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中日战争与日德中苏关系

社会科学研究 2010年第2期 160-167页

作者：田岛信雄日本成城大学法学部日本东京157-8511

中国国民党第一次全国大会(1924年)前后,孙文等国民党领导为了对抗英美日,明确了与苏联、德国合作的姿态(反凡尔赛体系即华盛顿体制)。但1941年12月太平洋战争爆发,中国为与日本对抗,求助于英美及苏联的合作。反过来,日本为对抗英美,与... 详细信息

中国国民党第一次全国大会(1924年)前后,孙文等国民党领导为了对抗英美日,明确了与苏联、德国合作的姿态(反凡尔赛体系即华盛顿体制)。但1941年12月太平洋战争爆发,中国为与日本对抗,求助于英美及苏联的合作。反过来,日本为对抗英美,与德国联合,对苏联保持中立,与中国一边进行战争,一边摸索和平的道路。本文从日德中苏关系的框架来考察这段时期内国际政治的联合关系的复杂推移。

关键词：中德苏合作构想德国的对中国军事合作 “第二次日德战争” 纳粹德国的 “亲华分子” “日德意苏中”合作构想

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利用GSI数字制图数据进行机助等高线综合

地图 1990年第1期 29-31页

作者： nobuo NAGAI 万晓霞

本文论述了利用国土地理院(GSI)的数字制图数据来进行等高线的综合。我们用一种简化法和三种光滑法进行了试验,得到一些成果。运用这些方法,我们能得到实用的等高线,对于方法的确定和参数的固定则需要更多的数据。

关键词：数学制图数据机助等高线国土地理院 GSI

Maternal Bias of Immunity to Her Offspring: Possibility of an Autoimmunity Twist out from Maternal Immunity to Her Young

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第1期3卷 40-55页

作者： nobuo Yamaguchi Takafumi Takei Rui Chen Palidan Wushuer Wen Hsin Wu Department of Serology Kanazawa Medical University Uchinada Japan Ishikawa Natural Medicinal Products Research Center Foundation Fukubatake Kanazawa Japan Taipei Medical Uni- versity Medical School College of Medicine Taipei City Taiwan Tongji Medical College Huazhong University of Science and Technology Wuhan China Xinjiang Medical University affiliated hospital of traditional Chinese Medicine Urumqi City China

The major interest in materno-foetal relation is why fetus is not rejected by the mother, even in a different genetic background. But in this article we have been investigating about the effect(s) of maternal antigenic stimulation or infection upon the active immune responses in her offspring. The results of various researchers have certainly pose significant problems as to the defense of infants against infectious agents, especially those introduced by their mothers. But we have already reported that maternal antigenic stimulation greatly suppresses the specific immune response of the offspring in a system of mouse vs. heterologous erythrocytes and other T-dependent antigens. This suppression was antigen specific and effective on 1/6 life of rodents. The mechanisms that concerned in this suppression were not antigen administered nor antibody produced in the mother. The supporting evidences were that this suppression was MHC restricted and limited in during pregnancy for induction between mother and her young. The system examined was separating genetic backgrounds that the haplotype was different in F2 family where half of the young were identical but not in remainder to the F1 mother mouse. From this backcross system, this suppression was MHC restricted, suggesting cell to cell contact with mother to her young. Moreover, cytokine level in both mother and her young, IFN-g levels was up-regulated in such a young whose mother was immunized with antigen. The significance of this phenomenon were accessed as biological and medical intervention especially for the mother and infant health care and prevention of hypersensitivities, autoimmune syndrome for her young after delivery.

关键词： Pregnancy Materno-Foetal Relation Maternal Bias of Immunity Active Immune Suppression MHC Restricted Suppression Lymphocyte Trafficking Micro Chimerism Morning Sickness

Fermented Ethnic Medicine (<i>Pueraria mirifica</i>) Designed by Lactobacillus Regulated Leukocyte Subsets via Activation of Complement Components

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第1期7卷 65-79页

作者： Yoshiichiroh Mastuba Kazuhiro Okamoto Yuma Kato nobuo Yamaguchi Sumiyo Akazawa-Kudoh Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Department of Rehabilitation Kanazawa Medical University Uchinada-machi Japan Department of General Medicine Kanazawa Medical University Ishikawa Japan

A plant fermentation was carried out by Lactobaccilli against the Rhizome from Pueraria milifica (f-PMF). This material was evidenced by safe in animal toxic study. The main aim of this study was to revise the traditional way of hot water extraction to fermentation so as to use up the original material and finding new activity. We tried to show the new activity through phytoestrogen and immune-competent cells from the host that administrated either of original remedy and the new fermented sample, plus activated water SRE. In mice, compromised host was prepared by cancer chemotherapeutic agent (Mitomycin-C). After administration of f-PMF to immno-suppressed animals, the effects by both samples were augmented by lymphocyte in number and functions, macrophage activities, anti-oxidative activity. However, the intense of effect was much more by fermented one but not by conventional one. The anti-oxidative assay was also carried out ex-vivo system by peritoneal macrophage that we proposed as suitable system for evaluating anti-oxidative assay. In our clinical study by 20 healthy volunteers, granulocyte and lymphocyte ratio was regulated as neutral in peripheral white blood cells, increasing one, two and three weeks after the administration of f-PMF. We have found the significant regulation of blood chemical factors that were important makers for the lifestyle-related diseases. The mechanism of augmentation by probing directory with immuno-electrophoretic method, generating new complement component, especially found by alternative pathway of complement. So we discussed the process concerning designed f-PMF molecule for activation of complement component and bound for the biological activity of each physical component. In a limited condition, fewer numbers of volunteers, the breast size was tending to increase along with the administration time. Including these evidences, we discussed the possibility of this traditional ethnic medicine, originally found and spread in the hi

关键词： Family Pueraria Fermentation Lactobacilli Cancer Chemotherapeutic Agent Immune-Compromised Host Lymphocyte Granulocyte Ant-Oxidative Activity Complement Alternative Complement Activation

Novel isolated cecal pouch model for endoscopic observation in rats

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World Journal of Gastroenterology 2015年第17期21卷 5242-5249页

作者： Kurodo Koshino nobuo Kanai Masayuki Yamato Teruo Okano Masakazu Yamamoto Institute of Gastroenterology School of SurgeryTokyo Women’s Medical UniversityShinjuku-kuTokyo 162-8666Japan Institute of Advanced Biomedical Engineering and Science Tokyo Women’s Medical UniversityShinjuku-kuTokyo 162-8666Japan

AIM:To create a new rat model for drug administration,cell transplantation,and endoscopic examination for the treatment of intestinal ***:F344/NJc l-rnu/rnu rats(10-wk-old males,350-400 g) were used in this *** rats were anesthetized via 2% isoflurane *** rat's cecum was isolated from the intestines,and a pouch was *** remainder of the intestines was rejoined to create an *** "side-to-side" anastomosis(SSA) technique initially involves the creation of a 2-cm longitudinal incision into each intestinal *** create an anastomosis along the ileal and colonic walls,both intestines were cut,and a continuous suture procedure was performed that included all layers of both *** serous membrane was sutured along the edge and on the anterior wall of the *** "end-toend" anastomosis(EEA) technique was compared with the SSA *** the EEA technique,the frontal surfaces of both cut intestinal lumens were joined together by continuous *** sutures were made at the *** the anastomotic intestine was successfully constructed,the two intestinal lumens that were cut at the isolated cecum were *** addition,one luminal side of the pouch remained open to create an artificial anus on the dorsum as a passage for the residual substances in the ***,small animal endoscopy was used to observe the inside of the ***:In this animal model,mucus and feces are excreted through the reconstructed ***,the cecal pouch mucosa was not obstructed or contaminated by feces,thus facilitating observations of the luminal surface of the *** endoscopic observation of the cecal pouch provided clear visualization given the absence of *** membrane surface of the cecum was clearly *** methods of creating an anastomotic intestine,the "SSA" and "EEA" techniques,were compared with regard to animal survival rate,complication rate,and operation *** S

关键词： Animal model Anastomosis Endoscopy Cecal pouch Microsurgery

Simplified Bernoulli Formula to Diagnose Ischemia-Causing Stenosis at Coronary CT Angiography: Comparison with SPECT

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Advances in Computed Tomography 2019年第2期8卷 11-23页

作者： nobuo Tomizawa Hiroaki Arakawa Kodai Yamamoto Shinichi Inoh Takeshi Nojo Sunao Nakamura Department of Radiology New Tokyo Hospital Tokyo Department of Cardiology New Tokyo Hospital Tokyo

Purpose: To compare the diagnostic performance of estimated energy loss (EEL) calculated using a simplified Bernoulli formula at coronary computed tomography (CT) and single photon emission computed tomography (SPECT) to diagnose ischemia-causing stenosis by invasive fractional flow reserve (FFR). Methods: We retrospectively included 43 patients who underwent coronary CT, SPECT, and FFR measurement by catheter within 3 months. When an intermediate stenosis (40% - 70%) was present at CT, EEL was calculated using the following parameters: lesion length, diameter stenosis, minimal lumen area, and the myocardial volume. An EEL > 1.17 or diameter stenosis > 70% was determined ischemic. Stress-induced ischemia by SPECT was determined when a perfusion defect at stress was accompanied with a fill-in at rest. An FFR ≤ 0.80 or diameter stenosis >70 % was determined as ischemic by catheter. Results: A total of 26 vessels were determined as ischemic by catheter exam. The per-vessel sensitivity and specificity of EEL and SPECT were 81% vs 42% and 92% vs 91%, respectively. The accuracy of EEL to diagnose stenosis causing ischemia was significantly higher than SPECT (90% vs 81%, p = 0.04). The area under the curve of the receiver operating characteristics curve was also significantly higher for EEL than SPECT (0.86 vs 0.67, p Conclusions: EEL showed higher accuracy than SPECT to diagnose ischemia-causing stenosis by improving the sensitivity.

关键词： Coronary Computed Tomography Angiography Estimated Energy Loss Fractional Flow Reserve

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血液凝固与纤维蛋白溶解

血栓与止血学 1997年第4期4卷 176-182,167页

作者： nobuo SAKUTAGAWA Dept. of Clinical Laboratory Medicine Toyama Medical and Pharmaceutical University 2630-Sugitani Toyama-city 930-01 Japan MD. PhD

导言血液凝固之研究早已始于20世纪初期,但有关止血机制筛选的实验方法,仅在1960年才开始建立,并被临床实验室广泛采用。随后,出血倾向与血友病的拟诊,亦基于这些结果的报告与分析。由于标记技术的发展,吾人对凝血机制使用了分子标记... 详细信息

导言血液凝固之研究早已始于20世纪初期,但有关止血机制筛选的实验方法,仅在1960年才开始建立,并被临床实验室广泛采用。随后,出血倾向与血友病的拟诊,亦基于这些结果的报告与分析。由于标记技术的发展,吾人对凝血机制使用了分子标记,俾使临床能得到早期、正确的诊断,对血栓与出血的病人始可作出适宜的治疗。 1 止血机制 “衰老来自于血管壁”,故吾人宜注意保持血管壁的健康使其情况良好。血液流经血管,并通过其未端抵达身体各处,以供给氧气与营养物质。但当出血时,凝血机制活化形成纤维蛋白使失血停止,并保获机体不受感染。在正常情况下。

关键词：血液凝固与纤维蛋白溶解肝素辅因子止血机制分子标记物纤溶酶凝血酶凝血机制血栓与止血血栓形成血管壁

DESIGN OF ELECTRODES IN GEOMETRICAL CONTROL TYPE ELECTROLYZER FOR OXIDE ELECTROWINNING PROCESS

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DESIGN OF ELECTRODES IN GEOMETRICAL CONTROL TYPE ELECTROLYZE...

A New Activated Water Charged by Electrophoresis, Effect on the Experimentally Immuno-Suppressed Animal and Their Anti-Oxidative Activity

第十三届国际核工程大会

作者： nobuo Okamura Kenji Koizumi Tadahiro Washiya Shinnichi Aose Japan Nuclear Cycle Development Institute

As a part of the feasibility study on commercialized fast reactor cycle systems being progressed since July 1999 around Japan Nuclear Cycle Development Institute(JNC) in Japan,the conceptual design

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Open Journal of Immunology 2015年第3期5卷 122-132页

作者： Yasuteru Eguchi nobuo Yamaguchi Nurmuhamamt Amat Dilxat Yimit Parida Hoxur Kei Yokokawa Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Department of Fundament Research for CAM Kanazawa Medical University Ishikawa Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumqi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumqi China

Every individuals expose to the lisk of conventional immunodeficiency in daily life with both internal and externals. In a series of investigation, we have been assessed the various health promoting menu such as hot spring hydrotherapy, acupuncture & moxibution, light excurse, evidenced Control water western medicine technique. In this report, we try to investigate the regulatory effect of hydrotherapy by activated water molecule as our representative menu under the influence of hypothalamus system. We set up both animal and human model for assessment of hydrotherapy. Before starting experimental assessment, six males and females seven-week-old ddY mice, are used for the acute oral toxicity study. There is no sign for toxicity as judged by body weight, organ inspection by veterinary doctor. Next, young ddY mice are experimentally induced diabetes and immune-deficient status by administrating cancer chemotherapeutic agent, Streptzotosin. Charged Water was evident to control the blood sugar level compared to the Control Water group together with conventional control group. Both experimental group of mice wear statistically significant for recovery from blood sugar level and antibody secreting cell both IgM and IgG plaque-forming cell. We confirm also activated water group delivered the granulocyte that slow down the oxidative stress by super oxide.

关键词： New Charged Water Hydrotherapy Peripheral Leukocyte Leukocyte Subsets Ratio Diabetes Meritesanti-Oxidative Activity CAM