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PGE mineralization and melt composition of chromitites in Proterozoic ophiolite complexes of Eastern Sayan,Southern Siberia

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Geoscience Frontiers 2017年第4期8卷 721-731页

作者： o.kiseleva S.Zhmodik V.S.Sobolev Institute of Geology and Mineralogy SB RAS Novosibirsk State University

The ospino-Kitoi and Kharanur ultrabasic massifs represent the northern and southern ophiolite branches respectively of the Upper onot ophiolitic nappe and they are located in the southeastern part of the Eastern Sayan（SEPES ophiolites）.Podiform chromitites with PGE mineralization occur as lensoid pods within dunites and rarely in harzburgites or serpentinized *** chromitites are classified into type I and type Ⅱ based on their Cr~#.Type I（Cr~# = 59-85） occurs in both northern and southern branches,whereas type Ⅱ（Cr~# = 76-90） occurs only in the northern *** contents range from ∑PGE 88-1189 ppb,Pt/Ir0.04-0.42 to ∑PGE 250-1700 ppb,Pt/Ir 0.03-0.25 for type I chromitites of the northern and southern branches *** type Ⅱ chromitites of the northern branch have ∑PGE contents higher than that of type Ⅰ（468-8617 ppb,Pt/Ir 0.1-0.33）.Parental melt compositions,in equilibrium with podiform chromitites,are in the range of boninitic melts and vary in Al_2o_3,Tio_2 and Feo/Mgo contents from those of type I and type Ⅱ *** melt compositions for type Ⅰ chromitites are（Al_2o_3）_（melt） = 10.6—13.5 wt.%,（Tio_2）_（melt） = 0.01-0.44 wt.%,（Fe/Mg）_（melt） = 0.42-1.81;those for type Ⅱ chromitites are：（Al_2o_3）_（melt） = 7.8-10.5 wt.%,（Tio_2）_（melt） = 0.01-0.25 wt.%,（Fe/Mg）_（melt） = *** are further divided into os-Ir-Ru（Ⅰ） and Pt-Pd（Ⅱ） based on their PGE *** type Ⅰ chromitites show only the os-Ir-Ru pattern whereas type Ⅱ shows both os-Ir-Ru and Pt-Pd *** mineralization in type Ⅰ chromitites is represented by the os-Ir-Ru system,whereas in type Ⅱ it is represented by the os-Ir-Ru-Rh-Pt *** results indicate that chromitites and PGE mineralization in the northern branch formed in a suprasubduction setting from a fluid-rich boninitic melt during active ***,the chromitites and PGE mineralization of the southern branch could have formed in a spreading zone *** peridotites have

关键词： Chromitites PGE mineralization os-Ir-Ru and Pt-Pd patterns ophiolite Eastern Sayan Parental melt

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Immune Profile of CoVID-19 Survivors and Contacts During 9 Months:A Cohort Study

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Infectious Diseases & Immunity 2023年第4期3卷 163-175页

作者： Valentina V.Tatarnikova Natalya o.kiseleva Valentina I.Dubrovina Vladimir A.Vishnyakov Darya D.Bryukhova Anna B.Pyatidesyatnikova Konstantin M.Korytov Munko B.Sharakshanov Sergey V.Balakhonov Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor Irkutsk 664047Russia

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes a multi-organ systemic damage that can lead to long-term *** is known about the possible long-term effects of CoVID-19 on circulating leukocyte kinetics and functional T-cell activity after *** investigate immune system changes,we designed a cohort ***:Volunteer screening and sample collectionwere performed at the Irkutsk Research Anti-Plague Institute of ***-four volunteers who have had CoVID-19(recovered volunteers(RVs))betweenMay 2020 andMay 2021,33 volunteers who had been in contact with CoVID-19 patients(contact volunteers(CVs))within the family setting but had not become ill,and 47 healthy volunteers(HVs)participated in the *** performed immunophenotyping of peripheral blood cells using flow *** was tested for SARS-CoV-2 anti-nucleocapsid immunoglobulin G antibodies by enzyme-linked immunosorbent assay(Ab(+),people with specific anti-N antibodies to SARS-CoV-2;Ab(−),people without specific antibodies).Results:There were no serious disturbances in the internal environment of the body in RVs and *** the evaluation of the general state of the immune system,the most informative indicator was the index of the ratio of neutrophils to bloodmonocytes–decreased on the 1st terms of observation(1 and 3 months post-symptom onset(PSo)/post-contact onset(PCo)),on average,1.3 times compared with HVs(8.6%(7.5%–10.5%),Povered by the 6th month of *** of the cells responsible for the development of the adaptive immune response was noted only in RVs–increased B-lymphocyte content(HVs,9.1%(6.4%–10.2%))and immunoregulatory index ratio(HVs,1.6%(1.2%–2.1%))due to redistribution of T-helper and cytotoxic T cells throughout the follow-up period by an average of 1.2-fold compared with HVs(Powever,CVs with specific antibodies to SARS-CoV-2 N-protein also had an increased proportion of CD3−CD19+c

关键词： CoVID-19 Flow cytometry Immunity Specific IgG T cells B cells

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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

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Drosophila melanogaster brain invasion pathogenic Wolbachia in central nervous system of the fly

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Insect Science 2016年第2期23卷 253-264页

作者： Anton Strunov Elena kiseleva Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Prospekt Lavrentyeva 10 Novosibirsk 630090Russia

The pathogenic Wolbachia strain wMelPop rapidly over-replicates in the brain, muscles, and retina of Drosophila melanogaster, causing severe tissue degeneration and premature death of the host. The unique features of this endosymbiont make it an excellent tool to be used for biological control of insects, pests, and vectors of human diseases. To follow the dynamics of bacterial morphology and titer in the nerve cells we used transmission electron microscopy of 3-d-old female brains. The neurons and glial cells from central brain of the fly had different Wolbachia titers ranging from single bacteria to large accumulations, tearing cell apart and invading extracellular space. The neuropile regions of the brain were free of wMelPop. Wolbaehia tightly interacted with host cell organelles and underwent several morphological changes in nerve cells. Based on different morphological types of bacteria described we propose for the first time a scheme of wMelPop dynamics within the somatic tissue of the host.

关键词： bacterial morphology dynamics brain Drosophila melanogaster electronmicroscopy pathogenic endosymbiont Wolbachia strain wMelPop

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla o Magro Marcello Imbrizi Ellen CS De oliveira Luiz C Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

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Molecular pathways of liver regeneration:A comprehensive review

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World Journal of Hepatology 2021年第3期13卷 270-290页

作者： Yana V kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri o Zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Emergency Surgical Gastroenterology N.V.Sklifosovsky Research Institute for Emergency MedicineMoscow 129010Russia Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of Minimally Invasive Surgery A.I.Evdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Pathology Department A.V.Vishnevsky National Medical Research Center of Surgery of the Russian Ministry of HealthcareMoscow 117997Russia

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its *** knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute *** liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver *** current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic *** studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases.

关键词： Liver regeneration Molecular pathways Hepatic progenitor cells Cytokines Micro ribonucleic acid Partial hepatectomy

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