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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 10-10页

作者： novotna k. Trk.va M. Pazdro A. 陈云茹(译) 史敏(校) Institute of Biology and Medical Genetics Charies University Second Medical School V uvalu 8415006 Prague 5 Czech Republic 不详

In search of potential prognostic mark.rs, we analyzed a large series of tissues of Barrett’s esophagus and samples of adenocarcinomas arising in the terrain of Barrett’s esophagus for TP53 gene mutations by direct sequencing of exons 5 to 9 of the TP53 gene. While 9 of 21 adenocarcinomas tested (42.9%)contained a TP53 mutation, none of 24 samples from Barrett’s esophagus were mutated. This observation suggests that TP53 gene mutation may be a relatively late event in the progression from nondysplastic Barrett’s esophagus to adenocarcinoma of esophagus. Therefore,TP53 gene mutations alone are not lik.ly to represent a widely useful prognostic mark.r of the risk.of progression to malignancy, at least not in Barrett’s esophagus without dysplasia.

关键词： Barrett食管 TP53基因基因突变体增生性 P53基因突变食管腺癌预后指标异常增生直接测序法

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Investigating the coagulation of non-proteinaceous algal organic matter: Optimizing coagulation performance and identification of removal mechanisms

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Journal of Environmental Sciences 2019年第5期31卷 25-34页

作者： Jana Naceradsk. k.terina novotna Lenk. Cermak.va Tomas Cajthaml Martin Pivok.nsk. Institute of Hydrodynamics of the Czech Academy of Sciences Institute of Microbiology of the Czech Academy of Sciences

The removal of algal organic matter(AOM) is a growing concern for the water treatment industry worldwide. The current study investigates coagulation of non-proteinaceous AOM(AOM after protein separation), which has been minimally explored compared with proteinaceous fractions. Jar tests with either aluminum sulphate(alum) or polyaluminium chloride(PACl) were performed at doses of 0.2–3.0 mg Al per 1 mg of dissolved organic carbon in the p H range 3.0–10.5. Additionally, non-proteinaceous matter was characterized in terms of charge, molecular weight and carbohydrate content to assess the treatability of its different fractions. Results showed that only up to 25% of non-proteinaceous AOM can be removed by coagulation under optimized conditions. The optimal coagulation p H(6.6–8.0 for alum and 7.5–9.0 for PACl) and low surface charge of the removed fraction indicated that the prevailing coagulation mechanism was adsorption of non-proteinaceous matter onto aluminum hydroxide precipitates. The lowest residual Al concentrations were achieved in very narrow p H ranges, especially in the case of PACl. High-molecular weight saccharidelik. organics were amenable to coagulation compared to low-molecular weight(k.Da)substances. Their high content in non-proteinaceous matter(about 67%) was the reason for its low removal. Comparison with our previous studies implies that proteinaceous and nonproteinaceous matter is coagulated under different conditions due to the employment of diverse coagulation mechanisms. The study suggests that further research should focus on the removal of low-molecular weight AOM, reluctant to coagulate, with other treatment processes to minimize its detrimental effect on water safety.

关键词： Algal organic matter Chlorella vulgaris Coagulation Flocculation Non-proteinaceous matter Water treatment

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Large-scale permafrost degradation as a primary factor in Larix sibirica forest dieback.in the k.entii massif,northern Mongolia

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Journal of Forestry Research 2020年第1期31卷 197-208页

作者： David Jurick. Jitk. novotna Jak.b Housk. Jana Parilk.va Jan Hladk. Vaclav Pecina Hana Cihlarova Marcela Burnog Jak.b Elbl Zdena Rosick. Martin Brtnick. Jindrich k.nick. Department of Geology and Pedology Faculty of Forestry and Wood TechnologyMendel University in BrnoZemedelska 161300 BrnoCzech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 656/12361200 BrnoCzech Republic Institute of Water Structures Faculty of Civil EngineeringBrno University of TechnologyZizkova 1760200 BrnoCzech Republic

The objective of this study is to investigate the potential causes of widespread Larix sibirica *** observed in the k.entii massif of northern *** ratio of deadwood to living trees in affected stands in the Goricho region,the southernmost study site situated close to the Gobi Desert,was as high as 3.6:*** fluctuations monitored over 2 years using electrical impedance spectrometry revealed that the Goricho study site had higher soil moisture levels than the two less affected sites Barun Bayan and Dzun *** soil moisture was recorded in an area characterized by highly sk.letal soils,ones with more than 35%by volume of rock.fragments,and comparatively shallow soil horizons,from valley to *** layer of permafrost influencing hydrogeological processes is much deeper in the Goricho region compared to the undisturbed study *** analysis confirmed a significant number of dead *** on sites with developed *** forest stands,however damaged,grow in this region on well-drained scree slopes or on rock. *** mass mortality observed for *** may be directly link.d to accelerated permafrost thaw in the area bordered by the Tuul and the Terelj *** assumption is that *** root system necrosis occurred as a result of long-term waterlogging of developed soils with high spatial heterogeneity,normally able to absorb high quantities of *** areas unaffected were scree fields and rock. bastions characterized by adequate *** of our findings support the primary stages of large-scale permafrost thaw,i.e.,correlating increases in soil moisture with increasing permafrost active layer thick.ess.

关键词： Larix sibirica Mortality Permafrost thawing Waterlogging Mongolia

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Limited validity of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis

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World Journal of Gastrointestinal Endoscopy 2024年第11期16卷 607-616页

作者： Pavel Wohl Alzbeta k.ausova Petr Wohl Ondrej Fabian Luk.s Bajer Jan Brezina Pavel Drastich Mojmir Hlavaty Petra novotna Michal k.hle Julius Spicak.Martin Gregor Department of Gastroenterology Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Integrative Biology Institute of Molecular Genetics of the Czech Academy of SciencesPrague 14220Czech Republic Department of Metabolism and Diabetes Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Clinical and Transplant Pathology Centre Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Data Analysis Statistics and Artificial IntelligenceInstitute for Clinical and Experimental MedicinePrague 14021Czech Republic

BACk.ROUND Ulcerative colitis(UC)with concomitant primary sclerosing cholangitis(PSC)represents a distinct disease entity(PSC-UC).Mayo endoscopic subscore(MES)is a standard tool for assessing disease activity in UC but its relevance in PSC-UC remains *** To assess the accuracy of MES in UC and PSC-UC patients,we performed histological scoring using Nancy histological index(NHI).METHODS MES was assessed in 30 PSC-UC and 29 UC adult patients during *** and inflammation were evaluated in biopsies from the cecum,rectum,and terminal *** addition,perinuclear anti-neutrophil cytoplasmic antibodies,fecal calprotectin,body mass index,and other relevant clinical characteristics were *** The median MES and NHI were similar for UC patients(MES grade 2 and NHI grade 2 in the rectum)but were different for PSC-UC patients(MES grade 0 and NHI grade 2 in the cecum).There was a correlation between MES and NHI for UC patients(Spearman's r=0.40,P=0.029)but not for PSC-UC *** examination revealed persistent microscopic inflammation in 88%of PSC-UC patients with MES grade 0(46%of all PSC-UC patients).Moreover,MES overestimated the severity of active inflammation in an additional 11%of PSCUC *** MES insufficiently identifies microscopic inflammation in *** indicates that histological evaluation should become a routine procedure of the diagnostic and grading system in both PSC-UC and PSC.

关键词： Primary sclerosing cholangitis Ulcerative colitis Diagnosis Nancy histological index Mayo endoscopic subscore

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