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Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor

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Chinese Chemical Letters 2023年第1期34卷 295-299页

作者： yue Li nong Lu Qitian Lin Haobing Wang Zhuoming Liang Yujuan Lu Pingyu Zhang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China Whittle School and Studios Shenzhen Campus Shenzhen 518066China

Carbon monoxide(CO)gas therapy,a novel anti-tumor technique based on the cytotoxicity from the CO released in situ,has become one of the hot topics in cancer *** the technique is oxygenindependent,it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration *** fully address these limitations of PDT,we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic *** this work,two rhenium(Ⅰ)tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO *** results indicated that the electron-donating NMe2-substituted complex(Re-NMe2)exhibits stronger luminescence intensity and generates more singlet oxygen(1O2)than the electron-withdrawing NO2-substituted complex(Re-NO2).In addition,Re-NMe2displays release of CO triggered by US,thus showing high sono-cytotoxicity to tumor cells in-vitro and *** strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe2has made it a powerful tool for the efficient treatment of hypoxic tumor.

关键词： Synergetic sonodynamic-gas therapy Carbon monoxide(CO) Rhenium(Ⅰ)tricarbonyl complex Hypoxic tumor

Gold nanoparticle-based anodic stripping voltammetry detection of transcription factor NF-kB

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Journal of Life Sciences 2008年第5期2卷 51-56页

作者： PAN Qin he nong-yue LU Zu-hong State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China

Transcription factor and sequence specific DNA interactions play important roles in drug genome and transcription diagnosis. Gold nanoparticles show high sensitivity, stability and compatibility for biological molecules as electrochemical intercalators. here unimolecular hairpin oligonucleotides were self-assembled onto Au electrode surface and elongation on solid phase was carried out to double strand oligonucleotides with transcription factor NF-r,13 binding site. Gold nanoparticle-catalyzed Ag deposition was detected by anodic stripping voltammetry （ASV） for NF-kB binding. It was indicated that this method for sequence specific DNA binding protein detection shows pronounced specificity, sensitivity and we can find application in transcription regulation research, open reading frame characterization and functional gene inspection by this method.

关键词： transcription factor NF-kB unimolecular hairpinoligonucleotide anodic stripping voltammetry goldnanoparticle

Incoporation of Fe(Ⅲ) in framework of zeolite L

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Chinese Journal of Chemistry 1997年第1期15卷 42-48页

作者： he, nong-yue BAO, Shu-Lin XU, Qin-HuaDepartment of Chemistry, Nanjing University, Nanjing, Jiangsu 210093, China

Zeolite L with Fe in lattice position is prepared from the gel with Fe/(Fe+Al) ratio up to 0.4 using ferric nitrate as Fe source. The incorporation of Fe(Ⅲ) in framework is characterized by XRD, IR, TG/DTA, BET and Mossbauer spectroscopy. Zeolite L is destabilized by Fe(Ⅲ) in framework and the reduction of Fe(Ⅲ) in framework of (Al,Fe )KL was first reported.

关键词： Zeolite L Fe-containing Fe/(Fe+Al) ratio preparation characterization

Seismogenic Structure around the Epicenter of the May 12,2008 Wenchuan Earthquake from Micro-seismic Tomography

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Acta Geologica Sinica(English Edition) 2009年第4期83卷 724-732页

作者： AN Meijian FENG Mei DONG Shuwen LONG Changxing ZHAO yue YANG nong ZHAO Wenjin ZHANG Jizhong Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China Chinese Academy of Geological Sciences Beijing 100037 China

A three-dimensional local-scale P-velocity model down to 25 km depth around the main shock epicenter region was constructed using 83821 event-to-receiver seismic rays from 5856 aftershocks recorded by a newly deployed temporary seismic network. Checkerboard tests show that our tomographic model has lateral and vertical resolution of -2 km. The high-resolution P-velocity model revealed interesting structures in the seismogenic layer：（1） The Guanxian-Anxian fault, Yingxiu-Beichuan fault and Wenchuan-Maoxian fault of the Longmen Shan fault zone are well delineated by sharp upper crustal velocity changes; （2） The Pengguan massif has generally higher velocity than its surrounding areas, and may extend down to at least -10 km from the surface; （3） A sharp lateral velocity variation beneath the Wenchuan-Maoxian fault may indicate that the Pengguan massif＇s western boundary and/or the Wenchuan-Maoxian fault is vertical, and the hypocenter of the Wenchuan earthquake possibly located at the conjunction point of the NW dipping Yingxiu-Beichuan and Guanxian-Anxian faults, and vertical Wenchuan-Maoxian fault; （4） Vicinity along the Yingxiu- Beichuan fault is characterized by very low velocity and low seismicity at shallow depths, possibly due to high content of porosity and fractures; （5） Two blocks of low-velocity anomaly are respectively imaged in the hanging wall and foot wall of the Guanxian-Anxian fault with a -7 km offset with -5 km vertical component.

关键词： Wenchuan earthquake seismogenic structure micro-seismic tomography Pengguan massif Longmen Shan fault zone

Peptide nucleic acid:a new artificial biomacromolecular with great potential applications in molecular biology and biom edicine

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Chinese Journal of Biomedical Engineering(English Edition) 2001年第4期10卷 165-168页

作者： WANG Jin-ke LU Zu-hong he nong-yue Laboratory for Molecular and Biomolecular Electronics Southeast University Nanjing 210096 China College of Life Sciences Nanjing Normal University Nanjing 210097China Laboratory for Molecular and Biomolecular Electronics Southeast University Nanjing 210096 China

Peptide nucleic acid (PNA) is a DNA mimic that was originally developed by Peter E Nielsen in 1991 as a reagent for sequence-specific recognition of double stranded (ds) DNA by a conventional triple helix type principle.

关键词： PNA acid Peptide nucleic acid

Simultaneous enhancement of energy storage performance and thermal stability of NaNbO_(3)-based ceramics via multi-scale modulation

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Journal of Materiomics 2024年第3期10卷 670-681页

作者： Peng nong Dafu Zeng yue Pan Qinpeng Dong Mingzhao Xu Xiang Wang Jiaming Wang Huanfu Zhou Xu Li Xiuli Chen Key Laboratory of Nonferrous Materials and New Processing Technology Ministry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin541004China

More and more attention is being paid to the environmental friendliness of the dielectric capacitors,which have a rapid charging and discharging speed and steady ***,the low recoverable energy storage density(W_(rec))limits the practical application of dielectric capacitors in solid-state energy storage *** this paper,(1-x)(0.92NaNbO_(3)-0.08Bi(Mg_(0.5)Ti_(0.5)O_(3))-xSrTiO_(3))(x=0.05,0.10,0.15,0.20)energy storage ceramics were fabricated based on various strategies such as nanodomain engineering,component and grain size *** excellent energy storage performance(W_(rec)~6.0 J/cm^(3),η~81.0%)was obtained in ***_(3)could enhance the internal disorder,improve the relaxation properties and increase the breakdown field strength of ***-cantly domain relaxor behavior,as evidenced by Vogel-Fulcher(V-F)model,provides strong evidence for restraining early polarization *** addition,Pulse charge/discharge tests have illustrated that the sample has excellent and stable charge/discharge performance(CD~1,068.9 A/cm^(2),PD~96.1 MW/cm^(3),t0.9 z 0.99 ms)It is concluded that there is a huge prospect of NN-BMT-0.15ST ceramics as a kind of pulsed-power-storing electronics.

关键词： NaNbO_(3) Breakdown field strength Lead-free ceramics Energy storage Power density

An Excellent Gas Chromatographic Stationary Phase for Separation of Phenol and Cresol Isomers--heptakis(2,6-di-O-pentyl-3-O-allyl)-β-Cyclodextrin

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Chinese Chemical Letters 2000年第3期11卷 265-266页

作者： yue Qin ZHANG, Xue Yan SHI, Ruo nong FU (School of Chemical Engineering and Materials Science. Beijing Institute of Technology, Beijing 10008) Beijing Inst Technol Sch Chem Engn & Mat Sci Beijing 100081 Peoples R China

heptakis(2.6-di-O-pentyl-3-O-ally)-β-cyclodextrin as an excellent gas chromatographic stationary phase separating phenol and cresol isomers is described.

关键词： Gas chromatographic stationary phase phenol and cresol isomers heptakis(2.6-di-Opentyl-3-O-allyl)-β-cyclodextrin.

Is oxygen therapy beneficial for normoxemic patients with acute heart failure?A propensity score matched study

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Military Medical Research 2022年第3期9卷 265-276页

作者： yue Yu Ren-Qi Yao Yu-Feng Zhang Su-Yu Wang Wang Xi Jun-Nan Wang Xiao-Yi Huang Yong-Ming Yao Zhi-nong Wang Department of Cardiothoracic Surgery Changzheng HospitalNaval Medical University415 Fengyang RoadHuangpu DistrictShanghai 200003China Trauma Research Center Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General Hospital51 Fucheng RoadHaidian DistrictBeijing 100048China Department of Burn Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China Medical Research Center of War Injuries and Trauma Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Pathology Changhai HospitalNaval Medical UniversityShanghai 200433China

Background:The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure(AHF)who do not have *** aim of this study was to investigate the association between oxygen therapy and clinical outcomes in normoxemic patients hospitalized with AHF using real-world ***:Normoxemic patients diagnosed with AHF on intensive care unit(ICU)admission from the electronic ICU(eICU)Collaborative Research Database were included in the current study,in which the study population was divided into the oxygen therapy group and the ambient air *** score matching(PSM)was applied to create a balanced covariate distribution between patients receiving supplemental oxygen and those exposed to ambient *** regression and logistic regression models were performed to assess the associations between oxygen therapy and length of stay(LOS),and all-cause in-hospital as well as ICU mortality rates,respectively.A series of sensitivity and subgroup analyses were conducted to further validate the robustness of our ***:A total of 2922 normoxemic patients with AHF were finally included in the ***,42.1%(1230/2922)patients were exposed to oxygen therapy,and 57.9%(1692/2922)patients did not receive oxygen therapy(defined as the ambient air group).After PSM analysis,1122 pairs of patients were matched:each patient receiving oxygen therapy was matched with a patient without receiving supplemental *** multivariable logistic model showed that there was no significant interaction between the ambient air and oxygen therapy for all-cause in-hospital mortality[odds ratio(OR)=1.30;95%confidence interval(CI)0.92–1.82;P=0.138]or ICU mortality(OR=1.39;95%CI 0.83–2.32;P=0.206)in the post-PSM *** addition,linear regression analysis revealed that oxygen therapy was associated with prolonged ICU LOS(OR=1.11;95%CI 1.06–1.15;Phe absence

关键词： Acute heart failure Death Hyperoxia Mortality Oxygen therapy

CRISPR-assisted transcription activation by phaseseparation proteins

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Protein & Cell 2023年第12期14卷 874-887页

作者： Jiaqi Liu Yuxi Chen Baoting nong Xiao Luo Kaixin Cui Zhan Li Pengfei Zhang Wenqiong Tan yue Yang Wenbin Ma Puping Liang Zhou Songyang State Key Laboratory of Biocontrol MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging ResearchSchool of Life SciencesSun Yat-senUniversityGuangzhou510275China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510275China Lumiere Therapeutics Suzhou215000China

The clustered regularly interspaced short palindromic repeats(CRISPR)-Cas9 system has been widely used for genome engineering and transcriptional regulation in many different *** CRISPR-activation(CRISPRa)platforms often require multiple components because of inefficient transcriptional ***,we fused different phase-separation proteins to dCas9-VPR(dCas9-VP64-P65-RTA)and observed robust increases in transcriptional activation ***,human NUP98(nucleoporin 98)and FUS(fused in sarcoma)IDR domains were best at enhancing dCas9-VPR activity,with dCas9-VPR-FUS IDR(VPRF)outperforming the other CRISPRa systems tested in this study in both activation efficiency and system ***9-VPRF overcomes the target strand bias and widens gRNA designing windows without affecting the off-target effect of *** findings demonstrate the feasibility of using phase-separation proteins to assist in the regulation of gene expression and support the broad appeal of the dCas9-VPRF system in basic and clinical applications.

关键词： CRISPR transcriptional activation phase-separation proteins