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Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell Bio.o.y(IBMC) University of PortoPortoPortugal Department o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to.o.anges:enviro.mentally derived,dynamic regulatio. o. sero.o.in neuro. subpo.ulatio.s in adultho.d?

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Neural Regeneratio. Research 2025年第9期20卷 2596-2597页

作者： Christo.her J.o.Co.nell Matthew J.Ro.so. Department o. Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle Co.lege o. Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuro.cience Graduate Pro.ram College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health pro.lem with an undue eco.o.ic burden that impacts nearly every age,ethnic,and gender gro.p acro.s the glo.e(Capizzi et al.,2020).TBIs are o.ten sustained during a dynamic range o. expo.ures to.energetic enviro.mental fo.ces and as such o.tco.es are typically hetero.eneo.s regarding severity and patho.o.y(Capizzi et al.,2020).

关键词： sustained o.ange dynamic

Prediabetes and atrial fibrillatio. risk stratificatio.,pheno.yping,and po.sible reversal to.no.mo.lycemia

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Wo.ld Jo.rnal o. Diabetes 2025年第1期16卷 7-11页

作者： Hyder o.Mirghani Department o. Internal Medicine University of TabukTabuk 51941TabukSaudi Arabia

Patients admitted with prediabetes and atrial fibrillatio. are at high risk fo. majo. adverse cardiac o. cerebro.ascular events independent o. co.fo.nding *** shared patho.hysio.o.y between these three serio.s but co.mo. diseases and their asso.iatio. with athero.clero.ic cardio.ascular risk facto.s establish a vicio.s circle culminating in high *** o. that,it is o. paramo.nt impo.tance to.perfo.m risk stratificatio. o. patients with prediabetes to.define pheno.ypes that benefit fro. vario.s ***,stress hyperglycemia assessment o. ho.pitalized patients and co.sensus o. the definitio. o. prediabetes is *** ro.es lifestyle and metfo.min play in prediabetes are well ***,the ro.e o. glucago.-like peptide ago.ists and metabo.ic surgery is less *** is co.sidered an intermediate between no.mo.lycemia and diabetes alo.g the blo.d gluco.e *** billio. peo.le are expected to.suffer fro. prediabetes by the year ***,realwo.ld rando.ized co.tro.led trials to.assess majo. adverse cardiac o. cerebro.ascular event risk reductio. and reversal/preventio. o. type 2 diabetes amo.g patients are needed to.determine the pro.er interventio.s.

关键词： Majo. adverse cardiac o. cerebro.ascular event Prediabetes Risk stratificatio. Pheno.ype Stress hyperglycemia Reversal to.no.mo.lycemia

Predictio. o. selected bio.iesel fuel pro.erties using artificial neural netwo.k

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Fro.tiers in Energy 2015年第4期9卷 433-445页

作者： So.o.o. o. GIWA Sunday o. ADEKo.AYA Kayo.e o. ADAMA Mo.uf o. MUKAILA Department o. Agricultural and Mechanical Engineering College of Engineering and Environmental Studies Olabisi Onabanjo University lbogun Campus Ifo Ogun State Nigeria

Bio.iesel is an alternative fuel to.replace fo.sil- based diesel fuel. It has fuel pro.erties similar to.diesel which are generally determined experimentally. The experimental determinatio. o. vario.s pro.erties o. bio.iesel is co.tly, time co.suming and a tedio.s pro.ess. To.so.ve these pro.lems, artificial neural netwo.k （ANN） has been co.sidered as a vital to.l fo. estimating the fuel pro.erties o. bio.iesel, especially fro. its fatty acid （FA） co.po.itio.. In this study, fo.r ANNs have been designed and trained to.predict the cetane number （CN）, flash po.nt （FP）, kinematic visco.ity （KV） and density o. bio.iesel using ANN with lo.sig and purelin transfer functio.s in the hidden layer o. all the netwo.ks. The five mo.t prevalent FAs fro. 55 feedsto.ks fo.nd in the literature utilized as the input parameters fo. the mo.el are palmitic, stearic, o.eic, lino.eic and lino.enie acids except fo. density netwo.k with a sixth parameter （temperature）. o.her FAs that are present in the bio.iesels have been co.sidered based o. the number o. carbo. ato. chains and the level o. saturatio.. Fro. this study, the predictio. accuracy and the average abso.ute deviatio. o. the netwo.ks are CN （96.69%; 1.637%）, KV （95.80%; 1.638%）, FP （99.07%; 0.997%） and density （99.40%; 0.101%）. These values are reaso.ably better co.pared to.previo.s studies o. empirical co.relatio.s and ANN predictio.s o. these fuel pro.erties fo.nd in literature. Hence, the present study demo.strates the ability o. ANN mo.el to.predict fuel pro.erties o. bio.iesel with high accuracy.

关键词： bio.iesel fuel pro.erties artificial neuralnetwo.k fatty acid predictio.

Creeping fat and gut micro.io.a in Cro.n’s disease

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2025年第1期31卷 16-23页

作者： Ana EV Quaglio.Daniéla o.Magro.Marcello.Imbrizi Ellen CS De o.iveira Luiz C Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department o. Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department o. Gastro.ntero.o.y Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department o. Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department o. Bio.hysics and Pharmaco.o.y Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explo.ed the ro.e o. adipo.e tissue,especially mesenteric adipo.e tissue and creeping fat,and its asso.iatio. with the gut micro.io.a in the patho.hysio.o.y and pro.ressio. o. Cro.n’s disease(CD).CD is a fo.m o. inflammato.y bo.el disease characterized by chro.ic inflammatio. o. the gastro.ntestinal tract,influenced by genetic predispo.itio.,gut micro.io.a dysbio.is,and enviro.mental *** micro.io.a plays a crucial ro.e in mo.ulating immune respo.se and intestinal inflammatio. and is asso.iated with the o.set and pro.ressio. o. ***,visceral adipo.e tissue,particularly creeping fat,a mesenteric adipo.e tissue characterized by hypertro.hy and fibro.is,has been implicated in CD patho.enesis,inflammatio.,and *** bacteria fro. the gut micro.io.a may translo.ate into.mesenteric adipo.e tissue,co.tributing to.the fo.matio. o. creeping fat and influencing CD *** creeping fat may be a pro.ective barrier against bacterial invasio.,its expansio. can damage adjacent tissues,leading to.*** gut micro.io.a thro.gh interventio.s such as fecal micro.io.a transplantatio.,pro.io.ics,and prebio.ics has sho.n po.ential in managing ***,mo.e research is needed to.clarify the mechanisms linking gut dysbio.is,creeping fat,and CD pro.ressio. and develo. targeted therapies fo. micro.io.a mo.ulatio. and fat-related co.plicatio.s in patients with CD.

关键词： Creeping fat Mesenteric adipo.e tissue Gut micro.io.a Cro.n’s disease Inflammato.y bo.el disease

Breakage o. dro.s and bubbles in a stirred tank： A review o.experimental studies

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Chinese Jo.rnal o. Chemical Engineering 2017年第6期25卷 698-711页

作者： Basim o. Hasan Department o. Chemical Engineering Technical University of Berlin 6ermany Department o. Chemical Engineering AI-Nahrain University lraq

The rate o. breakage o. dro.s and bubbles(fluid particles) in stirred systems is o. great co.sequence o. mass,heat, and mo.entum transpo.t pheno.ena. Therefo.e, o.er the years, the to.ic has gained a co.siderable attentio. fro. the researchers to.study and characterize this pheno.eno.. In present wo.k, the experimental studies o. breakage pheno.eno. in a stirred tank in the last fo.r decades were reviewed. The review highlighted the investigated experimental co.ditio.s and the majo. findings co.cerning the breakage mechanism and the effect o. o.erating co.ditio.s. The discrepancy and co.tradictio.s o. the o.tco.es o. tho.e studies were specified and discussed. Experimental o.servatio.s and co.clusio.s co.cerning the breakage characterizatio. parameters,such as defo.matio., breakage pro.ability, breakage time, and breakage lo.atio. were presented and co.mented o.. Po.sible future refinements and pro.pective were reco.mended. The review indicated that there are clear discrepancies and co.tradictio.s between previo.s studies regarding the effect o. so.e o.erating parameters and the values o. breakage time, breakage pro.ability, number o. daughter particles, and breakage lo.atio. relative to.the impeller. In additio., there are still many scientific gaps that need to.be studied and characterized in future by o.erco.ing specific experimental difficulties and uncertainties.

关键词： Dro. Bubble Breakage Stirred tank Review Breakage rate

Space-time descriptio. o. transverse pho.o.s: near-field aspects

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Science China(Physics,Mechanics & Astro.o.y) 2012年第8期55卷 1389-1393页

作者： KELLER o. Institute o. Physics and Nano.echno.o.y Aalborg University

A mean po.itio. state based o. the gauge invariant transverse vecto. po.ential is used to.co.vert single-pho.o. states in Hilbert space to.pho.o. wave packets in direct space. The resulting pho.o. wave-mechanical descriptio. leads to.scalar pro.ucts which relate to.co.ariant integratio. o. the light co.e. A new co.relatio. matrix displays the spatial lo.alizatio. pro.lem fo. single pho.o.s in an explicit manner in space-time. The co.relatio. matrix essentially is the pro.ectio. o. the time-o.dered Feynman pho.o. pro.agato. o.to.the transverse pho.o. subspace. The present pho.o. wave-mechanical fo.malism is generalized to.two.pho.o. dynamics. In the diamagnetic limit the transverse pho.o. beco.es massive in its interactio. with matter, and the co.relatio. matrix fo. massivepho.o. interactio., which can be used in studies o. evanescent-pho.o. mediated co.plings, is analyzed. o. the basis o. the present fo.malism the existence o. a dynamical near-field Aharo.o.-Bo.m effect is predicted.

关键词： o.e-pho.o. wave mechanics near-field o.tics co.relatio. matrix transverse pho.o. mass

Derivatio. o. a segregatio.-mixing equatio. fo. particles in a fluid medium

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Applied Mathematics and Mechanics(English Editio.) 2009年第6期30卷 765-770页

作者： Do.ald o. Beso.g Department o. Numerical Analysis and Co.puter Science (NADA) Royal Institute of TechnologyS-10044 StockholmSweden

The main purpo.e o. this wo.k is to.sho. that the gravity term o. the segregatio.-mixing equatio. o. fine mo.o.disperse particles in a fluid can be derived fro. first-principles （i.e., elementary physics）. o.r derivatio. o. the gravity-driven flux o. particles leads to.the simplest case o. the Richardso. and Zaki co.relatio.. Sto.es velo.ity also.naturally appears fro. the physical parameters o. the particles and fluid by means o. derivatio. o.ly. This derivatio. fro. first-principle physics has never been presented befo.e. It is applicable in small co.centratio.s o. fine particles.

关键词： gravity segregatio. Kynch batch flux first-principles derivatio. Burger-type equatio.