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N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer

World Journal of Gastroenterology 2011年第6期17卷 760-765页

作者： Tiago Donizetti da Silva Aledson Vitor Felipe Jacqueline Miranda de Lima Celina Tizuko Fujiyama Oshima nora manoukian forones Oncology Group Gastroenterology Division Universidade Federal de So Paulo Pathology Department Universidade Federal de So Paulo

AIM:To investigate the possible association between meat intake,cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) ***:Patients with CRC were matched for gender and age to healthy *** intake and cigarette smoking were assessed using a specific frequency *** was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length *** NAT2 alleles were studied (WT,M1,M2,M3 and M4) using specific digestion ***:A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were *** mean age of the two groups was 62 *** than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow *** odds ratio for colorectal cancer was 1.38 (95% CI:0.90-2.12) in slow *** the number of women was small (n=76 in the case group),the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR):0.55,95% confidence interval (95% CI):0.29-1.02].This difference was not observed in men (OR:0.56,95% CI:0.16-2.00).Among NAT2 fast acetylators (W/W or W/Mx),meat consumption more than 3 times a week increased the risk of colorectal cancer (OR:2.05,95% CI:1.01-4.16).In contrast,cigarette smoking increased the risk of CRC among slow acetylators (OR:1.97,95% CI:1.02-3.79).CONCLUSION:The risk of CRC was higher among fast acetylators who reported a higher meat *** NAT2 acetylation was associated with an increased risk of CRC.

关键词： N-acetyltransferase 2 Polymorphism Colorectal cancer

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