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Materials Sciences and Applications 2013年第4期4卷 225-230页

作者： norihiro Shimoi Shun-Ichiro Tanaka Graduate School of Environmental Studies Tohoku University of Aoba Sendai Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University Katahira Sendai Japan

To obtain a high field emission (FE) current with a low driving voltage, it is important to control and optimize carbon nanofiber (CNF) array patterns for FE. While there have been various means for controlling CNF array patterns reported over the past few decades, array patterning using lithography is the method typically used to control CNF morphology. Because lithography uses many masks and is costly, it is necessary to establish a simpler process. In this study, the grain size and distribution of catalysts with phase separation were controlled. A system which controls the morphology of small bundles of CNFs was constructed with the distance between the bundles kept constant in order to obtain a higher FE current. The Ni catalyst layer for forming the CNF morphology was separated by noncatalytic Cr grains formed by cosputtering. As a result, it was possible to control the Ni content, the grain size and synthesis density of CNFs in the alloy with a varying number of nickel pellets placed on the chromium target. This method is an epochmaking CNF patterning technique very different from lithography.

关键词： Alloys Carbon Fibres Metal-Matrix Composites X-Ray Diffraction Chemical Vapour Deposition (CVD)

Magnifying narrow-band imaging with acetic acid to diagnose early colorectal cancer

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World Journal of Gastroenterology 2014年第43期20卷 16306-16310页

作者： norihiro Goto Toshihiro Kusaka Yumi Tomita Hideyuki Tanaka Yoshio Itokawa Yorimitsu Koshikawa Daisuke Yamaguchi Yoshitaka Nakai Shigehiko Fujii Hiroyuki Kokuryu Department of Gastroenterology and Hepatology Kyoto Katsura HospitalKyoto 615-8256Japan

AIM: To evaluate the diagnostic characteristics of magnifying endoscopy with acetic acid spray and narrow-band imaging (MA-NBI) for early colorectal cancer.

关键词： Colorectal cancer Endoscopy Neoplasia Narrow-band imaging Acetic acid

Cilostazol Enhances Oxidative Glucose Metabolism in Both Neurons and Astroglia without Increasing Ros Production

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Pharmacology & Pharmacy 2011年第4期2卷 315-321页

作者： Shinichi Takahashi Yoshikane Izawa norihiro Suzuki 不详

Cilostazol, a potent inhibitor of type 3 phosphodiesterase (PDE3), has recently been reported to exert neuroprotective effects during acute cerebral ischemic injury. These effects are, at least in part, mediated by the inhibition of oxidative cell death. However, the effects of cilostazol on glucose metabolism in brain cells have not been determined. In the present study, we examined the effects of cilostazol on the oxidative metabolism of glucose and the resultant formation of reactive oxygen species (ROS) in cultured neurons and astroglia. Cultures of neurons or astroglia were prepared from Sprague-Dawley rats. The cells were treated with cilostazol (0 – 30 μM) for 48 hours prior to the assay. L-[U-14C]lactate ([14C]lactate) or [1-14C]pyruvate ([14C]pyruvate) oxidation was measured. ROS production was determined using an H2DCFDA assay with a microplate reader. Forty-eight hours of exposure to cilostazol resulted in dose-dependent increases in [14C]lactate and [14C]pyruvate oxidation in both the neurons and astroglia. Dibutyryl cyclic AMP (0 – 0.5 mM) also increased [14C]lactate oxidation, indicating cAMP-mediated PDH activation. In contrast, free radical formation was not affected by cilostazol in either the neurons or astroglia. Cilostazol enhanced the oxidative metabolism of glucose in both neurons and astroglia, while it did not augment ROS production.

关键词： Astrocyte Cilostazol Glucose Lactate Pyruvate Dehydrogenase

Rare combination of familial adenomatous polyposis and gallbladder polyps

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World Journal of Gastroenterology 2014年第46期20卷 17661-17665页

作者： Yasuhisa Mori norihiro Sato Nobutaka Matayoshi Toshihisa Tamura Noritaka Minagawa Kazunori Shibao Aiichiro Higure Mitsuhiro Nakamoto Masashi Taguchi Koji Yamaguchi Department of Surgery School of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuoka 807-8555Japan Department of Pathology and Cell Biology School of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuoka 807-8555Japan Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushuFukuoka 807-8555Japan

Familial adenomatous polyposis is associated with a high incidence of malignancies in the upper gastrointestinal tract (particularly ampullary adenocarcinomas). However, few reports have described a correlation between familial adenomatous polyposis and gallbladder neoplasms. We present a case of a 60-year-old woman with familial adenomatous polyposis who presented with an elevated mass in the neck of the gallbladder (measuring 16 mm × 8 mm in diameter) and multiple small cholecystic polyps. She had undergone a total colectomy for ascending colon cancer associated with familial adenomatous polyposis 22 years previously. The patient underwent laparoscopic cholecystectomy under a preoperative diagnosis of multifocal gallbladder polyps. Pathologic examination of the resected gallbladder revealed more than 70 adenomatous lesions, a feature consistent with adenoma of the gallbladder. This case suggests a requirement for long-term surveillance of the biliary system in addition to the gastrointestinal tract in patients with familial adenomatous polyposis.

关键词： Adenoma Adenomatous polyposis coli Biliary system Familial adenomatous polyposis Gallbladder polyp

Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 441-451页

作者： Kun-Li Yin Ming Li Pei-Pei Song Yu-Xin Duan Wen-Tao Ye Wei Tang norihiro Kokudo Qiang Gao Rui Liao Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina National Center for Global Health and Medicine TokyoJapan Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghaiChina State Key Laboratory of Genetic Engineering Fudan UniversityShanghaiChina

Hepatic stellate cells(HSCs)play an essential role in various liver diseases,and exosomes are critical mediators of intercellular communication in local and distant *** crosstalk between HSCs and surrounding multiple tissue-resident cells promotes or inhibits the activation of *** evidence has revealed that HSC-derived exosomes are involved in the occurrence and development of liver diseases through the regulation of retinoid metabolism,lipid metabolism,glucose metabolism,protein metabolism,and mitochondrial *** exosomes are underpinned by vehicle molecules,such as mRNAs and microRNAs,that function in,and significantly affect,the processes of various liver diseases,such as acute liver injury,alcoholic liver disease,nonalcoholic fatty liver disease,viral hepatitis,fibrosis,and *** such,numerous exosomes derived from HSCs or HSCassociated exosomes have attracted attention because of their biological roles and translational applications as potential targets for therapeutic ***,we review the pathophysiological and metabolic processes associated with HSC-derived exosomes,their roles in various liver diseases and their potential clinical application.

关键词： Myofibroblast Extracellular vesicle Hepatic fibrosis Cancer Metabolic reprogramming Biomarker

Transarterial chemoembolization for hepatocellular carcinoma: A review of techniques

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World Journal of Hepatology 2014年第12期6卷 844-850页

作者： norihiro Imai Masatoshi Ishigami Yoji Ishizu Teiji Kuzuya Takashi Honda Kazuhiko Hayashi Yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Aichi 466-8560 Japan

Hepatocellular carcinoma(HCC)is one of the most common malignant diseases *** curative therapies,including resection,liver transplantation,and percutaneous ablation(percutaneous ethanol injection and radiofrequency ablation),are applicable for only a portion of the HCC population,transcatheter arterial chemoembolization(TACE)has been recognized as an effective palliative treatment option for patients with advanced *** is also used even for single HCCs in which it is difficult to perform surgical resection or locoregional treatment due to systemic co-morbidities or anatomical *** has become widely adopted in the treatment of *** using computed tomography-angiography,TACE is capable of performing diagnosis and treatment at the same ***,TACE plays an important role in the multidisciplinary treatment for HCC when combined with other *** this review,we first discuss the history of TACE,and then review the previous findings about techniques of achieving a locoregional treatment effect(liver infarction treatment,e.g.,ultra-selective TACE,balloon-occluded TACE),and the use of TACE as a drugdelivery system for anti-cancer agents(palliative,e.g.,platinum complex agents,drug-eluting beads)for multiple lesions.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Balloon-occluded transcatheter arterial chemoembolization Drug-eluting bead

Effects of sclerostin antibody on bone healing

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World Journal of Orthopedics 2021年第9期12卷 651-659页

作者： Atsushi Mihara Kiminori Yukata Toshihiro Seki Ryuta Iwanaga norihiro Nishida Kenzo Fujii Yuji Nagao Takashi Sakai Department of Orthopedic Surgery Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Promoting bone healing after a fracture has been a frequent subject of ***,sclerostin antibody(Scl-Ab)has been introduced as a new anabolic agent for the treatment of ***-Ab activates the canonical Wnt(cWnt)-β-catenin pathway,leading to an increase in bone formation and decrease in bone *** of its rich osteogenic effects,preclinically,Scl-Ab has shown positive effects on bone healing in rodent models;researchers have reported an increase in bone mass,mechanical strength,histological bone formation,total mineralized callus volume,bone mineral density,neovascularization,proliferating cell nuclear antigen score,and bone morphogenic protein expression at the fracture site after Scl-Ab *** addition,in a rat critical-size femoral-defect model,the Scl-Ab-treated group demonstrated a higher bone healing *** the other hand,two clinical reports have researched Scl-Ab in bone healing and failed to show positive effects in the femur and *** review discusses why Scl-Ab appears to be effective in animal models of fracture healing and not in clinical cases.

关键词： Canonical Wnt-β-catenin pathway Fracture healing Osteoporosis Romosozumab Sclerostin antibody

Power-Assisted Cart Control Method with Motor Torque Limiter Based on Prediction of Torque Saturation

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Journal of Energy and Power Engineering 2012年第8期6卷 1349-1357页

作者： norihiro Kobayashi Takayuki Tanaka Shun' ichi Kaneko Graduate School of Information Science and Technology Hokkaido University Sapporo 060-0814 Japan

In this article, a method to control power-assisted carts with motor torque limiter that achieves the desired load-reduction ratio even if torque saturation occurs, is proposed to reduce the size and power consumption of power-assist systems. This method uses the ratio of the assist-force impulse to the operator-force impulse as an indicator for evaluating proposed method. Proposed method predicts the needs of the operator and delivers the desired load-reduction ratio by predicting operation. The results show that the target load-reduction ratio can be obtained with proposed control method and indicate that the target load-reduction ratio can be obtained with 80% force. By applying our proposed method, short available time of power-assisted carts will be improved.

关键词： Torque saturation power assisted cart minimum jerk model energy regeneration.

Combination of Cyclamen persicum Mill. floral gene promoters and chimeric repressors for the modification of ornamental traits in Torenia fournieri Lind.

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Horticulture Research 2017年第1期4卷 324-334页

作者： Ichiro Kasajima norihiro Ohtsubo Katsutomo Sasaki Institute of Vegetable and Floriculture Science National Agriculture and Food Research Organization(NARO)Ibaraki305-8519Japan Department of Agriculture Iwate UniversityIwate 020-8550Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural UniversityKyoto 606-8522Japan

Although chimeric repressors such as the Arabidopsis TCP3 repressor are known to have significant effects on flower morphology and color,their cellular-level effects on flower petals are not *** promoter sequences of the genes expressed in the flowers of cyclamen,a representative potted flower grown during the winter season,are also ***,we isolated eight promoters from cyclamen genes that are reportedly expressed in the *** promoters were then fused to four chimeric repressors and introduced into the model flower torenia to screen for effective combinations of promoters and repressors for flower *** expected,some of the constructs altered flower phenotypes upon *** further analyzed the effects of chimeric repressors at the cellular *** observed that complicated petal and leaf serrations were accompanied by excessive vascular *** in purple anthocyanin was inferred to result in bluish flowers,and imbalanced cell proliferation appeared to result in epinastic ***,the genetic constructs and phenotypic changes described in this report will benefit the future breeding and characterization of ornamental flowers.

关键词： traits flowers breeding