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Efficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1243-1249页

作者： Anis Baidura Azal Siti Husna Hussein Seng Fai Tang Othmaliza Othman norshamsiah md din Department of Ophthalmology Faculty of MedicineUniversiti Kebangsaan Malaysia(UKM)Kuala Lumpur 56000Malaysia

AIM:To evaluate whether latanoprost/timolol fixed combination(LTFC)dosed twice daily may provide further intraocular pressure(IOP)reduction and evaluate the safety profile at this ***:This is an open-labeled,randomized,prospective crossover study on fourty primary open angle glaucoma *** weeks of washout period were followed by randomization to either once daily(OD,group A)or twice daily dosing(BD,group B)of LTFC for *** another 2-week washout period,the patients’treatment dose was crossed-over for another *** reduction alongside ocular and systemic side effects were ***:Mean baseline IOP was 18.57±2.93 and 17.8±3.01 mm Hg before OD and BD dose respectively,(P=0.27).Mean IOP after BD dose was statistically lower(12.49±1.59 mm Hg)compared to OD(13.48±1.81 mm Hg,P=0.017).Although IOP reduction after BD dose was more(5.32±3.24 mm Hg,29.89%)than after OD dosing(5.04 mm Hg,27.14%),it did not reach statistical significance(P=0.68).Patients switched from OD to BD(group A)showed mean IOP reduction by 0.69 mm Hg[95%confidence interval(CI):-0.09 to 1.48 mm Hg,P=0.078];but patients switched from BD to OD(group B)had significantly higher mean IOP by 1.25 mm Hg(95%CI:-2.04 to-0.46 mm Hg,P=0.006).BD dose had more ocular side effects albeit ***:Mean IOP after LTFC dosed twice daily is statistically lower,with additional mild side effects.

关键词： efficacy fixed combination latanoprost timolol primary open angle glaucoma safety

Review of the management of sight-threatening diabetic retinopathy during pregnancy

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World Journal of Diabetes 2021年第9期12卷 1386-1400页

作者： Priscilla Peixi Choo norshamsiah md din Nooraniah Azmi Mae-Lynn Catherine Bastion Department of Ophthalmology Universiti Kebangsaan Malaysia Medical CentreKuala Lumpur 56000Wilayah PersekutuanMalaysia Department of Ophthalmology Universiti Putra MalaysiaSerdang 43400SelangorMalaysia

Diabetes mellitus(DM)is a noncommunicable disease reaching epidemic proportions around the *** affects younger individuals,including women of childbearing *** can cause diabetic retinopathy(DR),which is potentially sight threatening when severe nonproliferative DR(NPDR),proliferative DR(PDR),or sight-threatening diabetic macular oedema(STDME)*** is an independent risk factor for the progression of *** DR at the onset of pregnancy is an important indicator of progression,with up to 10% of women with baseline NPDR progressing to *** to sight-threatening DR(STDR)during pregnancy causes distress to the patient and often necessitates ocular treatment,which may have a systemic *** includes prepregnancy counselling and,when possible,conventional treatment prior to *** pregnancy,closer follow-up is required for those with a long duration of DM,poor baseline control of blood sugar and blood pressure,and worse DR,as these are risk factors for progression to *** treatment with anti-vascular endothelial growth factor agents for STDME can potentially lead to foetal *** with laser photocoagulation may be preferred,and surgery under general anaesthesia should be *** review provides a management plan for STDR from the perspective of practising ophthalmologists.A review of strategies for maintaining the eyesight of diabetic women with STDR with emphasis on prepregnancy counselling and planning,monitoring and safe treatment during pregnancy,and management of complications is presented.

关键词： Sight-threatening diabetic retinopathy Severe nonproliferative diabetic retinopathy Proliferative diabetic retinopathy Diabetic macula oedema Pregnancy Panretinal photocoagulation

Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1782-1790页

作者： Aimy Mastura Zurairah Yusof Othmaliza Othman Seng Fai Tang Mohd Rohaizat Hassan norshamsiah md din Department of Ophthalmology Tuanku Mizan Armed Forces HospitalKuala Lumpur 53300Malaysia Department of Ophthalmology UKM Medical CenterJalan Yaacob LatifCheras 56000Kuala LumpurMalaysia Department of Community Health UKM Medical CenterJalan Yaacob LatifCheras 56000Kuala LumpurMalaysia

AIM: To compare the diagnostic ability of glaucoma parameters measured by the optical coherence tomography(OCT) in normal, preperimetric glaucoma(PPG) and perimetric glaucoma(PG) patients. METHODS: This cross-sectional observational study includes 127 eyes of 127 subjects. Patients were divided into PPG(51 eyes), PG(46 eyes), and normal controls(30 eyes) based on clinical optic disc assessment and Humphrey visual field changes. The Heidelberg Spectralis OCT machine using Glaucoma Module Premium Edition software was used to measure the retinal nerve fiber layer(RNFL) and Bruch’s membrane opening-minimum rim width(BMO-MRW) to assess the optic nerve head and ganglion cell layer(GCL) thickness in the macula. RESULTS: RNFL, MRW, and GCL thickness were all significantly thinner in PG compared to PPG and the normal group. The BMO-MRW parameters showed better specificity(>70%) at 90% specificity compared to both RNFL and GCL parameters to discriminate normal, PPG, and PG patients. All BMO-MRW parameters showed higher area under curves(AUC) compared to RNFL and GCL parameters with the highest AUC observed in the superotemporal sector of the BMO-MRW(AUC=0.819 and and 0.897 between normal and PPG and PG groups respectively).CONCLUSION: While the BMO-MRW best discriminates PPG and PG against normal eyes, GCL parameters poorly differentiate the three groups.

关键词： glaucoma preperimetric ganglion cell layer Bruch’s membrane opening minimum rim width retinal nerve fibre layer

Central retinal artery occlusion and optic neuropathy secondary to platelet rich plasma injection:a case report

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 945-947页

作者： Norashikin Maslan Wan Haslina Wan Abdul Halim norshamsiah md din Seng Fai Tang Department of Ophthalmology Universiti Kebangsaan Malaysia Medical Centre(UKMMC)Cheras 56000Kuala LumpurMalaysia

Dear Editor.I am *** Maslan,from the Department of Ophthalmology of University Kebangsaan Malaysia Medical Centre in Kuala Lumpur,Malaysia.I am writing to present a case report on central retina artery occlusion(CRAO)... 详细信息

关键词： injection Malaysia neuropathy

Successful treatment of epithelial downgrowth with endoscopic photocoagulation and intracameral 5-fluorouracil after prolonged limbal wound leak

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 703-704页

作者： Zakaria Abdollah Aida Zairani Mohd Zahidin Amin Ahem Ropilah Abdul Rahman norshamsiah md din Department of Ophthalmology Universiti Kebangsaan Malaysia Medical Centre Kulliyyah of Medicine University College of Insaniah

Dear Editor,Epithelial downgrowth（EDG）is an uncommon and serious complication of intraocular surgery and trauma[1].It is recognized clinically by a translucent membrane on the corneal endothelium or *** of EDG is controversial and generally has a low success *** treatment modalities have been invasive and damaging to the anatomy of the eye[1].

关键词： ECP Successful treatment of epithelial downgrowth with endoscopic photocoagulation and intracameral 5-fluorouracil after prolonged limbal wound leak EDG Figure

Association of type Ⅱ Waardenburg syndrome with hypermetropic amblyopia

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 677-680页

作者： Shee Wen Chua Safinaz Mohd Khialdin Mushawiahti Mustapha norshamsiah md din Meng Hsien Yong Department of Ophthalmology Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia Ophthalmology Department Faculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400SabahMalaysia

Dear Editor, We present a case of hypermetropic amblyopia in type II Waardenburg syndrome(WS) to highlight the association. WS is an “oculo-dermato-auditif” dysplasia described in 1947 by Waardenburg and by Klein in... 详细信息

关键词： audit Waardenburg hyper

Ocular syphilis: resurgence of an old disease in modern Malaysian society

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1573-1576页

作者： Mushawiahti Mustapha Zakaria Abdollah Amin Ahem Hazlita Mohd Isa Mae-Lynn Catherine Bastion norshamsiah md din Department of Ophthalmology Pusat Perubatan Universiti

Dear Editor,Syphilis is a spirochaetal bacterial sexually transmitted disease（STD） caused by Treponema pallidum. Outbreaks of syphilis have been described in Western communities, especially in men who have sex with men（MSM） and people infected with human immunodeficiency virus（HIV）^（[1]）. Reports of the condition from Asian countries remains limited.

关键词： Ocular syphilis OS OD HIV MSM resurgence of an old disease in modern Malaysian society

A novel (G'/G)-expansion method and its application to the Boussinesq equation

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Chinese Physics B 2014年第2期23卷 34-43页

作者： md.Nur Alam md.Ali Akbar Syed Tauseef Mohyud-din Department of Mathematics Pabna University of Science and Technology Department of Applied Mathematics University of Rajshahi Department of Mathematics HITEC UniversityTaxila Cantt

In this article, a novel （G＇/G）-expansion method is proposed to search for the traveling wave solutions of nonlinear evolution equations. We construct abundant traveling wave solutions involving parameters to the Boussinesq equation by means of the suggested method. The performance of the method is reliable and useful, and gives more general exact solutions than the existing methods. The new （G＇/G）-expansion method provides not only more general forms of solutions but also cuspon, peakon, soliton, and periodic waves.

关键词： (G'/G)-expansion method Boussinesq equation solitary wave solutions auxiliary nonlinear ordinary differential equation

Influence of Electrolytes on the Micellar Growth of Amphiphilic Drug Chlorpromazine Hydrochloride

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物理化学学报 2008年第3期24卷 411-415页

作者： ALAM md. Sayem KABIR-UD-din Department of Chemistry Aligarh Muslim University Aligarh-202002 UP India

The effect of electrolytes on the micellar behavior of an amphiphilic drug, chlorpromazine (CPZ) hydrochloride, was studied using cloud point (CP) and dye solubilization techniques. In the presence of KBr, increase in pH led to decrease in the CP of 50 mmol·L-1 drug solution (prepared in 10 mmol·L-1 sodium phosphate (SP) buffer) because of deprotonation of drug molecules at high pH. The visible absorbance increased (due to dye solubilization) with the increase in pH from 6.5 to 6.9, which indicated micellar growth. At fixed pH (6.7), addition of inorganic salts (KF, KCl, and KBr) to drug solutions (50 mmol·L-1) caused an increase in the CP as well as in the visible absorbance, with effectiveness being in the order: F-ding and their effect toward micellar growth. Cations (co-ions) also led to an increase in the CP (and also the visible absorbance), with their effectiveness order being Li+ >Na+ >K+, which was explained by considering cognizance of their hydrated radii. Compared with anions, their effect was small. Increase in [CPZ] caused micellar growth and hence the CP as well as the visible absorbance increased. The overall behavior was discussed in terms of electrostatic interactions and micellar growth.

关键词：电解质胶束生长两性分子药物氯丙嗪氯化氢浊点染色增溶作用