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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 11-11页

作者： o'Connell J.B. Maggard M.A. C.Y. Ko 成虹 Department of Surgery David Geffen School of Medicine at UCLA 72- 215 CHS 10833 Le Conte Avenue Los Angeles CA 90095 United StatesDr.

PURPoSE: Most studies examining mucinous or signet-ring cell colorectal cancers are single institution reports. This study used a national cancer registry to analyze the epidemiology and survival outcomes of these two subtypes of colorectal cancer compared with adenocarcinoma tumors. METHoDS: All patients diagnosed with mucinous (n = 16,991), signet-ring cell (n = 1,522), or adenocarcinoma (n = 146,115) colorectal cancer in the Surveillance, Epidemiology, and End Results database (1991- 2000) were evaluated. Analyses were performed to obtain age-adjusted incidence rates, stage at presentation, tumor grade, and five-year relative survival for each subtype. RESULTS: Mucinous were slightly morin females (53.4 percent). Incidence rates per 100,000 persons were: mu-cinous, 5.5; signet-ring cell, 0.6; and adenocarcinoma 46.6. The annual percent change during ten years was stable for mucinous, increased for signet-ring cell (4.8 percent; P or adenocarcinoma (- 1.1 percent; P ous (18 percent) and signet-ring cell (21 percent) tumors were located in the rectum compared with adenocarcinoma (29 percent). Signet-ring cell presented at later stage (III/IV, 80.9 percent) more often than mucinous (52.8 percent) and adenocarcinoma (49.5 percent), and also had worse tumor grade (high grade: signet-ring cell, 73.5 percent; mucinous, 20.9 percent; adenocarcinoma, 17.5 percent). Rela-tive five-year survival was worse for signet-ring cell than mucinous or adenocarcinoma. CoNCLUSIoNS: We present a large population-based review of colorectal cancer subtypes by analyzing national data from the past decade. Although the incidence of colorectal adenocarcinoma is decreasing in the United States, mucinous and signet-ring cell subtypes are stable and increasing, respectively. Importantly, it seems that the signet-ring cell subtype has worse outcomes, whereas survival rates for mucinous tumors are similar to adenocarcinomas.

关键词：印戒细胞癌结肠直肠效果评价黏液癌大肠腺癌肿瘤分级肿瘤分期晚期肿瘤数据分析百分比变化

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