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Intraoperative radiation therapy deserves to be made more readily available to patients

Chinese Journal of Cancer research 2016年第4期28卷 461-462页

作者： Mohammed Keshtgar norman r.williams The Breast Unit Royal Free HospitalRoyal Free London Foundation Trust

Whole breast external beam radiotherapy is an effective adjuvant treatment for early breast cancer, and was a key factor in the move from mastectomy to breast-conserving surgery for women with low-risk disease. The logical development from partial surgical removal of the breast is partial breast radiotherapy. Several methods of delivery have been investigated, but as yet none has been widely accepted.

关键词： more Intraoperative radiation therapy deserves to be made more readily available to patients IMrT

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Brain Metastases in Patients with Gynecologic Cancers: A Single Institution Experience and review of the Literature

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Open Journal of Obstetrics and Gynecology 2016年第9期6卷 544-552页

作者： Madiha A. Gilani Noelle L. williams Carolyn Giordano norman rosenblum Wenyin Shi Pramila Anne russell J. Schilder Thomas Jefferson University Hospital Philadelphia PA USA Department of radiation Oncology Sidney Kimmel Cancer Center Thomas Jefferson University Hospital Philadelphia PA USA Office of Institutional research Thomas Jefferson University Philadelphia PA USA Sidney Kimmel Cancer Center Thomas Jefferson University Hospital Philadelphia PA USA

Objective: Brain Metastasis (BM) from primary gynecologic cancers is a rare entity. The advances and successes in the treatment of primary gynecologic malignancies, have led to prolonged survival and, a higher incidence of BM. This study aims to report the experience at our institution in managing these patients, and provide possible data points that may be essential to note as prognostic factors, and see if our findings are consistent with the literature in this subject. We also aim to provide a brief literature review of patients with gynecologic cancers and BM. Methods: This is a small single institution retrospective study of 23 patients with a gynecologic malignancy and BM, identified between the years 2007-2015. Data were collected on variables including patient demographics, disease and treatment. results: The median overall survival from the primary diagnosis was 28 months. Median time from diagnosis of BM to death was 9 months. Conclusion: The outcomes in our study are similar to what is stated in the current literature with regard to BM from gynecologic malignancies. Our literature search also revealed that the molecular analysis and treatment of the primary tumor remain important to prevent BMs. The tendency of tumors to metastasize varies for one tumor type to another for the same type of tumor. The tendency to develop BM may not only depend on risk factors such as stage, grade, and histology, but also on the genetic profile of the primary tumor. The study suggests that multimodal treatment of BM has better outcomes in managing BM from gynecologic cancers.

关键词： Gynecologic Malignancies Brain Metastasis Prognostic Factors Multimodality Therapy

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