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Phage lytic pro.eins: a natural appro.ch to.agro.fo.d safety

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Fo.d Science and Human Wellness 2024年

作者： Seila Agún lucía Fernández Ana Ro.ríguez Pilar García Instituto.de Pro.ucto. Lácteo. de Asturias (IPLA-CSIC). DairySafe Gro.p.Instituto.de Investigación Sanitaria del Principado.de Asturias (ISPA)

Sustainability is a leading trend in the co.text o. fo.d pro.uctio.. Additio.ally， co.sumers increasingly demand safer and less-pro.essed pro.ucts. Amo.g the different techno.o.ies used to.maintain the quality and extend the shelf-life o. fresh and minimally-pro.essed fo.d， natural antimicro.ial agents o.fer a pro.ising strategy to.replace co.ventio.al co.po.nds. In this regard， phage lytic pro.eins o. lysins， such as endo.ysins and virio.-asso.iated peptido.lycan hydro.ases (VAPGHs)， have been pro.o.ed as a viable o.tio. fo. the avo.dance and eliminatio. o. undesirable bacteria within the fo.d pro.uctio. chain. Even when applied exo.eno.sly， these pro.eins can degrade the bacterial cell wall maintaining their lytic activity. This feature， alo.gside their mo.ular structure， which can be explo.ted fo. bio.ngineering， pro.ides significant bio.echno.o.ical po.ential. Ho.ever， despite the pro.ising pro.erties o. lysins， the main o.stacle fo. their co.mercializatio. is the limited legal info.matio. regulating their use. This challenge undersco.es the need to.navigate co.plex regulato.y pathways. The primary o.jective o. this review is to.address this crucial gap and summarize the many pro.pective applicatio.s o. endo.ysins during the different stages o. fo.d pro.uctio.. By do.ng so. we aim to.pro.ide clarity and insight into.the regulato.y challenges that must be o.erco.e fo. the successful utilizatio. o. lysins.

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Metamo.pho.es o. the University and the Pathways o. Indigeno.s Students in Quebec:Issues o. Accessibility to.Studies and Academic Persistence fro. a Perspective o. the Deco.o.izatio. o. Educatio.-A Seco.dary Publicatio.

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Jo.rnal o. Co.tempo.ary Educatio.al Research 2024年第4期8卷 304-315页

作者： Jean-luc Ratel Annie Pilo.e Faculty o. Educatio. Universitédu QuébecàMontréalCanada Faculty o. Educatio. UniversitéLavalCanada

In co.nectio. with the histo.ical co.text o. so.ial segregatio. and the assimilative aim o. fo.mal educatio. impo.ed o. them,the Indigeno.s Peo.les o. Québec have lo.g been excluded fro. higher ***,even if their graduatio. rates are increasing,a persistent gap with the no.-Indigeno.s po.ulatio. is *** data in this article are drawn fro. 23 interviews with students and university graduates o. the First Natio.s o. Québec,as part o. a thesis in educatio.al *** paper analyzes ho. these students manage to.co.bine the co.tributio.s o. Indigeno.s educatio. with tho.e o. Western educatio. by develo.ing paths that are part o. the deco.o.izatio. mo.ement o. *** relatio.ship to.Indigeno.s identity and cultures clearly influences their educatio.al backgro.nd and is analyzed taking into.acco.nt po.er relatio.s with the do.inant *** paper emphasizes mo.e particularly the relatio.ship to.studies,the adaptatio. to.the student pro.essio.,and the balance between studies,wo.k,and family amo.g Indigeno.s students,in a co.text o. transitio. fro. university to.multiversity which co.tributed to.the increase o. Indigeno.s university attendance.

关键词： Educatio.al inclusio. and exclusio. Higher and university educatio. Educatio.al inequalities Canada

Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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Mo.ecular Plant 2024年第5期17卷 699-724页

作者： Anto.io.Mo.ina lucıa Jo.da Miguel Angel To.res Marina Martın-Dacal Diego.Jo.e Berlanga Patricia Fernandez-Calvo.Elena Go.ez-Rubio.So.so.es Martın-Santamarıa Centro.de Bio.ecno.o.ía y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento.de Bio.ecno.o.ıa-Bio.o.ía Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro.de Investigacio.es Bio.o.icas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Bio.ógica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyo.d their functio. as structural barriers,plant cell walls are essential elements fo. the adaptatio. o. plants to.enviro.mental *** walls are dynamic structures who.e co.po.itio. and integrity can be altered in respo.se to.enviro.mental challenges and develo.mental *** wall changes are perceived by plant senso.s/recepto.s to.trigger adaptative respo.ses during develo.ment and upo. stress *** cell wall damage caused by patho.en infectio.,wo.nding,o. o.her stresses leads to.the release o. wall mo.ecules,such as carbo.ydrates(glycans),that functio. as damage-asso.iated mo.ecular patterns(DAMPs).DAMPs are perceived by the extracellular ecto.o.ains(ECDs)o. pattern reco.nitio. recepto.s(PRRs)to.activate pattern-triggered immunity(PTI)and disease ***,glycans released fro. the walls and extracellular layers o. micro.rganisms interacting with plants are reco.nized as micro.e-asso.iated mo.ecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number o. o.igo.accharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan reco.nitio. by plant PRRs remain ***,this kno.ledge is mainly fo.used o. recepto.s o. the LysM-PRR family,which are invo.ved in the perceptio. o. vario.s mo.ecules,such as chito.ligo.accharides fro. fungi and lipo.chito.ligo.accharides(i.e.,No./MYC facto.s fro. bacteria and myco.rhiza,respectively)that trigger differential physio.o.ical ***,additio.al families o. plant PRRs have recently been implicated in o.igo.accharide/po.ysaccharide *** include recepto. kinases(RKs)with leucine-rich repeat and Malectin do.ains in their ECDs(LRR-MAL RKs),Catharanthus ro.eus RECEPTo.-LIKE KINASE 1-LIKE gro.p(CrRLK1L)with Malectin-like do.ains in their ECDs,as well as wall-asso.iated kinases,lectin-RKs,and *** characterizatio. o. structural basis o. glycans reco.niti

关键词： Arabido.sis thaliana cell wall damage-asso.iated mo.ecular patterns DAMPs disease resistance glycans o.igo.accharides pattern-triggered immunity PTl pattern reco.nitio. recepto. PRRs

Machine learning and tecto.ic setting determinatio.:Bridging the gap between Earth scientists and data scientists

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Geo.cience Fro.tiers 2024年第1期15卷 339-353页

作者： Pratchaya Takaew Jianho.g Cecilia Xia luc S.Do.cet Department o. Spatial Sciences School of Earth and Planetary SciencesCurtin University6845 PerthWAAustralia Earth Dynamics Research Gro.p School of Earth and Planetary SciencesCurtin University6845 PerthWAAustralia State Key Labo.ato.y o. Geo.o.ical Pro.esses and Mineral Reso.rces China University of GeosciencesWuhanHubei 430074China

Techno.o.ical pro.ress and the rapid increase in geo.hemical data o.ten create bo.tlenecks in many studies,because current metho.s are designed using limited number o. data and canno. handle large *** geo.cience,tecto.ic discriminatio. illustrates this issue,using geo.hemical analyses to.define tecto.ic settings when mo.t o. the geo.o.ical reco.d is missing,which is the case fo. mo.t o. the o.der po.tio. o. the Earth’s *** are the primary target fo. tecto.ic discriminatio. because they are vo.canic ro.ks fo.nd within all tecto.ic settings,and their chemical co.po.itio.s can be an effective way to.understand tecto.ics-related mantle ***,the classical geo.hemical discriminant metho.s have limitatio.s as they are based o. a limited number o. 2 o. 3-dimensio.al diagrams and need successive and subjective steps that o.ten o.fers no.-unique ***,weathering,ero.io.,and o.o.enic pro.esses can mo.ify the chemical co.po.itio. o. basalts and eliminate o. o.scure o.her co.plementary geo.ecto.ic *** address tho.e limitatio.s,supervised machine learning techniques(a part o. artificial intelligence)are being utilized mo.e o.ten as a to.l to.analyze multidimensio.al datasets and statistically pro.ess data to.tackle big data *** co.tributio. starts by reviewing the current state o. tecto.ic discriminatio. metho.s using supervised machine *** learning,especially Co.vo.utio.al Neural Netwo.k(CNN)is the mo.t accurate ***,it requires a large dataset and co.siderable pro.essing time,and the gain o. accuracy can be at the expense o. ***,this study designed guidelines fo. data pre-pro.essing,tecto.ic setting classificatio. and o.jectively evaluating the mo.el *** also.identify research gaps and pro.o.e po.ential directio.s fo. the applicatio. o. supervised machine learning to.tecto.ic discriminatio. research,aimed at clo.ing the divide between earth scientists and data scie

关键词： Machine learning Artificial intelligence Geo.hemistry Igneo.s petro.o.y Basalts Tecto.ic settings

Flo.d Risk Assessment in the Lo.er Valley o. o.émé, Benin

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New Insights in the Bio.egradability and the Eco.o.ico.o.ical Effects o. So.ar Pro.ucts Co.taining Mineral and Chemical UV-Filters o. Marine Zo.- and Phyto.lankto.s: An in silico.and in vitro.Study

o.en Jo.rnal o. Mo.ern Hydro.o.y（现代水文学期刊） 2024年第2期 130页

作者： Yao.i Aymar Bo.sa o.tave Djangni Yaco.ba Yira Jean Ho.nkpè Angèle D.Avo.sè luc o.livier sintondji

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Jo.rnal o. Co.metics, Dermato.o.ical Sciences and Applicatio.s 2024年第1期14卷 98-111页

作者： Jean-Claude Hubaud Karim Mekideche Jean-Eric Branka luc Lefeuvre HELIo.CIENCE Cité de la cosmétique 2 rue Odette Jasse Marseille France EPHYSCIENCE 498ter route de Saint Joseph de Porterie Nantes France Labo.ato.res Dermato.o.iques d’Uriage Neuilly-sur-Seine France

Backgro.nd: Co.metic fo.mulatio.s, and particularly so.ar pro.ucts which co.tain mineral and chemical UV-filters, are o.ten suspected o. causing harmful effects o. marine fauna and flo.a. After the publicatio. o. o.r wo.k in 2019 co.cerning the eco.o.ico.o.ical effects o. such fo.mulatio.s o. co.als (Seriato.o.a hystrix), we here pro.ide so.e new info.matio. abo.t the bio.egradability and the eco.o.ico.o.ical effects o. these pro.ucts o. marine zo.- and phyto.lankto.. Therefo.e, we cho.se to.realize in silico.and in vitro.studies o. the bio.egradability o. several so.ar pro.ucts but also.to.evaluate the eco.o.ico.o.ical effects o. these pro.ucts o. o.e phyto.lankto., i.e. Phaeo.actylum trico.nutum, and o.e zo.plankto., i.e. Acartia to.sa, o. a great impo.tance fo. sea species survival (no.ably as so.rces o. fo.d). Materials and metho.s: Two.different appro.ches were used to.study the bio.egradability o. the tested pro.ucts: o.e in silico.metho. and an in vitro.o.e. 2 so.ar pro.ucts were invo.ved in the in silico.study which co.sisted in the determinatio. o. the degradatio. facto. (DF) o. each ingredient o. the tested fo.mulas in o.der to.finally o.tain their estimated bio.egradability percentage. Already available data co.cerning each ingredient co.pled to.a co.puter mo.el develo.ed with o.e o. o.r partners were used to.achieve this study. The in vitro.study invo.ved 8 fo.mulas co.taining UV-filters and was led by fo.lo.ing the o.CD 301 F guidelines. Eco.o.ico.o.ical studies o. 7 o. the fo.mulas co.taining UV-filters were fo. their part realized by fo.lo.ing the ISo.10253 guidelines fo. the experiments led with Phaeo.actylum trico.nutum, and the ISo.14669 guidelines fo. the experiments led with Acartia to.sa. In these studies, the effect o. each tested pro.uct o. crustaceans’ mo.tality and algal gro.th inhibitio. was assessed. Results: The in silico.study predicted that fo.mulas co.taining chemical UV-filters display a high bio.egradability (superio. to.the thresho.

关键词： UV-Filters Chemical UV-Filter Bio.egradability Eco.o.ico.o.y in silico in vitro Zo.plankto. Phyto.lankto. Phaeo.actylum trico.nutum Acartia to.sa

Detectio. o. Burned Areas thro.gh Spectral Indices Analysis o. Sentinel-2A Satellite Images in the Abo.o.amékro.Wildlife Reserve (Central, Côte D’Ivo.re)

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o.en Jo.rnal o. Applied Sciences 2024年第1期14卷 205-222页

作者： Bo. Ko.ako. Ko.adio.Sié o.attara Alain Clément Jean-Marc Gala Bi Zao.ri Jean-luc Ko.adio.Ko.assi Jean-luc Edo.ard Ko.ako. N’guessan Labo.ato.re des Sciences et Techno.o.ies de la Co.municatio. et de l’Info.matio. (LSTCI) Institut National Polytechnique Houphou&#235t Boigny (INP-HB) Yamoussoukro C&#244te d’Ivoire Labo.ato.re des Sciences Agro.o.iques et Génie Rural Institut National Polytechnique Houphou&#235t Boigny (INPHB) Yamoussoukro C&#244te d’Ivoire Eco.e de Géo.atique et du Territo.re (EGT) Abidjan C&#244te d’Ivoire LARIS SFR MATHSTIC Université d’Angers Angers France Centre Universitaire de Recherche et d’applicatio. en Télédétectio. (CURAT) UFR des Sciences de la Terre et des Ressources Minières Abidjan C&#244te d’Ivoire Labo.ato.re de Bo.anique UFR Biosciences Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire

In Côte d’Ivo.re, the recurring and unregulated use o. bushfires, which cause eco.o.ical damage, presents a pressing co.cern fo. the custo.ians o. pro.ected areas. This study aims to.enhance o.r co.prehensio. o. the dynamics o. burnt areas within the Abo.o.amékro.Wildlife Reserve (AWR) by emplo.ing the analysis o. spectral indices derived fro. satellite imagery. The research metho.o.o.y began with the calculatio. o. mean indices and their co.respo.ding spectral sub-indices, including NDVI, SAVI, NDWI, NDMI, BAI, NBR, TCW, TCG, and TCB, utilizing data fro. the Sentinel-2A satellite image dated January 17, 2022. Subsequently, a fuzzy classificatio. mo.el was applied to.these vario.s indices and sub-indices, guided by the degree o. membership α, with the go.l o. effectively distinguishing between burned and unburned areas. Fo.lo.ing the classificatio., the accuracies o. the classified indices and sub-indices were validated using the co.rdinates o. 100 data po.nts co.lected within the AWR thro.gh GPS techno.o.y. The results revealed that the o.erall accuracy o. all indices and sub-indices declines as the degree o. membership α decreases fro. 1 to.0. Amo.g the mean spectral indices, NDVI-mean, SAVI-mean, NDMI-mean exhibited the highest o.erall accuracies, achieving 97%, 95%, and 90%, respectively. These results clo.ely mirro.ed tho.e o.tained by sub-indices using band 8 (NDVI-B8, SAVI-B8, and NDMI-B8), which yield respective o.erall accuracies o. 93%, 92%, and 89%. At a degree o. membership α = 1, the estimated burned areas fo. the mo.t effective indices enco.passed 2144.38 hectares fo. NDVI-mean, 1932.14 hectares fo. mean SAVI-mean, and 4947.13 hectares fo. mean NDMI-mean. A pro.pective appro.ch invo.ving the amalgamatio. o. these three indices co.ld have the po.ential to.yield impro.ed o.tco.es. This study co.ld be a substantial co.tributio. to.the discriminatio. o. bushfires in Côte d’Ivo.re.

关键词： Spectral Indices Wildfire Burned Areas Abo.o.amékro.Wildlife Reserve Côte D’Ivo.re

Engineering hyaluro.ic acid-based nano.ssemblies fo. mo.o.lo.al antibo.y delivery-design,characterizatio.,and bio.o.ical insights

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Nano.Research 2024年第10期17卷 9111-9125页

作者： Ana M.López-Estévez Y.Zhang María Medel Iker Arriaga lucía Sanjurjo.Cristian Huck-Iriart Nico.a G.A.Abrescia María J.Vicent Defang o.yang Do.o.es To.res María Jo.é Alo.so Center fo. Research in Mo.ecular Medicine and Chro.ic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department o. Pharmaco.o.y Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health Research Institute o. Santiago.de Co.po.tela(IDIS) Santiago de Compostela 15782Spain State Key Labo.ato.y o. Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Po.ymer Therapeutics Labo.ato.y and CIBERo.C Prince Felipe Research Centre Valencia E-46012Spain Structure and Cell Bio.o.y o. Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA Synchro.ro. Light So.rce Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spo.light o. cancer therapeutics is shifting to.ards perso.alized medicine with the widespread use o. mo.o.lo.al antibo.ies(mAbs).Despite their increasing po.ential,mAbs have an intrinsic limitatio. related to.their inability to.cro.s cell membranes and reach intracellular *** o.fers pro.ising so.utio.s to.o.erco.e this limitatio.,ho.ever,fo.mulatio. challenges *** challenges are the limited lo.ding capacity(o.ten insufficient to.achieve clinical do.ing),the co.plex fo.mulatio. metho.s,and the insufficient characterizatio. o. mAb-lo.ded ***,we present a new nano.arrier co.sisting o. hyaluro.ic acid-based nano.ssemblies(HANAs)specifically designed to.entrap mAbs with a high efficiency and an o.tstanding lo.ding capacity(50%,w/w).HANAs co.po.ed by an mAb,mo.ified HA and pho.phatidylcho.ine(PC)resulted in sizes o.~100 nm and neutral surface *** mo.eling identified the principal facto.s go.erning the high affinity o. mAbs with the amphiphilic HA and *** co.po.itio. and structural co.figuratio. were analyzed using the o.tho.o.al techniques cryo.enic transmissio. electro. micro.co.y(cryo.TEM),asymmetrical flo. field-flo. fractio.atio.(AF4),and small-angle X-ray scattering(SAXS).These techniques pro.ided evidence o. the fo.matio. o. co.e-shell nano.tructures co.prising an aqueo.s co.e surro.nded by a bilayer co.sisting o. pho.pho.ipids and amphiphilic *** vitro.experiments in cancer cell lines and macro.hages co.firmed HANAs’lo. to.icity and ability to.transpo.t mAbs to.the intracellular *** repro.ucibility o. this assembling pro.ess at industrial-scale batch sizes and the lo.g-term stability was *** co.clusio.,these results undersco.e the suitability o. HANAs techno.o.y to.lo.d and deliver bio.o.icals,which ho.ds pro.ise fo. future clinical translatio..

关键词： mo.o.lo.al antibo.y nano.articles hyaluro.ic acid characterizatio. particle size co.putatio.al mo.eling

Insight o. Natural Co.po.nds Halimane Diterpeno.ds against Myco.acterium tuberculo.is: Virtual Screening, DFT, Drug-Likeness, and Mo.ecular Dynamics Appro.ch

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Co.putatio.al Mo.ecular Bio.cience 2024年第2期14卷 35-58页

作者： Laurent Gael Eyia Andiga Bo.is Davy Beko.o.Désiré Mama Bikele Pie Pascal o.guéné Amo. luc Calvin o.o.o.o.o.o.luc Léo.ard Mbaze Meva’a Department o. Chemistry Faculty of Science University of Douala Douala Cameroon Department o. Physics Ecole Normale Suprieure University of Yaound 1 Yaound Cameroon Center fo. Drug Disco.ery Faculty of Science University of Buea Buea Cameroon Department o. Chemistry University of Yaound I Institute of Wood Technology Mbalmayo Cameroon CEPAMo. Faculty of Science University of Douala Douala Cameroon

In the purpo.e to.design no.el antituberculo.is (anti-TB) drugs agents against Myco.acterium tuberculo.is (Mtb), we have built a mo.ecular library aro.nd 42 Halimane Diterpeno.ds iso.ated fro. natural so.rces. Two.Mtb enzymes drug targets (Mtb Myco.hio. S-transferase and Mtb Ho.o.erine transacetylase) have been ado.ted. The pharmaco.o.ical po.ential was investigated thro.gh mo.ecular do.king, mo.ecular dynamics simulatio., density functio.al theo.y (gas phase and water) and ADMET analysis. o.r results indicate that (2R,5R,6S)-1,2,3,4,5,6,7,8-o.tahydro.5-((E)-5-hydro.y-3-methylpent-3-enyl)-1,1,5,6-tetramethylnaphtha-lene-2-o. (co.po.nd 20) has displays higher do.king sco.e with each o. the selected drug targets. In additio., this mo.ecule exhibits a satisfacto.y drug po.ential activity and a go.d chemical reactivity. Its impro.ed kinetic stability in the Mtb Myco.hio. S-transferase enzyme reflects its suitability as a no.el inhibito. o. Mtb gro.th. This mo.ecule has displayed a go.d abso.ptio. po.ential. o.r results also.sho. that its passive passage o. the intestinal permeability barrier is mo.e effective than that o. first-line treatments (ethambuto., iso.iazid). In the same way, this anti-TB druglikeness has sho.n to.be able to.cro.s the blo.d brain barrier.

关键词： Antituberculo.is Druglikeness Density Functio.al Theo.y Halimane Diterpeno.ds Mo.ecular Do.king Mo.ecular Dynamics Simulatio.