. coli strain with the functional reconstructed bovine cholesterol side-chain cleavage system has been firstly generated in this work. The findings are of importance for studies of mammalian steroidogenic system features, and may open some perspectives for further generation of novel microbial biocatalysts.

关键词： Cytochrome p450 CYp11A1 Adrenodoxin Adrenodoxin Reductase Steroid Hormone Biosynthesis Heterologous Expression