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平行轴齿轮传动系统布局设计的膨胀方法

机械工程学报 2001年第12期37卷 16-20页

作者：陆一平查建中 Tony C woo 北方交通大学机电学院北京100044 University of Washington

布局设计是齿轮传动系统设计中重要的核心问题之一，它的关键在于建立一种有效的问题表　达和求解模型。提出使用膨胀布局方法来解决这一问题。膨胀方法是一种通过构造布局物体　的膨胀和排斥而自适应地求解物体布局位置的计算方法，能... 详细信息

布局设计是齿轮传动系统设计中重要的核心问题之一，它的关键在于建立一种有效的问题表　达和求解模型。提出使用膨胀布局方法来解决这一问题。膨胀方法是一种通过构造布局物体　的膨胀和排斥而自适应地求解物体布局位置的计算方法，能够表达齿轮传动的多层结构和复　杂啮合约束，是较好的齿轮传动系统布局求解模型。

关键词：齿轮传动 CAD 膨胀布局设计

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Rheostatic Control of ABA signaling through HOs15-Mediated OsT1 Degradation

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Molecular Plant 2019年第11期12卷 1447-1462页

作者： Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe shen Junghoon Park Chae Jin Lim shah Hussain Dongwon Baek Kai Wang woo sik Chung Vicente Rubio sang yeol Lee Zhizhong Gong Woe yeon Kim Ray ABressan Jose MPardo Dae-Jin yun Department of Biomedical science&Engineering Konkuk UniversitySeoul 05029South Korea Department of Mathematical sciences Korea Advanced Institute of Science and TechnologyDaejeon 34131Korea Division of Applied Life science Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 660-701South Korea state Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Centro Nacional de Biotecnologia-CsIC Darwin 3.Campus de la UAM.Cantoblanco28049 MadridSpain Department of Horticulture and Landscape Architecture Purdue University625 Agriculture Mall DriveWest LafayetteIN 47907-2010USA lnstituto de Bioquimica Vegetal y Fotosintesis cicCartujaCSIC-Universidad de SevillaAmericoVespucio 49Sevilla 41092Spain

Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates snf1-Related Kinases(snRK2s)to mount adaptive ***,the regulatory circuits that terminate the snRK2s signal relay after acclimation or post-stress conditions remain to be ***,we show that the desensitization of the ABA signal is achieved by the regulation of OsT1(snRK2.6)protein stability via the E3-ubiquitin ligase *** ABA signal,HOs15-induced degradation of OsT1 is inhibited and stabilized OsT1 promotes the stress *** the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OsT1 via ***,we found that even in the presence of ABA,OsT1 levels are also depleted within hours of ABA signal *** unexpected dynamics of OsT1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OsT1-induced upregulation of ABI1/2 leads to the degradation of *** model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization.

关键词： ABA signaling drought stress HOs15 OsT1 ABI1/2 protein degradation and stability

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes sARs-CoV-2 entry and ACE2 autophagic degradation

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signal Transduction and Targeted Therapy 2023年第11期8卷 5353-5367页

作者： Ming Liu Bingtai Lu yue Li shuofeng yuan Zhen Zhuang Guangyu Li Dong Wang Liuheyi Ma Jianheng Zhu Jinglu Zhao Chris Chung-sing Chan Vincent Kwok-Man Poon Kenn Ka-Heng Chik Zhiyao Zhao Huifang Xian Jingxian Zhao Jincun Zhao Jasper Fuk-woo Chan yuxia Zhang Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CentreState Key Laboratory of Respiratory DiseasesGuangzhou Medical University510623 GuangzhouGuangdongChina Medical Research Institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangdongChina state Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of MedineThe University of Hong KongPokfulamHong KongChina Department of Clinical Microbiology and Infection Control The University of Hong Kong Shenzhen HospitalShenzhenGuangdongChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong KongChina state Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Third Afliated Hospital of Zhengzhou University 450052 ZhengzhouChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina Chongqing International Institute for Immunology ChongqingChina

severe acute respiratory syndrome coronavirus 2(sARs-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),has had a significant impact on healthcare systems and economies *** continuous emergence of new viral strains presents a major challenge in the development of effective antiviral *** that possess broad-spectrum antiviral activities are desirable to control sARs-CoV-2 ***2,an angiotensin-containing enzyme that prevents the overactivation of the renin angiotensin system,is the receptor for ***2 interacts with the spike protein and facilitates viral attachment and entry into host ***,sARs-CoV-2 infection also promotes ACE2 *** restoring ACE2 surface expression has an impact on sARs-CoV-2 infection is yet to be ***,we show that the ACE2-spike complex is endocytosed and degraded via autophagy in a manner that depends on clathrin-mediated endocytosis and PAK1-mediated cytoskeleton *** contrast,free cellular spike protein is selectively cleaved into s1 and s2 subunits in a lysosomal-dependent ***,we show that the pan-PAK inhibitor FRAX-486 restores ACE2 surface expression and suppresses infection by different sARs-CoV-2 ***-486-treated syrian hamsters exhibit significantly decreased lung viral load and alleviated pulmonary inflammation compared with untreated *** summary,our findings have identified novel pathways regulating viral entry,as well as therapeutic targets and candidate compounds for controlling the emerging strains of sARs-CoV-2 infection.

关键词： ACE2 inflammation rearrangement

双侧扣带前回毁损术治疗难治性强迫症患者的长期随访效果(英文)

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中国神经精神疾病杂志 2006年第5期32卷 392-398页

作者： Hyun Ho Jung Chan Hyung Kim Jong Hee Chang yong Gou Park sang sup Chung Jin woo Chang 韩国汉城延世大学医学院神经外科

背景强迫症是一种较为常见的慢性、致残的疾病，患者出现无法自控的强迫思维及强迫行为。10％以上的强迫症病人对药物和行为治疗无效。对一些常规治疗无效的难治性强迫症患者，神经外科已经开展一些手术治疗，例如：扣带前回毁损、脑白... 详细信息

背景强迫症是一种较为常见的慢性、致残的疾病，患者出现无法自控的强迫思维及强迫行为。10％以上的强迫症病人对药物和行为治疗无效。对一些常规治疗无效的难治性强迫症患者，神经外科已经开展一些手术治疗，例如：扣带前回毁损、脑白质切断术、尾状核下束切断、内囊前支毁损。扣带前回毁损相对来说比较安全同时没有明显的副作用，但是也有术后存在认知障碍的报道。为判断立体定向双侧扣带前回毁损是否是一种适合难治性强迫症的治疗，我们评价了立体定向双侧扣带前回毁损术的长期疗效及其副作用。方法患者筛选：在1999年3月至2003年4月间，17例难治性强迫症患者（男10例，女7例）接受了双侧扣带前回毁损术，并且接受了超过2年的随访。患者的选择标准如下：患者符合美国精神障碍诊断与统计手册第4版（DsM-Ⅳ）强迫症的诊断标准，病程超过3年，疾病导致社会心理功能降低。每位患者皆由两位精神科医师依照DsM-Ⅳ的AxisⅠ和AxisⅡ的疾病诊断标准行临床诊断。如伴有精神病性症状，就先用一线药物彻底治疗。手术方法：立体定向的靶点通过与MRI配套的Leksell适配器，在GEsigma1．5 T的机器上得以确认。局部麻醉下，在两侧的冠状缝中线外20mm颅骨钻孔。将尖端直径．1．8mm，长度10mm的电极插至靶点，用85℃，90s进行射频毁损。在双侧扣带前回，每侧各4个射频毁损灶，2个针道。第一个射频毁损灶在两侧侧脑室前角后缘15mm，侧脑室顶部上2mm，旁开中线7mm处。射频电极接着回撤8mm，制作第二个射频毁损灶。第三个射频毁损处在两侧侧脑室前角后缘22mm，侧脑室顶部上2mm，旁开中线7mm处。再往上8mm，制作第四个射频毁损灶。结果是出现类似椭圆柱形的射频毁损灶，大约高18mm、前后径13mm，横径6mm。术前和术后随访评估：两位精神科医师用yale-Brown强迫症量表（y-BOCs）、临床总体印象量表（CGI）、汉密顿抑郁量表（HAMD）、汉密顿焦虑量表（HAMA），分别在手术前1个月、术后12个月、术后24个月对患者进行评估。评估的精神科医师接受了培训，Kappa值超过0．75，以确保评估的准确性。在我们研究中，患者的y-BOCs得分改善35％或更高、CGI评分为1（极其显著改善）或者2（显著改善）；由专业的临床精神科医生对患者进行一套固定的神经心理测试，测试分别在术前1个月、术后12个月、24个月进行。这些测试包括：K—WAIs测验，视觉空间功能（RCFT），Hopkins语言学习测验（HVLT），威斯康星卡片分类测验（WCsT），口语流畅测验（COWAT）。K-WAIs评分由韦氏成人智力量表（WAIs—R）改编而来，以产生总智商（IQ）、言语IQ和行为IQ来测量智力水平。RCFT评分用于测试空间构建能力。记忆力也包括回忆的精确性、瞬时回忆、延迟回忆和识别指数等的得分。HVLT用于测量口头记忆能力和学习能力。使用WCsT和COWAT评分来检查认知的灵活性和执行功能。在WCsT中，正确、错误反应的总数，完成的项目数，持续的反应，持续的错误数都用于评分。COWAT评分采用字母翻译和目录翻译的单词数目，字母翻译用来检查语音的流利，目录翻译用来评价语义流利性。使用Wileoxon符号秩检验对术前的y—BOCs，HAMD，HAMA评分和术后6、12个月的评分进行比较，使用Wileoxon符号秩检验对手术前和手术后12个月的K—WAIs，RCFT，HVLT，WCsT，COWAT评分进行比较。统计软件采用sPss10。结果扣带回毁损术后强迫、抑郁、焦虑症状均改善：y-BOCs，CGI、HAMD，HAMA评分显示了扣带回毁损术的有效性，在12个月的随访中，与术前y-BOCs评分相比，改善率为36％，在24个月的随访中，改善率升至48％。术前、术后认知功能和记忆的改变：手术前和手术后24个月的K-WAIs，RCFT，HVLT，COWAT评分没有显著性差异。在WCsT评分中，与术前基线相比，术后的错误总数、持续错误数和反应数明显减少。术后的错误总数、持续错误数和反应数的改变说明在扣带回毁损术后执行功能的提高。在术后2—3个月，3例患者有记忆障碍，但持续时间少于2个月。结论强迫症的扣带回毁损术术后24个月的随访结果显示症状明显改善，但没有认知功能的改变，包括智商、言语、视觉空间记忆和执行功能等均没有改变。

关键词：强迫症扣带前回毁损术精神外科

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A review of potential conservation and fisheries benefits of breaching four dams in the Lower snake River(Washington,UsA)

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Water Biology and security 2022年第2期1卷 10-22页

作者： Adam J.storch Howard A.schaller Charles E.Petrosky Robert L.Vadas Jr. Benjamin J.Clemens Gary sprague norman Mercado-silva Brett Roper Michael J.Parsley Edward Bowles Robert M.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.s.Fish and Wildlife service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the snake River Basin continue to *** assessed the rationale for breaching the four lower snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding sockeye salmon(Oncorhynchus nerka),Chinook salmon(***),steelhead(***),Bull Trout(salvelinus confluentus),White sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River system(including the snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River system dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River system constrains survival and productivity of salmon,steelhead and Bull Trout;(6)snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower snake River Basin dams preclude passage of adult White sturgeon,constraining gene flow and recruitment;(9)the lower snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)snake River Basin Pacific Lamprey is at high risk of *** the four lower snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River system can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey salmon steelhead White sturgeon

Tracking domestic ducks:A novel approach for documenting poultry market chains in the context of avian influenza transmission

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Journal of Integrative Agriculture 2016年第7期15卷 1584-1594页

作者： Chang-yong Choi John y Takekawa XIONG yue LIU ying Martin Wikelski George Heine Diann J Prosser scott H Newman John Edwards Fusheng Guo Xiangming Xiao Department of Microbiology and Plant Biology Center for Spatial AnalysisUniversity of OklahomaNormanOK 73019USA Western Ecological Research Center U.S.Geological SurveyVallejoCA 94592USA National Audubon society San FranciscoCA 94104USA Key Laboratory of Poyang Lake Wetland and Watershed Research Jiangxi Normal UniversityNanchang 330022P.R.China Department of Migration and Immuno-Ecology Max Planck Institute for OrnithologyRadolfzell D-78315Germany Department of Biology University of KonstanzKonstanz D-78457Germany Patuxent Wildlife Research Center U.S.Geological SurveyBeltsvilleMD 20705USA Emergency Center for Transboundary Animal Diseases(ECTAD)Vietnam Office Food and Agriculture Organization of the United NationsHanoi 10000Vietnam Emergency Center for Transboundary Animal Diseases(ECTAD)China Office Food and Agriculture Organization of the United NationsBeijing 100600P.R.China Murdoch University MurdochWA 6150Australia Institute of Biodiversity sciences Fudan UniversityShanghai 200433P.R.China

Agro-ecological conditions associated with the spread and persistence of highly pathogenic avian inlfuenza （HPAI） are not well understood, but the trade of live poultry is suspected to be a major pathway. Although market chains of live bird trade have been studied through indirect means including interviews and questionnaires, direct methods have not been used to identify movements of individual poultry. To bridge the knowledge gap on quantitative movement and transportation of poultry, we introduced a novel approach for applying telemetry to document domestic duck movements from source farms at Poyang Lake, China. We deployed recently developed transmitters that record Global Positioning system （GPs） locations and send them through the Groupe spécial Mobile （GsM） cellular telephone system. For the ifrst time, we were able to track individually marked ducks from 3 to 396 km from their origin to other farms, distribution facilities, or live bird markets. Our proof of concept test showed that the use of GPs-GsM transmitters may provide di-rect, quantitative information to document the movement of poultry and reveal their market chains. Our ifndings provide an initial indication of the complexity of source-market network connectivity and highlight the great potential for future telemetry studies in poultry network analyses.

关键词： avian inlfuenza domestic duck market chain network poultry telemetry

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体素内不相干运动扩散加权成像对早期鼻咽癌与鼻咽良性增生性病变的鉴别诊断价值

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国际医学放射学杂志 2019年第6期 754-754页

作者： Q.y.Ai A.D.King J.s.M.Chan W.T.Chen K.C.A.Chan J.K.s.woo 张凯 Department of Imaging and Interventional Radiology The Chinese University of Hong Kong Prince of Wales Hospital

摘要目的 MRI可以检测早期鼻咽癌(NPC),但仍具有挑战性,因为其需要与鼻咽部的良性增生性病变相鉴别。本研究旨在探讨体素内不相干运动扩散加权成像(IVIM-DWI)

关键词：体素内不相干运动扩散加权成像 NPC 鉴别诊断价值增生性病变早期鼻咽癌

Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and security 2022年第3期1卷 28-42页

作者： Robert L.Vadas Jr. Robert M.Hughes yeon Jae Bae Min Jeong Baek Orestes Carlos Bello Gonzáles Marcos Callisto Débora ReisdeCarvalho Kai Chen Maria T.Ferreira Pablo Fierro Jon s.Harding Dana M.Infante C.J.Kleynhans Diego R.Macedo Isabela Martins norman Mercado silva Nabor Moya susan J.Nichols Paulo s.Pompeu Renata Ruaro Deborah R.O.silva R.Jan stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil state Key Laboratory of Marine Resource Utiliization in south China sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias Marinas y Limnologicas Universidad Austral de ChileValdiviaChile school of Biological sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(MMIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of MMIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)MMI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and MMI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI MMI Fish Macroinvertebrates Algae streams Rivers Lakes Wetlands Biological monitoring

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science in China,ser.A 1963年第3期 455-455页

作者： Chairman Wu you-xun(y.H.woo) Vice.Chairmen yun Zi-qiang(T.C.yun)Bei shi-zhang(s.Pai)Zhang Wen-yu(W.y.Chang)