检索结果-南通市图书馆

中国化学会第十五届全国氟化学会议

作者： norio Shibata Department of Nanopharmaceutical Sciences & Department of Life Science and Applied Chemistry Nagoya Institute of Technology

Fluoro-functionalized heterocycles with diverse ring sizes and ring systems have been well studied in pharmaceuticals and agrochemicals. Thus, a remarkable number of publications have been dedicated to the development of efficient synthetic methods to construct fluoro-functionalized heterocycles. In particular, heterocyclic molecules with a trifluoromethyl carbinol moiety, i.e., CFC(OR)RR, have gathered much attention on account of their promising biological properties. Efavirenz(anti-HIV), trifluoromethylated artemisinins(anti-malarial), and fluralaner(insecticide and acaricide) are representative examples.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Shelf-stable Electrophilic Trifluoromethylating Reagents

Shelf-stable Electrophilic Trifluoromethylating Reagents

引用

氟化学与美好生活——中国化学会第十一届全国氟化学会议

作者： norio Shibata Department of Frontier Materials Graduate School of EngineeringNagoya Institute of Technology

＜正＞Since the first discovery by Yagupolskii and co-workers that S-trifluoromethyl diarylsulfonium salts are effective for the trifluoromethylation of thiophenolates,the design and synthesis of electrophilic trifluoromethylating reagents have been extensively researched in both academia and industry,due to the significant unique

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

ANALYTICAL APPLICATIONS OF ABASIC-SITE BINDING LIGANDS

ANALYTICAL APPLICATIONS OF ABASIC-SITE BINDING LIGANDS

引用

第十四届北京分析测试学术报告会暨展览会(BCEIA 2011)

作者： norio TERAMAE Department of Chemistry Graduate School of ScienceTohoku University

We have recently proposed a new strategy of ligand-based fluorescence or electrochemical assay for single-nucleotide polymorphisms(SNPs)typing,in combination with abasic site(AP site)-containing DNAs.[1]We have succes...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

AN ALGORITHM FOR ACCURATE COMPUTATION OF FIELD VARIABLE AND ITS DERIVATIVE ADJACENT TO BOUNDARY IN BEM

AN ALGORITHM FOR ACCURATE COMPUTATION OF FIELD VARIABLE AND ...

引用

“力学2000”学术大会

作者： KAMIYA norio School of Informatics and Sciences. Nagoya University 464-8601 Nagoya Japan

An algorithm was proposed in the paper for the accurate computation of the field variables and its derivatives at the domain point adjacent to the boundary in anempt to solve the so-called the boundary layer effect in boundary element method. With the aid of the approximate distance function introduced, the formulations, independent of the kind of boundary elements, were presented explicitly for the accurate computation of the integrals with the logarithmic, Cauchy and Hadamard singularities in two-dimensional case. Numerical examples of the potential problem were given, showing the feasibility and the effectiveness of the proposed algorithm by using the cubic boundary elements.

关键词： BEM boundary layer effect singularity field variable numerical computation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Modulation of hippocampal function via activities of the amygdala

Modulation of hippocampal function via activities of the amy...

引用

第三届中日双边药理学和临床药理学学术会议

作者： MATSUKI norio Laboratory of Chemical Pharmacology Graduate School of Pharmaceutical SciencesUniversity of TokyoTokyo 113-0033Japan

＜正＞Synaptic plasticity in the hippocampus is a fundamental feature of brain function involved in the en- coding of information,and the capability of synapses to express plasticity is itself *** studies have shown that various drugs and physiological substances including neurotrophic factors,cytokines are effective in modulating the plasticity,and that more than one hundred molecules/genes are underlying the plastici- ***,little is known about interaction between the hippocampus and other brain *** amygdala transfers emotion to various brain regions including hip- pocampus and there are two kinds of projections to the hippocampus from the basolateral amygdala （ BLA）,di- rect and indirect pathways via the entorhinal *** modulation is not uniform and ventral hippocampus re- ceives more dense direct innervation,which is sensitive to stress,probably mediated by *** of the indirect pathway can modulate bidirectionally me- dial perforant path-dentate gyrus *** modula- tion depends not only the current but also past activities of *** results suggest a high-order dimension of heterosynaptic modulations of hippocampal synaptic plas- ticity.

关键词： learning memory emotion long-term depression long-term potentiation synaptic plasticity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Synthesis of 3,5-Diaryl-5-fluoromethyl-oxazolidin-2-ones by Asymmetric Desymmetrization via Non-metallic C-F Bond Activation

Synthesis of 3,5-Diaryl-5-fluoromethyl-oxazolidin-2-ones by ...

引用

中国化学会第十四届全国氟化学会议

作者： norio Shibata Department of Nanopharmaceutical Sciences Nagoya Institute of Technology

＜正＞Selective synthesis of fluorinated organic compounds and investigation of their properties have become a major topic in all fields of chemical sciences and in technological *** methods of formation of C–F bonds have been developed from the beginning of organic fluorine chemistry,application of C–F bond cleavage in poly-fluorinated carbon compounds for the preparation of partially fluorinated molecules was less

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A PERSONAL HISTORY OF DYNAMICAL DIFFRACTION THEORY

A PERSONAL HISTORY OF DYNAMICAL DIFFRACTION THEORY

引用

Sixteenth Congress of the International Union of Crystallography

作者： norio Kato Department of Physics Faculty of Science and TechnologyMeijo UniversityNagoyaJapan

＜正＞As introduction,the essence of the Ewald dynamical theory will be reviewed *** theory amounts to the microscopic foundation of X-ray optics in perfect *** predicts a characteristic line profile of the Bragg refl...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma:A case report

引用

World Journal of Clinical Cases 2021年第4期9卷 854-863页

作者： Katsuhiro Hayashi norio Yamamoto Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Yoshihiro Araki Hirotaka Yonezawa Sei Morinaga Yohei Asano Hiroyuki Tsuchiya Department of Orthopaedic Surgery Kanazawa UniversityKanazawa 9208641Japan

BACKGROUND Hutchinson-Gilford progeria syndrome(HGPS)is an extremely rare disease characterized by the rapid appearance of aging with an onset in *** cardiovascular complications can be life-threatening events for affected patients and the cause of early *** we report a HGPS patient with osteosarcoma hat was successfully managed and is alive 13 years after the *** is the first report describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with *** SUMMARY The patient was diagnosed with HGPS at 5 years of age with typical features and was referred to our department with a suspected bone tumor of the left proximal tibia at the age of *** biopsy of the tibial bone tumor revealed a conventional fibroblastic *** have developed and performed a freezing technique using liquid nitrogen for tumor *** technique overcame the small size of the tibia for megaprosthesis and avoided amputation and limb salvage was achieved 13 years *** the patient had a number of surgical site complications,such as wound dehiscence,and superficial and deep infections due to vulnerable skin in HGPS,no recurrence or metastases were detected for 13 years,and she walks assisted by *** general health was good at the latest follow-up at 31 years of *** A HGPS patient with osteosarcoma was successfully managed and she was alive 13 years after the diagnosis.

关键词： Hutchinson-Gilford progeria syndrome Osteosarcoma Frozen autograft Biological reconstruction Case report Thyroid cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pneumoscrotum: A rare manifestation of perforation associated with therapeutic colonoscopy

引用

World Journal of Gastroenterology 2005年第32期11卷 5061-5063页

作者： Kuang-I Fu Yasushi Sano Shigeharu Kato Takahiro Fujii Masanori Sugito Masato Ono norio Saito Kiyotaka Kawashima Shigeaki Yoshida Takahiro Fujimori Division of Gastrointestinal Oncology and Digestive EndoscopyNational Cancer Center Hospital East KashiwaChiba 277-8577Japan Division of SurgeryNational Cancer Center Hospital East KashiwaChiba 277-8577Japan Department of Surgical and Molecular PathologyDokkyo University School of Medicine 880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan

Pneumoscrotum is uncommon and also rarely reported as a complication associated with colonic perforation. A case of colonic perforation in delayed fashion associated with EMR, revealed by pneumoscrotum, is reported and the associated literatures are reviewed. A 52-year-old male received piecemeal EMR for a laterally spreading tumor 35 mm in size in our hospital. He complained of enlargement of the scrotum and revisited our hospital the day alter the procedure. A diagnosis of pneumoscrotum was made, and as most such cases have been reported to be associated with pneumoperitoneum, colonic perforation was suspected. Free air but no fluid collection was found by abdominal computed tomography, and delayed colonic perforation was diagnosed. However, as there were no clinical signs of peritoneal irritation, conservative treatment was administered and the patient recovered uneventfully. Pneumoscrotum could be a sign of colonic perforation alter EMR, and treatment should be carefully chosen.

关键词： Pneumoscrotum Colonic perforation Endoscopic mucosal resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical characteristics of null responders to Peg-IFNα2b/ ribavirin therapy for chronic hepatitis C

引用

World Journal of Hepatology 2010年第11期2卷 401-405页

作者： Hideyuki Suzuki Satoru Kakizaki norio Horiguchi Takeshi Ichikawa Ken Sato Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma Univ ersity Graduate School of Medicine

AIM: To predict which chronic hepatitis C patients are likely to be late-responders, we herein investigated the clinical characteristics of null-responders at 36 wk with hepatitis C virus (HCV) genotype Ib and a high viral load during the course of pegylated interferon (Peg-IFN)/ ribavirin ther apy. METHODS: One hundred forty-two patients with genotype Ib HCV and a high viral load were included in this study. Peg-IFNα2b (1.5 μg/kg once a week) and ribavirin (600-1000 mg per day according to body weight) were administered for 48 wk. We def ined nullresponders as the cases that never cleared serum HCV RNA as determined using RT-PCR until 36 wk. Other patients were def ined as responders. We compared the clinical characteristics (age, gender, body mass index, previous treatment) and HCV RNA titer during the therapy between null-responders and ***: The HCV RNA clearance rate was 17.9% (24/134), 46.3% (62/134), 60.6% (86/142), 86.6% (123/142), and 88.0% (125/142) at 4, 8, 12, 24, and 36 wk, respectively. There were 17 patients (12.0%) who were still null-responders at 36 wk. There were no differences in the clinical characteristics between the responders and null-responders except for the titer and decline rates of HCV RNA at 1 wk and 4 wk. The HCV RNA titers at 1 wk and after 4 wk of treatment were significantly higher in the null-responders in comp arison to the responders (P <0.01). The serum HCV RNA titers of the responders decreased by 1.3 log after 1 wk of treatment, and 1.6 log after 4 wk of treatm ent, respectively. On the other hand, the titers of the null responders decreased by only 0.5 log after 1 wk, and 0.7 log after 4 wk of treatment, respectively. The decrease rates of HCV RNA after 1 and 4 wk of treatm ent were signif icantly worse for null responders than for the responders (P <0.01). CONCLUSION: The HCV RNA titer at 1 wk and 4 wk after initiating treatment may be useful for predicting null-responders to Peg-IFNα2b/ribavirin therapy. Howe

关键词： Null responder Pegylated interferon α2b Ribavirin Chronic hepatitis C

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：