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Development of PLGA micro-and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 86-94页

作者： Jiafu Cao Jin-Seok Choi Murtada A.Oshi Juho Lee nurhasni hasan Jihyun Kim Jin-Wook Yoo College of Pharmacy Pusan National UniversityBusan 46241South Korea Department of Medical Management Chodang UniversityMuan-gun 58530South Korea College of Nanoscience&Nanotechnology Pusan National UniversityBusan 46241South Korea

Particle shape has been recognized as one of the key properties of nanoparticles in biomedical applications including targeted drug *** ability of shape-engineered particles depends largely on targeting ligands conjugated on the particle ***,poor capacity for surface ligand conjugation remains a problem in anisotropic nanoparticles made with biodegradable polymers such as *** this study,we prepared anisotropic PLGA nanoparticles with abundant conjugatable surface functional groups by a film stretching-based fabrication method with poly(ethylene-alt-maleic acid)(PEMA).Scanning electron microscopy images showed that microrods and nanorods were successfully fabricated by the PEMA-based film stretching *** presence of surface carboxylic acid groups was confirmed by confocal microscopy and zeta potential *** the improved film-stretching method,the amount of protein conjugated to the surface of nanorods was increased ***-conjugated,nanorods fabricated by the improved method exhibited higher binding and internalization than unmodified ***,the PEMA-based film-stretching system presented in this study would be a promising fabrication method for non-spherical biodegradable polymeric micro-and nanoparticles with high capacity of surface modifications for enhanced targeted delivery.

关键词： Particle shape PLGA nanoparticles Film-stretching method Surface modification Targeted drug delivery

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