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Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury

World Journal of Gastroenterology 2015年第35期21卷 10091-10103页

作者： Kazutaka Yoshida Yusuke Ushida Tomoko Ishijima Hiroyuki Suganuma Takahiro Inakuma nobuhiro yajima Keiko Abe Yuji Nakai Research and Development Division Kagome Co.Ltd. Department of Applied Biological Chemistry Graduate School of Agricultural and Life ScienceThe University of Tokyo Faculty of Contemporary Human Life Science Department of Food and NutritionTezukayama University Institute for Food Science Hirosaki University

AIM: To investigate the effects of broccoli sprout extract(BSEx) on liver gene expression and acute liver injury in the ***: First, the effects of BSEx on liver gene expression were examined. Male rats were divided into two groups. The Control group was fed the AIN-76 diet, and the BSEx group was fed the AIN-76 diet containing BSEx. After a 10-d feeding period, rats were sacrificed and their livers were used for DNA microarray and realtime reverse transcription-polymerase chain reaction(RT-PCR) analyses. Next, the effects of BSEx on acute liver injury were examined. In experiments using acute liver injury models, 1000 mg/kg acetaminophen(APAP) or 350 mg/kg D-galactosamine(D-Gal N) was used to induce injury. These male rats were divided into four groups: Control, BSEx, Inducer(APAP or D-Gal N), and Inducer+BSEx. The feeding regimens were identical for the two analyses. Twenty-four hours following APAP administration via p.o. or D-Gal N administration via i.p., rats were sacrificed to determine serum aspartate transaminase(AST) and alanine transaminase(ALT) levels, hepatic glutathione(GSH) and thiobarbituric acid-reactive substances accumulation and glutathioneS-transferase(GST) activity. RESULTS: Microarray and real-time RT-PCR analyses revealed that BSEx upregulated the expression of genes related to detoxification and glutathione synthesis in normal rat liver. The levels of AST(70.91 ± 15.74 IU/m L vs 5614.41 ± 1997.83 IU/m L, P < 0.05) and ALT(11.78 ± 2.08 IU/m L vs 1297.71 ± 447.33 IU/m L, P < 0.05) were significantly suppressed in the APAP + BSEx group compared with the APAP group. The level of GSH(2.61 ± 0.75 nmol/g tissue vs 1.66 ± 0.59 nmol/g tissue, P < 0.05) and liver GST activity(93.19 ± 16.55 U/g tissue vs 51.90 ± 16.85 U/g tissue, P < 0.05) were significantly increased in the APAP + BSEx group compared with the APAP group. AST(4820.05 ± 3094.93 IU/m L vs 12465.63 ± 3223.97 IU/m L, P < 0.05) and ALT(1808.95 ± 1014.04 IU/m L vs 3936.46 ± 777.52 IU/

关键词： Broccoli sprout Galactosamine Acute liver injury G

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Removal of hexavalent chromium from water by Z-scheme photocatalysis using TiO_(2)(rutile)nanorods loaded with Au core-Cu_(2)0 shell particles

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Journal of Environmental Sciences 2022年第5期34卷 173-189页

作者： Sayaka Yanagida Takumi yajima Takahiro Takei nobuhiro Kumada Center for Crystal Science and Technology University of YamanashiKofu 400-8511Japan Advanced Materials Development Sector Tokyo Metropolitan Industrial Technology Research Institute2-4-10AomiKoto-kuTokyo 135-0064Japan

All-solid-state Z-scheme photocatalysts,containing Cu_(2)O,TiO_(2)(rutile),and Au as the elec-tron mediator,were prepared and applied to the reduction of Cr(Ⅵ)in aqueous *** Cu_(2)O-Au-TiO_(2) composites were prepared by loading Au core-Cu_(2)O shell hemisphere particles on TiO_(2)(rutile)nanorods using a two-step photocatalytic deposition ***-der ultraviolet-visible(UV-vis)light illumination,the Cu_(2)O-Au-TiO_(2) composites exhibited higher photocatalytic Cr(Ⅵ)reduction activities than those exhibited by single TiO_(2)(rutile)and Cu_(2)*** this reaction,a precipitate containing Cr,which was considered to be Cr(OH)_(3),was deposited site-selectively on the Au core-Cu_(2)O shell particles of the composites,indi-cating that the reduction site of the composite was Cu_(2)O,and the reaction proceeded accord-ing to the *** Cu_(2)O-Au-TiO_(2) composites also exhibited photocatalytic activity under visible light *** oxidation state of Cu in the Cu_(2)O-Au-TiO_(2) composite gradually changed from Cu(Ⅰ)to Cu(Ⅱ)during the photocatalytic Cr(Ⅵ)*** the composite maintained its high photocatalytic performance even after *** role of Au in the Cu_(2)O-Au-TiO_(2) composite was examined by comparing the properties of the Cu_(2)O-Au-TiO_(2) composite with those of the Cu_(2)O-TiO_(2) composite prepared via direct Cu_(2)O deposition on TiO_(2).

关键词： Cu_(2)O TiO_(2)(rutile) Z-scheme Photocatalyst Chromium

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