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Finite Element Delamination Study of a Notched Composite Plate under Flexural Loads

材料科学与工程（中英文版） 2010年第8期4卷 66-73页

作者： Alann Andre Soren Nilsson leif E. Asp Swerea Sicomp AB Mondal SE-431 22 Sweden Dept. of Civil and Environmental Engineering Chalmers University of Technology Goteborg SE-41296 Sweden Dept. of Applied Physics and Mechanical Engineering Lulea University of Technology Lulea SE-97187 Sweden

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导致乳粉贮藏加工劣变的主要化学反应和物化因素的研究进展

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食品与发酵工业 2012年第11期38卷 120-126页

作者：刘玲 leif H Skibsted 蒋东华沈阳农业大学食品学院辽宁沈阳110866 哥本哈根大学科学学部食品科学系

我国乳制品安全日益受到大众的关注,其中乳粉是焦点之一。目前乳粉贮藏加工中引起质量劣变的因素主要为三类化学反应——脂质氧化,美拉德反应和乳糖结晶,它们之间存在相互作用,但机理尚未明确。文中针对乳粉贮藏加工中的重要化学变化和... 详细信息

我国乳制品安全日益受到大众的关注,其中乳粉是焦点之一。目前乳粉贮藏加工中引起质量劣变的因素主要为三类化学反应——脂质氧化,美拉德反应和乳糖结晶,它们之间存在相互作用,但机理尚未明确。文中针对乳粉贮藏加工中的重要化学变化和它们的影响因素、测定方法和相互作用的研究进展进行了综述,并对乳粉贮藏中化学反应的研究方向提出了展望,为进一步从机理上研究乳粉劣变并确保乳粉质量安全提供依据。

关键词：乳粉脂质氧化美拉德反应乳糖结晶

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More Stable, More Estrogenic: The SERM-ERα LBD Complex

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Journal of Biophysical Chemistry 2011年第3期2卷 233-243页

作者： Li Gao Yaoquan Tu leif A. Eriksson Department of Theoretical Chemistry and Biology School of Biotechnology Royal Institute of Technology Stockholm Sweden

Many synthetic selective estrogen receptor modulators (SERMs) have been cocrystallized with the human estrogen receptor α ligand binding domain (ERα LBD). Despite stabilizing the same canonical inactive conformation of the LBD, most SERMs display different ligand-dependent pharmacological profiles. We show here that increased partial agonism of SERMs is associated with increased conformational stability of the SERM-LBD complexes, by investigation of dihydrobenzoxathiin-based SERMs using molecular modelling techniques. Analyses of tamoxifen (TAM) and 4-hydroxytamoxifen (OHT) in complex with the LBD furthermore indicates that the conversion of TAM to OHT increases both the affinity to ERα and the partial agonism of the anti-cancer drug, which provides a plausible explanation of the counterintuitive results of TAM therapy.

关键词： Breast Cancer Tamoxifen Resistance Molecular Dynamics Simulations Dihydrobenzoxathiin SERM

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Wisdom of Artificial Crowds—A Metaheuristic Algorithm for Optimization

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Journal of Intelligent Learning Systems and Applications 2012年第2期4卷 98-107页

作者： Roman V. Yampolskiy leif Ashby Lucas Hassan Computer Engineering and Computer Science University of Louisville Louisville USA.

Finding optimal solutions to NP-Hard problems requires exponential time with respect to the size of the problem. Consequently, heuristic methods are usually utilized to obtain approximate solutions to problems of such difficulty. In this paper, a novel swarm-based nature-inspired metaheuristic algorithm for optimization is proposed. Inspired by human collective intelligence, Wisdom of Artificial Crowds (WoAC) algorithm relies on a group of simulated intelligent agents to arrive at independent solutions aggregated to produce a solution which in many cases is superior to individual solutions of all participating agents. We illustrate superior performance of WoAC by comparing it against another bio-inspired approach, the Genetic Algorithm, on one of the classical NP-Hard problems, the Travelling Salesperson Problem. On average a 3% - 10% improvement in quality of solutions is observed with little computational overhead.

关键词： NP-Complete Optimization TSP Bio-Inspired

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The Association of World Health Organisation (WHO) Safe Community Programme with Death Rate from Motorcycle Accidents in Iran

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Open Journal of Preventive Medicine 2014年第8期4卷 681-688页

作者： Alireza Moghisi Reza Mohammadi leif Svanstrom Hossein Kazemeini Department of Public Health Science Norrbacka Karolinska Institute Stockholm Sweden PHC Center Ministry of Health and Medical Education Tehran Iran

Background: Many developing countries are facing the problem of rapidly rising death rate from fatal accidents involving motorcycles. Objective: To determine the effect of participation and implementation of the World Health Organization (WHO) Safe Community Programme on death rate from fatal motorcycle accidents. Methods: Motorcycle’ fatal accident data were obtained from forensic medicine departments and hospital records in 11 cities located in three provinces in Iran during 2006-2007. Data were analyzed using chi-square and ANOVA tests. Fidelity of the data was safeguarded by using national security coding for each individual involved in the accident. Results: The highest death rate was found in the Fars province followed by Khorasan and Bushehr provinces. In Fars province, the highest mortality rate was found in Niriz city, which did not implement the Safe Community Programme and the lowest death rate was reported from Arsanjan city participating in Safe Community. Similar results were found in the Khorasan province. In Busher province, the highest death rate was found in Busher city participating in the program and the lowest in Genaveh city—not participating in the program. Among sex and age groups, males aged 19 - 39 years old had a highest death rate. Half of the death occurred at the accident scene—25% during a transfer to the hospital and 25% of death occurred at the hospital. Conclusions: The Safe Community Programme is a promising model to prevent death from fatal motorcycle accidents in urban areas in Iran.

关键词： Motorcyclists’ Death Epidemiology

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Consumer satisfaction, quality of life and distress with regard to social function and gender in severe mental illness

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Open Journal of Psychiatry 2011年第3期1卷 88-97页

作者： Bo Ivarsson leif Lindstrom Ulf Malm Torsten Norlander Psychiatric Services Boras HospitalBorasSweden Department of Neuroscience PsychiatryUppsala UniversityUppsalaSweden Institution for Clinical Neuropsychiatry Sahlgrenska University HospitalGothenburgSweden Department of Psychology Karlstad UniversityKarlstadSweden

OBJECTIVE. The relationships between subjective satisfaction, distress and quality of life for severely mental ill patients with different functional levels and gender was investigated in a multi-center cohort, using a balanced mix of subjective and clinician ratings in an outcome-informed model for a clinical management based on shared decision making, 'The Quality star'. METHODS. Naturalistic data for 2552 persons, mainly with schizophrenia diagnoses, in long-term treatment and rehabilitation, were analyzed in a cross-sectional study. RESULTS. With increasing Social Function, rated with the split-GAF Disability/Functioning scale, the better were patients' Satisfaction, subjective Quality of life and Perceived Global Distress. Women were more satisfied with the care but also more distressed. CONCLUSION. Main findings were in line with other studies. However, the gender differences are in line with some, but not with other, studies. This poses questions how patient factors, instrument constructs, and treatment, especially shared decision making, influence subjective reports.

关键词： Consumer Satisfaction Quality Of Life Perceived Distress Schizophrenia Social Function

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Na Induced Changes in the Electronic Band Structure of Graphene Grown on C-Face SiC

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Graphene 2013年第1期2卷 1-7页

作者： leif I.Johansson Chao Xia Chariya Virojanadara Department of Physics Chemistry and BiologyLinkoping UniversityLinkopingSweden

Studies of the effects induced on the electron band structure after Na deposition, and subsequent heating, on a C-face 2 MLs graphene sample are reported. Na deposition shifts the Dirac point downwards from the Fermi level by about 0.5 eV due to electron doping. After heating at temperatures from around 120℃ to 300℃,thep-band appears considerably broadened. Collected Si 2p and Na 2p spectra then indicate Na intercalation in between the graphene layers and at the graphene SiC interface. The broadening is therefore interpreted to arise from the presence of two slightly shifted, but not clearly resolved,p-bands. Constant energy photoelectron distribution patterns, E(kx,ky);s, extracted from the clean 2MLs graphene C-face sample look very similar to earlier calculated distribution patterns for monolayer, but not Bernal stacked bilayer, graphene. After Na deposition the patterns extracted at energies below the Dirac point appear very similar so the doping had no pronounced effect on the shape or intensity distribution. At energies above the Dirac point the extracted angular distribution patterns show the flipped, “mirrored”, intensity distribution predicted for monolayer graphene at these energies. An additional weaker outer band is also discernable at energies above the Dirac point, which presumably is induced by the deposited Na.

关键词： Graphene on C-Face SiC Graphene Band Structure Na Intercalation Constant Energy Photoelectron Angular Distribution Patterns

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A Structural Comparison Approach for Identifying Small Variations in Binding Sites of Homologous Proteins

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Computational Molecular Bioscience 2015年第3期5卷 45-55页

作者： Ivana Uzelac Thomas Olsson leif A. Eriksson Johan Gottfries Department of Chemistry and Molecular Biology University of Gothenburg G&oumlteborg Sweden

A method for analyzing the protein site similarity was devised aiming at understanding selectivity of homologous proteins and guiding the design of new drugs. The method is based on calculating Cα distances between selected pocket residues and subsequent analysis by multivariate methods. Five closely related serine proteases, the coagulation factors II, VII, IX, X, and XI, were studied and their pocket similarity was illustrated by PCA clustering. OPLS-DA was then applied to identify the residues responsible for the variation. By combining these two multivariate methods, we could successfully cluster the different proteases according to class and identify the important residues responsible for the observed variation.

关键词： Protein Comparison Coagulation Factor Serine Protease Binding Site PCA OPLS-DA

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Low Porosity in Cast Magnesium Welds by Advanced Laser Twin-Spot Welding

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Materials Sciences and Applications 2019年第1期10卷 53-64页

作者： Karl Fahlstrom Jon Blackburn leif Karlsson Lars-Erik Svensson Swerea KIMAB KistaSweden University West TrollhattanSweden TWI Ltd. CambridgeUK

Porosity is reported to be a major issue when welding cast magnesium. Therefore, it is important to understand the pore formation mechanisms and find procedures that could be used to reduce porosity. This study investigated the possibility of using twin-spot optics for reducing the porosity in laser welded cast magnesium. Two twin-spot welding setups were compared using either a beam splitter or twin-spot welding with primary and secondary (placed in front of the primary optic) optics. The results showed that welding with a dual optic setup with a defocused secondary beam reduced the volumetric porosity in the weld to 5%. The highest levels of volumetric porosity were 30%, and were a result of using the dual optic setup, but with a defocused primary beam. No clear relation between the level of porosity and power or welding speed was found. It was found that the amount of porosity depended on the balance of the energy input (controlled by defocusing) between the two beams. Porosity formation can be reduced if the energy from the first beam results in the nucleation and initial growth of pores. Reheating by the second beam then allows the pores to grow and escape from the molten material without melting additional base material. Furthermore, twin-spot welding is shown to be a promising combination of a production friendly solution and high quality welding.

关键词： Laser Welding Cast Magnesium Twin-Spot Metallurgy Porosity Automotive AM50 Alloy

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Switching dynamics in InP photonic-crystal nanocavity

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Frontiers of Optoelectronics 2016年第3期9卷 395-398页

作者： Yi YU Evarist PALUSHANI Mikkel HEUCK leif Katsuo OXENLOWE Kresten YVIND Jesper MORK Department of Photonics Engineering Technical University of Denmark 2800 Kgs. Lyngby Denmark

In this paper, we presented switching dynamic investigations on an InP photonic-crystal （PhC） nanocavity structure using homodyne pump-probe measurements. The measurements were compared with simulations based on temporal nonlinear coupled mode theory and carrier rate equations for the dynamics of the carrier density governing the cavity properties. The results provide insight into the nonlinear optical processes that govern the dynamics of nanocavities.

关键词： all-optical switching photonic-crystal (PhC) nanocavity nonlinear optics

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