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Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第1期8卷 26-38页

作者： Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos nuno B F Rocha Sérgio Machado Faculty of Medicine University of Lisbon Institute of Psychiatry Federal University of Rio de Janeiro School of Health Technologies Polytechnic Institute of Porto Postgraduate Program of Physical Activity Sciences Salgado de Oliveira University

The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity.

关键词： Liver Toxicity Psychotropic drugs Pharmacokinetics Hepatic disease

贝伐单抗治疗湿性年龄相关黄斑变性患者SD-OCT形态学变化(英文)

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国际眼科杂志 2017年第3期17卷 399-403页

作者： Manuel Noronha nuno Moura-Coelho Teresa Gomes Rita Flores Marco Dutra Medeiros 中央里斯本医疗中心眼科葡萄牙里斯本1169-050 新里斯本大学新医学院葡萄牙里斯本1169-050

目的:研究频域光学相干断层成像(spectral domain optical coherence tomography,SD-OCT)定量和定性检测指标在接受玻璃体腔内注射贝伐单抗的年龄相关性黄斑变性(agerelated macular degeneration,AMD)患者人群中的变化,以评估这些指标... 详细信息

目的:研究频域光学相干断层成像(spectral domain optical coherence tomography,SD-OCT)定量和定性检测指标在接受玻璃体腔内注射贝伐单抗的年龄相关性黄斑变性(agerelated macular degeneration,AMD)患者人群中的变化,以评估这些指标是否可以用于预测治疗后视力情况。方法:回顾性分析66眼61例未进行过AMD相关治疗的患者接受至少3mo玻璃体腔内注射贝伐单抗治疗的情况。治疗前后SD-OCT定量检测指标[中央视网膜厚度(central foveal thickness,CFT),外界膜(external limiting membrane,ELM)和椭圆区(ellipsoid zone,EZ)长度]和定性检测指标进行分析和比较。同时,分析这些指标和治疗前后的视力的相关性。结果:平均视力(Log MAR)、CFT、ELM和EZ长度治疗前为0.62±0.41、419.3±110.0μm、378.2±377.2μm和156.4±253.7μm,治疗后为0.53±0.44、325.8±117.9μm、547.1±421.5μm和173.1±207.1μm。治疗前视力和CFT(rs=0.27)、ELM长度(rs=-0.30)及ELM断裂(rs=0.43)有相关性。治疗后视力同样和治疗后ELM长度相关(rs=-0.40)。治疗后视力和治疗前视力(rs=0.66)、ELM长度(rs=-0.35)和ELM断裂(rs=0.46)相关。结论:研究显示:治疗前视力、ELM长度和ELM断裂可以用于预测治疗后视力。

关键词：光学相干断层扫描外界膜椭圆区年龄相关性黄斑变性

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Impact of Drug-Drug Interaction between CDK4/6 Inhibitors and Proton Pump Inhibitors on Survival Outcomes in the Treatment of Metastatic Breast Cancer—Real World Data from a Portuguese Center

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Journal of Cancer Therapy 2022年第5期13卷 266-274页

作者： Joana Reis Inês Costa Mariana Costa Ana Valente Catarina Almeida Marta Freitas Cláudia Caeiro Catarina Fernandes nuno Tavares Miguel Barbosa Centro Hospitalar SÃ O JOÃ O E.P.E. Porto Portugal

Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFS). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (OS) and PFS. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. SPSS software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value < 0.05 was considered significant. Results: 80 patients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p = 0.254) and PFS (PFS med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world dat

关键词： Drug Interaction Survival Impact Advanced Breast Cancer CDK4/6 Inhibitors Proton Pump Inhibitors

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食物:对患者安全的挑战

食品安全导刊 2018年第25期 25-26页

作者： nuno Soares Marcia Meyer Adriana Vargas 不详

在医院里,患者会接受多种治疗方法来努力治愈其所患疾病,采用的方法主要包括临床治疗、外科手术和内窥镜手术等。在治疗过程中,保证患者安全至关重要,其中营养补充和有计划的三餐是关键部分,因为良好的膳食可为病患提供必要的营养成分,... 详细信息

在医院里,患者会接受多种治疗方法来努力治愈其所患疾病,采用的方法主要包括临床治疗、外科手术和内窥镜手术等。在治疗过程中,保证患者安全至关重要,其中营养补充和有计划的三餐是关键部分,因为良好的膳食可为病患提供必要的营养成分,所以医院的食品生产过程和服务系统都需重点关注。在美国,2003年5月26日~6月16日期间,在医院员工、患者和访客中共检出101例培养确诊病例和540例流行病学相关的沙门氏菌病例。

关键词：患者安全食物临床治疗外科手术营养补充营养成分服务系统

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桉树优良个体的有效选择

桉树科技 1995年第2期12卷 1-9页

作者：韦先明 nuno M.G.Borralho 林业部桉树研究开发中心广东湛江524022 澳大利亚塔斯马尼亚大学

1、前言人工选择(以下简称选择)和交配是林木育种的两个核心环节(White 1987)。选择的目的在于筛选那些在目的性状为材积或制浆得率上有最高遗传值的个体,而交配的目的则是将这些高遗传值个体所携带的目的基因进行重组,从而培育出合乎... 详细信息

1、前言人工选择(以下简称选择)和交配是林木育种的两个核心环节(White 1987)。选择的目的在于筛选那些在目的性状为材积或制浆得率上有最高遗传值的个体,而交配的目的则是将这些高遗传值个体所携带的目的基因进行重组,从而培育出合乎人们需要的个体。

关键词：桉树人工选择优良个体

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锍叶立德的合成以及羰基化合物α位的芳基化反应研究

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锍叶立德的合成以及羰基化合物α位的芳基化反应研究

Primary Effusion Lymphoma in a HIV-1/2-Infected Patient

中国化学会第28届学术年会

作者：黄学良 nuno Maulide 马普煤炭所Kaiser-Wilhelm-Platz 1 Mülheim an der RuhrGermanyD45470

＜正＞锍叶立德作为一类重要的有机合成中间体,被广泛的用于各种小环化合物的合成。[1]迄今为止,最简单直接的合成锍叶立德的方法还是Corey和Yao小组在40多年前建立起来的锍叶立德两步合成法。[2]本文报道了一种新颖的锍叶立德的合成方... 详细信息

＜正＞锍叶立德作为一类重要的有机合成中间体,被广泛的用于各种小环化合物的合成。[1]迄今为止,最简单直接的合成锍叶立德的方法还是Corey和Yao小组在40多年前建立起来的锍叶立德两步合成法。[2]本文报道了一种新颖的锍叶立德的合成方法,室温下Martin’s失水剂1与二羰基化合物、吲哚或吡咯反应,即可得到各种锍叶立德,产率最高可达99%（Fig.1）。[3]非常有意思的是,当反应物由Martin’s失水剂1变成芳基亚砜

关键词：锍叶立德 Martin’s失水剂羰基化合物芳基亚砜芳基化

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World Journal of AIDS 2023年第3期13卷 116-124页

作者： Maria Caixas Lima Pedro Vasques Andreia Paulos André Valente Joana Santos Carla Antunes Matilde Gonçalves Maria Isabel Casella nuno Luis José Poças Department of Infectious Diseases Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of General Surgery Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of Hematology Hospital de Santo António dos Capuchos Centro Hospitalar Lisboa Central Lisboa Portugal Department of Anatomical Pathology Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal

Background: Primary effusion lymphoma (PEL) is a lymphoid proliferation related to Kaposi sarcoma herpesvirus 8/human herpesvirus 8 (KSHV/HHV8) that affects mainly human immunodeficiency virus (HIV) infected individuals but can also occur in other immunodeficiency settings. It is characterized by lymphomatous effusions in different serous body cavities without the presence of a detectable tumor mass. The diagnosis is challenging and the clinical outcomes are poor. Aim: The aim of this paper is to report a rare case of PEL in a man who have sex with women (MSW) with HIV-1/2 infection, history of visceral Kaposi sarcoma (KS) and the development of a seronegative arthritis previous to the lymphoproliferative disease diagnosis. PEL presented with ascites, was treated with high-dose chemotherapy and autologous stem cell transplantation, with a good clinical outcome. Case Presentation: We describe a case of a 48-year-old HIV-1/2-infected patient from a high HHV8 seroprevalent country, hospitalized following a three-month history of increased abdominal volume and general constitutional symptoms. Laboratory data revealed normocytic normochromic anemia and a high level of lactate dehydrogenase. A diagnostic paracentesis was performed with cytology compatible with high-grade B-cell lymphoma. Peritoneal fluid cytology showed large lymphoid cells expressing leucocyte-common antigen CD45 without expression of the CD20 antigen (B-lymphocytes) and positivity for HHV8 by immunocytochemical staining, compatible with the diagnosis of PEL.

关键词： Primary Effusion Lymphoma Acquired Immunodeficiency Syndrome HIV-1 HIV-2 Kaposi Sarcoma Herpesvirus 8/Human Herpesvirus 8 People Living with HIV

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Barreiro科技学校

城市环境设计 2010年第10期 200-205页

作者： ARX PORTUGAL Arquitectos Lda.–Jose Mateus nuno Mateus FG+SG-Fotografia de Arquitectura

ARX建筑事务所的建筑不遵循固定的建筑语言。在每一个新项目中,建筑师都试图找到特定建筑语言的"表皮语汇"以适应新情况。由于总是返回原点考虑

关键词：建筑师美术家建筑语言 Barreiro ARX

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骑术艺术的思考