检索结果-南通市图书馆

检索条件"作者=noboru MAnABE"

共 3 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

ROLE OF RECEPTOR-DEPENDENT APOPTOSIS SYSTEM ON REGULATION OF FOLLICULAR ATRESIA IN PIG OVARY

ROLE OF RECEPTOR-DEPENDENT APOPTOSIS SYSTEM ON REGULATION OF...

引用

中国畜牧兽医学会动物繁殖学分会第十五届学术研讨会

作者： Yasufumi GOTO Ichiro ONOYAMA noboru manabe Animal Resource Science Center and Research Center for Food Safety The University of TokyoJapan

Several hundred thousand primordial follicles are present in the mammalian ovary,however,only a limited number develop to the preovulatory stage,and then finally *** others,more than 99%,will be eliminated via a degenerative process called"atresia".The endocrinological regulatory mechanisms involved in follicular development and atresia have been characterized to a large extent,but the precise temporal and molecular mechanisms involved in the regulation of these events have remained *** many recent studies,it is suggested that the apoptosis in ovarian granulosa cells plays a crucial role in follicular atresia. Notably,death ligand and receptor interaction and subsequent intracellular signaling have been demonstrated to be the key mechanisms regulating granulosa cell ***,we provide an overview of granulosa cell apoptosis regulated by death ligand-receptor signaling in pig *** roles of death ligands and receptors[Fas ligand (FasL)-Fas,tumor necrosis factor(TNF)α-TNF receptor(TNFR),and TNFa-related apoptosis-inducing ligand (TRAIL)-TRAIL receptor(TRAILR)]and intracellular death-signal mediators[Fas-associated death domain protein(FADD),TNF receptor 1-associated death domain protein(TRADD),caspases,apoptotic protease-activating factor 1(Apaf1),TNFR-associated factor 2(TRAF2),and cellular FLICE-like inhibitory protein(cFLIP) etc.]in granulosa cells of each follicle will be discussed.

关键词： Apoptosis Apoptosis inhibitingfactor Cell death ligand and receptor Follicular atresia Pig

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

WEEKLY CYCLICAL OVULATION COULD BE MADE BY PGF2α INJECTION IN RUMINANTS

WEEKLY CYCLICAL OVULATION COULD BE MADE BY PGF2α INJECTION ...

引用

中国畜牧兽医学会动物繁殖学分会第十五届学术研讨会

作者： A.K.M Ahsan KABIR noboru manabe Animal Resource Science Center Graduate School of Agricultural and Life Sciences

Follicular growth of ruminant species occurs more than once during an estrous cycle either resulting in ovulation(ovulatory follicular wave) or not resulting in ovulation(latent follicular wave).Using Shiba-goats,we examined if ovulation could be induced from every latent follicular wave and if the resulting ova were *** follicular development was monitored daily by transrectal ultrasonographic examination in 20 female goats for 2 consecutive estrous *** the second spontaneous ovulation(day 0=ovulation),all animals were each treated with a luteoiytic dose of prostaglandin F(PGF) on days 3 and 4,which resulted in ovulation from the first latent *** males goats(n=2) were immediately introduced to the first group of animals(n=5),resulting in 4 *** the second group of goats(n=9),4 consecutive short estrous cycles were induced by the PGF treatment at a mean interval of 6.5±1.2 days with a range of 4-9 *** of 9 goats were allowed to mate following 4 consecutive short ovulatory cycles;normal behavioral estrus was observed at each estrus,and four of five animals became *** remaining goats(n=6),in addition to PGF treatment,received exogenous progesterone supplement which allowed latent follicular development to occur,but prevented ovulation until the effect of progesterone supplement subsided. These results suggest that female Shiba-goats possess physiological mechanisms for final steps of follicular maturation and subsequent ovulation at short intervals when progesterone production from the newly developed corpus luteum is terminated.

关键词： Follicular wave Ovulation Progesterone Prostaglandin F2α(PGF2α) Goat

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

CHARACTERISTICS OF PRION,BOVINE SPONGIFORM ENCEPHALOPATHY PATHOGEN,GENE KNOCKOUT COWS

CHARACTERISTICS OF PRION,BOVINE SPONGIFORM ENCEPHALOPATHY PA...

引用

中国畜牧兽医学会动物繁殖学分会第十五届学术研讨会

作者： noboru manabe Ichiro ONOYAMA Yasufumi GOTO Takashi ONODERA Yasuhiro YOSHIKAWA Yutaka SENDAI Yoshito AOYAGI Animal Resource Science Center and Research Center for Food Safety The University of Tokyo

Prion(Pr) protein plays a pivotal role in the infection of bovine spongiform encephalopathy(BSE). The aim of the present research was to make Pr gene knockout(KO) cows,which lack Pr mRNA or protein,and to reveal their characteristics for estimating the *** were successful in production of Pr gene homo KO Japanese Black cows using leading-edge genetic engineering techniques,cell culture techniques and animal reproductive techniques(somatic cell nuclear transfer:SCNT and so on) as follows:Firstly,hetero Pr gene was knockouted in fibroblastic cells derived from bovine *** somatic cell nucleus with hetero Pr gene KO was transferred into oocyte without germinal vesicle(GV).After activation and in vitro culture,somatic cell nucleus of the somatic cell nuclear cloning embryo at blastocyst stage was pulled out and transferred into oocyte without GV to make homo Pr gene KO *** homo Pr gene KO embryos were transferred in to the uterus. In the present meeting,we would like to show and discuss the procedure to make Pr gene homo KO cows and their usefulness,and to propose the importance of animal biotechnological techniques on food safety and public ***,detailed data of Pr distribution in organs of somatic cell nuclear cloning Japanese Black cows (used as controls) will be demonstrated as follows:A sandwich enzyme linked immunosorbent assay(ELISA) revealed that high levels of Pr proteinrotein(9.0-11.0μg/g wet tissue) was demonstrated in brain of somatic cell nuclear transfer-cows(wild-type control animals).Lower levels of Pr proteinrotein were shown in other organs as follows in decreasing order:skeletal muscles(longissimus,iliocostalis thoracis,splenius,femoris biceps,triceps brachii,longissimus thoracis and omotransversarius muscles),intestinal tracts(ileum,jejunum,duodenum,colon and cecum) and tongue(apex,posterior,anterior and radix areas)(approx.5.0-to 31.0-fold less Pr proteinrotein than the brain).Immunohistochemical analyses showed t

关键词： Bovine spongiform encephalopathy(BSE) Japanese black cow Prion(Pr) protein Pr gene homo knockout(KO)

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：