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Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery

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World Journal of Gastroenterology 2005年第47期11卷 7473-7479页

作者： Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza noemí esquivel-callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi Unidad de Investigación Médica en Inmunoquímica Hospital de EspecialidadesCentro Médico Nacional Siglo ⅩⅪInstituto Mexicano del Seguro Social (IMSS)México Laboratorio de Oncología Molecular Unidad de Investigación Médica en Enfermedades OncológicasHospital de OncologíaCentro Médico Nacional Siglo ⅩⅪIMSSMéxico Servicio de Gastrocirugía Hospital de EspecialidadesCentro Médico Nacional Siglo ⅩⅪIMSSMéxico Unidad de Investigación en Epidemiología Clínica Hospital de PediatríaCentro Médico Nacional Siglo ⅩⅪIMSSMéxico

AIM： To evaluate the surface expression of triggering receptor on myeloid cell 1 （TREM-1）, class Ⅱ major histocompatibility complex molecules （HLA-DR）, and the expression of the splicing variant （svTREH-1） of TREM-1 in septic patients and those subjected to major abdominal surgery. METHODS： Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers, svTREM-1 levels were analyzed by RT-PCR. RESULTS： Basal expression of TREM-1 and HLA- DR in healthy volunteers was 35.91±14.75 MFI and 75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant difference between healthy and septic groups （P〈0.05） for both molecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 HFI and 71±13.8% before surgery and 72.65±29.92 MFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different （P = 0.0087） between the samples before and after surgery and svTREM-1 expression was 0.8590± 0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873 MF1 in the healthy, surgical （after surgery） and septic groups, respectively. There was a significant difference （P = 0.048） in svTREM-1 expression between the healthy and surgical groups and the septic group. CONCLUSION： TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response, svTREM-1 expression is significantly increased during sepsis, appearing to be a

关键词： TRFM-1 HLA-DR SIRS CARS Sepsis

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Context-dependent role of sirtuin 2 in inflammation

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Neural Regeneration Research 2025年第3期20卷 682-694页

作者： noemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

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Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 603-611页

作者： Diana Cholico-González noemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño CONACYT-Metallurgy and Materials Research Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico Metallurgy and Materials Research Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico

The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert *** effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron *** with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass *** metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave *** results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing ***,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking.

关键词： magnetite concentrate agave bagasse biomass reduction metallization degree

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Inflammation and cancer

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World Journal of Gastrointestinal Surgery 2012年第3期4卷 62-72页

作者： noemí Eiró Francisco J Vizoso Research Unit Fundación Hospital de Jove

There is evidence supporting the hypothesis that inflammation participates in providing conditions that lead to *** unresolved inflammation due to any failure in the precise control of the immune response can continue to perturb the cellular microenvironment, thereby leading to alterations in cancer-related genes and posttranslational modification in crucial cellular proteins involved in the cell cycle,DNA repair and *** addition,there are data indicating that inflammatory cells and immunomodulatory mediators present in the tumor microenvironment influence tumor progression and ***,tumor-infiltrating leukocytes have been considered to be manifestations of an intrinsic defence mechanism against developing ***,increasing evidence indicates that leukocyte infiltration can promote tumor phenotypes, such as angiogenesis,growth and *** may be due to inflammatory cells that probably can influence cancer promotion by secreting cytokines,growth factors,chemokines and proteases,which stimulate proliferation and invasiveness of cancer ***-quently,events and molecules implicated in this cross talk between the tumor microenvironment and inflam- matory process may emerge as attractive targets in anticancer therapeutic interventions with significant clinical impact.

关键词： Inflammation Cancer Cytokines Proliferation Cancer progression Metastasis

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Comparative Pharmacokinetic Study between Metformin Alone and Combined with Orlistat in Healthy Mexican Volunteers

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Pharmacology & Pharmacy 2012年第3期3卷 300-306页

作者： noemí Santos-Caballero Francisco Javier Flores-Murrieta Landsteiner Scientific S.A. de C.V. México D.F. Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional México D.F. Mexico

Traditional treatment of type 2 diabetes mellitus (T2DM) has focused on correcting hyperglycemia. However, T2DM is almost always accompanied by other conditions and risk factors that affect its morbidity and mortality. Obesity represents one of the main risk factors associated in the T2DM and a modest weight loss around 5% is linked with significant reduction in the blood glucose levels. The objective of this study was to compare the pharmacokinetic parameters between two formulations of metformin, alone or combined with orlistat, in healthy volunteers. A single-blinded, single dose, two-period, two-sequence, crossover, randomized and balanced study design with a 7-day washout period was performed in 26 Mexican volunteers. Plasma samples were collected over a 24-hour period after administration of 500 mg metformin alone or combined with 60 mg orlistat in each period. A validated high-performance liquid chromatography coupled with a ultraviolet detector was used to analyze metformin concentration in plasma. Bioequivalence between metformin alone and metformin combined with orlistat was determined when the ratio for the 90% confidence intervals (CI) of area under the curve (AUC24h) and maximum concentration (Cmax) of the two formulations were within 80% and 125%. In the current study, the mean ± standard deviation (SD) of Cmax, AUC24h and AUC∞ of the formulation containing only metformin were 1.39 ± 0.44 μg/mL, 7.59 ± 3.17 μg h/mL and 8.48 ± 4.13 μg h/mL, respectively, while the mean ± SD of Cmax, AUC24h and AUC∞ of the formulation containing metformin and orlistat were 1.38 ± 0.48 μg/mL, 7.80 ± 2.83 μg h/mL and 9.13 ± 4.29 μg h/mL, respectively. The parametric 90% CI for Cmax and AUC24h were 87.5-109.3 and 88.7-124.7, respectively. These results suggest that both formulations are bioequivalent and there is not pharmacokinetic interaction between metformin and orlistat.

关键词： Metformin Orlistat Diabetes Obesity Bioequivalence Pharmacokinetic

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Chronic model of tympanic perforation in rats with mitomycin C and dexamethasone

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Journal of Otology 2019年第1期14卷 12-16页

作者： Tomás Esteban noemí M.Atucha Jose María Moraleda Joaquín Garcia-Esta? Carmen L.Insausti Javier Moraleda-Deleyto Servicio de Otorinolaringologia Hospital General Universitario Santa Lucia Departamento de Fisiologia Facultad de Medicina Universidad de Murcia Instituto Murciano de Investigacion Biosanitaria Departamento de Medicina Facultad de Medicina Universidad de MurciaInstituto Murciano de Investigacion Biosanitaria ENT Service University Hospital of Lewisham

A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations. A longitudinal study was carried out in rats subjected to incisional myr-ingotomy followed by the application of mitomycin C alone or with dexamethasone. Rats were checked at days 3, 7,1 0,1 4 and weekly thereafter until perforation closure, for up to 6 months. The addition of dexamethasone is a key component in order to obtain a chronic opening. Myringotomies treated w ith saline had a mean healing time of 8.5 days. At 8 weeks, between 62.5% and 77.7% of tympanic membranes treated w ith mitomycin C and dexamethasone remained perforated and at 6 months this number fell to 21.4%. This technique is able to maintain most tympanic membrane perforations patent for at least 8 weeks. This rat model is adequate for its use in preclinical or translational research.

关键词： Animal model Chronic tympanic membrane perforation Mitomycin C Myringotomy Dexamethasone

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Safety and Efficacy of Oral Mirodenafil in Mexican with Erectile Dysfunction

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International Journal of Clinical Medicine 2016年第9期7卷 628-638页

作者： Juan Gerardo Reyes-García noemí Santos-Caballero Francisco Javier Flores-Murrieta Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional Ciudad de México Mexico Landsteiner Scientific S.A. de C.V. Ciudad de México Mexico Unidad de Investigación en Farmacología Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” Ciudad de México Mexico

Erectile dysfunction is treated with 5-phospodiesterase inhibitors as Mirodenafil, which has shown its efficacy and safety in Koreans, however;no information in other populations is available. An open clinical trial study was designed to evaluate the efficacy and safety in real life of a fixed-dose of Mirodenafil in Mexican patients with erectile dysfunction. Forty-seven male patients received a 100 mg tablet of Mirodenafil, during 12 weeks. Primary outcome efficacy measure was the percentage of male patients with successful intercourse. Secondary outcomes measures included patient satisfaction, mood and self-esteem level. Safety assessments included laboratory tests, vital signs, physical examination, 12-lead electrocardiogram recordings, and incidence of adverse events by patients. Oral administration of Mirodenafil improved in an 80% - 90% the number of successful intercourses from 7 to 84 days of treatment. Moreover, patients reported a significant increment in their sexual satisfaction, mood and self-esteem. Mirodenafil treatment did not modify vital signs nor anthropometric parameters during 84 days. Mild headache was the most frequent adverse event (17.0%) and there were no severe adverse events during pharmacological treatment. Data suggest that oral Mirodenafil is safety, well tolerated and effective in the Mexican population with erectile dysfunction.

关键词： Efficacy Erectile Dysfunction Mexicans Mirodenafil Safety

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纳米纤维素纤维对降低高填料再生纸掉毛掉粉的效果

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中国造纸 2017年第11期 79-80页

作者： ANA BALEA ANGELES BLANCO noemíMERAYO CARLOS NEGRO

细小颗粒从纸张表面剥落及其在印刷橡皮布上的积聚(或称掉毛掉粉),是新闻纸印刷中遇到的最复杂的问题之一,且在高填料再生纸中更为严重。纳米纤维素纤维(NFC)通过增加纤维与纤维之间以及纤维内部的结合而成为高填料纸的增强剂具有巨大... 详细信息

细小颗粒从纸张表面剥落及其在印刷橡皮布上的积聚(或称掉毛掉粉),是新闻纸印刷中遇到的最复杂的问题之一,且在高填料再生纸中更为严重。纳米纤维素纤维(NFC)通过增加纤维与纤维之间以及纤维内部的结合而成为高填料纸的增强剂具有巨大的潜力,目前受到极大关注。然而,添加NFC对掉毛掉粉的影响尚未得到研究。本研究的目的是量化NFC对新闻纸掉毛掉粉的影响。通过在含有14%(质量分数)灰分的再生纸的浆中添加不同浓度的PCC和NFC来评估NFC作为掉毛掉粉控制剂的效果。结果表明,添加1.5%(质量分数)的NFC,再生纸的掉毛掉粉减少了47%以上;助留助滤也得到了改善。

关键词：纳米纤维素纤维掉毛掉粉新闻纸再生纸沉淀碳酸钙助留助滤

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Smart Grid Functionalities Evaluation

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Smart Grid and Renewable Energy 2016年第6期7卷 175-189页

作者： Laura Giménez de Urtasun Samuel Borroy Vicente noemí Galán Hernández CIRCE Foundation Zaragoza Spain

In the last years, with the advent of Smart Grids, many research and demonstration projects have seen the light in order to involve electric system in the implementation of advances in information and communication technologies, in order to improve network efficiency, reliability, security and quality of service. Before new implementations are performed, previous results have to be studied, and taken into account. In this line, this work presents the methodology, results and conclusions of the evaluation of the Smart Grid functionalities developed by 5 different DSOs during DISCERN project in order to select the optimal, cost-effective and most replicable solutions for the strategic development of the intelligence at medium voltage (MV) and low voltage (LV) networks.

关键词： Smart Grid Power System Reliability ASIDI KPIs Simulation

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Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina

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World Journal of Gastroenterology 2013年第35期19卷 5813-5827页

作者： noemí del Pino José Raúl Oubia Francisco Rodríguez-Frías Juan Ignacio Esteban María Buti Teresa Otero Josep Gregori Damir García-Cehic Silvia Camos María Cubero Rosario Casillas Jaume Guàrdia Rafael Esteban Josep Quer Apunlab Laboratories Institute of Medical Microbiology and Parasitology (IMPAM) UBA-CONICET Department of MicrobiologyParasitology and Immunology Faculty of Medicine University of Buenos Aires CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos Ⅲ and Biochemistry Department Hospital Universitari Vall d’Hebrón (HUVH) CIBERehd del Instituto de Salud Carlos Ⅲ Autonomous University of Barcelona and Liver Unit Internal Medicine Lab. Malalties Hepatiques Vall d’Hebron Institut de Recerca (VHIR) Hospital Universitari Vall d’Hebrón (HUVH) Unitat de Diagnostic Molecular HUVH Liver Unit Internal Medicine Lab Malalties Hepatiques VHIR-HUVH Roche Diagnostics SL CIBERehd del Instituto de Salud Carlos Ⅲ Liver Unit Internal Medicine Lab MalaltiesHepatiques VHIR-HUVH Liver Unit and Biochemistry Department HUVH

AIM:To study the subtype prevalence and the phylogenetic relatedness of hepatitis C virus(HCV)sequences obtained from the Argentine general population,a large cohort of individuals was ***:Healthy Argentinian volunteers(n=6251)from 12 provinces representing all geographical regions of the country were *** parents or legal guardians of individuals younger than 18 years provided informed written consent for *** corresponding written permission from all municipal authorities was obtained from each city or town where subjects were to be *** RNA reverse transcription-polymerase chain reaction products were sequenced and phylogenetically *** 5’untranslated region(5’UTR)was used for RNA detection and initial genotype *** NS5B polymerase region,encompassing nt 8262-8610,was used for ***:An unexpectedly low prevalence of HCV infection in the general population(0.32%)was *** data contrasted with previous studies that reported rates ranging from 1.5%to 2.5%,mainly performed in selected populations of blood donors or vulnerable *** latter values are in keeping with the prevalence reported by the 2007 Argentinian HCV Consensus(approximately 2%).HCV subtypes weredistributed as follows:1a(25%),1b(25%),2c(25%),3a(5%),and 2j(5%).Two isolates ascribed either to genotype 1(5%)or to genotype 3(5%)by 5’UTR phylogenetic analysis could not be *** 1a sequences comprised a highly homogeneous population and clustered with United States ***1b sequences represented a heterogeneous population,suggesting that this genotype might have been introduced from different *** subtype 2c sequences clustered close to the 2c reported from Italy and Southern ***:HCV has a low prevalence of 0.32%in the studied general population of *** pattern of HCV introduction and transmission in Argentina appears to be a consequence of multiple events and different

关键词： Hepatitis C virus NS5B subtyping Molecular epidemiology Hepatitis C virus Argentina Hepatitis C virus 5’ untranslated region

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