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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan Lam Thanh Hien Ha Manh Toan Nguyen Trong Vinh pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the u-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

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越南昆嵩地体早古生代花岗岩地球化学特征及对三岐–福山洋俯冲的响应

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大地构造与成矿学 2024年

作者：赖宗婷张玉芝余小清钱鑫 pham Trung Hieu 徐畅王岳军中山大学地球科学与工程学院广东省地球动力作用与地质灾害重点实验室南方海洋科学与工程广东省实验室(珠海) university of Science VNu-HCM 227Nguyen Van Cu Street

昆嵩地体位于印支陆块东部,广泛发育早古生代岩浆作用,是了解东南亚原特提斯洋演化的关键地区。但长久以来此地区原特提斯洋的俯冲极性与时间争议较大。本文对该地体的一套早古生代花岗岩进行了岩相学、锆石u-Pb年代学、锆石原位Hf同位... 详细信息

昆嵩地体位于印支陆块东部,广泛发育早古生代岩浆作用,是了解东南亚原特提斯洋演化的关键地区。但长久以来此地区原特提斯洋的俯冲极性与时间争议较大。本文对该地体的一套早古生代花岗岩进行了岩相学、锆石u-Pb年代学、锆石原位Hf同位素以及全岩主微量和Sr-Nd-Pb同位素研究。年代学结果显示该套花岗岩的结晶年龄为446～440Ma。花岗岩样品的K2O为2.14%～5.92%, Na2O+K2O为5.49%～8.25%,显示高钾钙碱性特征。其A/CNK值为1.03～1.18,为过铝质S型花岗岩。样品均显示明显的大离子亲石元素（如Rb、Th和u等）富集以及高场强元素（如Nb、Ta、Sr和Ti等）亏损,并具有强烈的Eu负异常（Eu/Eu*=0.23～0.69）。样品呈现变化范围较大的锆石原位Hf同位素组成(εHf（t）=-19.84～+1.99)以及新太古代-中元古代的Hf二阶模式年龄(tDM2=2.70～1.28 Ga),且具有富集的全岩Nd同位素组成(εNd（t）=-10.3～-6.5)。本文研究显示该套早古生代花岗岩是古老变沉积岩和基性变火成岩部分熔融的产物。结合区域地质研究表明,越南中部昆嵩地块早古生代花岗岩形成于俯冲作用下的岛弧背景,响应于区域上印支陆块内部原特提斯三岐–福山洋的南向俯冲过程。

关键词：昆嵩地体早古生代 S型花岗岩原特提斯洋三岐–福山洋俯冲作用

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Static and free vibration analyses of functionally graded porous variable-thickness plates using an edge-based smoothed finite element method

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Defence Technology（防务技术） 2021年第3期17卷 971-986页

作者： Trung Thanh Tran Quoc-Hoa pham Trung Nguyen-Thoi Department of Mechanics Le Quy Don Technical UniversityHanoiViet Nam Division of Computational Mathematics and Engineering Institute for Computational ScienceTon Duc Thang UniversityHo Chi Minh CityViet Nam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityViet Nam

The main purpose of this paper is to present numerical results of static bending and free vibration of functionally graded porous(FGP) variable-thickness plates by using an edge-based smoothed finite element method(ES-FEM) associate with the mixed interpolation of tensorial components technique for the three-node triangular element(MITC3), so-called ES-MITC3. This ES-MITC3 element is performed to eliminate the shear locking problem and to enhance the accuracy of the existing MITC3 element. In the ES-MITC3 element, the stiffness matrices are obtained by using the strain smoothing technique over the smoothing domains formed by two adjacent MITC3 triangular elements sharing an edge. Materials of the plate are FGP with a power-law index(k) and maximum porosity distributions(u) in the forms of cosine functions. The influences of some geometric parameters, material properties on static bending, and natural frequency of the FGP variable-thickness plates are examined in detail.

关键词： Functionally graded porous(FGP)plates Edge-based smoothed finite element method(ES-FEM) Mixed interpolation of tensorial components(MITC) Static bending Free vibration

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Rapid design of top-performing metal-organic frameworks with qualitative representations of building blocks

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npj Computational Materials 2023年第1期9卷 585-598页

作者： Yigitcan Comlek Thang Duc pham Randall Q.Snurr Wei Chen Department of Mechanical Engineering Northwestern UniversityEvanstonILUSA Department of Chemical and Biological Engineering Northwestern UniversityEvanstonILUSA

Data-driven materials design often encounters challenges where systems possess qualitative(categorical)***,representing Metal-organic frameworks(MOFs)through different building blocks poses a challenge for designers to incorporate qualitative information into design optimization,and leads to a combinatorial challenge,with large number of MOFs that could be *** this work,we integrated Latent Variable Gaussian Process(LVGP)and Multi-Objective Batch-Bayesian Optimization(MOBBO)to identify top-performing MOFs adaptively,autonomously,and *** showcased that our method(i)requires no specific physical descriptors and only uses building blocks that construct the MOFs for global optimization through qualitative representations,(ii)is application and property independent,and(iii)provides an interpretable model of building blocks with physical *** searching only~1%of the design space,LVGP-MOBBO identified all MOFs on the Pareto front and 97%of the 50 top-performing designs for the CO_(2) working capacity and CO_(2)/N2 selectivity properties.

关键词： properties qualitative autonomous

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PAMAM树状大分子对酮基布洛芬溶解度的影响

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高分子学报 2010年第7期20卷 876-883页

作者：张怀敬何华吕燕妮顾艳 CHuONG pham-Huy 中国药科大学基础部药物质量与安全预警教育部重点实验室 Faculty of Pharmacy University of Paris V4 avenue de l’Observatoire 75006ParisFrance

以酮洛芬为模型药物,研究聚酰胺-胺(PAMAM)树状大分子对酮洛芬的增溶作用,并探讨其作用机理.采用紫外光谱法测定了G1.0、G1.5、G2.0、G2.5、G3.0、G3.5PAMAM在不同浓度和不同pH时对酮洛芬的增溶量.并运用计算机模拟方法对PAMAM与酮洛芬... 详细信息

以酮洛芬为模型药物,研究聚酰胺-胺(PAMAM)树状大分子对酮洛芬的增溶作用,并探讨其作用机理.采用紫外光谱法测定了G1.0、G1.5、G2.0、G2.5、G3.0、G3.5PAMAM在不同浓度和不同pH时对酮洛芬的增溶量.并运用计算机模拟方法对PAMAM与酮洛芬相互作用的机理进行了探讨.实验结果表明,酮洛芬的溶解度随溶液pH值变化而变化,在pH4.0～6.0范围内,PAMAM树状大分子对酮洛芬的增溶量随着PAMAM的代数、浓度和溶液pH的增加而增大.整代和半代都具有增溶作用.然而,在同一pH条件下,对于具有相同官能团数目的整代和半代,整代增溶效果要高于半代.计算机模拟结果表明PAMAM与酮洛芬主要靠静电作用力结合.增溶机理可能是酮洛芬的羧基与PAMAM的伯胺和叔胺发生静电作用.

关键词： PAMAM树状大分子酮洛芬增溶作用

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Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam

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Asian Pacific Journal of Tropical Medicine 2020年第7期13卷 295-300页

作者： Giao Huynh Quang Vinh Bui Ngoc Lan Nguyen Le An pham Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Department of Pediatrics University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Department of Microbiology and Parasitology University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Center for training of Family Medicine university of Medicine and Pharmacy at Ho Chi Minh City Vietnam

Objective:To assess levels of HBs Ab amongst infants who received hepatitis B vaccine in the Expanded Program on Immunization in ***:A cross-sectional study was carried out at 16 community health centers from February 2016 to July *** infants were tested for HBs Ab and HBs *** questionnaires were used to collect relevant information about the demographics of the parents/caregivers and their infants after physical ***:A total of 199 eligible infants were selected with a mean age of(17.3±4.5)*** antibody levels with HBs Ab≥10 m Iu/m L were detected in 68.3%of *** these,antibody levels from 10 to 99 m Iu/m L were 48.5%of those tested and antibody levels≥100 ml u/m L were recorded as 51.5%.No cases were recorded of being infected with hepatitis B *** rate of positive HBs Ab level in those who were not wasting and≥18 months old was less than that among those who wereup(OR 0.15,95%CI:0.04-0.55,Pusions:Seroprotection against hepatitis B virus was low in the infants tested(at 68.3%),which suggests that the hepatitis B vaccine should be administered with one additional dose for infants between 12 and 24 months of age,particularly those with wasting.

关键词： Hepatitis B virus Hepatitis B Vaccine Vaccination Expanded Program on Immunization

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越南西北部Phan Si Pan地区新生代埃达克质侵入岩时代、成因及构造意义——u-Pb锆石年龄、元素地球化学和Hf同位素证据

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岩石学报 2012年第9期28卷 3031-3041页

作者： HIEu pham Trung 王涛童英 Faculty of Geology University of Sciences VNU-HCM227-Nguyen Van Cu StrHo Chi MinhVietnam Department of Geology Hanoi University of Mining and GeologyHanoiVietnam 中国地质科学院地质研究所北京100037

越南西北部PhanSiPan地区新生代花岗岩,高SiO2(69.95%～70.52%)、A12O3(15.77%～17.11%)、K2O(4.97%～5.63%)、Na2O(4.29%～4.98%),K2O/Na2O=1.02～1.31、Sr(744×10-6～1316×10-6),贫Y(6.93×10-6～8.06×10-6),低MgO和CaO,富集LILE元素及LREE,亏损HREE具有典型的埃达克岩特征。采用LA-ICPMS方法对该岩体进行了u-Pb同位素定年和Hf同位素分析,结果表明该岩体为始新世(38Ma)岩浆活动的产物。锆石Hf同位素研究结果显示,εHf(t)变化范围为-5.5至+7.3,二阶段Hf模式年龄(tDM2)为652Ma至1466Ma、集中在1.1～1.3Ga,说明花岗岩岩体主要由中-(新)元古代地壳物质部分熔融形成。部分锆石具有正的εHf(t)值,可能指示花岗岩岩浆形成的过程中存在壳-幔混合相互作用。越南西北部Phan Si Pan地区新生代花岗岩和扬子地块-(哀牢山-金沙江-红河带)高钾富碱的岩石形成的时代和机制具有密切的关系,可能与印度-亚洲大陆的碰撞导致红河带区域性走滑断裂系统的形成有关。

关键词：埃达克质岩锆石u-Pb年龄 Hf同位素越南西北部

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Dynamic connectedness and network in the high moments of cryptocurrency,stock,and commodity markets

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Financial Innovation 2023年第1期9卷 2388-2427页

作者： Waqas Hanif Hee‑un Ko Linh pham Sang Hoon Kang CEFAGE‑Center for Advanced Studies in Management and Economics University of AlgarveFaroPortugal Department of Management Sciences COMSATS University IslamabadAttock CampusAttockPakistan Korea Housing and urban Guarantee Corporation BusanRepublic of Korea Economics Business and Finance DepartmentLake Forest CollegeLake ForestIL 60045USA PNu Business School Pusan National UniversityJangjeon2‑DongGeumjeong‑GuBusan 609‑735Republic of Korea

This study examines the connectedness in high-order moments between cryptocurrency,major stock(u.S.,u.K.,Eurozone,and Japan),and commodity(gold and oil)*** intraday data from 2020 to 2022 and the time and frequency connectedness models of Diebold and Yilmaz(Int J Forecast 28(1):57–66,2012)and Barunik and Křehlik(J Financ Econom 16(2):271–296,2018),we investigate spillovers among the markets in realized volatility,the jump component of realized volatility,realized skewness,and realized *** higher-order moments allow us to identify the unique characteristics of financial returns,such as asymmetry and fat tails,thereby capturing various market risks such as downside risk and tail *** results show that the cryptocurrency,stock,and commodity markets are highly connected in terms of volatility and in the jump component of volatility,while their connectedness in skewness and kurtosis is ***,jump and volatility connectedness are more persistent than that of skewness and kurtosis *** rolling-window analysis of the connectedness models shows that connectedness varies over time across all moments,and tends to increase during periods of high ***,we show the potential of gold and oil as hedging and safe-haven investments for other markets given that they are the least connected to other markets across all moments and investment *** findings provide useful information for designing effective portfolio management and cryptocurrency regulations.

关键词： Spillovers High moments High frequency Hedging

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Effect of self-weight consolidation on a hydro-sedimentological model for the Río de la Plata estuary

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International Journal of Sediment Research 2019年第5期34卷 444-454页

作者： Pablo Santoro Mónica Fossati Pablo Tassi Nicolas Huybrechts Damien pham Van Bang Ismael Piedra-Cueva Instituto de Mecánica de los Fluidos e Ingeniería Ambiental Facultad de Ingeniería Universidad de la República université Paris-Est Laboratory for Hydraulics Saint-Venant (ENPC-EDF/R& D-CEREMA) Electricity of France R&D Department Sorbonne universités Université de Technologie de Compiègne FRE UTC-CNRS 3023 Roberval Centre de Recherche Royallieu Cerema Direction Technique Eau Mer et Fleuves Institut National de la Recherche Scientifique Centre-Eau Terre Environnement

The effect of the consolidation process on the morphodynamics and fine sediment dynamics of the Río de la Plata estuary is explored through a circulation-wave-sediment transport model. The consolidation model is calibrated based on settling column experimental data. Different simulations are done in order to initialize the mud layer distribution and to investigate the impact of different erosion parameter assumptions on the modeled sediment dynamics. Finally a two-year simulation is done with and without the consolidation process and realistic hydrodynamic forcings. Considering the consolidation process, the model correctly reproduces measured vertical density profiles in the Montevideo Bay access channel. The simulated suspended sediment dynamics behavior in Montevideo Bay with the consolidation process provides a more realistic deposition pattern in regard to the dredging activities.

关键词： Cohesive sediment Self-weight consolidation Morphodynamics Numerical modeling

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越南西北部Phan Si Pan地区Ngoi Chi岩组的锆石u-Pb年龄和Hf同位素组成

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地球学报 2015年第6期36卷 755-760页

作者：范忠孝 Faculty of Geology University of Science Vietnam National University-Ho Chi Minh City

本文对越南西北部Phan Si Pan地区变质地体中的一个Ngoi Chi片麻岩进行了锆石CL内部结构分析、LA-（MC）-ICP-MS锆石u-Pb定年和Hf同位素分析。CL图象和Th/u比值特征显示该片麻岩样品中的锆石主要为岩浆锆石,有少量窄的变质边。岩浆锆石... 详细信息

本文对越南西北部Phan Si Pan地区变质地体中的一个Ngoi Chi片麻岩进行了锆石CL内部结构分析、LA-（MC）-ICP-MS锆石u-Pb定年和Hf同位素分析。CL图象和Th/u比值特征显示该片麻岩样品中的锆石主要为岩浆锆石,有少量窄的变质边。岩浆锆石的年龄为-2.9 Ga,表明该样品是越南西北部Phan Si Pan地区的基底岩石。它们的εHf（t）值为–4.70±0.92,二阶段Hf模式年龄为-3.5 Ga,表明其为更古老的（〉3.5 Ga）冥太古代地壳物质部分熔融作用形成。变质边部锆石给出了-1.8 Ga的年龄,表明变质作用发生在古元古代早期,Phan Si Pan地区在这一时期可能经历了一次重要的构造热事件。

关键词： Vietnam Phan Si Pan u-Pb锆石 Hf同位素古老岩石

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