检索结果-南通市图书馆

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 813-819页

作者： Izatus Shima TAIB Siti Balkis BUDIN Seri Maseran SITI nor AIN Jamaludin MOHAMED Santhana Raj LOUIS Srijit DAS Sulaiman SALLEHUDIN nor fadilah rajab Othman HIDAYATULFATHI Department of Biomedical Sciences Faculty of Allied Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia Unit of Electron Microscope Institute for Medical ResearchJalan Pahang50588 Kuala LumpurMalaysia Department of Anatomy Universiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia

Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity,chemopreventative and insecticidal properties. In this study,the toxic effects of L. elliptica essential oil against Sprague-Dawley rat’s red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125,250,and 500 mg/(kg body weight),respectively,and the control group received distilled water. Full blood count,RBC osmotic fragility,RBC morphological changes,and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb),mean cell hemoglobin concentration (MCHC),mean cell volume (MCV),and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (Pnormal range. L. elliptica induced morphological changes of RBC into the form of echinocyte. The percentage of echinocyte increased significantly among the treated groups in a dose-response manner (P0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.

关键词： SD大鼠毒性作用木姜子红细胞精油椭圆

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

蒌叶提取物增强5-氟尿嘧啶对结肠癌细胞HT29和HCT116的生长抑制作用(英文)

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第8期15卷 692-700页

作者： Pek Leng NG nor fadilah rajab Sue Mian THEN Yasmin Anum MOHD YUSOF Wan Zurinah WAN NGAH Kar Yong PIN Mee Lee LOOI Department of Biomedical Sciences Faculty of Allied Health Universiti Kebangsaan Malaysia (UKM) Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur Malaysia UKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia (UKM) Jalan Yaacob Latiff Bandar Tun Razak Cheras56000 Kuala Lumpur Malaysia School of Biomedical Science University of Nottingham Malaysia Campus43500 Semenyih Selangor Malaysia Department of Biochemistry Faculty of Medicine Universiti Kebangsaan Malaysia (UKM) Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur Malaysia Forest Research Institute Malaysia (FRIM) 52109 Kuala Lumpur Kepong Malaysia School of Biosciences Taylor’s University Lakeside Campus47500 Subang Jaya Selangor Malaysia

研究目的:探讨蒌叶(PB)提取物对5-氟尿嘧啶(5-FU)抑制结肠癌细胞HT29和HCT116生长的影响。研究方法:HT29和HCT116细胞分别给予PB、5-FU以及两种药物联合治疗24小时,应用等效线图法分析PB和5-FU的药效学相互作用,Annexin V/PI染色法检测H... 详细信息

研究目的:探讨蒌叶(PB)提取物对5-氟尿嘧啶(5-FU)抑制结肠癌细胞HT29和HCT116生长的影响。研究方法:HT29和HCT116细胞分别给予PB、5-FU以及两种药物联合治疗24小时,应用等效线图法分析PB和5-FU的药效学相互作用,Annexin V/PI染色法检测HT29和HCT116细胞的凋亡情况,高效液相色谱法排除PB和5-FU间任何可能的相互化学作用。重要结论:联合PB,低剂量5-FU可以在短时间内起到细胞毒作用,而单独应用PB或5-FU治疗较联合治疗可以诱导更多细胞发生凋亡。进一步采用等效线图法分析显示PB和5-FU的联合作用在抑制结肠癌细胞HT29和HCT116的生长中分别体现出协同和拮抗作用。因此可以认为在HT29细胞中,PB使得较低剂量5-FU发挥最大抑制结肠癌细胞生长效果,然而在HCT116细胞中,PB没有显著降低5-FU的药物浓度,说明PB和5-FU的相互作用不仅仅体现在诱导细胞凋亡方面。

关键词：胡椒科蒌叶 5-氟尿嘧啶等效线图法草药-药物相互作用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genotoxic Potential of Shrimp Pastes (Belacan) Extracts Using <i>Umu</i>Test

引用

Food and Nutrition Sciences 2012年第4期3卷 522-525页

作者： Ahmad Rohi Ghazali Yvonne Sipain nor fadilah rajab Siew Ee Ling norain Ramli Rozaini Abdullah Zaliha Harun Firdaus Kamarulzaman Biomedical Science Program Faculty of Health Sciences School of Diagnostic and Applied Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia Environmental Health Program Faculty of Health Sciences School of Diagnostic and Applied Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia.

This study was conducted to observe the genotoxic effects of aqueous, methanol, hexane and dichloromethane extracts of “belacan” (shrimp paste) taken from three local districts in Melaka, Malaysia (Kelemak, Batang Tiga & Pantai Puteri). The umu test which was used as the screening test was conducted with and without the presence of metabolic activation system. Without the presence of metabolic activation system, aqueous extracts from Kelemak showed mutagenicity activity at 5 mg/ml with IR (Induction Rate) = 1.52 ± 0.57 and the methanol extracts showed mutagenic activities at 0.625 mg/ml and 5 mg/ml, which the IR was the highest at 5 mg/ml (2.08 ± 0.09). On the other hand, samples from Batang Tiga, Melaka showed mutagenic effects at all five concentrations for the dichloromethane extract, with IR = 2.09 ± 0.64 as the highest value at 1.25 mg/ml. Methanol extracts also showed positive results at 1.25 mg/ml and 2.5 mg/ml with IR = 1.70 ± 0.33 and IR = 2.12 ± 0.51 respectively, and aqueous extract at 0.625 mg/ml with IR = 1.54 ± 0.48 and 5 mg/ml with IR = 1.74 ± 0.50. There was a significant difference of the mean values of IR between the four different types of “belacan” extracts from Batang Tiga (p < 0.05). All four “belacan” extracts from Pantai Puteri, Melaka did not show any mutagenic effect. With the presence of metabolic activation system, there was no mutagenic effect observed in all four extracts from the three districts. Further study to analyze the contents in the food samples should be done in the future to determine the possible contents in the food samples that might be responsible for the mutagenic activities.

关键词： Shrimp Pastes Mutagenicity Umu Test Melaka Genotoxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of urban air pollution on the population in the Klang Valley,Malaysia:a spatial approach

引用

Ecological Processes 2022年第1期11卷 126-141页

作者： Siti Haslina Mohd Shafie Mastura Mahmud Suzani Mohamad nor Lita fadilah Rameli Ramdzani Abdullah Ahmad Fariz Mohamed Centre for Research in Development Social and Environment(SEEDS)Faculty of Social Sciences and HumanitiesUniversiti Kebangsaan MalaysiaBangiSelangorMalaysia Department of Environment Faculty of Forestry and Envi-ronmentUniversiti Putra MalaysiaSerdangSelangorMalaysia Institute for Environment and Development(LESTARI) Universiti Kebangsaan MalaysiaBangiSelangorMalaysia.

Background:Urban air pollution resulting from economic growth as well as urbanization impacts the health of *** study aims to examine the spatial distribution of particulate matter(PM_(10))and the risk of exposure for the population in the Klang Valley,an urban conglomeration centred in Kuala Lumpur,***:The inverse distance weighted(IDW)interpolation technique in the ArcGIS platform was used to map the air quality from five air monitoring *** statistics of the Global Moran’s I Spatial Autocorrelation and Optimized Hot Spot Analysis were used to estimate the spatial clustering of PM_(10).The population-weighted exposure level(PWEL)technique was used to calculate the population density susceptible to PM_(10)and the AirQ+model was applied to estimate the proportion of the adult population at risk of chronic bronchitis due to long-term exposure to PM_(10)concentrations in the Klang ***:The highest annual mean PM_(10)concentrations at the Klang station ranged between 80 and 100μg/m^(3)from 2000 to 2009 and exceeded the New Malaysia Ambient Air Quality Standard(NMAAQS)and the World Health Organi-zation Air Quality Guidelines(WHOAQG)levels of 40 and 20μg/m^(3),*** Moran’s I results indicated that the statistically significant clusters of high PM_(10)in Klang present a health risk to the local *** PWEL results showed that levels of PM_(10)in Petaling Jaya exceeded the WHOAQG limits,potentially posing a health risk to the high-density *** AirQ+model found Klang to be a significantly high-risk area for chronic bronchitis among the adult population with 804,240 people(with a relative risk of 1.85)in ***:These high-risk values are due to rapid urbanization and high motor vehicle usage in the Klang Valley and therefore the impact of PM_(10)on the population needs to be *** situation should be taken seriously by the Department of Environment and Kuala Lumpur City Hall in addre

关键词： Population Urban air pollution Spatial distribution PM_(10) Adult chronic bronchitis risk

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：