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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1385-1391页

作者： Kazunori Hirasawa nobuyuki shoji Department of Orthoptics and Visual Science School of Allied Health SciencesKitasato UniversitySagamiharaKanagawa 252-0373Japan Department of Ophthalmology School of medicineKitasato UniversitySagamiharaKanagawa 252-0373Japan

AIM：To evaluate the influence of corneal power on circumpapillary retinal nerve fiber layer（cp RNFL）and optic nerve head（ONH）measurements by spectral-domain optical coherence tomography（SD-OCT）.METHODS：Twenty-five eyes of 25 healthy participants（mean age 23.6±3.6y）were imaged by SD-OCT using horizontal raster *** soft contact lenses of different powers（from-11 to＋5 diopters including 0diopter）were worn to induce 2-diopter changes in corneal *** in the cp RNFL and ONH measurements per diopter of change in corneal power were ***：As corneal power increased by 1 diopter,total and quadrant cp RNFL thicknesses,except for the nasal sector,decreased by-0.19 to-0.32μm（P〈0.01）.Furthermore,the disc,cup,and rim areas decreased by-0.017,-0.007,and-0.015 mm2,respectively（P〈0.001）;the cup and rim volumes decreased by-0.0013 and-0.006 mm3,respectively（P〈0.01）;and the vertical and horizontal disc diameters decreased by-0.006 and-0.007 mm,respectively（P〈0.001）.CONCLUSION：For more precise OCT imaging,the ocular magnification should be corrected by considering both the axial length and corneal ***,the effect of corneal power changes on cp RNFL thickness and ONH topography are small when compare with those of the axial length.

关键词： optical coherence tomography ocularmagnification corneal power circumpapillary retinal nervefiber layer optic nerve head

Comparison of magnitude and summated vector mean of surgically induced astigmatism vector according to incision site after phakic intraocular lens implantation

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Eye and Vision 2021年第6期8卷 317-323页

作者： Kazutaka Kamiya Wakako Ando Masahide Takahashi nobuyuki shoji Visual Physiology School of Allied Health SciencesKitasato University1‑15‑1 KitasatoMinamiSagamiharaKanagawa 252‑0373Japan Department of Ophthalmology School of MedicineKitasato UniversitySagamiharaJapan

Background:To compare the arithmetic mean(M-SIA)and the summated vector mean of surgically induced astigmatism(SVM-SIA)according to the incision site after phakic intraocular lens(Visian implantable collamer lens(ICL),STAAR Surgical)***:This study comprised 121 eyes of 121 consecutive patients undergoing ICL surgery through a 3.0-mm temporal or superior clear corneal *** magnitude and the axis of corneal astigmatism preoperatively and 3 months postoperatively were measured using an automated *** M-SIA and the SVM-SIA were determined according to the incision ***:The magnitude of corneal astigmatism significantly increased from 1.23±0.59 D preoperatively to 1.46±0.72 D postoperatively in the temporal incision group(Wilcoxon signed-rank test,P<0.001),but it significantly decreased from 1.09±0.36 D preoperatively to 0.86±0.41 D postoperatively in the superior incision group(P<0.001).The M-SIA was 0.48±0.30 D,and the SVM-SIA was 0.23±0.52 D at a meridian of 82°in the temporal incision *** M-SIA was 0.57±0.30 D,and the SVM-SIA was 0.47±0.45 D at a meridian of 1°in the superior incision ***:ICL implantation induces the M-SIA by approximately 0.5 D,but the SVM-SIA decreased to 50%and 80%of the M-SIA in magnitude through temporal and superior incisions,*** direction of the SVM-SIA showed a tendency toward corneal flattening to the incisional *** should be noted that the M-SIA is somewhat different from the SVM-SIA according to the incision site.

关键词： Surgically induced astigmatism Corneal astigmatism Mean Summated vector mean Centroid Vector analysis Temporal incision Superior incision ICL implantation

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Evaluation of refractive correction for standard automated perimetry in eyes wearing multifocal contact lenses

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1559-1565页

作者： Kazunori Hirasawa Hikaru Ito Yukari Ohori Yui Takano nobuyuki shoji Department of Orthoptics and Visual Science School of Allied Health SciencesKitasato University Department of Ophthalmology School of medicineKitasato University

AIM：To evaluate the refractive correction for standard automated perimetry（SAP）in eyes with refractive multifocal contact lenses（CL）in healthy young ***：Twenty-nine eyes of 29 participants were *** was paralyzed in all participants with 1%cyclopentolate *** was performed using the Humphrey SITA-standard 24-2 and 10-2 protocol under three refractive conditions：monofocal CL corrected for near distance（baseline）;multifocal CL corrected for distance（m CL-D）;and m CL-D corrected for near vision using a spectacle lens（m CL-N）.Primary outcome measures were the foveal threshold,mean deviation（MD）,and pattern standard deviation（PSD）.RESULTS：The foveal threshold of m CL-N with both the24-2 and 10-2 protocols significantly decreased by 2.2-2.5 d B（P〈0.001）,while that of m CL-D with the 24-2 protocol significantly decreased by 1.5 d B（P=0.0427）,as compared with that of *** there was no significant difference between the MD of baseline and m CL-D with the24-2 and 10-2 protocols,the MD of m CL-N was significantly decreased by 1.0-1.3 d B（P〈0.001）as compared with that of both baseline and m CL-D,with both 24-2 and 10-2 *** was no significant difference in the PSD among the three refractive conditions with both the 24-2 and 10-2 ***：Despite the induced mydriasis and the optical design of the multifocal lens used in this study,our results indicated that,when the dome-shaped visual field test is performed with eyes with large pupils and wearing refractive multifocal CLs,distance correction without additional near correction is to be recommended.

关键词： intraocular lens multifocal contact lens refractive correction standard automated perimetry visual field

Comparison of corneal biomechanical properties in normal tension glaucoma patients with different visual field progression speed

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 973-978页

作者： Ying Hong nobuyuki shoji Tetsuya Morita Kazunori Hirasawa Kazuhiro Matsumura Masayuki Kasahara Kimiya Shimizu Department of Ophthalmology Peking University Third Hospital Key Laboratory of Vision Loss and RestorationMinistry of Education Beijing 100191 China Department of Rehabilitation Orthoptics and Visual Science Course Kitasato University School of Allied Health Sciences Sagamihara City 252-0373 Japan Department of Ophthalmology Kitasato University Hospital Sagamihara City 252-0373 Japan Kitasato University Sagamihara City 252-0373 Japan

AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients with well-controlled Goldmann applanation tonometer（GAT） who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were *** and ORA parameters including corneal compensated intraocular pressure（lOPcc）,Goldmann estimated intraocular pressure（lOPg）,corneal hysteresis（CH）,corneal resistance factor（CRF） were *** was tested by Swedish interactive threshold algorithm（SITA）-standard 30-2 *** patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow *** were divided into four groups according to VF change over 3y,and ORA findings were compared between the upper 25th percentile group（slow progression group） and the lower 25th percentile group（rapid progression group）.RESULTS：Eighty-two eyes of 56 patients were *** were 21 eyes（21 patients） each in rapid and slow progression groups ***,lOPcc,lOPg,CH,CRF were 12.1＋1.4 mm Hg,15.8±1.8 mm Hg,12.8±2.0 mm Hg,8.4±1.1 mm Hg,7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg,13.5±2.1 mm Hg,11.2±1.6 mm Hg,9.3±1.1 mm Hg,8.2±0.9 mm Hg respectively in slow progression group（P=0.214,〈0.001,0.007,0.017,0.413,respectively）.In bivariate correlation analysis,lOPcc,lOPcc-GAT and CH were significant correlated with m△MD（r =-0.292,-0.312,0.228 respectively,P =0.008,0.004,0.039 respectively）.CONCLUSION：Relatively rapid VF progression occurred in NTG patients whose lOPcc are rather high,CH are rather low and the difference between lOPcc and GAT are relatively *** lOPcc and lower CH are associated with VF progression in NTG *** study suggests that GAT measures might underestimate the IOP in such patients.

关键词： ocular response analyzer intraocular pressure corneal biochemical properties visual field normal tension glaucoma

iStent inject? and cataract surgery for mild-to-moderate primary open angle glaucoma in Japan: a cost-utility analysis

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 954-961页

作者： Ataru Igarashi Kyoko Ishida nobuyuki shoji Alice Chu Heather Falvey Ru Han Maki Ueyama Yoshie Onishi Unit of Public Health and Preventive Medicine Yokohama City University School of MedicineYokohama 236-0027Japan Ohashi Medical Center Toho UniversityTokyo 153-8515Japan Department of Ophthalmology Kitasato University HospitalKanagawa 252-0375Japan Market Access and Medical Marketing Glaukos SingaporeSingapore 068896Singapore Global Health Economics Glaukos CorpCalifornia 92672USA Health Economics and Outcomes Research Creativ-CeuticalParis 75008France Health Economics and Outcomes Research Creativ-CeuticalTokyo 108-6028Japan

AIM: To evaluate the cost-utility of iStent inject;with cataract surgery vs cataract surgery alone in patients with mild-to-moderate primary open angle glaucoma(POAG) in the Japanese setting from a public payer’s ***: A Markov model was adapted to estimate the cost-utility of iStent inject;plus cataract surgery vs cataract surgery alone in one eye in patients with mild-tomoderate POAG over lifetime horizon from the perspective of Japanese public payer. Japanese sources were used for patients’ characteristics, clinical data, utility, and costs whenever available. Non-Japanese data were validated by Japanese clinical experts. RESULTS: In the probabilistic base case analysis, iStent inject;with cataract surgery was found to be cost-effective compared with cataract surgery alone over a lifetime horizon when using the ￥5 000 000/quality-adjusted life year(QALY)willingness-to-pay threshold. The incremental cost-utility ratio(ICUR) was estimated to be ￥1 430 647/QALY gained and the incremental cost-utility ratio(ICER) was estimated to be ￥12 845 154/blind eye avoided. iStent inject;with cataract surgery vs cataract surgery alone was found to increase costs(￥1 025 785 vs ￥933 759, respectively) but was more effective in increasing QALYs(12.80 vs 12.74) and avoiding blinded eyes(0.133 vs 0.141). The differences in costs were mainly driven by costs of primary surgery(￥279 903 vs ￥121 349). In the scenario analysis from a societal perspective, which included caregiver burden, iStent inject;with cataract surgery was found to dominate cataract surgery ***: The iStent inject;with cataract surgery is a cost-effective strategy over cataract surgery alone from the public payer’s perspective and cost-saving from the societal perspective in patients with mild-to-moderate POAG in Japan.

关键词： iStent inject? glaucoma cataract surgery health-economic model cost-utility

The Effect of Monocular Blur on the Binocular Visual Field

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Open Journal of Ophthalmology 2018年第1期8卷 12-17页

作者： Fusako Fujimura nobuyuki shoji Department of Rehabilitation Orthoptics and Visual Science Course School of Allied Health Sciences Kitasato University Kanagawa Japan Department of Ophthalmology School of Medicine Kitasato University Kanagawa Japan

Purpose/Aim: We aimed to investigate the effect of monocular blur on the binocular visual field. Materials and Methods: A total of 13 healthy young volunteers participated in this study. The mean subjective refractive error of the dominant eye (DE) was -3.33 ± 1.65D, and the non-dominant eye (NDE) was -3.15 ± 2.84D. The DE was determined by using the hole-in-the-card test. The visual field was examined by the Humphrey Visual Field Analyzer using the 30-2 SITA Standard program. The visual field was measured while wearing soft contact lens under three conditions;① both eyes: near vision correction;② DE: near vision correction +3.00D added, NDE: near vision correction;and ③ DE: near vision correction, NDE: near vision correction +3.00D added. The foveal threshold, mean deviation (MD), and pattern standard deviation (PSD) values were investigated. Results: The foveal threshold value (dB) at ①, ②, and ③ was 41.2, 37.8, and 38.1, respectively. The values at ② and ③ were both significantly lower than that at ① (p Conclusion: These results suggest that monocular blur reduced the sensitivity within the binocular visual field.

关键词： Binocular Visual Field Monocular Blur Binocular Inhibition Eye Dominance Humphrey Visual Field Analyze

The Effect of Ocular Dominance on Accommodation and Miosis under Binocular Open Viewing Conditions

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Open Journal of Ophthalmology 2017年第3期7卷 158-166页

作者： Fusako Fujimura Tomoya Handa Takushi Kawamorita nobuyuki shoji Department of Rehabilitation Orthoptics and Visual Science Course School of Allied Health Sciences Kitasato University Kanagawa Japan Department of Ophthalmology School of Medicine Kitasato University Kanagawa Japan

Background/Aims: We investigated the relationship between ocular dominance and accommodation on the pupils of the dominant eye and the non-dominant eye under binocular open viewing conditions. Methods: Seventeen healthy young volunteers participated in this study. The dominant eye was determined using the hole-in-the-card test. The objective refraction and pupil diameter were measured under binocular open viewing and monocular single viewing conditions using a binocular open auto-refractor, the WAM-5500 (SHIGIYA MACHINERY WORKS LTD., Hiroshima, Japan). The accommodative response was calculated using the objective refraction, and the rate of miosis was calculated using the pupil diameter. These values were then compared between the dominant and the non-dominant eyes. Results: Under binocular open viewing conditions, the accommodative response in the dominant eye was greater than in the non-dominant eye (p = 0.001). In contrast, under monocular single viewing conditions, there were no differences in the accommodative response between the dominant and non-dominant eyes. In both binocular open viewing and monocular single viewing conditions, there were no differences in the miosis ratio between the dominant and non-dominant eyes. Conclusion: These results suggest that the accommodative response under binocular open viewing conditions is influenced by ocular dominance.

关键词： Ocular Dominance Binocular Vision Open Viewing Conditions Accommodation

Comparison of the Normal, Preperimetric Glaucoma, and Glaucomatous Eyes with Upper-Hemifield Defects Using SD-OCT

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Open Journal of Ophthalmology 2015年第4期5卷 167-173页

作者： Fusako Fujimura nobuyuki shoji Kazunori Hirasawa Kazuhiro Matsumura Tetsuya Morita Kimiya Shimizu Department of Rehabilitation Orthoptics and Visual Science Course School of Allied Health Sciences Kitasato University Tokyo Japan Department of Ophthalmology School of Medicine Kitasato University Tokyo Japan

Purpose: We compared the thickness of circumpapillary retinal nerve fiver layer (cpRNFL) and macular ganglion cell layer with inner plexiform layer (GCL + IPL) using Cirrus HD-OCT (Ver.6.0: Carl Zeiss). Materials and Methods: This study included 12 eyes of normal controls, 10 eyes of preperimetric glaucoma (PPG) with loss of RNFL either in superior or in inferior hemisphere without visual field defects, and 22 eyes of glaucoma eyes with visual field defects restricted to upper hemifield (UHFD: early 10 eyes, severe 12 eyes). The cpRNFL thickness analyzed from disk center by dividing into 12 sectors. The GCL + IPL thickness analyzed from central fovea by dividing into six sectors. Both compared between normal eye group and other 3 groups using the average value of each sectors. Result: The cpRNFL and the GCL + IPL thickness were obviously thin as compared with normal eyes. Conclusion: Even if it is in the state where abnormalities are not detected using the Humphrey field Analyzer, it is suggested that the early structural change of glaucoma has already arisen.

关键词： Glaucoma Ganglion Cell Layer Inner Plexiform Layer Retinal Nerve Fiver Layer SD-OCT

Switching Study of Tafluprost/Timolol Fixed-Combination Ophthalmic Solution, Following Unfixed Combination of Tafluprost Ophthalmic Solution 0.0015% and Timolol Ophthalmic Gel-Forming Solution 0.5%

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Open Journal of Ophthalmology 2019年第4期9卷 168-182页

作者： Kazuhiro Matsumura Masayuki Kasahara Yoshiaki Ichibe Rie Amano Hiroko Kasugai Yayoi Yamakawa Masayo Hashimoto nobuyuki shoji Department of Ophthalmology School of Medicine Kitasato University Sagamihara Kanagawa Japan Department of Ophthalmology Tomei Atsugi Clinic Atsugi Kanagawa Japan Department of Ophthalmology Kanagawa Dental University Yokohama Clinic Yokohama Kanagawa Japan Department of Ophthalmology Toshiba Rinkan Hospital Sagamihara Kanagawa Japan Department of Ophthalmology Sagamino Hospital Sagamihara Kanagawa Japan Department of Ophthalmology Yamato Municipal Hospital Yamato Kanagawa Japan Japan Medical Affairs Santen Pharmaceutical Co. Ltd. Osaka Osaka Japan

Purpose: Fixed-combination medication to treat glaucoma can reduce intraocular pressure (IOP) without negative effects of concomitant medication. Tafluprost/timolol fixed-combination ophthalmic solution (TTFC) has been reported to show similar effectiveness in lowering IOP, compared with concomitant use of its component drugs, tafluprost and timolol. However, the difference in IOP-lowering effects between TTFC and concomitant use of tafluprost and gel-forming timolol is unknown. Hence, we conducted this switching study from tafluprost and gel-forming timolol to TTFC in glaucoma patients undergoing multi-drug therapy. Design: Multi-center, open-label, interventional clinical study. Methods: Twenty-eight patients (28 eyes;safety analysis set) with primary open-angle glaucoma and ocular hypertension, who had completed the 4-week-concomitant phase of tafluprost and gel-forming timolol, were treated for 8 weeks with TTFC. IOP, adherence, ocular surface safety, and the usability of ophthalmic solution were compared before and after switching. This study was approved by the ethics committees of Kitasato University Hospital and all other study sites. All patients provided written informed consent to participate. Results: IOP at 8 weeks after switching was significantly lower than before switching (P = 0.0001) in the efficacy analysis set (n = 24). The self-reported adherence rate remained high after switching;moreover, there was no meaningful change in ocular surface safety. Patient questionnaires regarding usability of medication revealed that 85.7% of patients preferred their instillation prescription after switching, including TTFC. Among the safety analysis set (n = 28), no adverse events were reported in relation to the study drug. Conclusion: TTFC showed greater IOP reduction than concomitant therapy. Thus, TTFC may be a better option in glaucoma patients than concomitant therapy.

关键词： Glaucoma Intraocular Pressure Switching Tafluprost/Timolol Fixed-Combination Timolol Gel-Forming Solution

Analysis of in-bore balloting and control of jump variability

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Defence Technology（防务技术） 2019年第5期15卷 721-734页

作者： Satoru shoji Wakayama-dai ShimamotoOsakaJapan21-104

The variability of projectile jump is the long-term issue to improve weapon *** we have many simulation codes to predict ***,these codes cannot explain explicitly how the variability of jump *** aims of this paper are,(1)to give fundamental explanations for the variability of Jump,and (2)to offer design factors to make the variability of Jump *** model presented here was formulated in accordance with the transition of the system in reverse way commencing from the target impact stage to the chambering *** of the simulation are generic 120mm smooth bore and long rod system which are extremely simplified to the vibration of tube,the spring effect by sabot,and the free-ends beam of *** calculations clarified that high Jump-variability is generated only when the last rebound is on the muzzle *** particular state of rebound is achieved by many combinations of *** map named JV-Chart is proposed to show the high Jumpvariability zone.

关键词： Jump variability Coupled vibration In-bore balloting Cantilever tube