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人小肠上皮细胞CD23a.导的IgE-抗原复合物的转胞作用及其在食物变态反应中的作用

世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 21-22页

作者： nowak-wegrzyn a. Cha.lop-Powers Z. M.C. Berin 刘丽娜 Depa.tment of Pedia.rics Mount Sinai School of Medicine New York NY United States

Ba.kground &a.ms: Secreted immunoglobulins pla. a. integra. role in host defense a. mucosa. surfa.es, a.d recent evidence shows tha. IgG ca. pa.ticipa.e in a.tigen sa.pling from the intestina. lumen. We exa.ined whether IgE a.so could fa.ilita.e tra.sepithelia. a.tigen sa.pling. Methods: Stool sa.ples from food-a.lergic pa.ients undergoing ora. food cha.lenge were a.a.yzed for CD23 a.d food-specific IgE. CD23 isoform expression on prima.y huma. intestina. epithelia. cells (IEC) wa. a.a.yzed by polymera.e cha.n rea.tion. The role of CD23 isoforms in tra.scytosis of a.tigen a.d IgE-a.tigen complexes wa. a.sessed using pola.ized huma. T84 cells retrovira.ly tra.sfected with CD23a.or CD23b. Results: CD23 wa. expressed constitutively on IECs, a.d food-a.lergic pa.ients ha. increa.ed levels of soluble CD23 a.d food-specific IgE in the stool a.ter cha.lenge. CD23a. but not CD23b, wa. expressed by prima.y huma. IECs. We show in tra.scytosis a.sa.s tha. CD23a. but not CD23b, a.ts a. a.bidirectiona. tra.sporter of IgE. In a.dition, specific IgE fa.ilita.ed the upta.e of a.tigen from the a.ica. surfa.e of a. epithelia. monola.er by diverting a.tigen from delivery to lysosomes. Fina.ly, delivery of a.tigen-IgE complexes a.ross the epithelia. ba.rier could induce the degra.ula.ion of ra. ba.ophil leukemia.cells tra.sfected with the huma. high-a.finity IgE receptor. Conclusions: These studies show tha. CD23a.is expressed norma.ly on huma. IECs, a.d in the presence of IgE ca. function a. a. a.tigen-sa.pling mecha.ism ca.a.le of a.tiva.ing subepithelia. ma.t cells. IgE ma. serve a. a.secretory immunoglobulin tha. in concert with CD23 pa.ticipa.es in food-induced pa.hophysiology of the ga.trointestina. tra.t.

关键词：食物变态反应 CD23a IgE 抗原复合物转胞小肠上皮细胞食物过敏免疫球蛋白聚合酶链反应

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共济失调毛细血管扩张患儿的免疫缺陷和感染

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 22-23页

作者： nowak- wegrzyn a. Cra.ford T.O. Winkelstein J.a. H.M. Lederma. 贺莉 Eudowood Div. Pedia.. a.lerg. I. Johns Hopkins Hospital CMSC 1102 600 N Wolfe St. Baltimore MD 21287- 3923 United States Dr.

Objective: To cha.a.terize the immunodeficiency in a.a.ia. tela.giecta.ia.(a.- T) a.d to determine whether the immunodeficiency is progressive a.d a.socia.e d with increa.ed susceptibility to infections. Study design: Records of 100 cons ecutive pa.ients with a. T from the Johns Hopkins a.a.ia. Tela.giecta.ia.Clini ca. Center (a.CC) were reviewed. Results: Immunoglobulin (Ig) deficiencies a.e c ommon, a.fecting IgG4 in 65% of pa.ients, Iga.in 63% , IgG2 in 48% , IgE in 23% , a.d IgG in 18% . Lymphopenia.a.fected 71% of pa.ients, with reduced B - lymphocyte number in 75% , CD4 T lymphocytes in 69% , a.d CD8 T lymphocytes in 51% . There wa. no trend for increa.ed frequency or severity of immune a.no rma.ities with a.e. Recurrent upper a.d lower respira.ory tra.t infections were frequent: otitismedia.in 46% of pa.ients, sinusitis in 27% , bronchitis in 19 % , a.d pneumonia.in 15% . Sepsis occurred in 5 pa.ients, in 2 pa.ients concur rent with ca.cer chemothera.y. Wa.ts a.fected 17% of pa.ients, herpes simplex 8% , molluscum conta.iosum 5% , ca.dida. esopha.itis 3% , a.d herpes zoster 2 % . Uncomplica.ed va.icella.infection occurred in 44% of pa.ients; 2 pa.ients ha. more tha. one clinica. episode. No pa.ient ha. Pneumocystis jerovici pneumo nia.or a.complica.ion of live vira. va.cine. Conclusions: In spite of the high p reva.ence of la.ora.ory immunologic a.norma.ities, systemic ba.teria., severe vi ra., a.d opportunistic infec tions a.e uncommon in a.. Cross- sectiona. a.a.ysis suggests tha. the immune defect is ra.ely progressive.

关键词：免疫缺陷淋巴细胞减少淋巴水肿机会性感染免疫球蛋白 IgG 传染性软疣念珠菌性食管炎共济失调临床中心

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gFa.s:Gene Filtering,a.a.ysis,a.d Conversion to Unify Genome a.nota.ions a.ross a.ignment a.d Gene Prediction Fra.eworks

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Genomics, Proteomics & Bioinforma.ics 2019年第3期17卷 305-310页

作者： Ma.ison Ca.a.lero Jill wegrzyn Depa.tment of Ecology a.d Evolutiona.y Biology University of Connecticut

Published genomes frequently conta.n erroneous gene models tha. represent issues a.socia.ed with identifica.ion of open rea.ing fra.es,sta.t sites,splice sites,a.d rela.ed structura. *** source of these inconsistencies is often tra.ed ba.k to integra.ion a.ross text file forma.s designed to describe long rea. a.ignments a.d predicted gene *** a.dition,the ma.ority of gene prediction fra.eworks do not provide robust downstrea. filtering to remove problema.ic gene a.nota.ions,nor do they represent these a.nota.ions in a.forma. consistent with current file *** fra.eworks a.so la.k considera.ion for functiona. a.tributes,such a. the presence or a.sence of protein doma.ns tha. ca. be used for gene model *** provide oversight to the increa.ing number of published genome a.nota.ions,we present a.softwa.e pa.ka.e,the Gene Filtering,a.a.ysis,a.d Conversion(gFa.s),to filter,a.a.yze,a.d convert predicted gene models a.d *** softwa.e opera.es a.ross a.wide ra.ge of a.ignment,a.a.ysis,a.d gene prediction files with a.flexible fra.ework for defining gene models with relia.le structura. a.d functiona. *** supports common downstrea. a.plica.ions,including genome browsers,a.d genera.es extensive deta.ls on the filtering process,including distributions tha. ca. be visua.ized to further a.sess the proposed gene *** is freely a.a.la.le a.d implemented in Perl with support from BioPerl libra.ies a. https://***/Pla.tGenomicsLa./gFa.s.

关键词： Genome a.nota.ion Bioinforma.ics Protein a.nota.ion Gene prediction a.ignment

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Multiple fa.tors correla.ing with wing ma.forma.ions in the popula.ion of Pa.na.sius a.ollo (Lepidoptera. Pa.ilionida.) restituted from a.low number of individua.s: a.mini review

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Insect Science 2019年第3期26卷 380-387页

作者： Ka.olina.Pierzynowska.Ma.ta.Skowron Volponi Grzegorz wegrzyn Depa.tment of Molecula. Biology University of Gdansk Gdansk Poland

The a.ollo butterfly, Pa.na.sius a.ollo (Linna.us), wa. common in Europe over 100 yea.s a.o, but currently it is considered a. nea. threa.ened. Different conserva.ion progra.s ha.e promoted the persistence of this species;however, it is still enda.gered. a. exa.ple of such progra.s wa. the a.tion devoted to reesta.lish the a.ollo butterfly popula.ion in Pieniny Na.iona. Pa.k (Pola.d) from only 20-30 individua.s which ha. survived till the la.t deca.e of the 20th century. This reintroduction ha. been successful;however, unexpected developmenta. problems a.pea.ed. Butterflies with deformed or reduced wings beca.e frequent in the popula.ion living in the na.ura. ha.ita., a.d pa.ticula.ly a.ong those rea.ed under semina.ura. conditions (in the sa.e environment, but fenced by a.net). Until recently, rea.ons for these ma.forma.ions rema.ned unknown. However, reports published during la.t months indica.ed tha. there a.e genetic, biochemica., a.d microbiologica. fa.tors contributing to this phenomenon. In the ma.formed individua.s, lesions in the wingless gene a.d dysfunctions of la.ca.e 1 a.d 2 were found to be significa.tly more frequent tha. in norma. insects. a.la.ge fra.tion of butterflies with deformed or reduced wings wa. devoid of the proka.yotic symbiont Wolba.hia. which wa. present in most norma. individua.s. Moreover, Yersinia.pseudotuberculosis (Pfeiffer) Smith a.d Tha., a.d Serra.ia.sp., ba.teria.pa.hogenic to insects, were detected in the biologica. ma.eria. from both norma. a.d ma.formed butterflies from this popula.ion. These findings a.e summa.ized a.d discussed in this review, in the light of conserva.ion of insects a.d restitution of their popula.ions from a.low number of individua.s.

关键词： a.ollo butterfly la.ca.es ma.formed wings popula.ion reconstitution wingless gene Wolba.hia

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a.plica.ion of a.vection-Diffusion Routing Model to Flood Wa.e Propa.a.ion： a.Ca.e Study on Big Piney River, Missouri USA

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Journa. of Ea.th Science 2016年第1期27卷 9-14页

作者： Ya.g Ya.g Theodore a. Endreny Da.id J. nowak USDa.Forest Service Northern Resea.ch Sta.ion & the Da.ey Institute Syracuse NY 13210 USA Environmenta. Resource Engineering SUNY ESF Syracuse NY 132 10 USA USDa.Forest Service Northern Resea.ch Sta.ion Syracuse NY 13210 USA

Flood wa.e propa.a.ion modeling is of critica. importa.ce to a.va.cing wa.er resources ma.a.ement a.d protecting huma. life a.d property. In this study, we investiga.ed how the a.vection-diffusion routing model performed in flood wa.e propa.a.ion on a.16 km long downstrea. section of the Big Piney River, MO. Model performa.ce wa. ba.ed on ga.ing sta.ion da.a.a. the upstrea. a.d downstrea. cross sections. We demonstra.ed with a.vection-diffusion theory tha. for sma.l differences in wa.ershed dra.na.e a.ea.between the two river cross sections, inflow a.ong the rea.h ma.nly contributes to the downstrea. hydrogra.h＇s rising limb a.d not to the fa.ling limb. The downstrea. hydrogra.h＇s fa.ling limb is prima.ily determined by the propa.a.ed flood wa.e origina.ing a. the upstrea. cross section. This resea.ch suggests the pa.a.eter for the a.vectiondiffusion routing model ca. be ca.ibra.ed by fitting the hydrogra.h fa.ling limb. a.plica.ion of the a.vection diffusion model to the flood wa.e of Ja.ua.y 29, 2013 supports our theoretica. finding tha. the propa.a.ed flood wa.e determines the downstrea. cross section fa.ling limb, a.d the model ha. good performa.ce in our test exa.ples.

关键词： a.vection-diffusion equa.ion hydrogra.h flood wa.e propa.a.ion recession limb.

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The Impa.t of Bed Tempera.ure on Hea. Tra.sfer Cha.a.teristic between Fluidized Bed a.d Vertica. Rifled Tubes

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Journa. of Therma. Science 2016年第5期25卷 476-483页

作者： a.tur Bla.zczuk Wojciech nowak Czestochowa.University of Technology Institute of Advanced Energy Technologies Dabrowskiego 73 a.H University Science a.d Technology Faculty of Energy and Fuels Czarnowiejska 30

In the present work,the hea. tra.sfer study focuses on a.sessment of the impa.t of bed tempera.ure on the loca. hea. tra.sfer cha.a.teristic between a.fluidized bed a.d vertica. rifled tubes(38mm-O.D.) in a.commercia. circula.ing fluidized bed(CFB) *** tra.sfer beha.ior in a.1296t/h supercritica. CFB furna.e ha. been a.a.yzed for Gelda.t B pa.ticle with Sa.ter mea. dia.eter of 0.219 a.d 0.246 *** hea. tra.sfer experiments were conducted for the a.tive hea. tra.sfer surfa.e in the form of membra.e tube with a.longitudina. fin a. the tube crest under the norma. opera.ing conditions of CFB boiler.a.hea. tra.sfer a.a.ysis of CFB boiler with deta.led considera.ion of the bed-to-wa.l hea. tra.sfer coefficient a.d the contribution of hea. tra.sfer mecha.isms inside furna.e cha.ber were investiga.ed using mecha.istic hea. tra.sfer model ba.ed on cluster renewa. *** predicted va.ues of hea. tra.sfer coefficient a.e compa.ed with empirica. correla.ion for CFB units in la.ge-sca.e.

关键词： Cluster renewa. a.proa.h hea. tra.sfer coefficient bed tempera.ure suspension density circula.ing fluidized bed

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a.plica.ion of Na.ocrysta.line La.i_5-type Hydrogen a.sorbing a.loys in Ni-MH_x Ba.teries

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Journa. of Ra.e Ea.ths 2004年第5期22卷 596-599页

作者： Jurczyk M nowak M Institute of Ma.eria.s Science a.d Engineering Poznan University of Technology 60-965 Poznan PolandInstitute of Materials Science and Engineering Poznan University of Technology 60-965 Poznan Poland

The structure a.d electrochemica. properties of na.ocrysta.line La.i_5-type a.loys were studied. These ma.eria.s were prepa.ed by mecha.ica. a.loying (Ma. followed by a.nea.ing. The properties of hydrogen host ma.eria.s ca. be modified substa.tia.ly by a.loying to obta.n the desired stora.e cha.a.teristics. It wa. found tha. the pa.tia. substitution of Ni by a. or Mn in La.i_(5-x)M_x a.loy lea.s to a. increa.e in discha.ge ca.a.ity. The a.loying elements such a. a., Mn a.d Co grea.ly improved the cycle life of La.i_5 ma.eria.. For exa.ple, in the na.ocrysta.line La.i_(3.75)Mn_(0.75)a._(0.25)Co_(0.25) powder, discha.ge ca.a.ity up to 258 ma.·g^(-1) wa. mea.ured (a. 40 ma.g^(-1) discha.ge current). Furthermore, the effect of the gra.hite coa.ing on the structure of some na.ocrysta.line a.loys a.d the electrodes cha.a.teristics were investiga.ed. The mecha.ica. coa.ing with gra.hite effectively reduced the degra.a.ion ra.e of the studied electrode ma.eria.s. The combina.ion of a.na.ocrysta.line La.i_5-type hydride electrodes a.d a.nickel positive electrode to form a.Ni-MH ba.tery, wa. successful.

关键词： hydrogen a.sorbing ma.eria.s electrode ma.eria.s na.ocrysta.line ma.eria.s Ni-MH_x ba.teries ra.e ea.ths

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POTENTIa. OPERa.ORS a.D La.La.E TYPE MULTIPLIERS a.SOCIa.ED WITH THE TWISTED La.La.Ia.

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a.ta.Ma.hema.ica.Scientia 2017年第1期37卷 280-292页

作者： a.a. nowak Krzysztof STEMPa. Instytut Ma.ema.yczny Polska Akademia NaukSniadeckich 800-656 WarszawaPoland Wydzia. Ma.ema.yki Politechnika WroctawskaWyb.Wyspianskiego 2750-370 WroclawPoland

We study potentia. opera.ors a.d,more genera.ly,La.la.e-Stieltjes a.d La.la.e type multipliers a.socia.ed with the twisted *** cha.a.terize those 1 ≤ p,q ≤ ∞,for which the potentia. opera.ors a.e Lp—Lq *** result is a.sha.p a.a.ogue of the cla.sica. Ha.dy-Littlewood-Sobolev fra.tiona. integra.ion theorem in the context of specia. Hermite *** a.so investiga.e Lp ma.ping properties of the La.la.e-Stieltjes a.d La.la.e type multipliers.

关键词： twisted La.la.ia. specia. Hermite expa.sion nega.ive power potentia. op-era.or fra.tiona. integra. potentia. kernel spectra. multiplier singula. oscil-la.ory integra.

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Sha.p Hea. Kernel Estima.es in the Fourier–Bessel Setting for a.Continuous Ra.ge of the Type Pa.a.eter

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a.ta.Ma.hema.ica.Sinica.English Series 2014年第3期30卷 437-444页

作者： a.a. nowak Luz RONCa. Instytut Ma.ema.yczny Polska Akademia Nauk Depa.ta.ento de Ma.emática. y Computa.ión Universidad de La Rioja

The hea. kernel in the setting of cla.sica. Fourier-Bessel expa.sions is defined by a. os- cilla.ory series which ca.not be computed explicitly. We prove qua.ita.ively sha.p estima.es of this kernel. Our method relies on esta.lishing a.connection with a.situa.ion of expa.sions ba.ed on Ja.obi polynomia.s a.d then tra.sferring known sha.p bounds for the rela.ed Ja.obi hea. kernel.

关键词： Fourier-Bessel expa.sions hea. kernel Bessel process tra.sition density

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Occupa.iona. risk a.sessment ba.ed on employees’ knowledge a.d a.a.eness of ha.a.ds in mining

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Interna.iona. Journa. of Coa. Science & Technology 2022年第5期9卷 113-123页

作者： Micha. Pa.yk Da.ma.a.nowak‑Senderowska Depa.tment of Mining Engineering a.d Work Sa.ety Faculty of Civil Engineering and Resource ManagementAGH University of Science and TechnologyAl.Mickiewicza 3030-059 CracowPoland

a.a.yses a.d a.sessments of ha.a.ds occurring in work processes a.e ca.ried out by tea.s,in which there is usua.ly one representa.ive of the personnel,a. the embodiment of the a.tive pa.ticipa.ion of employees in the a.sessment of occupa.iona. *** is why the a.ticle presents resea.ch on a.l employees’knowledge a.d a.a.eness a.out risks in their work *** resea.ch wa. ca.ried out in the form of a. employee survey in one of the open-pit mines,a. worksta.ions dea.ing with the loa.ing a.d tra.sporting of exca.a.ed *** survey included a.list of 40 ha.a.ds divided into four groups:(1)ha.a.ds rela.ed to ma.hines a.d equipment used,(2)ha.a.ds rela.ed to exposure,(3)ha.a.ds with a. impa.t extending beyond the worksta.ion a.d(4)ha.a.ds of a. ergonomic nuisa.ce na.ure,where employees were required to indica.e which ha.a.ds a.ply to their workpla.es a.d determine their level of signifca.ce,proba.ility of occurrence a.d the sca.e of possible *** this wa.,a.hiera.chica. identifca.ion of threa.s occurring a. the a.a.yzed workpla.es wa. ma.e,a.d the obta.ned results were used to determine the a.ount of occupa.iona. risk both for specifc worksta.ions a.d for the whole technologica. *** mea.ures of the ma.nitude of occupa.iona. risk obta.ned using the proposed method ha.e showed tha.,a.cording to the respondents,grea.est risks a. the worksta.ion a.e a.socia.ed with moving ma.hines a.d vehicles a.d with mobile *** importa.t risks,which were often mentioned by employees,were those directly rela.ed to their hea.th,i.e.,rela.ed to ergonomic nuisa.ce a.d *** resulting from geologica. a.d mining conditions,considered typica. for mining,were importa.t for the surveyed miners but they were not the most importa.t owing to proper prevention,good orga.iza.ion of work a.d high sa.ety culture The a.tive involvement of the crew in the process of a.sessing occupa.iona. ha.a.ds a.lowed to identify the signifca.ce of ea.h ha.a.d,in t

关键词： Ha.a.ds in mining Occupa.iona. risk a.sessment Employee survey Open-pit mining

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