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World Journal of Gastroenterology 2021年第1期27卷 129-142页

作者： Takeshi Okamoto Takaaki Yoshimoto nobuyuki ohike Aoi Fujikawa Takayoshi Kanie Katsuyuki Fukuda Department of Gastroenterology St.Luke's International HospitalTokyo 104-8560Japan Department of Pathology Shizuoka Cancer CenterShizuoka 411-8777Japan Department of Surgery St.Luke’s International HospitalTokyo 104-8560Japan Department of Cardiology St.Luke’s International HospitalTokyo 104-8560Japan

BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely *** report the first case of spontaneous regression of gastric *** SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed *** tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle *** esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 *** removal of the abdominal mass confirmed it to be a metastatic gastrinoma *** gastric lesion was subsequently diagnosed as primary gastric *** months later,the gastric lesion had disappeared without *** patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of *** Gastric gastrinoma may arise as a polypoid lesion in the gastric *** regression can rarely occur after biopsy.

关键词： Neuroendocrine neoplasm Functional tumor Biopsy Gastrin Stomach Case report

Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 86-90页

作者： Kyoko Kashima nobuyuki ohike Seishiro Mukai Masashi Sato Manabu Takahashi Toshio Morohoshi Department of Pathology Showa University School of Medicine Department of Internal MedicineShowa University Toyosy Hospital Department of Pathology Showa University School of Medicine Department of Pathology Showa University School of Medicine Department of SurgeryShowa University School of Medicine Division of Pathology Ebara HospitalTokyo Japan

BACKGROUND: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis. We examined maspin expression immunohistochemically and assessed its significance in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. METHODS: We examined 39 surgically resected specimens of IPMN that included 17 adenomas (IPMAs), 5 borderline tumors (IPMBs), 4 non-invasive carcinomas (non-invasive IPMCs), and 13 invasive carcinomas (invasive IPMCs). Immunostaining was performed according to the EnVision ChemMate method. The degree of maspin expression was scored and assessed according to the percentage and staining intensity of positive cells. RESULTS: Maspin expression was minimal in normal pancreatic duct epithelium, whereas in IPMNs, maspin was expressed in neoplasms of all stages. Maspin expression increased with increasing grade from IPMAs, IPMBs, to non-invasive IPMCs but decreased significantly in invasive IPMCs. No specific association between maspin expression and mucin type was found. Analysis of maspin expression with respect to clinicopathologic factors in cases of invasive IPMC revealed a greater extent of invasion in cases of low maspin expression and significantly fewer apoptotic cells in the ***: Maspin was expressed at high levels in IPMNs at various stages from adenoma to invasive carcinoma, and our results suggest that maspin may be involved in the occurrence and progression of IPMN. In addition, our data suggest that the apoptosis-inducing action of maspin suppresses invasion and progression of IPMN.

关键词： maspin intraductal papillary mucinous neoplasm pancreas apoptosis immunohistochemistry

Gastric-and intestinal-type marker expression in invasive ductal adenocarcinoma of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 424-428页

作者： Yuichi Takano nobuyuki ohike Takuma Tajiri Kunio Asonuma Kenji Harada Hiroshi Takahashi Toshio Morohoshi First Department of Pathology Showa University School of MedicineTokyo 142-8555Japan Division of Gastroenterology KanagawaJapan Department of Diagnostic Pathology KanagawaJapan

BACKGROUND:Although invasive ductal adenocarcinoma of the pancreas(PDAC) manifests as a relatively uniform histomorphological feature of the pancreatobiliary type,it may be complicated by metaplastic changes and heterogeneous gastric and intestinal *** study aimed to investigate the complication rate and clinicopathological significance of such heterogeneous ***:Fifty-nine patients who underwent resection of PDAC were examined in this ***,tumors showing high expression(>25%) of the intestinal-type(INT) marker CDX2 were classified as PDAC with *** with high expression(>25%) of the gastric-type(GAS) marker MUC5AC were classified as PDAC with GAS,while those with high expression of both markers were classified as PDAC with INT/*** patients were compared with those with PDAC of the negative group in which neither markers was highly expressed to examine their clinicopathological ***:In the 59 patients,31(52.5%) showed high CDX2 or MUC5AC ***-eight patients(47.5%) belonged to a negative group,11(18.6%) to a PDAC with INT group,15(25.4%) to a PDAC with GAS group,and 5(8.5%) to a PDAC with INT/GAS *** significant differences were observed for age,gender,size,localization,T classification,or prognosis among the four *** the PDAC with GAS group had well differentiated types significantly more than the other groups,the rate of lymph node metastasis in this group was significantly higher(PDAC with GAS:73%;other groups:36%).CONCLUSION:Complications with heterogeneous elements are not uncommon in PDAC,and this should be considered during the diagnosis and treatment of PDAC along with histogenesis of the disease.

关键词： ductal adenocarcinoma pancreatic neoplasms gastric-type intestinal-type immunohistochemistry

Right colon cancer presenting as hemorrhagic shock

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World Journal of Gastrointestinal Pathophysiology 2011年第1期2卷 15-18页

作者： Tomoyuki Iwata Kazuo Konishi Takahisa Yamazaki Katsuya Kitamura Atsushi Katagiri Takashi Muramoto Yutaro Kubota Yuichiro Yano Yoshiya Kobayashi Toshiko Yamochi nobuyuki ohike Masahiko Murakami Takehiko Gokan Nozomi Yoshikawa Michio Imawari Division of Gastroenterology Department of MedicineShowa University School of Medicine Second Department of Pathology Showa University School of Medicine First Department of Pathology Showa University School of Medicine Division of Gastroenterogical Surgery Department of SurgeryShowa University School of Medicine Department of Radiology Showa University School of Medicine Endoscopic Center Showa University HospitalShowa University School of Medicine

A 67-year-old man visited our hospital with a history of continuous hematochezia leading to hemorrhagic *** abdominal computed tomography scan re-vealed a large mass in the ascending colon invading the duodenum and pancreatic head as well as extra-vasation of blood from the gastroduodenal artery(GDA) into the *** revealed an irregular ulcerative lesion and stenosis in the ascending ***,right hemicolectomy combined with pylorus-preser ving pancreaticoduodenectomy was ***,the tumor was classified as a moderately differentiated ***,cancer cells were mainly located in the colon but had also invaded the duode-num and pancreas and involved the ***,the tumor cells were positive for cytokeratin(CK)20 and carcinoembryonic antigen(CEA)but not forCK7 and carbohydrate antigen(CA)*** patient died 23 d after the surgery because he had another episode of arterial bleeding from the anastomosis *** En bloc resection of the tumor with pancreatico duodenectomy and colectomy performed for locally advanced colon cancer can ensure long-term survival,patients undergoing these procedures should be carefully monitored,particularly when the tumor involves the main artery.

关键词： Colon cancer Hemorrhagic shock Adjacent organs invasion En bloc resection Complication

FE FORMULATION FOR THE VISCOELASTIC BODY MODELED BY FRACTIONAL CONSTITUTIVE LAW

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Acta Mechanica Sinica 2001年第4期17卷 354-365页

作者：张卫 nobuyuki Shimizu Institute of Applied Mechanics Jinan UniversityGuangzhou 510632China Department of Mechanical Engineering Iwaki Meisei UniversityJapan

This paper presents finite element (FE) formulation of the viscoelastic materials described by fractional constitutive law. The time-domain three-dimensional constitutive equation is constructed. The FE equations are set up by treating the fractional operator as a special case of the hereditary integration. The equations are solved by numerical integration method. The numerical algorithm developed by the authors for Liouville-Riemann's fractional derivative was adopted to formulate FE procedures and extended to solve the more general case of the hereditary integration. The numerical examples were given to show the correctness and effectiveness of the integration algorithm.

关键词： viscoelasticity fractional calculus FEM polymer materials

Large Deformation Analysis and Synthesis of Elastic Closed-loop Mechanism Made of a Certain Spring Wire Described by Free Curves

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 756-762页

作者： IWATSUKI nobuyuki KOSAKI Takashi Department of Mechanical Sciences and Engineering Graduate School of Science and EngineeringTokyo Institute of Technology

Recently novel mechanisms with compact size and without many mechanical elements such as bearing are strongly required for medical devices such as surgical operation devices. This paper describes analysis and synthesis of elastic link mechanisms of a single spring beam which can be manufactured by NC coiling machines. These mechanisms are expected as disposable micro forceps. Smooth Curvature Model（SCM） with 3rd order Legendre polynomial curvature functions is applied to calculate large deformation of a curved cantilever beam by taking account of the balance between external and internal elastic forces and moments. SCM is then extended to analyze large deformation of a closed-loop curved elastic beam which is composed of multiple free curved beams. A closed-loop elastic link is divided into two free curved cantilever beams each of which is assumed as serially connected free curved cantilever beams described with SCM. The sets of coefficients of Legendre polynomials of SCM in all free curved cantilever beams are determined by taking account of the force and moment balance at connecting point where external input force is applied. The sets of coefficients of Legendre polynomials of a nonleaded closed-loop elastic link are optimized to design a link mechanism which can generate specified output motion due to input force applied at the assumed dividing point. For example, two planar micro grippers with a single pulling input force are analyzed and designed. The elastic deformation analyzed with proposed method agrees very well with that calculated with FEM. The designed micro gripper can generate the desired pinching motion. The proposed method can contribute to design compact and simple elastic mechanisms without high calculation costs.

关键词： elastic link mechanism closed-loop spring beam large deformation analysis smooth curvature model force balance equation synthesi

An Inverse Problem of Determining Coefficients in a One-Dimensional Radiative Transport Equation

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Advances in Applied Mathematics and Mechanics 2014年第4期6卷 515-522页

作者： nobuyuki Higashimori Faculty of Engineering Shibaura Institute of Technology307 FukakusaMinumaSaitamaJapan

We consider an inverse problem of determining unknown coefficients for a one-dimensional analogue of radiative transport *** show that some combination of the unknown coefficients can be uniquely determined by giving pulse-like inputs at the boundary and observing the corresponding *** result can be applied for determination of absorption and scattering properties of an optically turbid medium if the radiative transport equation is appropriate for describing the propagation of light in the medium.

关键词： Inverse problem radiative transport equation first-order hyperbolic system optical tomography

DISTRIBUTED WATER BALANCE WITH RIVER DYNAMIC-DIFFUSIVE FLOW ROUTING MODEL

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Journal of Hydrodynamics 2009年第4期21卷 564-572页

作者： HASSAN Ahmed NORIO Tanaka nobuyuki Tamai Graduate School of Science and Engineering Saitama University Graduate School Kanazawa Gakuin University

This article focuses on the application of coupling both river dynamic and river diffusive modeling techniques that can be used with distributed water balance model. In an upstream watershed, both overland and river diffusive flows are routed by diffusive wave approximation of the free surface flow equations. In river downstream reaches, the river dynamic flow is routed by one-dimensional dynamic wave equations （full dynamic St. Venant equations with lateral flow）. The developed model is applied in a part of Arakawa River basin, Kanto area, Japan. The geographic data of river cross sections could be accurately represented by an 11-point cross-section approximation. The effects of both the grid size and lateral flow on the simulated results of the river dynamic flow model were studied. The grid size should be greater than the average width of the river cross-sections. The lateral flow from small drainage systems has significant effects on the simulated results using the river dynamic flow model. The simulated results show good and acceptable agreements with the observed flow discharges and water depths. Both the river discharge and water depth at any location of river network of compound channels with one/two complex floodplains could be correctly estimated.

关键词： diffusive model dynamic model natural compound channels floodplains

DEM simulation of polydisperse systems of particles in a fluidized bed

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Particuology 2009年第1期7卷 9-18页

作者： nobuyuki Tagami Ajit Mujumdar Masayuki Horio Bio Applications and Systems Engineering Tokyo University of Agriculture & TechnologyNaka-choKoganei-shiTokyo 184-8588Japan

Numerical simulations based on three-dimensional discrete element model （DEM） are conducted for mono-disperse, binary and ternary systems of particles in a fluidized bed. Fluid drag force acting on each particle depending on its size and relative velocity is assigned. The drag coefficient corresponding to Ergun＇s correlation is applied to the system of fluidized bed with particle size ratios of 1：1 for the mono-disperse system, 1：1.2, 1：1.4 and 1：2 for the binary system and 1：1.33：2 for the ternary system by keeping total volume and surface area of the particles constant. Results indicated that a reasonable estimation of drag force based on individual particle diameters as compared to that of the mean diameter of the particles is achieved in the fluid cells. The total translational kinetic energy of the particles is found to increase as the particle size ratio increases, suggesting an enhanced momentum transfer in polydisperse particle systems. Systems with wide particle size distribution exhibited higher particle velocities around bubbles, resulting in faster bubble growth and its subsequent rise through the fluidized bed.

关键词： Discrete element method Fluid drag force Fluidized bed Particle size distribution

Protein-loosing enteropathy associated with rotavirus infection in an infant

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World Journal of Gastroenterology 2008年第10期14卷 1630-1632页

作者： Tadashi Iwasa nobuyuki Matsubayashi Department of Pediatrics Mie University Graduate School of Medicine Tsu Mie Japan Department of Pediatrics Shima Prefectural Hospital Shima Mie Japan

Rotavirus is an acute enteric pathogen in infants and children. We reported a rare case of a 6-mo-old infant with protein-loosing enteropathy (PLE) caused by rotavirus gastroenteritis, and evaluated the immunological profile in peripheral blood lymphocytes. Laboratory examinations showed lymphopenia, hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and elevation of alpha-1-antitrypsin (α1-AT) clearance. Lymphocytes subpopulation study revealed the reversal of CD4+/CD8+ ratio with the selective decrease of CD4- positive lymphocytes. Moreover, the excessive increase of T cells producing IFN-gamma (IFN-γ) was found, which plays an important role in the protection against viral infection. The primary or secondary activation of immune system by rotavirus may influence structural integrity and vascular permeability, which may play a triggering role in protein-loosing enteropathy.

关键词： Protein-loosing enteropathy Rotavirus Lymphocytes producing IFN-γ Alpha-1-antitrypsin Reversal of CD4+/CD8+ ratio