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Proapoptotic activities of Oroxylum indicum leave extract in HeLa cells

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Asian Pacific Journal of Tropical Biomedicine 2019年第8期9卷 339-345页

作者： nurul Hidayah Wahab Nur afina Mohd Din Yee Ying Lim Noor Izani Noor Jamil Nor Fazila Che Mat School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: To examine the proapoptotic properties of Oroxylum indicum methanol extract on cervical cancer cells. Methods: Methylene blue assay was used to determine the IC50 value of the extract. Western blotting assays were done to analyze the expression of HPV oncoproteins (HPV18 E6 and E7) and apoptotic molecules (caspase-3 and caspase-8). Reverse transcriptase PCR assays were performed to determine genetic alteration of tumor suppressors p53 and pRb and apoptosis markers Fas and FasL. Enzyme-linked immunosorbent assay (ELISA) was done to determine the expression of cytokine levels (IL-6 and IL-12). Results: The determination of IC50 value indicated a higher anti-proliferative activity of the extract compared to cisplatin. After 24 hours of treatment, Western blot analysis showed that treated HeLa cells exhibited a significant down-regulation of HPV18 oncoproteins E6 and E7, and a significant induction of caspase-8 and caspase-3 activation level. Meanwhile, the mRNA expressions of p53, pRb, Fas and FasL were significantly upregulated in treated cells. Moreover, ELISA showed an increased IL-12 and decreased IL-6 production after Oroxylum indicum treatment. Conclusions: The methanol extract of Oroxylum indicum has an anti-proliferative activity and proapoptotic potential. It induces localized-immunity improvements by altering cytokine production in HPV-positive cervical cancer cells.

关键词： Oroxylum indicum Proapoptotic Anti-proliferative HeLa cells

N-Doped rGO-Like Carbon Prepared from Coconut Shell:Structure and Specific Capacitance

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Journal of Renewable Materials 2023年第4期11卷 1823-1833页

作者： Imam Khambali Budhi Priyanto Retno Asih Malik Anjelh Baqiya Muhammad Mahyiddin ramli nurul Huda Osman Sarayut Tunmee Hideki Nakajima Triwikantoro Mochamad Zainuri Darminto Department of Physics Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh NopemberSurabaya60111Indonesia Department of Electrical Engineering Faculty of EngineeringUniversity of Muhammadiyah MalangMalang65144Indonesia Geopolymer&Green Technology Centre of Excellence Universiti Malaysia PerlisArauPerlis02600Malaysia Applied Electromagnetic Laboratory 1 Department of PhysicsFaculty of ScienceUniversiti Putra MalaysiaSelangor43400Malaysia Synchrotron Light Research Institute(SLRI) Nakhon Ratchasima3000Thailand

An rGO−like carbon compound has been synthesized from biomass,i.e.,old coconut shell,by a carbonization process followed by heating at 400°C for 5 *** nitrogen doping was achieved by adding the urea(CH4N2O)and stirring at 70°C for 14 *** morphology and structure of the rGO-like carbon were investigated by electron microscopies and Raman *** presence of C-N functional groups was analyzed by Fourier transform infrared and synchrotron X-ray photoemission spectroscopy,while the particle and the specific capacitance were measured by particle sizer and cyclic *** highest specific capacitance of 72.78 F/g is achieved by the sample with 20%urea,having the smallest particles size and the largest surface *** corresponding sample has shown to be constituted by the appropriate amount of C–N pyrrolic and pyridinic defects.

关键词： N-doped rGO−like carbon coconut shell specific capacitance

铋和镍对钒磷氧化物催化剂性能的影响(英文)

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催化学报 2014年第2期35卷 270-276页

作者： Yun Hin Taufiq-Yap Choon Seon Yuen Nawi Mohamed nurul Suziana ramli Irmawati Catalysis Science and Technology Research Centre Faculty of ScienceUniversity Putra Malaysia Department of Chemistry Faculty of ScienceUniversiti Putra Malaysia

Vanadium phosphorus oxide (VPO) catalysts were synthesized by the dihydrate method which involved the two steps for the preparation of the dihydrate (VOPO4 2H2 O) and the precursor hemi-hydrate (VOHPO4 0.5H2 O). Bi and Ni salt were added into the mixture of VOPO4 2H2 O and isobu-tanol, and the obtained precursors were calcined in a flow of a n-butane/air mixture to produce the promoted VPO catalysts. The catalysts were characterized by X-ray diffraction (XRD), N2 adsorp-tion- desorption, inductively coupled plasma-atomic emission spectroscopy, scanning electron mi-croscopy (SEM), and H2 temperature-programmed reduction (H2 -TPR). Their catalytic properties were tested using a fixed-bed microreactor. All the catalysts gave main XRD peaks at 2θ = 22.9°, 28.5°, and 30.0°, attributing to the (020), (204), and (221) planes of the pyrophosphate phase (VO)2 P2 O7, respectively. The promoted catalysts have smaller crystallite size and higher specific surface areas. SEM micrographs revealed the formation of more prominent plate-like crystallites that were arranged as rosette clusters. H2 -TPR results showed that the promoted catalysts had lower reduction peak temperatures and possessed higher amounts of V5+-O2– and V4+-O– pairs, which gave higher selectivity and activity in the selective oxidation of n-butane to maleic anhydride.

关键词：氧化物催化剂钒磷氧化物催化性能电感耦合等离子体原子发射光谱法 Bi 镍盐 VPO催化剂扫描电子显微镜

Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study

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World Journal of Pediatrics 2020年第4期16卷 416-421页

作者： nurul Azmawati Mohamed Mohd Dzulkhairi Mohd Rani Tengku Zetty Maztura Tengku Jamaluddin Zarini Ismail Shalinawati ramli Habibah Faroque Farisha Nur Abd Samad Abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaPandan Indah55100Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Putra Malaysia43400SerdangSelangorMalaysia

Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst *** is because of weak immunity and lack of knowledge on proper hand *** quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,*** A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control *** the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based *** numbers of absent days of all the children were recorded for 2 months before the intervention and during the *** In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(P<0·05)between the absenteeism rates for the test and control group during the intervention *** These results suggest that proper education and intervention increase hand hygiene compliance,which may help decrease school absenteeism due to illness;however,a longer study duration may be necessary to evaluate the benefit further.

关键词： Absenteeism Hand hygiene Povidone-iodine Pre-school children

Depression,Anxiety,and Behavioural Changes during the COVID-19 Pandemic among Medical and Nursing Students

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International Journal of Mental Health Promotion 2022年第5期24卷 749-757页

作者： Siti Roshaidai Mohd Arifin Siti Mardhiah Saiful Azmi Khadijah Hasanah Abang Abdullah nurul Ain Hidayah Abas Rohayah Husain Edre MAidid Karimah Hanim Abd Aziz ramli Musa Fathima Begum Syed Mohideen Asma Perveen Khairi Che Mat Izazol Idris Department of Special Care Nursing Kulliyyah of NursingInternational Islamic University MalaysiaIndera Mahkota CampusKuantan25200Malaysia Thomson Hospital Kota Damansara Petaling Jaya47810Malaysia Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaBandar Baru Nilai71800Malaysia Department of Psychology and Counselling Faculty of Human DevelopmentUniversiti Pendidikan Sultan IdrisTanjong Malim35900Malaysia Psychological Medicine Unit Faculty of MedicineUniversiti Sultan Zainal AbidinKuala Terengganu21300Malaysia Department of Community Medicine Kulliyyah of MedicineInternational Islamic University MalaysiaIndera Mahkota CampusKuantan25200Malaysia Department of Psychiatry Kulliyyah of MedicineInternational Islamic University MalaysiaIndera Mahkota CampusKuantan25200Malaysia Department of Educational Studies Faculty of Human DevelopmentUniversiti Pendidikan Sultan IdrisTanjong Malim35900Malaysia

During the COVID-19 pandemic,medical and nursing students are faced with various challenges such as the need to attend online classes and juggling clinical postings under the new *** study aimed to assess the asso-ciation between depression,anxiety,and behavioural changes among medical and nursing students during the COVID-19 *** online self-administered questionnaire was distributed between March 2021 and July 2021 to 292 undergraduates medical and nursing students in a higher education institute on the East Coast of *** questionnaires consisted of four parts:sociodemographic data,the Generalised Anxiety Disor-der-7,the Patient Health Questionnaire-9,and questions related to behaviours during the COVID-19 *** study found that 23.6%and 33.6%of the students experienced anxiety and depression respectively,possibly caused by the COVID-19 *** was associated with a high level of behavioural changes during the pandemic with a total of 87%of the students showing behavioural *** interventions such as online counselling and consultation should be implemented by the university to reduce the prevalence of depres-sion and anxiety resulting from the COVID-19 pandemic among medical and nursing students.

关键词： Nursing students medical students depression anxiety behavioural changes pandemic COVID-19