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Retina stem cells,hopes and obstacles

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World Journal of Stem Cells 2021年第10期13卷 1446-1479页

作者： Olga L German Harmonie Vallese-Maurizi Tamara B Soto nora P Rotstein Luis Enrique Politi Department of Biology Biochemistry and PharmacyUniversidad Nacional del SurBahia blanca 8000Buenos AiresArgentina Department of Biology Biochemistry and PharmacyUniversidad Nacional del Surand Neurobiology DepartmentInstituto de Investigaciones Bioquímicas de Bahía Blanca(INIBIBB)ConicetBahía Blanca 8000Buenos AiresArgentina

Retinal degeneration is a major contributor to visual dysfunction *** it comprises several eye diseases,loss of retinal pigment epithelial(RPE)and photoreceptor cells are the major contributors to their *** therapies included diverse treatments,such as provision of anti-vascular endothelial growth factor and many survival and trophic factors that,in some cases,slow down the progression of the degeneration,but do not effectively prevent *** finding of stem cells(SC)in the eye has led to the proposal of cell replacement strategies for retina *** using different types of SC,such as retinal progenitor cells(RPCs),embryonic SC,pluripotent SCs(PSCs),induced PSCs(iPSCs),and mesenchymal stromal cells,capable of self-renewal and of differentiating into multiple cell types,have gained ample *** preclinical studies have assessed transplantation of SC in animal models,with encouraging *** aim of this work is to revise the different preclinical and clinical approaches,analyzing the SC type used,their efficacy,safety,cell attachment and integration,absence of tumor formation and immunorejection,in order to establish which were the most relevant and *** addition,we examine the questions and concerns still open in the *** data demonstrate the existence of two main approaches,aimed at replacing either RPE cells or *** evidence suggests that RPCs and iPSC are the best candidates,presenting no ethical concerns and a low risk of *** trials have already supported the safety and efficacy of SC *** concerns are pending,such as the risk of tumor formation,lack of attachment or integration of transplanted cells into host retinas,immunorejection,cell death,and also ***,the amazing progress in the field in the last few years makes it possible to envisage safe and effective treatments to restore vision loss in a near future.

关键词： Retina regeneration Stem cells Retina stem cell transplantation Cancer stem cells Photoreceptor replacement

Immunologic, metabolic and genetic factors in hepatitis C virus infection

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World Journal of Gastroenterology 2014年第13期20卷 3443-3456页

作者： nora A Fierro Karina Gonzalez-Aldaco Rafael Torres-Valadez Erika Martinez-Lopez Sonia Roman Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara"Fray Antonio Alcalde" and Health Sciences CenterUniversity of GuadalajaraGuadalajara 44280JaliscoMexico

The mechanisms that regulate disease progression during hepatitis C virus(HCV)infection and the response to treatment are not clearly *** studies have demonstrated that a strong host immune response against HCV favors HCV *** addition,genetic factors and metabolic machinery,particularly cholesterol modulation,are involved in HCV *** is likely that the interplay between all of these factors contributes to the outcome of HCV *** recent years,the world has experienced its largest epidemic of *** and the United States are the leading sufferers from this epidemic at the global *** is associated with the development ofnumerous pathologies including hypercholesterolemia which is one of the eight most important risk factors for mortality in *** may be related to the course of HCV infection in this ***,we focus on the urgent need to study the progression of HCV infection in relation to ethnic *** are discussed that hold promise in identifying immune,metabolic and genetic factors that,in conjunction,could be therapeutic targets or predictors of the progression of HCV infection.

关键词： Hepatitis C virus Immune response Lipids Metabolism Genetics

Metabolic dysfunction-associated steatotic liver disease-associated fibrosis and cardiac dysfunction in patients with type 2 diabetes

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World Journal of Cardiology 2024年第10期16卷 580-594页

作者： Simona Cernea Danusia Onișor Andrada Larisa Roiban Theodora Benedek nora Rat Department M3/Internal Medicine I George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTârgu Mureş540142Romania Diabetes Nutrition and Metabolic Diseases Outpatient UnitEmergency County Clinical HospitalTârgu Mureş540136Romania Department ME2/Internal Medicine VII George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureşTârgu Mureş540142Romania Gastroenterology Clinic MureșCounty Clinical HospitalTârgu Mureş540103Romania Diabetes Compartment MediașMunicipal HospitalMediaș551030Romania Doctoral School of Medicine and Pharmacy George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department M3/Internal Medicine VI George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department of Cardiology Emergency County Clinical HospitalTârgu Mureş540136Romania

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepatic interaction in the context type 2 diabetes mellitus(T2DM)is not fully *** To evaluate the changes in cardiac morphology and function in patients with T2DM and MASLD-associated liver *** T2DM patients with MASLD underwent a medical evaluation that included an assessment of lifestyle,anthropometric measurements,vital signs,an extensive laboratory panel,and a standard *** fibrosis was evaluated using two scores[Fibrosis-4(FIB4)and Non-alcoholic fatty liver disease-Fibrosis Score(NFS)],and subjects were classified as having advanced fibrosis,no fibrosis,or an indeterminate *** correlations between structural and functional cardiac parameters and markers of liver fibrosis were evaluated through bivariate and multiple regression *** significance was set at P<*** Data from 267 T2DM-MASLD subjects with complete assessment was *** with scores indicating advanced fibrosis exhibited higher interventricular septum and left ventricular(LV)posterior wall thickness,atrial diameters,LV end-systolic volume,LV mass index(LVMi),and epicardial adipose tissue thickness(EATT).Their mean ejection fraction(EF)was significantly lower(49.19%±5.62%vs 50.87%±5.14%vs 52.00%±3.25%;P=0.003),and a smaller proportion had an EF≥50%(49.40%vs 68.90%vs 84.21%;P=0.0017).Their total and mid LV wall motion score indexes were higher(P<0.05).Additionally,they had markers of diastolic dysfunction,with a higher E/e’ratio[9.64±4.10 vs 8.44(2.43-26.33)vs 7.35±2.62;P=0.026],and over 70%had lateral e’values<10 cm/second,though without significant differences between *** multiple regression analyses,FIB4 correlated with left atrium diameter(LAD;β=0.044;P<0.05),and NFS with both LAD(β=0.039;P<0.05)and right

关键词： Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes mellitus Liver fibrosis Cardiac dysfunction Sex-hormone binding protein

Hamstring autograft utilization in reconstructing anterior cruciate ligament:Review of harvesting techniques,graft preparation,and different fixation methods

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World Journal of Orthopedics 2022年第10期13卷 876-890页

作者： Waleed Albishi Baraa Baltow nora Albusayes Ameer A Sayed Hamza M Alrabai Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia Department of Orthopedic Surgery AlHada Armed Forces HospitalMinistry of DefenseAlHada 26792Saudi Arabia Department of Orthopedic Surgery King Fahad Armed Forces HospitalMinistry of DefenseJeddah 23311Saudi Arabia

Rupture of the anterior cruciate ligament(ACL)is a common orthopedic *** graft options are available for the reconstruction of ruptured *** the hamstring muscle as an autograft was first described in 1934,and it remains a commonly harvested graft for ACL *** autografts can be harvested using the traditional anteromedial approach or the newer posteromedial *** isolated semitendinosus tendon can be used or combined with the gracilis *** are numerous methods for graft fixation,such as intra-tunnel or extra-tunnel *** comprehensive review discusses the different hamstring muscle harvesting techniques and graft preparation options and fixation *** provides a comprehensive overview for choosing the optimal surgical technique when treating patients.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Graft fixation Hamstring autograft Infrapatellar nerve injury Patient reported outcomes

Experimental control of optical helicity in nanophotonics

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Light(Science & Applications) 2014年第1期3卷 166-172页

作者： nora Tischler Ivan Fernandez-Corbaton Xavier Zambrana-Puyalto Alexander Minovich Xavier Vidal Mathieu L Juan Gabriel Molina-Terriza ARC Centre for Engineered Quantum Systems Department of Physics&AstronomyMacquarie UniversitySydneyNSW 2109Australia Department of Physics&Astronomy Macquarie UniversitySydneyNSW 2109Australia Nonlinear Physics Centre and Centre for Ultrahigh-bandwidth Devices for Optical Systems(CUDOS) Research School of Physics and EngineeringThe Australian National UniversityCanberraACT 0200Australia

An analysis of light–matter interactions based on symmetries can provide valuable insight,particularly because it reveals which quantities are conserved and which ones can be transformed within a physical *** this context,helicity can be a useful addition to more commonly considered observables such as angular *** question arises how to treat helicity,the projection of the total angular momentum onto the linear momentum direction,in practical *** this paper,we put forward a simple but versatile experimental treatment of *** then apply the proposed method to the scattering of light by isolated cylindrical nanoapertures in a gold *** allows us to study the helicity transformation taking place during the interaction of focused light with the *** particular,we observe from the transmitted light that the scaling of the helicity transformed component with the aperture size is very different to the direct helicity component.

关键词： helicity nanoaperture nanophotonics optics symmetry

Sex ratio of mirid populations shifts in response to hostplant co-infestation or altered cytokinin signaling

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Journal of Integrative Plant Biology 2017年第1期59卷 44-59页

作者： nora Adam Theresa Erler Mario Kallenbach Martin Kaltenpoth Grit Kunert Ian T.Baldwin Meredith C.Schuman Department of Molecular Ecology Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 07745 Jena Germany German Centre for Integrative Biodiversity Research (iDiv) Deutscher Platz5e 04103 Leipzig Germany Max Planck Research Group Insect Symbiosis Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 07745 Jena Germany Department of Biochemistry Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 07745 Jena Germany

Herbivore species sharing a host plant often compete. In this study, we show that host plant-mediated interaction between two insect herbivores-a generalist and a specialist-results in a sex ratio shift of the specialist＇s offspring. We studied demographic parameters of the specialist Tupiocoris notatus（Hemiptera： Miridae）when co-infesting the host plant Nicotiana attenuata（Solanaceae） with the generalist leafhopper Empoasca sp.（Hemiptera： Cicadellidae）. We show that the usually female-biased sex ratio of T. notatus shifts toward a higher male proportion in the offspring on plants coinfested by Empoasca sp. This sex ratio change did not occur after oviposition, nor is it due differential mortality of female and male nymphs. Based on pyrosequencing and PCR of bacterial 16 S rRNA amplicons, we concluded that sex ratio shifts were unlikely to be due to infection with Wolbachia or other known sex ratio-distorting endosymbionts. Finally, we used transgenic lines of *** to evaluate if the sex ratio shift could be mediated by changes in general or specialized host plant metabolites. We found that the sex ratio shift occurred on plants deficient in two cytokinin receptors（irCHK2/3）.Thus, cytokinin-regulated traits can alter the offspring sex ratio of the specialist ***.

关键词： Empoasca populations specialist offspring Hemiptera altered Nicotiana specialized Solanaceae transgenic

Metal removal studied by a laboratory scale immobilized microalgal reactor

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Journal of Environmental Sciences 1998年第4期10卷 91-95页

作者： Arthur Lau Yuk Shan Wong Zhang Tong nora F.Y.Tam Research Center/Biology Department Hong Kong University of Science and TechnologyClearwater RoadKowloonH.K. CEDRC Beijing 100028China Department of Biology and Chemistry City University of Hong KongKowloonH.K.

A laboratory scale algal column reactor packed with 75 ml alginate algal beads was used to treat 30 mg/L Cu and Ni with a HRT of 30 minutes. At the end of loading 4L metal solution, over 97% of Cu and 91% of Ni were removed from the wastewater with a final residual of 1.76 mg/L Cu and 8.8 mg/L Ni. Up flow was preferred to down flow in maintaining a constant flow rate and hence HRT. Amount of metal recovered during regeneration depended on concentration and nature of regenerant used. Dilute acid was a better regenerant than calcium in terms of metal recovered (90%) and volume needed for regeneration. The consistency in the metal removal performance by the algal column over 10 metal treatment and regeneration cycles suggested that the algal beads can treat Cu or Ni bearing wastewater over 400 times its own volume.

关键词： immobilized microalgal reactor industrial wastewater treatment metal.

Study of a Strongly Dispersive Solitary Wave in Two-Component Plasma

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材料科学与工程（中英文A版） 2011年第3X期1卷 408-414页

作者： nora Nassiri Mofakham Reactor and Accelerator Research and Development School Nuclear Science and Technology Institute (NSTI) Tehran 14155-1239 Iran Department of Science Payame Noor University Noor Blvd. Shahin Shahr Iran

Reproductive strategies in males of the world’s southernmost lizards

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Integrative Zoology 2017年第2期12卷 132-147页

作者： Jimena B.FERNÁNDEZ Marlin MEDINA Erika L.KUBISCH JoséA.SCOLARO nora R.IBARGÜENGOYTÍA INIBIOMA-CONICET Zoology DepartmentCentro Regional Universitario Bariloche InstituteUniversidad Nacional del ComahueSan Carlos de BarilocheArgentina CIEMEP-CONICET Biology DepartmentUniversidad Nacional de la Patagonia San Juan BoscoEsquelArgentina CENPAT-CONICET Universidad Nacional de la Patagonia San Juan BoscoTrelewArgentina

Reproductive and life history patterns in reptiles are tightly related to the environmental conditions,so male reproductive cycles have been historically characterized as continuous,for tropical lizards,or seasonal,for temperate ***,males of Liolaemus and Phymaturus lizards(Liolaemidae),from cold temperate climates of high altitudes or latitudes in Argentina and Chile,have developed a variety of reproductive cycles to coordinate with the short female reproductive season and to deal with the low frequency of reproductive females in the *** gonadal histology and morphological analysis,we describe the male reproductive biology,fat storage and sexual dimorphism of the viviparous lizards Liolaemus sarmientoi and Liolaemus magellanicus that inhabit an austral grass steppe at 51°S,in the southern limit of the American *** of *** and *** are reproductively available during the entire activity season of approximately 5 *** addition,males of both species exhibit greater body sizes than females in morphological variables relevant in sexual ***,females of both species exhibit larger inter-limb length than conspecific males,which suggests fecundity selection to increase space for a larger litter *** continuous sperm production throughout the activity season allows these liolaemids to mate at any time when females ovulate,representing a selective advantage to deal with the short activity season and the adversities of the cold environment they inhabit.

关键词： adaptations Liolaemidae reproductive activity sexual dimorphism temperate-cold environments