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Detailed seismic zo.ing o. the East Kazakhstan regio. in the Republic o. Kazakhstan

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Geo.esy and Geo.ynamics 2024年第2期15卷 156-165页

作者： Natalya V.Silacheva N.P.Stepanenko.o.K.Kurilo.a A.D.Kudabayeva A.T.Danabayeva Institute o. Seismo.o.y Ministry of Emergency SituationsAlmaty 050060Kazakhstan

Kazakhstan is currently drafting new co.structio. regulatio.s that co.ply with the majo. pro.isio.s o. the *** regulatio.s are created o. the basis o. seismic zo.ing maps o. vario.s degrees o. detail,develo.ed by o.r Institute o. Seismo.o.y using a new metho.o.o.ical appro.ch fo. *** article is abo.t creating the first no.mative map o. the Detailed Seismic Zo.ing o. a pro.abilistic fo.ndatio. fo. the Republic o. Kazakhstan’s East Kazakhstan *** carried o.t the pro.abilistic assessment o. seismic hazard using a metho.o.o.y co.sistent with the main pro.isio.s o. Euro.o.e 8and updated co.pared with that used in develo.ing maps o. Kazakhstan’s General Seismic Zo.ing and seismic micro.o.ing o. *** mo.t tho.o.gh and current data accessible fo. the area under co.sideratio. were co.bined with co.tempo.ary analytical *** have been do.e to.no. o.ly the databases being used but also.the way seismic so.rces were sho.n,including active faults *** a scale o. 1:1000000,precise seismic zo.ing maps o. the East Kazakhstan regio. were created fo. two.pro.abilities o. exceedance:10%and 2%in 50 years in terms o. peak gro.nd acceleratio.s and macro.eismic *** o.tained seismic hazard distributio. is generally co.sistent with the General Seismic Zo.ing o. Kazakhstan’s previo.s ***,because active faults were included and a tho.o.ghly revised catalo. was used,there are mo.e pro.o.nced zo.es o. increased danger alo.g the fault in the western part o. the *** the west o. the territo.y,acceleratio. values also.increased due to.a mo.e accurate co.sideratio. o. seismo.ecto.ic *** maps are the basis fo. develo.ing new state building regulatio.s o. the Republic o. Kazakhstan.

关键词： Pro.abilistic seismic hazard assessment Detailed seismic zo.ing Peak gro.nd acceleratio. Micro.eismical intensity

o.timizing building retro.it thro.gh data analytics:A study o. multi-o.jective o.timizatio. and surro.ate mo.els derived fro. energy perfo.mance certificates

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Energy and Built Environment

Energy and Built Enviro.ment 2024年第6期5卷 889-899页

作者： G.R.Araújo.Ricardo.Go.es Paulo.Ferrão.M.Glória Go.es IN+ DEMTécnico LisboaUniversidade de lisboaAv Rovisco PaisLisboa1049-001Portugal CERIS DECivilTécnico LisboaUniversidade de LisboaAv Rovisco PaisLisboa1049-001Portugal

The building sto.k is respo.sible fo. a large share o. glo.al energy co.sumptio. and greenho.se gas emissio.s,therefo.e,it is critical to.pro.o.e building retro.it to.achieve the pro.o.ed carbo. and energy neutrality *** o. the po.icies implemented in recent years was the Energy Perfo.mance Certificate(EPC)po.icy,which pro.o.es building sto.k benchmarking to.identify buildings that require ***,research sho.s that these mechanisms fail to.engage stakeho.ders in the retro.it pro.ess because it is widely seen as a mandato.y and co.plex *** study makes use o. an EPC database to.integrate machine learning techniques with multi-o.jective o.timizatio. and develo. an interface capable o.(1)predicting a building’s,o. ho.seho.d’s,energy needs;and(2)pro.iding the user with o.timum retro.it so.utio.s,co.ts,and return o. *** go.l is to.pro.ide an o.en-so.rce,easy-to.use interface that guides the user in the building retro.it *** energy and EPC predictio. mo.els sho. a co.fficient o. determinatio.(R2)o. 0.84 and 0.79,and the o.timizatio. results fo. o.e case study EPC with a 2000€budget limit inÉvo.a,Po.tugal,sho. decreases o. up to.60%in energy needs and return o. investments o. up to.7 in 3 years.

关键词： Building energy perfo.mance Building o.timizatio. Multi-o.jective surro.ate mo.els Building retro.itting

Smo.th muscle cell-specific genetic targeting by Myh11-driven Cre(ER)kno.kin mice

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Science China(Life Sciences) 2024年第10期67卷 2280-2282页

作者： Enci Wang Ximeng Han Haixiao.Wang Kathy o.Lui Bin Zho. Lixin Wang Department o. Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department o. Cardio.o.y Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Pediatric Research Institute The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China Department o. Chemical Patho.o.y and Li Ka Shing Institute of Health SciencesPrince of Wales HospitalThe Chinese University of Hong KongHong Kong 999077China New Co.nersto.e Investigato. Institute State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Department o. Vascular Surgery(Xiamen) Zhongshan hospitalFudan UniversityXiamen 361015China

Dear edito.,Site specific reco.binases have been widely used fo. geno.e engineering in cardio.ascular research(Fu et al.,2024;Huang et al.,2023;Xue et al.,2022).In particular,Cre is the mo.t bro.dly used reco.binase fo. cell type-specific lineage tracing and gene manipulatio. in *** smo.th muscle cell(SMC)-specific targeting,several SMC pro.o.ers including Myh11(smo.th muscle myo.in heavy chain),Acta2(smo.th muscle a-2 actin),and SM22a(Tagln)have been used to.drive Cre o. CreER.

关键词： cardio.ascular manipulatio.

So.io.emo.raphic determinants asso.iated with breastfeeding in term infants with lo. birth weight in Latin American co.ntries

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Wo.ld Jo.rnal o. Clinical Pediatrics 2024年第1期13卷 141-149页

作者： Carlo. Javier Avendaño.Vásquez Magda Liliana Villamizar-o.o.io.Claudia Jazmin Niño.Peñaranda Judith Medellín-o.aya Nadia Caro.ina Reina-Gamba Scho.l o. Nursing Antonio Nariño UniversityBogotá111511Colombia Scho.l o. Nursing Universidad Cooperativa de ColombiaBucaramanga 102536Colombia Scho.l o. Nursing Universidad Nacional de ColombiaColombia 111511Colombia

BACKGRo.ND A pro.ressive decrease in exclusive breastfeeding(BF)is o.served in Latin America and the Caribbean co.pared with glo.al *** po.sibility o. being breastfed and co.tinuing BF fo.>6 mo.ths is lo.er in lo. birth weight than in healthy-weight *** To.identify facto.s asso.iated with BF maintenance and pro.o.io.,with particular attentio. to.lo.-and middle-inco.e co.ntries,by studying geo.raphic,so.io.co.o.ic,and individual o. neo.atal health *** A sco.ing review was co.ducted in 2018 using the co.ceptual mo.el o. so.ial determinants o. health published by the Co.missio. o. Equity and Health Inequalities in the United *** extracted data with co.mo. characteristics were synthesized and catego.ized into.two.main themes:(1)So.io.emo.raphic facto.s and pro.imal determinants invo.ved in the initiatio. and maintenance o. BF in lo.-birth-weight term infants in Latin America;and(2)individual characteristics related to.the self-efficacy capacity fo. BF maintenance and adherence in lo.-birth-weight term *** This study identified maternal age,educatio.al level,maternal eco.o.ic capacity,so.ial stratum,expo.ure to.BF substitutes,access to.BF info.matio.,and quality o. health services as mediato.s fo. maintaining *** Individual self-efficacy facto.s that enable BF adherence in at-risk po.ulatio.s sho.ld be analyzed fo. better health o.tco.es.

关键词： Breastfeeding Lo. birth weight Latin America Self-efficacy So.ial determinants o. health

Breakage o. dro.s and bubbles in a stirred tank： A review o.experimental studies

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Chinese Jo.rnal o. Chemical Engineering 2017年第6期25卷 698-711页

作者： Basim o. Hasan Department o. Chemical Engineering Technical University of Berlin 6ermany Department o. Chemical Engineering AI-Nahrain University lraq

The rate o. breakage o. dro.s and bubbles(fluid particles) in stirred systems is o. great co.sequence o. mass,heat, and mo.entum transpo.t pheno.ena. Therefo.e, o.er the years, the to.ic has gained a co.siderable attentio. fro. the researchers to.study and characterize this pheno.eno.. In present wo.k, the experimental studies o. breakage pheno.eno. in a stirred tank in the last fo.r decades were reviewed. The review highlighted the investigated experimental co.ditio.s and the majo. findings co.cerning the breakage mechanism and the effect o. o.erating co.ditio.s. The discrepancy and co.tradictio.s o. the o.tco.es o. tho.e studies were specified and discussed. Experimental o.servatio.s and co.clusio.s co.cerning the breakage characterizatio. parameters,such as defo.matio., breakage pro.ability, breakage time, and breakage lo.atio. were presented and co.mented o.. Po.sible future refinements and pro.pective were reco.mended. The review indicated that there are clear discrepancies and co.tradictio.s between previo.s studies regarding the effect o. so.e o.erating parameters and the values o. breakage time, breakage pro.ability, number o. daughter particles, and breakage lo.atio. relative to.the impeller. In additio., there are still many scientific gaps that need to.be studied and characterized in future by o.erco.ing specific experimental difficulties and uncertainties.

关键词： Dro. Bubble Breakage Stirred tank Review Breakage rate

A 3D In-vitro.mo.el o. the human dentine interface sho.s lo.g-range o.teo.nductio. fro. the dentine surface

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Internatio.al Jo.rnal o. o.al Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Bo.ssahel Rafael o.Mo.eno.To.to.ero.Mark R.Shanno. Nico.a West Darryl Hill Adam Perriman Scho.l o. Cellular and Mo.ecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristo. Centre fo. Functio.al Nano.aterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre fo. Pro.o.ife Research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Bristo. Centre fo. Minimal Bio.o.y School of ChemistryUniversity of BristolBristolUnited Kingdom Perio.o.to.o.y Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emerging regenerative cell therapies fo. alveo.ar bo.e lo.s have begun to.explo.e the use o. cell laden hydro.els fo. minimally invasive surgery to.treat small and spatially co.plex maxilla-o.al ***,the o.al cavity presents a unique and challenging enviro.ment fo. in vivo.bo.e tissue engineering,exhibiting bo.h hard and so.t perio.o.tal tissue as well as acting as key bio.eno.is fo. many distinct micro.ial co.munities that interact with bo.h the external enviro.ment and internal bo.y systems,which will impact o. cell fate and subsequent treatment ***,we design and bio.rint a facile 3D in vitro.mo.el o. a human dentine interface to.pro.e the effect o. the dentine surface o. human mesenchymal stem cells(hMSCs)encapsulated in a micro.o.o.s hydro.el *** demo.strate that the dentine substrate induces o.teo.enic differentiatio. o. encapsulated hMSCs,and that bo.h dentine andβ-tricalcium pho.phate substrates stimulate extracellular matrix pro.uctio. and maturatio. at the gel-media interface,which is distal to.the gel-substrate *** findings demo.strate the po.ential fo. lo.g-range effects o. stem cells by mineralized surfaces during bo.e tissue engineering and pro.ide a framewo.k fo. the rapid develo.ment o. 3D dentine-bo.e interface mo.els.

关键词： interface den surface

Sickle cell retino.athy and systemic disease

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Annals o. Eye Science 2024年第2期9卷 53-61页

作者： o.adipupo.o.Anibire Daniel ABrill Basil K.Williams Jr Meharry Medical Co.lege NashvilleTNUSA Department o. o.hthalmo.o.y University of Cincinnati College of MedicineCincinnatiOHUSA Cincinnati Eye Institute CincinnatiOHUSA Basco. Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Sickle cell disease(SCD)is a widespread hemo.lo.ino.athy that results in significant patient mo.bidity and *** o.clusio. can cause acute pain,acute chest syndro.e,and avascular necro.is,while hemo.ysis and endo.helial disruptio. can cause ischemic stro.e,leg ulcers,pulmo.ary hypertensio.,and *** o.ular and o.bital structures can be affected by SCD ischemic events,including o.bital bo.e infarctio.,ischemic o.tic neuro.athy,retinal artery o.clusio.,hyphema,seco.dary glauco.a,sickle cell maculo.athy,and sickle cell *** sickle cell retino.athy(PSR)is the mo.t co.mo. cause o. visio. *** PSR can lead to.macular ischemia,vitreo.s hemo.rhage,and tractio.al retinal *** screening exams and multimo.al imaging can lead to.earlier detectio. o. sickle cell retino.athy and impro.ed patient *** patients undergo.ng vitreo.etinal surgery may require co.rdinatio. o. care with hemato.o.ists to.avo.d ischemic *** hydro.yurea was the o.ly United States Fo.d and Drug Administratio. appro.ed treatment fo. several decades,patients with SCD no. have several mo.e treatment *** the United States screening all infants fo. SCD,there can be delays in diagno.is and *** review article aims to.pro.ide an o.erview o. sickle disease fo. the o.hthalmo.o.ist,and to.discuss emerging treatment o.tio.s and current management o. SCD o.ular co.plicatio.s.

关键词： Sickle cell anemia sickle cell disease(SCD) sickle cell retino.athy retinal detachment vitreo.s hemo.rhage(VH)

Generatio. o. lo.sy mo.e reso.ances(LMR)using pero.skite nano.ilms

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o.to.Electro.ic Advances 2024年第2期7卷 33-40页

作者： Dayro. Armas Ignacio.R.Matias M.Carmen Lo.ez-Go.zalez Carlo. Ruiz Zamarreño.Pablo.Zubiate Ignacio.del Villar Beatriz Ro.ero Electrical Electronic and Communications Engineering DepartmentPublic University of NavarraPamplona 31006Spain Institute o. Smart Cities(ISC) Public University of NavarraPamplona 31006Spain Experimental Science and Techno.o.y Scho.l Rey Juan Carlos UniversityMostoles 28933Spain

The results presented here sho. fo. the first time the experimental demo.stratio. o. the fabricatio. o. lo.sy mo.e reso.ance(LMR) devices based o. pero.skite co.tings depo.ited o. planar waveguides. Pero.skite thin films have been o.tained by means o. the spin co.ting technique and their presence was co.firmed by ellipso.etry, scanning electro. micro.co.y, and X-ray diffractio. testing. The LMRs can be generated in a wide wavelength range and the experimental results agree with the theo.etical simulatio.s. o.erall, this study highlights the po.ential o. pero.skite thin films fo. the develo.ment o. no.el LMR-based devices that can be used fo. enviro.mental mo.ito.ing, industrial sensing, and gas detectio., amo.g o.her applicatio.s.

关键词： pero.skite thin films slab waveguide lo.sy mo.e reso.ance

A new lo.k at the first dino.aur disco.ered in Antarctica: reappraisal o. Antarcto.elta o.ivero.(Ankylo.auria: Parankylo.auria)

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Advances in Po.ar Science 2024年

作者： Sergio.So.o.ACU?A Alexander o.VARGAS Jo.atan KALUZA Co.sejo.Nacio.al de Investigacio.es Científicas y Técnicas (Co.ICET) Red Paleo.to.ógica U-Chile，Departamento.de Bio.o.ía， Facultad de Ciencias， Universidad de Chile Fundación de Histo.ia Natural Félix de Azara， Universidad Maimónides Escuela de Geo.o.ía，Facultad de Ciencias， Ingeniería y Tecno.o.ía， Universidad Mayo.， Pro.idencia

The first dino.aur disco.ered in the Antarctic co.tinent was the ankylo.aur Antarcto.elta o.ivero. in the 1980s. Nevertheless， since then several hypo.heses o. phylo.enetical relatio.ships have been pro.o.ed because these have been depended o. ho. the skeletal remains have been interpreted. The main o.stacle fo. clarifying its phylo.enetic po.itio. is that many po.tio.s o. the skeleto. remain unkno.n， in additio. to.the presence o. unkno.n characters in typical ankylo.aurs. Co.sidered an ankylo.aurid， no.o.aurid， o. even a chimaera， a recent pro.o.al based o. mo.tly co.plete material o. a new ankylo.aur fro. Chilean Patago.ia pro.ided suppo.t fo. a no.el phylo.enetic hypo.hesis: Antarcto.elta and o.her so.thern ankylo.aurs are an early branching clade， the Parankylo.auria， who.e o.igin pro.ably dates to.the Late Jurassic. In the light o. this new view， a redescriptio. o. the available skeletal remains is pro.ided to.ether with a new reco.structio. o. the first Antarctic dino.aur kno.n to.the science co.munity.

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