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Potentially Toxic Element Concentration in Fruits Collected from Markazi Province(Iran): A Probabilistic Health Risk Assessment

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Biomedical and Environmental Sciences 2019年第11期32卷 839-853页

作者： Mohammad Rezaei Bahareh Ghasemidehkordi Babak Peykarestan Nabi Shariatifar Maryam Jafari Yadolah Fakhri Maryam Jabbari amin Mousavi Khaneghah Department of Food Hygiene Faculty of Veterinary MedicineUniversity of TehranTehranIran Department of Food Safety and Hygiene School of Public HealthTehran University of Medical SciencesTehranTran Department of Biochemistry Payame Noor UniversityIsfahanIran Department of Agriculture Payame Noor UniversityTehranTran Department of Environmental Health Engineering School of Public Health and SafetyStudent Research CommitteeShahid Beheshti University of Medical SciencesTehranTran Department of Public Health School of Paramedical and HealthZanjan University of Medical SciencesZanjaniran Department of Food Science Faculty of Food EngineeringUniversity of Campinas(UNICAMP)Rua Monteiro Lobato80.Caixa Postal:6121.CEP:13083-862.Campinas.Sao Paulo.Brazil

Objective This study was conducted to evaluate the concentration of potentially toxic elements(PTEs)such as arsenic(As),cadmium(Cd),mercury(Hg),and lead(Pb)in fruit samples collected from Markazi Province,Iran.A probabilistic health risk assessment due to ingestion of PTEs through the consumption of these fruits was also *** The concentration of PTEs in 90 samples of five types of fruits(n=3)collected from six geographic regions in Markazi Province was *** potential health risk was evaluated using a Monte Carlo simulation *** A significant difference was observed in the concentration of PTEs between fruits as well as soil and water samples collected from different regions in Markazi *** order of PTE concentration in the soil and water samples was as follows:Pb>As>Hg>***,the highest level of transfer factor for Cd and Hg correlated with the *** estimated daily intake for adults and children was lower than the recommended tolerable daily *** The population in Markazi Province,Iran,is not at considerable noncarcinogenic or carcinogenic risk due to the ingestion of PTEs through the consumption of the examined fruits.

关键词： Fruits Soil Water Toxic elements Target Hazard Quotient(THQ) Estimated Hazard Index(HI)

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Isolation and Identification of Multi-Drug Resistant Strains of Non-Lactose Fermenting Bacteria from Clinical Isolates

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Open Journal of Medical Microbiology 2014年第2期4卷 115-123页

作者： Minhas Akbar Muhammad Zahid Pir Asmat Ali Aftab Alam Sthanadar Mudassir Shah Iram Alam Sthanadar Muhammad Kaleem Muhammad Aslam Khayyam Zahirullah Syeda Mahreen ul Hassan noor Jehan Muhammad Ismail Khan Department of Microbiology Shaheed Benazir Bhutto Women University Peshawar Pakistan Department of Zoology Islamia College University Peshawar Pakistan Department of Zoology Islamia College University Peshawar Pakistan Department of Zoology and Animal Sciences Post Graduate College Dargai Malakand Pakistan Department of Zoology Islamia College UniversityPeshawar Pakistan Government Degree College Dara Adam Kheil FR Kohat Pakistan Lady Reading Hospital Peshawar Pakistan

Purpose: We studied the drug resistance of different microbes from clinical isolates. The morphological characteristics of bacteria were observed through culture characteristics and by carrying out gram staining techniques while the biochemical characteristics of bacteria were carried out by biochemical test. Methods: A total of 324 samples were collected from suspected patients visiting different hospitals at district Peshawar. For morphological identification, samples of clinical isolates were analyzed by blood agar, MacConkey agar and Eosine Methylene Blue, identified by gram staining and characterized by different biochemical tests. Antibiotic Sensitivity test by Modified Kirby-Bauer Disc diffusion method was used to test the in-vitro susceptibility of the identified isolates to different antibiotics such as Ceftazidime, Ceftazidime, Ceftriaxone, Cefepime and Imipenem. Results: These resistant non-lactose fermenting gram negative bacteria were isolated from samples of pus/wound (33.30%, n = 108/324), blood (33.30%, n = 108/324), urine (23.30%, n = 75/324) and from ascetic/pleural fluids (10.20%, n = 33/324). The study revealed that the percentage of non-fermenting bacterial infection was higher in females (53%) as compared to males (47%) along with higher infection observed in the age group of 11 - 30 years. Pseudomonas aeroginosa showed high resistance against Cefepime (88.80%), followed by Cefoperazone (55.50%), Ceftazidime (48.10%), Ceftriaxone (33.30%). Imipenem was active with low resistance (7.40%). More resistance was seen in Morganella morganii against Imipenem (66.70%) followed by Cefoperazone (55.50%), Ceftriaxone (55.50%). Cefepime showed low resistance (11%). Multi-drug resistant Proteus mirabillis was highly resistance to Ceftriaxone (74.07%), followed by Cefepime (59.20%), Cefoperazone (44.40%) and low resistance for Imipenem (25.90%). Salmonella typhi demonstrated high resistance against Imipenem (74.07%), followed by Ceftriaxone (40.70%), Ceftazi

关键词： Multidrug Resistant Non-Lactose Fermenting Gram Negative Bacteria Disc Diffusion Technique

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Antimicrobial chemical constituents from endophytic fungus Phoma sp.

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 699-702页

作者： Hidayat Hussain Ines Kock Ahmed Al-Harrasi Ahmed Al-Rawahi Ghulam Abbas Ivan R.Green Afzal Shah amin Badshah Muhammad Saleem Siegfried Draeger Barbara Schulz Karsten Krohn Department of Chemistry University of PaderbornWarburger Strasse 10033098 PaderbornGermany UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of NizwaP.O Box 33Postal Code 616Birkat Al MauzNizwaSultanate of Oman Department of Chemistry CUTAbbottabad CampusAbbottabad-22060Pakistan Department of Chemistry and Polymer Science University of StellenboschP/Bag X1 Matieland 7602South Africa Department of Chemistry Quaid-i-Azam University45320 IslamabadPakistan Department of Chemistry The Islamia University of BahawalpurBaghdad Campus-ul-JadidBahawalpurPakistan Institute of Microbiology University of BraunschweigSpielmannstraβe 738106 BraunschweigGermany

Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma *** the tentative identification of their active ***:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion *** compounds were purified using column chromatography and tlieir structures were assigned using～1H and～(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC ***:The ethyl acetate fraction of Phoma *** good antifungal,antibacterial,and algicidal *** new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma *** studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal ***(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal ***:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma *** isolated compounds clearly demonstrate that Phoma *** its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries.

关键词： Natural product Endrophytic fungi Phoma sp

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Optimization of Liver Iron Load Assessment by Pixel-Based T2* MRI in Thalassemic Patients

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Open Journal of Radiology 2012年第2期2卷 46-51页

作者： Neda Gholizadeh Shahram Akhlaghpoor Hamid Soltanian-Zadeh Emad Fatemizadeh Mohammad Reza Alinaghizadeh amin Shams Akhtari Mohammad Nourizadeh Cardivascular Disease Research Center Ahvaz Joundishapour University Ahvaz Iran Control and Intelligent Processing Center of Excellence (CIPCE) School of Electrical Engineering College of Engineering University of Tehran Tehran Iran Department of CT & MRI Imaging Tehran Medical Imaging Center Tehran Iran Department of Magnetic Resonance Imaging Noor Medical Imaging Center Tehran Iran Department of Nuclear Engineering Science and Research Branch of Azad University Tehran Iran School of Electrical Engineering Sharif University of Technology Tehran Iran

Purpose: To improve liver iron load assessment by investigating the precision of different approaches of T2* Measurement. Background: Iron overload is a major problem in the treatment of thalassemic patients. Liver iron concentration (LIC) is an important index toward the management of body iron load. The accuracy of iron load estimation may suffer from the methodology of T2* measurement and there is no complete agreement upon the best approach of T2* calculation. Methods: 32 β-thallasemic patients (18 male) with the mean age of 20.0 ± 6.5 years were involved in this study. A multi-echo fast gradient-echo technique on a 1.5 T MRI system was used to measure liver iron overload and the T2* map of liver was reconstructed on a pixel-by-pixel basis. The T2* map and MRI images were utilized to deter- mine accurate location of ROI (region of interest). The mean of T2* were computed from the ROIs. The reproducibility of calculated T2* values in two methods were obtained. Moreover, the mean of the pixel’s T2* was calculated in the entire liver parenchyma of one slice. The T2* value of the entire slice was compared with the ROI approach. Results: In the ROI based method, the CoV for the intra-observer reproducibility was 8.5% and for the inter-observer was 9.78%. In the pixel based method, the CoVs for intra-observer and inter-observer reproducibility were 2.79% and 3.91%. There was an acceptable correlation (r = 0.96) between the T2* values calculated by the ROI and the entire slice. Conclusions: The pixel-based approach is more precise to determine the appropriate placement of the ROI. The assessment of T2* in the entire slice reduces the user-based errors significantly.

关键词： Thalassemia Liver Iron Overload MRI T2*

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