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Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 794-805页

作者： Muhammad Zulfiqah Sadikan nurul alimah abdul nasir Mohammad Johari Ibahim Igor Iezhitsa Renu Agarwal Department of Pharmacology Faculty of MedicineManipal University College Malaysia(MUCM)Bukit BaruMelaka 75150Malaysia Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Medical Education Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Biochemistry and Molecular Medicine Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgograd 400131Russia

AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat ***:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic *** stability analysis of gene expression was investigated using geNorm,NormFinder,BestKeeper,and comparative delta-Ct(ΔCt)***:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic *** 18s gene was expressed consistently in both normal control and diabetic rats’retinal *** this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic ***,there was no ideal gene stably expressed for use in all experimental ***:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.

关键词： housekeeping genes stability real-time reverse transcription polymerase chain reaction retinal tissue streptozotocin-induced diabetic rats

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Can NogoA Be a Suitable Target to Treat Ischemic Stroke?

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Neuroscience Bulletin 2024年第4期40卷 557-560页

作者： Suliman Khan abdul nasir Medical Research Center The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou540014China

Treating stroke or restoring brain function after stroke remains challenging for clinicians[1,2].Researchers have largely focused on developing neuroprotective strategies and translating these discoveries from rodent experiments to the clinical setting;however,these have been typified by several failures[2].It is known that astrocytes play a crucial role in the pathogenesis of ischemic stroke[3,4].They are activated in response to stimuli arising from injury,characterized by drastic changes to their morphology and function-associated gene *** astrocytes exacerbate secondary neurodegeneration(repair of nervous tissue by the generation of new neurons,glial cells,axons,myelin,or synapses)[5]as well as provide neuroprotection during CNS pathologies[6].It is worth noting that myelin-related neurite growth inhibitors induce the suppression of axon regeneration after stroke[7].

关键词： protective NogoA clinical

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Spatio-temporal clustering analysis of COVID-19 cases in Johor

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Infectious Disease Modelling 2024年第2期9卷 387-396页

作者： Fong Ying Foo Nuzlinda abdul Rahman Fauhatuz Zahroh Shaik abdullah nurul Syafiah Abd Naeeim School of Mathematical Sciences Universiti Sains Malaysia11800Pulau PinangMalaysia

At the end of the year 2019,a virus named SARS-CoV-2 induced the coronavirus disease,which is very contagious and quickly spread around the *** new infectious disease is called *** areas,such as the economy,social services,education,and healthcare system,have suffered grave consequences from the invasion of this deadly ***,a thorough understanding of the spread of COVID-19 is required in order to deal with this outbreak before it becomes an infectious *** this research,the daily reported COVID-19 cases in 92 sub-districts in Johor state,Malaysia,as well as the population size associated to each sub-district,are used to study the propagation of COVID-19 disease across space and time in *** time frame of this research is about 190 days,which started from August 5,2021,until February 10,*** clustering technique known as spatio-temporal clustering,which considers the spatio-temporal metric was adapted to determine the hot-spot areas of the COVID-19 disease in Johor at the sub-district *** results indicated that COVID-19 disease does spike in the dynamic populated sub-districts such as the state's economic centre(Bandar Johor Bahru),and during the festive *** findings empirically prove that the transmission rate of COVID-19 is directly proportional to human mobility and the presence of *** the other hand,the result of this study will help the authority in charge in stopping and preventing COVID-19 from spreading and become worsen at the national level.

关键词： Disease mapping COVID-19Hot-spot areas Sub-district level Spatio-temporal clustering Scan statistics

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A review of salivary composition changes induced by fasting and its impact on health

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Food Science and Human Wellness 2024年第1期13卷 50-64页

作者： nurul Fadhilah Kamalul Aripin NIdayu Zahid Mohd Aizat abdul Rahim Hashim Yaacob Parvez I.Haris Zubaidah Haji AbdRahim Rauzah Hashim School of Chemical Engineering College of EngineeringUniversiti Teknologi MARAShah Alam 40450Malaysia Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly Department of ChemistryFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Department of Oral and Craniofacial Sciences Faculty of DentistryUniversiti MalayaKuala Lumpur 50603Malaysia UMSC Dental Specialist Clinic UM Dentistry TowerUniversiti MalayaMedical CentreKuala Lumpur 50603Malaysia Leicester School of Allied Health Sciences De Montfort UniversityLeicester LE19BHUnited Kingdom Chancellery(Research and Innovation) Universiti MalayaKuala Lumpur 50603Malaysia

Human saliva is an indispensable fluid that maintains a healthy oral cavity which otherwise can lead to oral diseases(dental caries and periodontitis).In addition,salivary metabolites and microbiome profile provide early detection of systemic diseases such as cancer and *** diagnostic has gained popularity due to its non-invasive sampling ***(abstinence from food or drink or both)research for weight loss and improve health is common,but studies using fasting saliva are *** metabolites in fasting saliva have been reported with interesting results,which can be enhanced by considering different confounding *** example,fasting saliva contains higher salivary nitrite,which is related to nitric oxide(NO).NO is a vasodilator supporting the healthy function of endothelial cells and its deficiency is connected to many *** timely supply of NO through exogenous and endogenous means is highlighted and the potential advantage of fasting salivary composition changes in relation to COVID-19 infection is *** review aims to provide a general discussion on the salivary composition,properties,and functions of the whole saliva,including the health benefits of fasting.

关键词： Saliva Fasting Nitrate Nitrite Nitric oxide

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Occurrence of K1 and K2 serotypes and genotypic characteristics of extended spectrumβ-lactamases-producing Klebsiella pneumoniae isolated from selected hospitals in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 30-38页

作者： nurul Syazrah Anuar Hazmin Hazman Sharven Raj Jeyakumar Mohd nasir Mohd Desa Hasni Idayu Saidi Siti Norbaya Masri Nur Afiza Aziz Nurshahira Sulaiman Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia Microbiology Unit Department of PathologyHospital Sultanah AminahJalan Persiaran Sultan Abu Bakar80100 Johor BahruJohorMalaysia

Objective:To determine the distribution,phenotypic and genetic background of extended spectrumβ-lactamases(ESBL)-producing Klebsiella(K.)pneumoniae clinical isolates associated with K1 and K2 serotypes in two selected hospitals in ***:A total of 192 *** isolates were collected and subjected to antibiotic susceptibility,hypermucoviscosity test and multiplex PCR to detect the presence of K1-and K2-serotype associated *** sequence typing(MLST)was performed on ESBL-producing *** isolates presented with K1 and K2 serotypes,followed by phylogenetic ***:A total of 87 out of 192(45.3%)of the *** isolates collected were ESBL ***,only 8.3%(16/192)and 10.9%(21/192)of the total isolates were detected to carry K1-and K2-serotype associated genes,*** analysis showed that K1 and K2 capsular serotypes were not significantly associated with ESBL phenotype(P=0.196).However,they were significantly associated with hypervirulent,as demonstrated by the positive string test(P<0.001).MLST analysis revealed that ST23 as the predominant sequence type(ST)in the K1 serotype,while the ST in the K2 serotype is more ***:Although the occurrence of ESBL-producing isolates among the hypervirulent strains was low,their coexistence warrants the need for continuous *** showed that these isolates were genetically heterogeneous.

关键词： Extended spectrumβ-lactamases Klebsiella pneumoniae Capsular serotypes Genotypic

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A Comprehensive Classification and Analysis of Geomagnetic Storms Over Solar Cycle 24

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Research in Astronomy and Astrophysics 2024年第8期24卷 75-84页

作者： Raja Adibah Raja Halim Shah nurul Shazana abdul Hamid Mardina abdullah Adlyka Annuar Idahwati Sarudin Zahira Mohd Radzi Akimasa Yoshikawa Department of Applied Physics Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiMalaysia Space Science Centre(ANGKASA) Institute of Climate ChangeUniversiti Kebangsaan Malaysia43600 BangiMalaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 BangiMalaysia School of Physics Universiti Sains Malaysia11800 USMPulau PinangMalaysia Malaysian Space Agency(MYSA) Kuala Lumpur50480Malaysia International Research Center for Space and Planetary Environmental Science(i-SPES) Kyushu University819-0395 FukuokaJapan

A geomagnetic storm is a global disturbance of Earth?s magnetosphere,occurring as a result of the interaction with magnetic plasma ejected from the *** considerable research,a comprehensive classification of storms for a complete solar cycle has not yet been fully developed,as most previous studies have been limited to specific storm *** study,therefore,attempted to present complete statistics for solar cycle 24,detailing the occurrence of geomagnetic storm events and classifying them by type of intensity(moderate,intense,and severe),type of complete interval(normal or complex),duration of the recovery phase(rapid or long),and the number of steps in the storm?s *** analysis was applied to data from ground-based magnetometers,which measured the Dst index as provided by the World Data Center for Geomagnetism,Kyoto,*** study identified 211 storm events,comprising moderate(177 events),intense(33 events),and severe(1 event)*** 36%of ICMEs and 23%of CIRs are found to be geoeffective,which caused geomagnetic *** to four-step development of geomagnetic storms was exhibited during the main phase for this solar *** showed the geomagnetic storms developed one or more steps in the main phase,which were probably related to the driver that triggered the geomagnetic storms.A case study was additionally conducted to observe the variations of the ionospheric disturbance dynamo(Ddyn)phenomenon that resulted from the geomagnetic storm event of 2015July *** attenuation of the Ddyn in the equatorial region was analyzed using the H component of geomagnetic field data from stations in the Asian sector(Malaysia and India).The variations in the Ddyn signatures were observed at both stations,with the TIR station(India)showing higher intensity than the LKW station(Malaysia).

关键词： (Sun)sunspots-Sun activity-(Sun)solar-terrestrial relations-Sun coronal mass ejections(CMEs)

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Epidemiological observations of invasive group B Streptococcus infections in six major hospitals in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 384-391页

作者： abdulRahman Muthanna Mohd nasir Mohd Desa nurul Asyikin abdul Rahman nurul Diana Dzaraly nurul Hana Zainal Baharin Nur Afiza Aziz Chua Hui Shan Zalina Ismail Lailatul Akmar Mat Nor Marlindawati Mohd Ali Nur Hanani Ahmad Mohammad Noor Amal Azmai Syafinaz Amin-Nordin Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARANegeri Sembilan72000 Kuala PilahMalaysia Department of Oral Biology&Biomedical Sciences Faculty of DentistryMAHSA University42610 JenjaromSelangorMalaysia School of Bioscience Faculty of Pharmacy and Biomedical SciencesMAHSA University42610 JenjaromSelangorMalaysia Department of Pathology Sultanah Aminah Hospital80100 Johor BahruJohorMalaysia Department of Pathology Melaka General Hospital75400 MelakaMalaysia Department of Medical Microbiology and Immunology Faculty of MedicineUniversiti Kebangsaan Malaysia56000 CherasKuala LumpurMalaysia Department of Pathology Sultan Idris Shah Serdang Hospital43000 KajangSelangorMalaysia Department of Pathology Tuanku Ja'afar Hospital70300 SerembanNegeri SembilanMalaysia Department of Pathology Sungai Buloh Hospital47000 Sungai BulohSelangorMalaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Aquatic Animal Health and Therapeutics Laboratory Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Sultan Abdul Aziz Shah HospitalUniversiti Putra MalaysiaPersiaran MARDI-UPM43400SelangorMalaysia

Objective:To address the lack of research on invasive group B Streptococcus(GBS)infections in Malaysia and Southeast Asia through a comprehensive analysis of GBS isolates obtained from ***:Medical records from patients with GBS infection isolated from the sterile site,such as blood and cerebrospinal fluid from 14 July 2019 to 15 December 2020,were reviewed from six major hospitals in Peninsular *** criteria were invasive GBS,sterile sites and non-repeated GBS isolated from the same patients in the same *** isolates were re-identified for GBS and ***:A total of 118 patients were eligible,with a majority of non-pregnant adults(76.3%).Over half of the patients(62.7%)had underlying medical conditions,with diabetes as the most common disease,followed by respiratory disease,renal disease,cardiovascular disease and skin and soft tissue *** most common manifestations were sepsis,followed by soft tissue abscess,diabetic foot ulcer,wet gangrene and *** overall mortality was 7.6%.The most common serotype was serotype桋.Conclusions:Invasive GBS infection among non-pregnant adults showed a rising trend,particularly among diabetic *** study underscores the importance of reducing risk factors and highlights the necessity of developing GBS vaccination as a preventive strategy for both infants and adults.

关键词： Streptococcus agalactiae Group B Streptococcus Invasive GBS infections Malaysia

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Hybrid Effects on MHD Mixed Convective Boundary Layer Flow through a Sloped Plate in Existence of Nanofluid-Saturated Porous Medium

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Journal of Applied Mathematics and Physics 2024年第9期12卷 3037-3052页

作者： Md. nasir Uddin abdul Halim Bhuiyan Zahurul Islam Tahmina Tahrim Department of Mathematics Bangladesh Army University of Engineering & Technology Natore Bangladesh Department of Mathematics Bangladesh University of Engineering and Technology Dhaka Bangladesh Department of Computer Science and Engineering Jagannath University Dhaka Bangladesh

This study examines the effects of heat, mass, and boundary layer assumptions-based nanoparticle characteristics on the hybrid effects of using MHD in conjunction with mixed convective flow through a sloped vertical pore plate in the existence of medium of porous. Physical characteristics such as thermo-diffusion, injection-suction, and viscous dissipation are taken into consideration, in addition to an equally distributed magnetic force utilized as well in the completely opposite path of the flow. By means of several non-dimensional transformations, the momentum, energy, concentration, and nanoparticle volume fraction equations under investigation are converted in terms of nonlinear boundary layer equations and computationally resolved by utilizing the sixth-order Runge-Kutta strategy in combination together with the iteration of Nachtsheim-Swigert shooting procedure. By contrasting the findings produced for a few particular examples with those found in the published literature, the correctness of the numerical result is verified, and a rather good agreement is found. Utilizing various ranges of pertinent factors, computing findings are determined not only regarding velocity, temperature, and concentration as well as nanoparticle fraction of volume but also concerning with local skin-friction coefficient, local Nusselt and general Sherwood numbers associated with nanoparticle Sherwood number. The findings of the study demonstrate that increasing the fluid suction parameter decreases the velocity and temperature of the flow field in conjunction with concentration and has a variable impact on the nanoparticle fraction of volume, despite an increasing behavior in the local skin friction coefficient and local Nusselt as well as general Sherwood numbers and an increasing behavior in the local nanoparticle Sherwood number. Furthermore, enhancing a Schmidt number leads to a reduction in the local nanoparticle Sherwood number and a rise in the nanoparticle proportion of vo

关键词： Hybrid Effects Mixed Convection MHD Nanofluid Viscous Dissipation

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Design of a Novel Robotic Fish Structure Utilizing PVC Gel Actuators

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Modern Mechanical Engineering 2024年第3期14卷 57-72页

作者： Ruyhan Nazia Bibi Sara Rahman abdullah Al Hossain Newaz abdul Kadir nasir Uddin School of Mechanical Engineering Xian Jiaotong University Xian China School of Mechanical Engineering University of Bridgeport Bridgeport USA

In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-long, fish structure design incorporates a 55.52 angle to optimize the fish dynamics movement. It’s a fast and smooth operation and can swim. The robot can swim fast and quietly by using the right positions and the appropriate actuators on PVC gel actuators. This design entails a unique architecture that enables the robot to move safely and unobtrusively at the same time, which makes it suitable equipment for different exploration and surveillance missions in the water with speed and silent operation as the foremost concern.

关键词： Biomimetic Robotics Structural Design PVC Gel Actuators Swimming Mechanisms

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Is the Sundarbans of Bangladesh in a State of Pollution?

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Open Journal of Forestry 2024年第1期14卷 19-41页

作者： Mahmood Hossain Chameli Saha Sanjoy Saha Hawlader Mohammed nurul Islam Mushfiq Ahmed Tanvir Ahmed abdul Halim Farhad Sikder Md. Mutasim Billah Forestry and Wood Technology Discipline Khulna University Khulna Bangladesh Institute for Integrated Studies on the Sundarbans and Coastal Ecosystems (IISSCE) Khulna University Khulna Bangla-desh Ecology Forestry and Biodiversity Division Center for Environmental and Geographic Information Services (CEGIS) Dhaka Bangladesh

The Sundarbans is the world’s most extensive natural mangrove forest and home to various natural resources. The population in the vicinity has increased, causing more dependency on the resources of the Sundarbans. The increasing industrialization, urbanization, aquaculture, intensive agricultural practices, seaports, tourism facilities, and so on in the peripheral areas of the Sundarbans have made significant changes in the surrounding and upstream land uses of the Sundarbans. This situation may have detrimental influences on the ecosystem components of the Sundarbans. Therefore, it is highly demanded to prepare a piece of baseline information or database of different sources of pollution and their present status in the various components of the Sundarbans. This effort helps to identify issues and concerns, determine the key elements of the ecosystem to monitor the level or overall quality of the Sundarbans ecosystem. The present study systematically collects the potential sources of pollution, types, and current levels in the ecosystem components of the Sundarbans using academic databases, libraries, and online resources. Discharge of industrial waste into water, soil and air, heavy metal pollution, use of agrochemicals, oil (refined and crude) pollution, plastic materials from urban areas, and tourism are the major issues and concerns related to the sustainability of the Sundarbans ecosystem. The air quality of the Sundarbans is in good condition with 0 - 50 AQI of Bangladesh. While BOD, COD, TDS, TSS varied from 2.0 to 3.8 mg/L, 21.6 to 416 mg/L, 146.9 to 24,100 mg/L and 54 to 155 mg/L, respectively. Soil EC, organic carbon, total nitrogen, and total phosphorus ranged from 3.01 - 5.82 mS/cm, 1.41% - 2.69%, 0.51 - 1.05 mg/g, and 0.32 - 0.51 mg/g respectively. The air, water and soil quality parameters varied with the sites and seasons and not much at the state of contamination. Indeed, we must pay much attention to the Sundarbans’ air, water and soil quality with

关键词： Ecosystem Mangroves Monitoring Pollution Soil Sundarbans

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