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Growth inhibitory response and ultrastructural modification of oral-associated candidal reference strains (ATCC) by Piper betle L. extract

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International Journal of Oral Science 2014年第1期6卷 15-21页

作者： mohd-Al-Faisal nordin Wan Himratul-Aznita Wan Harun Fathilah Abdul Razak Md Yusoff Musa Department of Oral Biology and Biomedical Sciences Faculty of Dentistry University of Malaya Institute of Biological Sciences Faculty of ScienceUniversity of Malaya

Candida species have been associated with the emergence of strains resistant to selected antifungal agents. Plant products have been used traditionally as alternative medicine to ease mucosal fungal infections. This study aimed to investigate the effects of Piper betle extract on the growth profile and the ultrastructure of commonly isolated oral candidal cells. The major component of Po betle was identified using liquid chromatography-mass spectrophotometry （LC-MS/MS）. Seven ATCC control strains of Candida species were cultured in yeast peptone dextrose broth under four different growth environments：（i） in the absence of P. betle extract; and in the presence of P. beUeextract at respective concentrations of （ii） 1 ***-1; （iii） 3 ***-1; and （iv） 6 ***- 1 The growth inhibitory responses of the candidal cells were determined based on changes in the specific growth rates （μ）. Scanning electron microscopy （SEM） was used to observe any ultrastructural alterations in the candida colonies. LC-MS/MS was performed to validate the presence of bioactive compounds in the extract. Following treatment, it was observed that the p-values of the treated cells were significantly different than those of the untreated cells （P〈0.05）, indicating the fungistatic properties of the P. beUe extract. The candidal population was also reduced from an average of 13.44× 10^6 to 1.78×10^6 viable cell counts （CFU）.mL-1, SEM examination exhibited physical damage and considerable morphological alterations of the treated cells. The compound profile from LC-MS/MS indicated the presence of hydroxybenzoic acid, chavibetol and hydroxychavicol in P. betle extract. The effects of P. betle on candida cells could potentiate its antifungal activity.

关键词： antifungal activity Candida cell morphology growth inhibitory effect Piperbetle L.

Energy-Efficient Low-Complexity Algorithm in 5G Massive MIMO Systems

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Computers, Materials & Continua 2021年第6期67卷 3189-3214页

作者： Adeeb Salh Lukman Audah Qazwan Abdullah nor Shahida M.Shah Shipun A.Hamzah Shahilah nordin Nabil Farah Wireless and Radio Science Centre(WARAS) Faculty of Electrical and Electronic EngineeringUniversiti Tun Hussein Onn MalaysiaBatu PahatJohor86400Malaysia Faculty of Engineering Technology Universiti Tun Hussein Onn MalaysiaPagohMuarJohorMalaysia Fakulti Kejuruteraan Elektrik Universiti Teknologi MARA Kampus Permatang Pauh Permatang PauhPulau Pinang13500Malaysia

Energy efficiency(EE)is a critical design when taking into account circuit power consumption(CPC)in fifth-generation cellular *** problems arise because of the increasing number of antennas in massive multiple-input multiple-output(MIMO)systems,attributable to inter-cell interference for channel state *** from that,a higher number of radio frequency(RF)chains at the base station and active users consume more power due to the processing activities in digital-to-analogue converters and power ***,antenna selection,user selection,optimal transmission power,and pilot reuse power are important aspects in improving energy efficiency in massive MIMO *** work aims to investigate joint antenna selection,optimal transmit power and joint user selection based on deriving the closed-form of the maximal EE,with complete knowledge of large-scale fading with maximum ratio *** also accounts for channel estimation and eliminating pilot contamination as antennas M→∞.This formulates the optimization problem of joint optimal antenna selection,transmits power allocation and joint user selection to mitigate inter-cellinterference in downlink multi-cell massive MIMO systems under minimized reuse of pilot sequences based on a novel iterative low-complexity algorithm(LCA)for Newton’s methods and Lagrange *** analyze the precise power consumption,a novel power consumption scheme is proposed for each individual antenna,based on the transmit power amplifier and *** results demonstrate that the maximal EE was achieved using the iterative LCA based on reasonable maximum transmit power,in the case the noise power is less than the received power *** maximum EE was achieved with the desired maximum transmit power threshold by minimizing pilot reuse,in the case the transmit power allocationρd=40 dBm,and the optimal EE=71.232 Mb/j.

关键词： Massive MIMO energy efficiency base station active users pilot contamination low-complexity algorithm radio frequency

Disseminated strongyloidiasis in an immunocompromised host:A case report

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 587-590页

作者： Nurul Suhaiza Hassanudin Zubaidah Abdul Wahab Khalid Ibrahim Fadzilah mohd nor Microbiology Unit Department of PathologyHospital Sg.Buloh Director Office Hospital Sg.Buloh Microbiology Discipline Faculty of MedicineUniversiti Teknologi MARASg.Buloh CampusJalan Hospital Integrative Pharmacogenomics Institute (iPROMISE) Level 7FF3Universiti Teknologi MARAPuncak Alam Campus

Infections caused by Strongyloides stercoralis(***) in human are generally asymptomatic,however in immunocompromised individual,hyperinfection may develop with dissemination of larvae to extra-intestinal *** diagnosis could be easily missed due to asymptomatic presentation and insufficient exposure towards the infection itself,which may lead to low index of suspicion as a *** this report,a case of a Malaysian male with underlying diabetes mellitus,hypertension,cerebrovascular accident,bullous pemphigus and syndrome of inappropriate antidiuretic hormone secretion who initially complained of generalized body weakness and poor appetite without any history suggestive of sepsis is ***,he developed septicemic shock later,and *** larvae was incidentally found in the tracheal aspirate that was sent to look for acid fast *** of aggressive resuscitation,the patient succumbed due to pulmonary hemorrhage and acute respiratory distress *** was revealed that the current case has alarmed us via incidental finding of *** larvae in the tracheal aspirate,indicating that the importance of the disease should be emphasized in certain parts of the world and population respectively.

关键词： Disseminated strongyloidiasis Immunocompromised host Hyperinfection Strongyloides stercoralis

Effect of intermetallic compounds on the fracture behavior of dissimilar friction stir welding joints of Mg and Al alloys

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International Journal of Minerals,Metallurgy and Materials 2019年第10期26卷 1285-1298页

作者： Amir Hossein Baghdadi Zainuddin Sajuri nor Fazilah Mohamad Selamat mohd Zaidi Omar Yukio Miyashita Amir Hossein Kokabi Centre for Materials Engineering and Smart Manufacturing Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor 43600Malaysia Department of Mechanical Engineering Nagaoka University of TechnologyNagaoka940-2188Japan Department of Materials Science and Engineering Sharif University of TechnologyTehran 11365-11155Iran

Joining Mg to Al is challenging because of the deterioration of mechanical properties caused by the formation of intermetallic compounds(IMCs) at the Mg/Al interface. This study aims to improve the mechanical properties of welded samples by preventing the fracture location at the Mg/Al interface. Friction stir welding was performed to join Mg to Al at different rotational and travel speeds. The microstructure of the welded samples showed the IMCs layers containing Al12Mg17(γ) and Al3Mg2(β) at the welding zone with a thickness(< 3.5 μm). Mechanical properties were mainly affected by the thickness of the IMCs, which was governed by welding parameters. The highest tensile strength was obtained at 600 r/min and 40 mm/min with a welding efficiency of 80%. The specimens could fracture along the boundary at the thermo-mechanically affected zone in the Mg side of the welded joint.

关键词： aluminum alloy magnesium alloy intermetallic compounds dissimilar welded joint friction stir welding

3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors

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Acta Pharmaceutica Sinica B 2017年第4期7卷 479-484页

作者： Hasnah Osman nor Hashima Idris Ezatul Ezleen Kamarulzaman Habibah A.Wahab mohd.Zaheen Hassan School of Chemical Sciences Universiti Sains Malaysia School of Pharmaceutical Sciences Universiti Sains Malaysia

Dengue is a severe mosquito-borne viral infection causing half a million deaths *** virus NS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a–4j were synthesized and screened in silico against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the active sites. Results were validated through an in vitro DENV2 NS2B/NS3 protease assay using a fluorogenic Boc-Gly-Arg-Arg-AMC substrate. Nitro derivatives of 3,5-bis(arylidene)-4-piperidones(4e and 4j) emerged as promising lead molecules for novel protease inhibitors with an IC50 of 15.22 and16.23 mmol/L, respectively, compared to the standard, panduratin A, having IC50 of 57.28 mmol/L.

关键词：登革热病毒 NS2B/NS3 朊酶 Piperidone ,不饱和的酉同类朊酶禁止者

Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects

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Neural Regeneration Research 2018年第11期13卷 2014-2021页

作者： Natasha Najwa nor Arfuzir Renu Agarwal Igor Iezhitsa Puneet Agarwal Sabrilhakim Sidek Nafeeza mohd Ismail Center for Neuroscience Research Faculty of MedicineUniversiti Teknologi MARA Sungai Buloh Campus Volgograd State Medical University Research Institute of Pharmacology Faculty of Medicine International Medical UniversityIMU Clinical School

Endothelin-1（ET-1）, a potent vasoconstrictor, is involved in retinal vascular dysregulation and oxidative stress in glaucomatous eyes. Taurine（TAU）, a naturally occurring free amino acid, is known for its neuroprotective and antioxidant properties. Hence, we evaluated its neuroprotective properties against ET-1 induced retinal and optic nerve damage. ET-1 was administered intravitreally to Sprague-Dawley rats and TAU was injected as pre-, co-or post-treatment. Animals were euthanized seven days post TAU injection. Retinae and optic nerve were examined for morphology, and were also processed for caspase-3 immunostaining. Retinal redox status was estimated by measuring retinal superoxide dismutase, catalase, glutathione, and malondialdehyde levels using enzyme-linked immuosorbent assay. Histopathological examination showed significantly improved retinal and optic nerve morphology in TAU-treated groups. Morphometric examination showed that TAU pre-treatment provided marked protection against ET-1 induced damage to retina and optic nerve. In accordance with the morphological observations, immunostaining for caspase showed a significantly lesser number of apoptotic retinal cells in the TAU pre-treatment group. The retinal oxidative stress was reduced in all TAU-treated groups, and particularly in the pre-treatment group. The findings suggest that treatment with TAU, particularly pre-treatment, prevents apoptosis of retinal cells induced by ET-1 and hence prevents the changes in the morphology of retina and optic nerve. The protective effect of TAU against ET-1 induced retinal and optic nerve damage is associated with reduced retinal oxidative stress.

关键词： endothelin-1 retina optic nerve taurine oxidative stress

Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 14-21页

作者： Emey Suhana mohd AZAMAI Suhaniza SULAIMAN Shafina Hanim mohd HABIB Mee Lee LOOI Srijit DAS nor Aini ABDUL HAMID Wan Zurinah WAN NGAH Yasmin Anum mohd YUSOF Department of Biochemistry Universiti Kebangsaan Malaysia Department of Anatomy Faculty of Medicine UKM Medical Center Universiti Kebangsaan Malaysia

小球藻粗俗(CV ) 被报导了有抗氧化剂和反癌症性质。我们在肝在 apoptotic 管理者蛋白质表示上评估了 CV 的效果导致癌症的老鼠。男 Wistar 老鼠(200 ∼250 g ) 被划分成八个组：控制组(正常食谱)， CDE 组(在喝与乙基硫氨酸补充的缺乏... 详细信息

小球藻粗俗(CV ) 被报导了有抗氧化剂和反癌症性质。我们在肝在 apoptotic 管理者蛋白质表示上评估了 CV 的效果导致癌症的老鼠。男 Wistar 老鼠(200 ∼250 g ) 被划分成八个组：控制组(正常食谱)， CDE 组(在喝与乙基硫氨酸补充的缺乏的饮食浇导致 hepatocarcinogenesis 的胆碱)，有 CV ( 50 ， 150 ，和 300 mg/kg 身体重量)的三不同剂量的 CV 组，和 CDE 组与 CV 的不同剂量对待( 50 ， 150 ，和 300 mg/kg 身体重量)。老鼠在各种各样的星期被牺牲，肝纸巾为免疫组织化学研究在石蜡块被嵌入。在增加剂量， CV 减少了 anti-apoptotic 蛋白质的表示， Bcl-2 ，但是增加了 pro-apoptotic 蛋白质的表示， caspase 8 在 CDE 老鼠，它与减少的 hepatoctyes 增长被相关并且增加了由标记的 bromodeoxy-uridine ( BrdU )和终端 deoxynucleotidyl 转移决定了的 apoptosis 标记的调停的 dUTP 刻痕结束( TUNEL )试金分别地。我们的学习证明 CV 让明确的 chemopreventive 由经由减少导致 apoptosis 完成 Bcl-2 的表示并且增加 caspase 的表示 8 在导致 hepatocarcinogenesis 的老鼠。

关键词：肝癌癌细胞临床研究

Eco-friendly method for synthesis of zeolitic imidazolate framework 8 decorated graphene oxide for antibacterial activity enhancement

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Particuology 2020年第2期18卷 24-32页

作者： Nazerah Ahmad Nik Abdul Hadi Md nordin Juhana Jaafar Nik Ahmad Nizam Nik Malek Ahmad Fauzi Ismail Muhammad Nabil Fikri Yahya Siti Aishah mohd Hanim mohd Sohaimi Abdullah Advanced Membrane Technology Research Centre Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia Malaysian Institute of Chemical Engineering Technology-Universiti Kuala Lumpur Lot 1988Bandar VendorTaboh Naning78000 Alor GajahMelakaMalaysia Chemical Engineering Department Universiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia Department of Biosciences Faculty of ScienceUniversiti Teknologi Malaysia81310 SkudaiJohorMalaysia Centre for Student Innovation and Technology Entrepreneurship Universiti Teknologi Malaysia81310 SkudaiJohorMalaysia

We report a rapid method for synthesis of zeolitic imidazolate framework 8(ZIF-8)-decorated graphene oxide(GO)composites(ZGO)with good antibacterial *** ZGO composites were synthesized at room temperature with low GO to metal salt *** samples were characterized by X-ray diffraction,transmission electron microscopy,Fourier transform infrared spectroscopy,thermal gravimetric analysis,and surface area *** characterization results show that ZIF-8 with a size of approximately 120 nm is successfully decorated on the surface of GO sheets with the host ZIF-8 framework maintained in the synthesized composite,but there is a significant reduction in the Brunauer-Emmett-Teller surface *** antibacterial activities of the samples against Escherichia coli ATCC 11229 and Staphylococcus aureus ATCC 6538 as model strains of gram-negative and-positive bacteria,respectively,were determined by disc diffusion and minimum inhibitory concentration(MIC)***-1.0(1 wt%of ratio of GO to metal salt)shows the highest antibacterial activity with MIC values required to inhibit bacterial growth of *** and *** of 5 times lower than those of pristine *** antibacterial mechanisms are proposed based on field-emission scanning electron microscope images of the two bacteria after contact with the synthesized ***,owing to the simple synthesis,good stability,low chemical usage,and excellent antibacterial activity of the ZGO composites,they show great potential for application in the field of microbial contamination control.

关键词： Graphene oxide Metal-organic framework Hybrid nanocomposite Zeolitic imidazolate framework Antibacterial agent

以对二甲苯氧化为对苯二甲酸为例简要综述一级C–H键活化(英文)

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催化学报 2014年第10期35卷 1641-1652页

作者： nor Aqilah mohd Fadzil mohd Hasbi Ab.Rahim Gaanty Pragas Maniam Faculty of Industrial Sciences & Technology Universiti Malaysia PahangLebuhraya Tun Razak26300 Gambang KuantanPahangMalaysia

The oxidation of para‐xylene to terephthalic acid has been commercialised as the AMOCO process(Co/Mn/Br) that uses a homogeneous catalyst of cobalt and manganese together with a corrosive bromide compound as a promoter. This process is conducted in acidic medium at a high tempera‐ture(175–225 °C). Concerns over environmental and safety issues have driven studies to find mild‐er oxidation reactions of para‐xylene. This review discussed past and current progress in the oxida‐tion of para‐xylene process. The discussion concentrates on the approach of green chemistry in‐cluding(1) using heterogeneous catalysts with promising high selectivity and mild reaction condi‐tion,(2) application of carbon dioxide as a co‐oxidant, and(3) application of alternative promoters. The optimisation of para‐xylene oxidation was also outlined.

关键词：二甲苯氧化对苯二甲酸非均相催化剂活化氧化反应对二甲苯应用程序 AMOCO